Abstract:
:One of the plant extracts, glycyrrhizin (GL) was investigated for its antiviral action on varicella-zoster virus (VZV) in vitro. When human embryonic fibroblast (HEF) cells were treated with GL after inoculation of virus (post-treatment), the average 50%-inhibitory dose (ID50) for five VZV strains was 0.71 mM, and the selectivity index (ratio of ID50 for host-cell DNA synthesis to ID50 for VZV replication) was 30. GL was also effective against VZV replication when HEF cells were treated 24 h before the inoculation (pretreatment). Furthermore, at a concentration of 2.4 mM GL inactivated more than 99% of virus particles within 30 min at 37 degrees C. In combination with other anti-herpes drugs (acyclovir, adenine arabinoside, bromovinyldeoxyuridine, and phosphonoformate) or human native beta-interferon, GL had an additive or slightly synergistic effect on VZV replication. The mechanism of anti-VZV action is still unclear. We postulate that GL inhibits the penetration, uncoating or release of virus particles.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Baba M,Shigeta Sdoi
10.1016/0166-3542(87)90025-8subject
Has Abstractpub_date
1987-02-01 00:00:00pages
99-107issue
2eissn
0166-3542issn
1872-9096pii
0166-3542(87)90025-8journal_volume
7pub_type
杂志文章abstract::There are no drugs approved specifically to treat disseminated adenovirus (Ad) infections in humans. Cidofovir is active against Ad in cell culture, and it is used frequently in the clinic with disseminated infection in pediatric transplant patients; however, controlled clinical studies have not been conducted to prov...
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journal_title:Antiviral research
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journal_title:Antiviral research
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journal_title:Antiviral research
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2004.07.001
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(86)90010-0
更新日期:1986-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0166-3542(97)00055-7
更新日期:1998-01-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章,评审
doi:10.1016/j.antiviral.2011.06.004
更新日期:2011-09-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(94)90041-8
更新日期:1994-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0166-3542(95)00955-8
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journal_title:Antiviral research
pub_type: 历史文章,杂志文章,评审
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更新日期:2016-02-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(84)90032-9
更新日期:1984-10-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2018.09.005
更新日期:2018-12-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2017.11.002
更新日期:2018-01-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/s0166-3542(98)00006-0
更新日期:1998-04-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2011.01.005
更新日期:2011-03-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2018.03.013
更新日期:2018-06-01 00:00:00
abstract::Classical swine fever virus (CSFV) is the causative pathogen of classical swine fever (CSF), a highly contagious disease of swine. Mx proteins are interferon-induced dynamin-like GTPases present in all vertebrates with a wide range of antiviral activities. Although Zhao et al. (2011) have reported that human MxA can i...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2014.01.020
更新日期:2014-04-01 00:00:00
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journal_title:Antiviral research
pub_type: 临床试验,杂志文章
doi:10.1016/0166-3542(82)90016-x
更新日期:1982-08-01 00:00:00