Abstract:
:Saliva is secreted from the salivary glands and has multiple functions, including mouth cleaning and protection, antibacterial effects and digestion. With the rapid advancement in salivaomics, saliva is well recognized as a pool of biological markers. Saliva, as a non-invasive and safe source, could be a substitute for blood in the diagnosis and prognosis of diseases. This review summarizes the latest advancements in saliva-related studies and addresses the potential value of saliva in the early diagnosis of oral diseases, such as dental caries and periodontal disease, as well as cancer, diabetes and other systemic disorders. Saliva biomarkers range from changes in the biochemical indices of DNA, RNA and proteins to the diversification of microbiota structures. This study integrates data reported in the recent literature and discusses the clinical significance and prospects for the application of saliva in the early diagnosis of diseases, translational medicine and precision medicine.
journal_name
Int J Oral Scijournal_title
International journal of oral scienceauthors
Zhang CZ,Cheng XQ,Li JY,Zhang P,Yi P,Xu X,Zhou XDdoi
10.1038/ijos.2016.38subject
Has Abstractpub_date
2016-09-29 00:00:00pages
133-7issue
3eissn
1674-2818issn
2049-3169pii
ijos201638journal_volume
8pub_type
杂志文章,评审abstract::In this study, we evaluate the influence of post surface pre-treatments on the bond strength of four different cements to glass fiber posts. Eighty extracted human maxillary central incisors and canines were endodontically treated and standardized post spaces were prepared. Four post pre-treatments were tested: (i) no...
journal_title:International journal of oral science
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pub_type: 杂志文章,评审
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