Abstract:
:Bone defects caused by trauma, tumour resection, infection and congenital deformities, together with articular cartilage defects and cartilage-subchondral bone complex defects caused by trauma and degenerative diseases, remain great challenges for clinicians. Novel strategies utilising cell sheet technology to enhance bone and cartilage regeneration are being developed. The cell sheet technology has shown great clinical potential in regenerative medicine due to its effective preservation of cell-cell connections and extracellular matrix and its scaffold-free nature. This review will first introduce several widely used cell sheet preparation systems, including traditional approaches and recent improvements, as well as their advantages and shortcomings. Recent advances in utilising cell sheet technology to regenerate bone or cartilage defects and bone-cartilage complex defects will be reviewed. The key challenges and future research directions for the application of cell sheet technology in bone and cartilage regeneration will also be discussed.
journal_name
Int J Oral Scijournal_title
International journal of oral scienceauthors
Lu Y,Zhang W,Wang J,Yang G,Yin S,Tang T,Yu C,Jiang Xdoi
10.1038/s41368-019-0050-5subject
Has Abstractpub_date
2019-05-21 00:00:00pages
17issue
2eissn
1674-2818issn
2049-3169pii
10.1038/s41368-019-0050-5journal_volume
11pub_type
杂志文章,评审abstract::To evaluate the feasibility and accuracy of a three-dimensional augmented reality system incorporating integral videography for imaging oral and maxillofacial regions, based on preoperative computed tomography data. Three-dimensional surface models of the jawbones, based on the computed tomography data, were used to c...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.1038/ijos.2013.26
更新日期:2013-06-01 00:00:00
abstract::The oral microbial community is widely regarded as a latent reservoir of antibiotic resistance genes. This study assessed the molecular epidemiology, susceptibility profile, and resistance mechanisms of 35 methicillin-resistant Staphylococcus epidermidis (MRSE) strains isolated from the dental plaque of a healthy huma...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.1038/s41368-020-0079-5
更新日期:2020-05-09 00:00:00
abstract::Tooth development is a complex process that involves precise and time-dependent orchestration of multiple genetic, molecular, and cellular interactions. Ameloblastin (AMBN, also named "amelin" or "sheathlin") is the second most abundant enamel matrix protein known to have a key role in amelogenesis. Amelogenesis imper...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.1038/s41368-018-0027-9
更新日期:2018-09-03 00:00:00
abstract::Apoptosis or programmed cell death plays an essential role in chemotherapy-induced tumor cell killing, and inducers of apoptosis are commonly used in cancer therapy. Treatment with Zelkova serrata extracts was performed in human gingival fibroblast (HGF), mouth epidermoid carcinoma cell (KB), lower gingival squamous c...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.1038/ijos.2012.14
更新日期:2012-06-01 00:00:00
abstract::Bacterial biofilms can be viewed as a specific type of persistent bacterial infection. After initial invasion, microbes can attach to living and non-living surfaces, such as prosthetics and indwelling medical devices, and form a biofilm composed of extracellular polysaccharides, proteins, and other components. In host...
journal_title:International journal of oral science
pub_type: 杂志文章,评审
doi:10.4248/IJOS11022
更新日期:2011-04-01 00:00:00
abstract::A previous study demonstrated that alexidine has greater affinity for the major virulence factors of bacteria than chlorhexidine. The aim of this study was to compare the antimicrobial activity of 1% alexidine with that of 2% chlorhexidine using Enterococcus faecalis-infected dentin blocks. Sixty bovine dentin blocks ...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.1038/ijos.2013.11
更新日期:2013-03-01 00:00:00
abstract::Optical spectroscopy devices are being developed and tested for the screening and diagnosis of oral precancer and cancer lesions. This study reports a device that uses white light for detection of suspicious lesions and green-amber light at 545 nm that detect tissue vascularity on patients with several suspicious oral...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.1038/ijos.2014.39
更新日期:2014-09-01 00:00:00
abstract::Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the per...
