Abstract：
:Apoptosis or programmed cell death plays an essential role in chemotherapy-induced tumor cell killing, and inducers of apoptosis are commonly used in cancer therapy. Treatment with Zelkova serrata extracts was performed in human gingival fibroblast (HGF), mouth epidermoid carcinoma cell (KB), lower gingival squamous cancer cell (YD38) and tongue mucoepidermoid carcinoma cells (YD15). We observed that extract prepared from Zelkova serrata twig selectively inhibited proliferation of various oral cancer cells, but not normal gingival fibroblasts, in a dose-dependent manner. Caspase-8-mediated apoptosis was induced by treatment with the extract only in mouth epidermoid carcinoma and not in other types of cancer cells, including lower gingival squamous cell carcinoma. The selective apoptotic effect of Zelkova serrata twig extract in mouth epidermoid carcinoma was dependent on normal p53 status. Apoptosis was not remarkably induced by treatment with the extract in either lower gingival squamous or tongue mucoepidermoid carcinoma cells, both of which contain abnormalities of p53. Upon treatment with Zelkova serrata twig extract, mouth epidermoid carcinoma cells accumulated in S phase by activation of p21. These data indicate that Zelkova serrata twig extract exerted a cancer type-specific, p53-dependent apoptotic effect and disturbed the cell cycle, which suggests that herbal medicine could be a treatment for specific types of cancers.
journal_name
Int J Oral Scijournal_title
International journal of oral scienceauthors
Kang HJ,Jang YJdoi
10.1038/ijos.2012.14subject
Has Abstractpub_date
2012-06-01 00:00:00pages
78-84issue
2eissn
1674-2818issn
2049-3169pii
ijos201214journal_volume
4pub_type
杂志文章abstract：:Tooth decay is prevalent, and secondary caries causes restoration failures, both of which are related to demineralization. There is an urgent need to develop new therapeutic materials with remineralization functions. This article represents the first review on the cutting edge research of poly(amido amine) (PAMAM) in ...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/s41368-019-0048-z
更新日期：2019-05-09 00:00:00
abstract：:Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the per...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/ijos.2017.1
更新日期：2017-03-01 00:00:00
abstract：:Retention wires permanently bonded to the anterior teeth are used after orthodontic treatment to prevent the teeth from relapsing to pre-treatment positions. A disadvantage of bonded retainers is biofilm accumulation on the wires, which produces a higher incidence of gingival recession, increased pocket depth and blee...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2014.69
更新日期：2015-03-23 00:00:00
abstract：:Halitosis, bad breath or oral malodour are all synonyms for the same pathology. Halitosis has a large social and economic impact. For the majority of patients suffering from bad breath, it causes embarrassment and affects their social communication and life. Moreover,halitosis can be indicative of underlying diseases....
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/ijos.2012.39
更新日期：2012-06-01 00:00:00
abstract：:Dental caries are the most prevalent chronic infections in the oral cavity, and Streptococcus mutans acts as the main cariogenic bacterial species. Antibacterial quaternary ammonium compounds (QAs) have been developed to preveFnt or treat dental caries. However, there is no report on the tolerance of S. mutans to QAs....
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2017.46
更新日期：2017-12-01 00:00:00
abstract：:Tooth development is a complex process that involves precise and time-dependent orchestration of multiple genetic, molecular, and cellular interactions. Ameloblastin (AMBN, also named "amelin" or "sheathlin") is the second most abundant enamel matrix protein known to have a key role in amelogenesis. Amelogenesis imper...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/s41368-018-0027-9
更新日期：2018-09-03 00:00:00
abstract：:In this study, we evaluate the influence of post surface pre-treatments on the bond strength of four different cements to glass fiber posts. Eighty extracted human maxillary central incisors and canines were endodontically treated and standardized post spaces were prepared. Four post pre-treatments were tested: (i) no...
