Abstract：
:The human microbiome functions as an intricate and coordinated microbial network, residing throughout the mucosal surfaces of the skin, oral cavity, gastrointestinal tract, respiratory tract, and reproductive system. The oral microbiome encompasses a highly diverse microbiota, consisting of over 700 microorganisms, including bacteria, fungi, and viruses. As our understanding of the relationship between the oral microbiome and human health has evolved, we have identified a diverse array of oral and systemic diseases associated with this microbial community, including but not limited to caries, periodontal diseases, oral cancer, colorectal cancer, pancreatic cancer, and inflammatory bowel syndrome. The potential predictive relationship between the oral microbiota and these human diseases suggests that the oral cavity is an ideal site for disease diagnosis and development of rapid point-of-care tests. The oral cavity is easily accessible with a non-invasive collection of biological samples. We can envision a future where early life salivary diagnostic tools will be used to predict and prevent future disease via analyzing and shaping the infant's oral microbiome. In this review, we present evidence for the establishment of the oral microbiome during early childhood, the capability of using childhood oral microbiome to predict future oral and systemic diseases, and the limitations of the current evidence.
journal_name
Int J Oral Scijournal_title
International journal of oral scienceauthors
Xiao J,Fiscella KA,Gill SRdoi
10.1038/s41368-020-0082-xsubject
Has Abstractpub_date
2020-04-30 00:00:00pages
12issue
1eissn
1674-2818issn
2049-3169pii
10.1038/s41368-020-0082-xjournal_volume
12pub_type
杂志文章,评审abstract：:To evaluate the feasibility and accuracy of a three-dimensional augmented reality system incorporating integral videography for imaging oral and maxillofacial regions, based on preoperative computed tomography data. Three-dimensional surface models of the jawbones, based on the computed tomography data, were used to c...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2013.26
更新日期：2013-06-01 00:00:00
abstract：:Tooth development is a complex process that involves precise and time-dependent orchestration of multiple genetic, molecular, and cellular interactions. Ameloblastin (AMBN, also named "amelin" or "sheathlin") is the second most abundant enamel matrix protein known to have a key role in amelogenesis. Amelogenesis imper...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/s41368-018-0027-9
更新日期：2018-09-03 00:00:00
abstract：AIM:To examine what impact the loss of funding had on the utilization of the oral pathology service. METHODOLOGY:Biopsy records were retrieved and examined in the two year period before and after the elimination of the subsidies in 2003. RESULTS:After the loss of funding, there was a 31% decrease in the number of spe...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.4248/IJOS.09032
更新日期：2009-09-01 00:00:00
abstract：:Both bone morphogenetic protein 2 (BMP2) and the wingless-type MMTV integration site (WNT)/β-catenin signalling pathway play important roles in odontoblast differentiation and dentinogenesis. Cross-talk between BMP2 and WNT/β-catenin in osteoblast differentiation and bone formation has been identified. However, the ro...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2015.7
更新日期：2015-06-26 00:00:00
abstract：:Apoptosis or programmed cell death plays an essential role in chemotherapy-induced tumor cell killing, and inducers of apoptosis are commonly used in cancer therapy. Treatment with Zelkova serrata extracts was performed in human gingival fibroblast (HGF), mouth epidermoid carcinoma cell (KB), lower gingival squamous c...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2012.14
更新日期：2012-06-01 00:00:00
abstract：:All-trans retinoic acid (ATRA) inhibits matrix metalloproteinase (MMP)-2 and MMP-9 in synovial fibroblasts, skin fibroblasts, bronchoalveolar lavage cells and cancer cells, but activates MMP-9 in neuroblast and leukemia cells. Very little is known regarding whether ATRA can activate or inhibit MMPs in human dental pul...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2013.63
更新日期：2014-09-01 00:00:00
abstract：:A previous study demonstrated that alexidine has greater affinity for the major virulence factors of bacteria than chlorhexidine. The aim of this study was to compare the antimicrobial activity of 1% alexidine with that of 2% chlorhexidine using Enterococcus faecalis-infected dentin blocks. Sixty bovine dentin blocks ...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2013.11
更新日期：2013-03-01 00:00:00
abstract：AIM:The purpose of this study is to compare the effects of the two clutches on recording the condylar movement. METHODOLOGY:Ten subjects (6 women, 4 men; mean age 25.4 years) participated in the study. The mandibular movement, sagittal condylar inclination angle, and transversal condylar inclination angle of each subj...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.4248/IJOS10071
更新日期：2010-12-01 00:00:00
abstract：:This in vitro study aims to evaluate the crystal and surface microstructure of dental enamel after cold-light bleaching treatment. Twelve sound human premolars were cross-split into four specimens, namely, mesio-buccal (Group LP), disto-buccal (Group P), mesio-lingual (Group NP) and disto-lingual (Group L) specimens. ...
