Abstract：
:In the past few years a steadily increasing number of substances have been suggested to qualify as sleep-inducing factors. Most 'sleep factors' appear to exert their effects on slow-wave sleep. Recently, however, it has been shown that the cerebrospinal fluid (CSF) of sleep-deprived cats may contain a rapid eye movement (REM) sleep factor, and that vasoactive intestinal peptide (VIP) may be a specific REM sleep inducer. The purpose of this study is to determine whether the CSF of sleep-deprived cats and VIP can reverse insomnia produced by parachlorophenylalanine (PCPA). Donor cats were sleep-deprived for 24 h and their CSF extracted. Some donor cats were additionally pre-treated with chloramphenicol, and some extracted CSF was heated. Recipient cats were injected with 400 mg/kg i.p. of PCPA on two consecutive days. Twenty-four h after the second injection, the recipient cats were intraventricularly injected with a 100-microliters of the various CSF types or 200 ng of VIP. The results showed that only CSF from sleep-deprived cats and VIP were capable of restoring REM sleep in the otherwise PCPA insomniac cats. Since the return of REM sleep was through an increase in its frequency, it is suggested that the CSF of sleep-deprived cats contains a VIP-like sleep factor possibly involved in triggering REM sleep.
journal_name
Brain Resjournal_title
Brain researchauthors
Prospéro-Garcia O,Morales M,Arankowsky-Sandoval G,Drucker-Colin Rdoi
10.1016/0006-8993(86)91561-1subject
Has Abstractpub_date
1986-10-15 00:00:00pages
169-73issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(86)91561-1journal_volume
385pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The neurophysiological correlates of autoinhibition at the terminals of nigrostriatal dopaminergic neurons were studied by measuring the changes in antidromic excitability of nigrostriatal neurons following local infusions of various catecholamine agonists and antagonists into the neostriatum. Infusions of apomorphine...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1984-09-10 00:00:00
abstract：:Dorsal root ganglia (DRG) are key elements in sensory signaling under physiological and pathological conditions. Little is known about electrical coupling among cells in these ganglia. In this study, we injected the fluorescent dye Lucifer yellow (LY) into single cells to examine dye coupling in DRG. We found no dye c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.12.021
更新日期：2005-03-02 00:00:00
abstract：:Substance P (SP) and neurokinin A (NKA), two coexisting neuropeptides of the tachykinin family, stimulated the basal (5 mM K+) and evoked (40 mM K+) release of [3H]5-HT (5-hydroxytryptamine) from tissue slices of the rat cerebral cortex. Spantide ([DArg1,-DTrp7,9,Leu11]SP; 10(-5) M) inhibited the effects of SP but pot...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91275-l
更新日期：1990-01-08 00:00:00
abstract：:The roles of noradrenergic and serotonergic projections to the hippocampus were investigated with respect to their involvement in the intracranial self-stimulation of this structure. In the first study, 6-hydroxydopamine-induced lesions of the dorsal tegmental noradrenergic bundle, which depleted hippocampal NE by 97%...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90136-6
更新日期：1977-11-04 00:00:00
abstract：:Endothelin (ET) is a small peptide that activates astrocyte proliferation, regulates proliferation and migration of embryonic neural precursor cells and stimulates glioblastoma growth. We found that in mouse brain, ET and its receptor B (ETRB) were highly expressed in the subependymal zone (SEZ), an adult neurogenic n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.01.056
更新日期：2010-03-19 00:00:00
abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces dopaminergic neuron death in substantia nigra and dopamine loss in striatum, similar to those observed in Parkinson disease. Given MPTP can also induce alterations in brain cytokines and in peripheral immune parameters, we hypothesize that MPTP can induce an ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.03.009
更新日期：2005-05-31 00:00:00
abstract：:Serotonin 1A receptor (5-HT(1A)R) agonists have emerged as valuable supplements to l-DOPA therapy, demonstrating that they can decrease side effects and enhance motor function in animal models of Parkinson's disease (PD) and human PD patients. The precise mechanism by which these receptors act remains unknown and ther...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.05.005
更新日期：2007-07-16 00:00:00