journal_title：International journal of oral science
pub_type： 杂志文章,随机对照试验
doi：10.1038/ijos.2013.83
更新日期：2014-03-01 00:00:00
abstract：:The aim of this study was to evaluate the biological efficacy of a unique perpendicular protrusion of type-I collagen (Col-I) from TiO2 nanotubes (NT-EPF surface). We hypothesized that the NT-EPF surface would play bifunctional roles in stimulating platelet-mediated fibroblast recruitment and anchoring fibroblast-deri...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/s41368-020-00103-3
更新日期：2020-12-30 00:00:00
abstract：:The aim of the present real time in vivo micro-computed tomography (µCT) and histologic experiment was to assess the efficacy of guided bone regeneration (GBR) around standardized calvarial critical size defects (CSD) using bone marrow-derived mesenchymal stem cells (BMSCs), and collagen membrane (CM) with and without...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2015.34
更新日期：2016-03-30 00:00:00
abstract：AIM:The purpose of this study is to compare the effects of the two clutches on recording the condylar movement. METHODOLOGY:Ten subjects (6 women, 4 men; mean age 25.4 years) participated in the study. The mandibular movement, sagittal condylar inclination angle, and transversal condylar inclination angle of each subj...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.4248/IJOS10071
更新日期：2010-12-01 00:00:00
abstract：:Dentin matrix metalloproteinases (MMPs) are a family of host-derived proteolytic enzymes trapped within mineralized dentin matrix, which have the ability to hydrolyze the organic matrix of demineralized dentin. After bonding with resins to dentin there are usually some exposed collagen fibrils at the bottom of the hyb...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.4248/IJOS.09044
更新日期：2009-12-01 00:00:00
abstract：:It is known that human papillomavirus (HPV) infection can cause squamous cell neoplasms at several sites, such as cervix uteri carcinoma and oral squamous carcinoma. There is little information on the expression of HPV and its predictive markers in tumours of the major and minor salivary glands of the head and neck. W...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2014.28
更新日期：2015-03-23 00:00:00
abstract：:Although a few studies have shown that vascularity is increased from normal mucosa to dysplasia to carcinoma suggesting that disease progression in the oral mucosa is accompanied by angiogenesis. The role in lymph node metastasis in oral squamous cell carcinoma (OSCC) is equivocal. Role of angiogenesis in OSCC develop...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.4248/IJOS11077
更新日期：2011-10-01 00:00:00
abstract：:Bone defects caused by trauma, tumour resection, infection and congenital deformities, together with articular cartilage defects and cartilage-subchondral bone complex defects caused by trauma and degenerative diseases, remain great challenges for clinicians. Novel strategies utilising cell sheet technology to enhance...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/s41368-019-0050-5
更新日期：2019-05-21 00:00:00
abstract：:The human microbiome functions as an intricate and coordinated microbial network, residing throughout the mucosal surfaces of the skin, oral cavity, gastrointestinal tract, respiratory tract, and reproductive system. The oral microbiome encompasses a highly diverse microbiota, consisting of over 700 microorganisms, in...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/s41368-020-0082-x
更新日期：2020-04-30 00:00:00
abstract：:Effective control of oral biofilm infectious diseases represents a major global challenge. Microorganisms in biofilms exhibit increased drug tolerance compared with planktonic cells. The present review covers innovative antimicrobial strategies for controlling oral biofilm-related infections published predominantly ov...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/s41368-019-0062-1
更新日期：2019-10-01 00:00:00
abstract：:The aim of the study was a determination of the levels of nitric oxide (NO) and its biological markers such as malonyldialdehyde (MDA) and nitrotyrosine in the serum of patients with squamous cell carcinoma (SCC) of the oral cavity and identification of the relationships between NO and those markers. These studies wer...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2013.59
更新日期：2013-09-01 00:00:00
abstract：:Bacterial biofilms can be viewed as a specific type of persistent bacterial infection. After initial invasion, microbes can attach to living and non-living surfaces, such as prosthetics and indwelling medical devices, and form a biofilm composed of extracellular polysaccharides, proteins, and other components. In host...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.4248/IJOS11022
更新日期：2011-04-01 00:00:00