journal_title：International journal of oral science
pub_type： 杂志文章,随机对照试验
doi：10.1038/ijos.2012.70
更新日期：2012-12-01 00:00:00
abstract：:To modify two-step experimental etch-and-rinse dentin adhesive with different concentrations of riboflavin and to study its effect on the bond strength, degree of conversion, along with resin infiltration within the demineralized dentin substrate, an experimental adhesive-system was modified with different concentrati...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2014.49
更新日期：2015-06-26 00:00:00
abstract：:Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the per...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/ijos.2017.1
更新日期：2017-03-01 00:00:00
abstract：:Dentin matrix metalloproteinases (MMPs) are a family of host-derived proteolytic enzymes trapped within mineralized dentin matrix, which have the ability to hydrolyze the organic matrix of demineralized dentin. After bonding with resins to dentin there are usually some exposed collagen fibrils at the bottom of the hyb...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.4248/IJOS.09044
更新日期：2009-12-01 00:00:00
abstract：:Bone remodelling keeps going through the lifespan of human by bone formation and bone resorption. In the craniofacial region, mandibles act as the main force for biting and chewing, and also become susceptible to a common bone-loss disease, namely, apical periodontitis, once infected dental pulp is not treated timely,...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/s41368-019-0058-x
更新日期：2019-08-26 00:00:00
abstract：:Although a few studies have shown that vascularity is increased from normal mucosa to dysplasia to carcinoma suggesting that disease progression in the oral mucosa is accompanied by angiogenesis. The role in lymph node metastasis in oral squamous cell carcinoma (OSCC) is equivocal. Role of angiogenesis in OSCC develop...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.4248/IJOS11077
更新日期：2011-10-01 00:00:00
abstract：:Bone defects caused by trauma, tumour resection, infection and congenital deformities, together with articular cartilage defects and cartilage-subchondral bone complex defects caused by trauma and degenerative diseases, remain great challenges for clinicians. Novel strategies utilising cell sheet technology to enhance...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/s41368-019-0050-5
更新日期：2019-05-21 00:00:00
abstract：:Retention wires permanently bonded to the anterior teeth are used after orthodontic treatment to prevent the teeth from relapsing to pre-treatment positions. A disadvantage of bonded retainers is biofilm accumulation on the wires, which produces a higher incidence of gingival recession, increased pocket depth and blee...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2014.69
更新日期：2015-03-23 00:00:00
abstract：:The root is crucial for the physiological function of the tooth, and a healthy root allows an artificial crown to function as required clinically. Tooth crown development has been studied intensively during the last few decades, but root development remains not well understood. Here we review the root development proc...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/ijos.2012.61
更新日期：2012-12-01 00:00:00
abstract：:This study aimed to compare epithelial cells derived from human embryonic stem cells (hESCs) to human ameloblast-lineage cells (ALCs), as a way to determine their potential use as a cell source for ameloblast regeneration. Induced by various concentrations of bone morphogenetic protein 4 (BMP4), retinoic acid (RA) and...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2013.14
更新日期：2013-03-01 00:00:00
abstract：:By removing a part of the structure, the tooth preparation provides restorative space, bonding surface, and finish line for various restorations on abutment. Preparation technique plays critical role in achieving the optimal result of tooth preparation. With successful application of microscope in endodontics for >30 ...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/s41368-019-0057-y
更新日期：2019-10-02 00:00:00
abstract：AIM:To investigate the effect of DAPT (gamma-secretase inhibitor) on the growth of human tongue carcinoma cells and to determine the molecular mechanism to enable the potential application of DAPT to the treatment of tongue carcinoma. METHODOLOGY:Human tongue carcinoma Tca8113 cells were cultured with DAPT. Cell growt...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.4248/ijos.08025
