Saliva in the diagnosis of diseases.

Abstract:

:Saliva is secreted from the salivary glands and has multiple functions, including mouth cleaning and protection, antibacterial effects and digestion. With the rapid advancement in salivaomics, saliva is well recognized as a pool of biological markers. Saliva, as a non-invasive and safe source, could be a substitute for blood in the diagnosis and prognosis of diseases. This review summarizes the latest advancements in saliva-related studies and addresses the potential value of saliva in the early diagnosis of oral diseases, such as dental caries and periodontal disease, as well as cancer, diabetes and other systemic disorders. Saliva biomarkers range from changes in the biochemical indices of DNA, RNA and proteins to the diversification of microbiota structures. This study integrates data reported in the recent literature and discusses the clinical significance and prospects for the application of saliva in the early diagnosis of diseases, translational medicine and precision medicine.

journal_name

Int J Oral Sci

authors

Zhang CZ,Cheng XQ,Li JY,Zhang P,Yi P,Xu X,Zhou XD

doi

10.1038/ijos.2016.38

subject

Has Abstract

pub_date

2016-09-29 00:00:00

pages

133-7

issue

3

eissn

1674-2818

issn

2049-3169

pii

ijos201638

journal_volume

8

pub_type

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