[Vitamin D levels in patients with recent cancer diagnosis].

Abstract:

INTRODUCTION:apart from the known effects of vitamin D on phospho-calcium homeostasis, in recent years there is great interest in its extrabone effects. OBJECTIVES:to know the concentration of 25-hydroxyvitamin D (25[OH] D) in newly diagnosed patients of cancer and to verify if there are differences between the different types of cancer. MATERIAL AND METHODS:cross-sectional study of a cohort of recent diagnosed cancer patients who were referred to Endocrinology consultation for a nutritional pre-surgery evaluation. One hundred and thirty-nine medical histories were reviewed. The socio-demographic and biometric data and 25(OH) D concentration were collected. RESULTS:seventy-one of 139 patients had urological cancer, 27 had colorectal cancer (CRC), 35 had head and neck cancer and six, other types of cancer. The mean concentration of 25(OH) D was 50.41 nmol/l (95% CI = 46.67-54.14); 57.97% of patients showed vitamin D deficiency (< 50 nmol/l) and 21.74%, insufficiency (50-75 nmol/l). We found a statistically significant higher prevalence of deficiency (p < 0.01) in head and neck cancer compared to urological cancer: 68.57% and 49.29%, respectively. Year season significantly modifies 25(OH) D concentration (p < 0.01). CONCLUSIONS:there is a high prevalence of vitamin D deficiency among recent diagnosed cancer patients (especially in CRC and head and neck cancer). The use of reference values adjusted by year season could improve the study of 25(OH) D concentrations. :Introducción: aparte de los conocidos efectos de la vitamina D sobre la homeostasis fosfo-cálcica, en los últimos años están cobrando gran relevancia sus efectos extraóseos.Objetivos: conocer la concentración de 25(OH) vitamina D en pacientes recién diagnosticados de cáncer y comprobar si existen diferencias entre los distintos tipos de cáncer.Material y métodos: estudio transversal de una cohorte de pacientes recién diagnosticados de cáncer que fueron remitidos a Consultas Externas de Endocrinología para una valoración nutricional preoperatoria. Se revisaron 139 historias clínicas y se obtuvieron los datos sociodemográficos, biométricos y la concentración de 25(OH) vitamina D de los pacientes.Resultados: de los 139 pacientes, 71 padecían cáncer urológico; 27, cáncer colorrectal (CCR); 35, cáncer de cabeza y cuello (C y C); y seis, cáncer de otro tipo. La concentración media de 25(OH) vitamina D fue de 50,41 nmol/l (IC 95% = 46,68-54,14). El 57,97% presentó déficit de vitamina D (< 50 nmol/l) y un 21,74%, insuficiencia (50-75 nmol/l). Hallamos una mayor prevalencia de déficit estadísticamente significativa (p < 0,01) en el C y C frente al cáncer urológico: 68,57% y 49,29% respectivamente. La estación del año modifica de manera significativa la concentración de 25(OH) vitamina D (p < 0,01).Conclusiones: hay una alta prevalencia de déficit de vitamina D en los pacientes recién diagnosticados de cáncer (sobre todo en CCR y C y C); por ello, se debe priorizar la corrección de los niveles de 25(OH) vitamina D en estos pacientes. La utilización de valores de referencia ajustados según la estación del año podría mejorar la interpretación de resultados.

journal_name

Nutr Hosp

journal_title

Nutricion hospitalaria

authors

Calmarza P,Sanz París A,Prieto López C,Llorente Barrio M,Boj Carceller D

doi

10.20960/nh.1675

subject

Has Abstract

pub_date

2018-04-05 00:00:00

pages

903-908

issue

4

eissn

0212-1611

issn

1699-5198

journal_volume

35

pub_type

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  • [Not Available].

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    pub_type: 杂志文章

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    pub_type: 杂志文章,评审

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