abstract：:Many parts of the brainstem are known to be innervated by the cholinergic neurons of the pontomesencephalic tegmentum, but other possible sources of this innervation have rarely been considered. We sought to examine whether other cells in the brainstem were responsible for this cholinergic input using axonal tract tra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90185-6
更新日期：1994-02-04 00:00:00
abstract：:We assessed the application of a replication deficient recombinant adenovirus vector as a retrograde tracer in neural pathway studies. The adenovirus vector, Ad. RSV betagal, containing the intracellular marker gene, beta-galactosidase, was injected directly into the laterodorsal striatum of rats. The retrograde trans...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01065-3
更新日期：1995-12-24 00:00:00
abstract：:The cortex receives a cholinergic input which is considered to be involved in mediating the effects of arousal. The experiments reported here have examined the nature of the cholinergic influence on the neuronal organization of the cat visual cortex. Out of 83 cells studied, 92% exhibited a modification in their visua...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90015-x
更新日期：1983-12-19 00:00:00
abstract：:Activation of cAMP-dependent protein kinase (kinase A) has recently been shown to enhance responses evoked by stimulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors in cultured hippocampal pyramidal neurons. Here we report results of experiments designed to determine if activation of the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90803-h
更新日期：1992-03-06 00:00:00
abstract：:Proechimys, a rodent living in the Amazon region, has shown resistance to developing chronic epilepsy when submitted to different experimental models. Recently, many studies have attributed a potent anticonvulsant action to cannabinoid receptor CB1. This study investigated the distribution and expression of the CB1 re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.03.031
更新日期：2010-06-04 00:00:00
abstract：:The effect of isradipine, a dihydropyridine calcium antagonist, on morphine-induced place preference and analgesia in rats and mice was studied. Isradipine (0.6-5.0 mg/kg s.c.) inhibited an acquisition of morphine-induced place preference in rats and mice in a dose-related manner. Isradipine did not affect or strength...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91311-2
更新日期：1992-10-16 00:00:00
abstract：:Opioid receptor subtype antagonists differentially alter food intake under deprivation (24 h), glucoprivic (2-deoxy-D-glucose, 500 mg/kg, i.p.) or palatable (10% sucrose) conditions with mu (beta-funaltrexamine) and kappa (nor-binaltorphamine), but not delta1 ([D-Ala2,Leu5,Cys6]enkephalin) opioid antagonists reducing ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00539-8
更新日期：1997-08-29 00:00:00
abstract：:Phenylethanolamine N-methyltransferase (PNMT) activity was measured in adrenal glands and medulla oblongata from 4 inbred rat strains, Fischer 344, Buffalo, Lewis and Sprague-Dawley rats. Adrenal enzyme activity was markedly different among the strains with the highest in Fischer, followed by Sprague-Dawley, Lewis and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91476-9
更新日期：1986-04-30 00:00:00
abstract：:The visual Wulst (VW) in the avian telencephalon is thought to be an avian equivalent of the mammalian striate cortex. Effects of electrical stimulation of VW were studied in the isthmo-optic nucleus (ION) of the Japanese quail by extracellular recording. Most ION neurons examined were activated by VW stimulation, and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90800-6
更新日期：1987-03-17 00:00:00
abstract：:Corticotropin-releasing hormone (CRH) and vasopressin (AVP) participate in the endocrine, autonomic, immunological and behavioral response to stress. CRH and AVP receptors are found in hippocampus and anterior pituitary, where mineralocorticoid (MR) and glucocorticoid (GR) receptors are abundant. We investigated the p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02585-x
更新日期：2003-06-27 00:00:00
abstract：:To investigate whether differences in vulnerability to free radicals might underlie differences among striatal neurons in their vulnerability to neurodegenerative processes such as occur in ischemia and Huntington's disease, we have analyzed the localization of superoxide free radical scavengers in different striatal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01320-2
更新日期：1996-02-05 00:00:00
abstract：:The hippocampus is involved in key neuronal circuits that underlie cognition, memory, and anxiety, and it is increasingly recognized as a vulnerable structure that contributes to the pathogenesis of HIV-associated neurocognitive disorder (HAND). However, the mechanisms responsible for hippocampal dysfunction in neuroH...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146431