abstract：:Optical spectroscopy devices are being developed and tested for the screening and diagnosis of oral precancer and cancer lesions. This study reports a device that uses white light for detection of suspicious lesions and green-amber light at 545 nm that detect tissue vascularity on patients with several suspicious oral...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2014.39
更新日期：2014-09-01 00:00:00
abstract：:Biofilms at the tooth-restoration bonded interface can produce acids and cause recurrent caries. Recurrent caries is a primary reason for restoration failures. The objectives of this study were to synthesize a novel bioactive dental bonding agent containing dimethylaminohexadecyl methacrylate (DMAHDM) and 2-methacrylo...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/s41368-018-0019-9
更新日期：2018-06-21 00:00:00
abstract：:Osteoporosis is a serious public bone metabolic disease. However, the mechanisms underlying bone loss combined with ageing, which is known as senile osteoporosis, remains unknown. Here we show the detailed phenotype of this disease caused by SIRT6 knock out (KO) in mice. To the best of our knowledge, this is the first...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2015.57
更新日期：2016-06-30 00:00:00
abstract：:Both bone morphogenetic protein 2 (BMP2) and the wingless-type MMTV integration site (WNT)/β-catenin signalling pathway play important roles in odontoblast differentiation and dentinogenesis. Cross-talk between BMP2 and WNT/β-catenin in osteoblast differentiation and bone formation has been identified. However, the ro...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2015.7
更新日期：2015-06-26 00:00:00
abstract：:For a long time, oral disease is one of the major problems of the public health for its high prevalence and incidence throughout the world, which is especially true for low-income populations. Since China's economic reform in 1978, great changes have taken place in China. These changes have significant impact on and h...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.4248/IJOS11006
更新日期：2011-01-01 00:00:00
abstract：:A previous study demonstrated that alexidine has greater affinity for the major virulence factors of bacteria than chlorhexidine. The aim of this study was to compare the antimicrobial activity of 1% alexidine with that of 2% chlorhexidine using Enterococcus faecalis-infected dentin blocks. Sixty bovine dentin blocks ...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2013.11
更新日期：2013-03-01 00:00:00
abstract：AIM:To investigate the effect of DAPT (gamma-secretase inhibitor) on the growth of human tongue carcinoma cells and to determine the molecular mechanism to enable the potential application of DAPT to the treatment of tongue carcinoma. METHODOLOGY:Human tongue carcinoma Tca8113 cells were cultured with DAPT. Cell growt...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.4248/ijos.08025
更新日期：2009-06-01 00:00:00
abstract：:To modify two-step experimental etch-and-rinse dentin adhesive with different concentrations of riboflavin and to study its effect on the bond strength, degree of conversion, along with resin infiltration within the demineralized dentin substrate, an experimental adhesive-system was modified with different concentrati...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2014.49
更新日期：2015-06-26 00:00:00
abstract：:Formation of the periodontium begins following onset of tooth-root formation in a coordinated manner after birth. Dental follicle progenitor cells are thought to form the cementum, alveolar bone and Sharpey's fibers of the periodontal ligament (PDL). However, little is known about the regulatory morphogens that contro...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2013.41
更新日期：2013-06-01 00:00:00
abstract：:After teeth are replanted, there are two possible healing responses: periodontal ligament healing or ankylosis with subsequent replacement resorption. The purpose of this study was to compare the fatigue resistance of vertically fractured teeth after bonding the fragments under conditions simulating both healing modes...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2014.51
更新日期：2015-06-26 00:00:00
abstract：:By removing a part of the structure, the tooth preparation provides restorative space, bonding surface, and finish line for various restorations on abutment. Preparation technique plays critical role in achieving the optimal result of tooth preparation. With successful application of microscope in endodontics for >30 ...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/s41368-019-0057-y
更新日期：2019-10-02 00:00:00
abstract：:This study aimed to compare epithelial cells derived from human embryonic stem cells (hESCs) to human ameloblast-lineage cells (ALCs), as a way to determine their potential use as a cell source for ameloblast regeneration. Induced by various concentrations of bone morphogenetic protein 4 (BMP4), retinoic acid (RA) and...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2013.14
更新日期：2013-03-01 00:00:00