journal_title:International journal of oral science
pub_type: 杂志文章,评审
doi:10.1038/ijos.2017.1
更新日期:2017-03-01 00:00:00
abstract:AIM:The purpose of this study is to compare the effects of the two clutches on recording the condylar movement. METHODOLOGY:Ten subjects (6 women, 4 men; mean age 25.4 years) participated in the study. The mandibular movement, sagittal condylar inclination angle, and transversal condylar inclination angle of each subj...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.4248/IJOS10071
更新日期:2010-12-01 00:00:00
abstract::The aim of the present real time in vivo micro-computed tomography (µCT) and histologic experiment was to assess the efficacy of guided bone regeneration (GBR) around standardized calvarial critical size defects (CSD) using bone marrow-derived mesenchymal stem cells (BMSCs), and collagen membrane (CM) with and without...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.1038/ijos.2015.34
更新日期:2016-03-30 00:00:00
abstract::It is known that human papillomavirus (HPV) infection can cause squamous cell neoplasms at several sites, such as cervix uteri carcinoma and oral squamous carcinoma. There is little information on the expression of HPV and its predictive markers in tumours of the major and minor salivary glands of the head and neck. W...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.1038/ijos.2014.28
更新日期:2015-03-23 00:00:00
abstract::By removing a part of the structure, the tooth preparation provides restorative space, bonding surface, and finish line for various restorations on abutment. Preparation technique plays critical role in achieving the optimal result of tooth preparation. With successful application of microscope in endodontics for >30 ...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.1038/s41368-019-0057-y
更新日期:2019-10-02 00:00:00
abstract::Saliva is secreted from the salivary glands and has multiple functions, including mouth cleaning and protection, antibacterial effects and digestion. With the rapid advancement in salivaomics, saliva is well recognized as a pool of biological markers. Saliva, as a non-invasive and safe source, could be a substitute fo...
journal_title:International journal of oral science
pub_type: 杂志文章,评审
doi:10.1038/ijos.2016.38
更新日期:2016-09-29 00:00:00
abstract:AIM:To investigate the effect of DAPT (gamma-secretase inhibitor) on the growth of human tongue carcinoma cells and to determine the molecular mechanism to enable the potential application of DAPT to the treatment of tongue carcinoma. METHODOLOGY:Human tongue carcinoma Tca8113 cells were cultured with DAPT. Cell growt...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.4248/ijos.08025
更新日期:2009-06-01 00:00:00
abstract::The human microbiome functions as an intricate and coordinated microbial network, residing throughout the mucosal surfaces of the skin, oral cavity, gastrointestinal tract, respiratory tract, and reproductive system. The oral microbiome encompasses a highly diverse microbiota, consisting of over 700 microorganisms, in...
journal_title:International journal of oral science
pub_type: 杂志文章,评审
doi:10.1038/s41368-020-0082-x
更新日期:2020-04-30 00:00:00
abstract::Bone remodelling keeps going through the lifespan of human by bone formation and bone resorption. In the craniofacial region, mandibles act as the main force for biting and chewing, and also become susceptible to a common bone-loss disease, namely, apical periodontitis, once infected dental pulp is not treated timely,...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.1038/s41368-019-0058-x
更新日期:2019-08-26 00:00:00
abstract::To modify two-step experimental etch-and-rinse dentin adhesive with different concentrations of riboflavin and to study its effect on the bond strength, degree of conversion, along with resin infiltration within the demineralized dentin substrate, an experimental adhesive-system was modified with different concentrati...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.1038/ijos.2014.49
更新日期:2015-06-26 00:00:00
abstract::Sites of implantation with compromised biology may be unable to achieve the required level of angiogenic and osteogenic regeneration. The specific function and contribution of different cell types to the formation of prevascularized, osteogenic networks in co-culture remains unclear. To determine how bone marrow-deriv...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.1038/ijos.2016.39
更新日期:2016-12-16 00:00:00
abstract::Tooth decay is prevalent, and secondary caries causes restoration failures, both of which are related to demineralization. There is an urgent need to develop new therapeutic materials with remineralization functions. This article represents the first review on the cutting edge research of poly(amido amine) (PAMAM) in ...
