Abstract:
:FTIR spectroscopy is a powerful diagnostic tool that can also derive biochemical signatures of a wide range of cellular materials, such as cytology, histology, live cells, and biofluids. However, while classification is a well-established subject, biomarker identification lacks standards and validation of its methods. Validation of biomarker identification methods is difficult because, unlike classification, there is usually no reference biomarker against which to test the biomarkers extracted by a method. In this paper, we propose a framework to assess and improve the stability of biomarkers derived by a method, and to compare biomarkers derived by different method set-ups and between different methods by means of a proposed "biomarkers similarity index".
journal_name
J Biophotonicsjournal_title
Journal of biophotonicsauthors
Trevisan J,Park J,Angelov PP,Ahmadzai AA,Gajjar K,Scott AD,Carmichael PL,Martin FLdoi
10.1002/jbio.201300190subject
Has Abstractpub_date
2014-04-01 00:00:00pages
254-65issue
3-4eissn
1864-063Xissn
1864-0648journal_volume
7pub_type
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journal_title:Journal of biophotonics
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