更新日期：2019-12-01 00:00:00
abstract：:Baclofen-sensitive GABAB receptor binding to various brain regions was compared in age-matched spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rat. The specific [3H]baclofen binding was significantly higher in SHR cerebellum, hippocampus and nucleus tractus solitarii (NTS), but lower in medulla, w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90941-2
更新日期：1985-12-09 00:00:00
abstract：:To date several circuities in supraspinal site of the central nervous system have been known to engage in pain modulation. Lateral hypothalamus (LH) is known as part of the circuit of pain modulation among supraspinal sites. Its role in several animal pain models has been well defined. In this study, we examined the r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146674
更新日期：2020-04-01 00:00:00
abstract：:Administration of aminooxyacetic acid, (an inhibitor of gamma-aminobutyric acid (GABA)-transaminase which enhances the hypothalamic GABA content) increased luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in prepubertal rats (16 days of age), and decreased the levels of these pituitary hormones i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91508-x
更新日期：1991-11-01 00:00:00
abstract：:The current study explored the effects of prolonged antidepressant treatment on mRNA levels of two nuclear receptors in specific brain regions of an animal model of depression, the Wistar-Kyoto (WKY) rat. Both nuclear receptors have been implicated in the development or treatment of depression. The expression of nucle...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.09.041
更新日期：2010-11-29 00:00:00
abstract：:The effects of various nucleotides on the fast tetrodotoxin-sensitive (f-TTX-S) and the slow tetrodotoxin-resistant (s-TTX-R) sodium currents in rat dorsal root ganglion (DRG) neurons were investigated using the patch-clamp technique. Nucleoside triphosphates (NTPs; ATP, GTP, UTP and CTP) and nucleoside diphosphates (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.01.061
更新日期：2004-05-01 00:00:00
abstract：:The aim of the present study was to investigate the anxiolytic effects of long-term treatment with fluoxetine in rats. Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, are used to treat anxiety and panic disorders, in addition to treating depression. A major concern with SSRIs is a 2-3-week delay i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02289-1
更新日期：2000-02-07 00:00:00
abstract：:Intraocular injections of ethylcholine mustard aziridinium ion (AF64A) in the rat depressed retinal choline acetyltransferase (ChAT) activity in a dose-dependent manner without any significant change in the content of amino acid neurotransmitters GABA, glycine, aspartate and glutamate. ChAT reduction was already detec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91466-7
更新日期：1988-01-26 00:00:00
abstract：:YM-14673 is a thyrotropin-releasing hormone (TRH) analog that has a modification of the N-terminal (pyroglutamyl) moiety of the tripeptide. It is longer acting than TRH and has substantially greater potency with regard to central facilitatory activity. In the present studies, the effect of YM-14673 was examined in rat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90509-x
更新日期：1989-05-08 00:00:00
abstract：:Astaxanthin (AST) is a powerful antioxidant that occurs naturally in a wide variety of living organisms. Much experimental evidence has proved that AST has the function of eliminating oxygen free radicals and can protect organisms from oxidative damage. The present study was carried out to further investigate the neur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.09.016
更新日期：2010-11-11 00:00:00
abstract：:Choline acetyltransferase (ChAT) and glutamic acid decarboxylase (GAD) activities were measured in various visual structures of the pigeon brain after long-term monocular deprivation followed by short-term binocular presence or absence of light stimulation. The short-term phase (45 min) was coupled with a 2-deoxygluco...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91253-7
更新日期：1982-09-16 00:00:00
abstract：:Neurons in the ventromedial tegmental area that project to the rostral part of the dorsal cap of the ipsilateral inferior olive were labeled by the technique of retrograde transport of horseradish peroxidase (HRP). Following iontophoresis of HRP into the rostral part of the dorsal cap a cluster of labeled cells are fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90574-2
更新日期：1979-08-31 00:00:00