journal_title:International journal of oral science
pub_type: 杂志文章,评审
doi:10.1038/s41368-019-0048-z
更新日期:2019-05-09 00:00:00
abstract::Osteoporosis is a serious public bone metabolic disease. However, the mechanisms underlying bone loss combined with ageing, which is known as senile osteoporosis, remains unknown. Here we show the detailed phenotype of this disease caused by SIRT6 knock out (KO) in mice. To the best of our knowledge, this is the first...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.1038/ijos.2015.57
更新日期:2016-06-30 00:00:00
abstract::Effective control of oral biofilm infectious diseases represents a major global challenge. Microorganisms in biofilms exhibit increased drug tolerance compared with planktonic cells. The present review covers innovative antimicrobial strategies for controlling oral biofilm-related infections published predominantly ov...
journal_title:International journal of oral science
pub_type: 杂志文章,评审
doi:10.1038/s41368-019-0062-1
更新日期:2019-10-01 00:00:00
abstract::Formation of the periodontium begins following onset of tooth-root formation in a coordinated manner after birth. Dental follicle progenitor cells are thought to form the cementum, alveolar bone and Sharpey's fibers of the periodontal ligament (PDL). However, little is known about the regulatory morphogens that contro...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.1038/ijos.2013.41
更新日期:2013-06-01 00:00:00
abstract::All-trans retinoic acid (ATRA) inhibits matrix metalloproteinase (MMP)-2 and MMP-9 in synovial fibroblasts, skin fibroblasts, bronchoalveolar lavage cells and cancer cells, but activates MMP-9 in neuroblast and leukemia cells. Very little is known regarding whether ATRA can activate or inhibit MMPs in human dental pul...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.1038/ijos.2013.63
更新日期:2014-09-01 00:00:00
abstract:AIM:To evaluate the effect of single or dual field irradiation (IR) with the same dose on damage to miniature pig parotid glands. METHODOLOGY:Sixteen miniature pigs were divided into two IR groups (n=6) and a control group (n=4). The irradiation groups were subjected to 20 Gy X-radiation to one parotid gland using sin...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.4248/ijos.08001
更新日期:2009-03-01 00:00:00
abstract::Halitosis, bad breath or oral malodour are all synonyms for the same pathology. Halitosis has a large social and economic impact. For the majority of patients suffering from bad breath, it causes embarrassment and affects their social communication and life. Moreover,halitosis can be indicative of underlying diseases....
journal_title:International journal of oral science
pub_type: 杂志文章,评审
doi:10.1038/ijos.2012.39
更新日期:2012-06-01 00:00:00
abstract::The presence of a large palatal or maxillary defect after partial or total maxillectomy for tumor, trauma or congenital deformation poses a challenge to prosthodontists, particularly when the use of an implant cannot be considered. This case report described the use of an air valve in a hollow silicone obturator to ma...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.1038/ijos.2012.22
更新日期:2012-06-01 00:00:00
abstract::Dental caries are the most prevalent chronic infections in the oral cavity, and Streptococcus mutans acts as the main cariogenic bacterial species. Antibacterial quaternary ammonium compounds (QAs) have been developed to preveFnt or treat dental caries. However, there is no report on the tolerance of S. mutans to QAs....
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.1038/ijos.2017.46
更新日期:2017-12-01 00:00:00
abstract::This in vitro study aims to evaluate the crystal and surface microstructure of dental enamel after cold-light bleaching treatment. Twelve sound human premolars were cross-split into four specimens, namely, mesio-buccal (Group LP), disto-buccal (Group P), mesio-lingual (Group NP) and disto-lingual (Group L) specimens. ...
journal_title:International journal of oral science
pub_type: 杂志文章,随机对照试验
doi:10.1038/ijos.2012.70
更新日期:2012-12-01 00:00:00
abstract::The aim of this study was to evaluate the biological efficacy of a unique perpendicular protrusion of type-I collagen (Col-I) from TiO2 nanotubes (NT-EPF surface). We hypothesized that the NT-EPF surface would play bifunctional roles in stimulating platelet-mediated fibroblast recruitment and anchoring fibroblast-deri...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.1038/s41368-020-00103-3
更新日期:2020-12-30 00:00:00
abstract::This study aimed to compare epithelial cells derived from human embryonic stem cells (hESCs) to human ameloblast-lineage cells (ALCs), as a way to determine their potential use as a cell source for ameloblast regeneration. Induced by various concentrations of bone morphogenetic protein 4 (BMP4), retinoic acid (RA) and...
journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.1038/ijos.2013.14
更新日期:2013-03-01 00:00:00