Abstract:
PURPOSE:Prostate cancer ranks as one of the most common malignancies and currently represents the second leading cancer-specific cause of death in men. The current use of single modality transrectal ultrasound (TRUS) for biopsy guidance has a limited sensitivity and specificity for accurately identifying cancerous lesions within the prostate. This study introduces a novel prostate cancer imaging method that combines TRUS with electrical impedance tomography (EIT) and reports on initial clinical findings based on in vivo measurements. METHODS:The ultrasound system provides anatomic information, which guides EIT image reconstruction. EIT reconstructions are correlated with semiquantitative pathological findings. Thin plate spline warping transformations are employed to overlay electrical impedance images and pathological maps describing the spatial distribution of prostate cancer, with the latter used as reference for data analysis. Clinical data were recorded from a total of 50 men prior to them undergoing radical prostatectomy for prostate cancer treatment. Student's t-tests were employed to statistically examine the electrical property difference between cancerous tissue and benign tissue as defined through histological assessment of the excised gland. RESULTS:Example EIT reconstructions are presented along with a statistical analysis comparing EIT and pathology. An average transformation error of 1.67% is found when 381 spatially coregistered pathological images are compared with their target EIT reconstructed counterparts. At EIT signal frequencies of 0.4, 3.2, and 25.6 kHz, paired-testing demonstrated that the conductivity of cancerous regions is significantly greater than that of benign regions ( p < 0.0304). CONCLUSIONS:These preliminary clinical findings suggest the potential benefits electrical impedance measurements might have for prostate cancer detection.
journal_name
Med Physjournal_title
Medical physicsauthors
Wan Y,Borsic A,Heaney J,Seigne J,Schned A,Baker M,Wason S,Hartov A,Halter Rdoi
10.1118/1.4803498subject
Has Abstractpub_date
2013-06-01 00:00:00pages
063102issue
6eissn
0094-2405issn
2473-4209journal_volume
40pub_type
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