更新日期：2009-06-01 00:00:00
abstract：:Formation of the periodontium begins following onset of tooth-root formation in a coordinated manner after birth. Dental follicle progenitor cells are thought to form the cementum, alveolar bone and Sharpey's fibers of the periodontal ligament (PDL). However, little is known about the regulatory morphogens that contro...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2013.41
更新日期：2013-06-01 00:00:00
abstract：:Sites of implantation with compromised biology may be unable to achieve the required level of angiogenic and osteogenic regeneration. The specific function and contribution of different cell types to the formation of prevascularized, osteogenic networks in co-culture remains unclear. To determine how bone marrow-deriv...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2016.39
更新日期：2016-12-16 00:00:00
abstract：:For a long time, oral disease is one of the major problems of the public health for its high prevalence and incidence throughout the world, which is especially true for low-income populations. Since China's economic reform in 1978, great changes have taken place in China. These changes have significant impact on and h...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.4248/IJOS11006
更新日期：2011-01-01 00:00:00
abstract：:It is known that human papillomavirus (HPV) infection can cause squamous cell neoplasms at several sites, such as cervix uteri carcinoma and oral squamous carcinoma. There is little information on the expression of HPV and its predictive markers in tumours of the major and minor salivary glands of the head and neck. W...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2014.28
更新日期：2015-03-23 00:00:00
abstract：:The aim of this study was to evaluate the biological efficacy of a unique perpendicular protrusion of type-I collagen (Col-I) from TiO2 nanotubes (NT-EPF surface). We hypothesized that the NT-EPF surface would play bifunctional roles in stimulating platelet-mediated fibroblast recruitment and anchoring fibroblast-deri...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/s41368-020-00103-3
更新日期：2020-12-30 00:00:00
abstract：:The aim of the study was a determination of the levels of nitric oxide (NO) and its biological markers such as malonyldialdehyde (MDA) and nitrotyrosine in the serum of patients with squamous cell carcinoma (SCC) of the oral cavity and identification of the relationships between NO and those markers. These studies wer...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2013.59
更新日期：2013-09-01 00:00:00
abstract：:When adipose-derived stem cells (ASCs) are retrieved from the stromal vascular portion of adipose tissue, a large amount of mature adipocytes are often discarded. However, by modified ceiling culture technique based on their buoyancy, mature adipocytes can be easily isolated from the adipose cell suspension and dediff...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.4248/IJOS11044
更新日期：2011-07-01 00:00:00
abstract：:Halitosis, bad breath or oral malodour are all synonyms for the same pathology. Halitosis has a large social and economic impact. For the majority of patients suffering from bad breath, it causes embarrassment and affects their social communication and life. Moreover,halitosis can be indicative of underlying diseases....
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/ijos.2012.39
更新日期：2012-06-01 00:00:00
abstract：:Biofilms at the tooth-restoration bonded interface can produce acids and cause recurrent caries. Recurrent caries is a primary reason for restoration failures. The objectives of this study were to synthesize a novel bioactive dental bonding agent containing dimethylaminohexadecyl methacrylate (DMAHDM) and 2-methacrylo...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/s41368-018-0019-9
更新日期：2018-06-21 00:00:00
abstract：:After teeth are replanted, there are two possible healing responses: periodontal ligament healing or ankylosis with subsequent replacement resorption. The purpose of this study was to compare the fatigue resistance of vertically fractured teeth after bonding the fragments under conditions simulating both healing modes...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2014.51
更新日期：2015-06-26 00:00:00
