The prognostic significance of N-myc downregulated gene 1 in lung adenocarcinoma.

abstract：:The protective effect of Brazilian propolis and its extract Artepillin C against ferric nitrilotriacetate (Fe-NTA)-induced renal lipid peroxidation and carcinogenesis was studied in male ddY mice. Fe-NTA-induced renal lipid peroxidation leads to a high incidence of renal cell carcinoma (RCC) in mice. Administration of...

journal_title：Pathology international

authors： Kimoto T,Koya S,Hino K,Yamamoto Y,Nomura Y,Micallef MJ,Hanaya T,Arai S,Ikeda M,Kurimoto M

更新日期：2000-09-01 00:00:00

abstract：:Aerobes, including humans, are consistently exposed to oxidative stress by consuming oxygen. The biological significance of oxidative stress via reactive oxygen and nitrogen species consists of two stages: reversible redox regulation and irreversible oxidative molecular damage, which are sometimes intermingled. During...

journal_title：Pathology international

authors： Toyokuni S,Akatsuka S

更新日期：2007-08-01 00:00:00

abstract：:Infantile myofibromatosis (IM) is a rare disorder present at birth or in early infancy with a biphasic histological pattern. We present a neonatal-onset case of generalized IM with visceral (central nervous system, heart, lungs, liver, spleen, small intestine, kidneys and bones) and placental involvement, showing a mo...

journal_title：Pathology international

authors： Iwafuchi H,Tsuzuki T,Ito R,Miyake H,Okita H,Hamazaki M

更新日期：2015-08-01 00:00:00

abstract：:Ovarian non-gestational choriocarcinomas co-existing with adenocarcinoma are extremely rare and have been reported as epithelial ovarian carcinomas of a "non-germ cell origin" with "choriocarcinomatous differentiation". Although the cellular origin of non-gestational choriocarcinoma may be post-meiotic ovarian germ ce...

journal_title：Pathology international

authors： Koyanagi T,Fujiwara H,Usui H,Ariga H,Machida S,Takei Y,Saga Y,Shozu M,Fukushima N,Niki T,Matsubara S,Suzuki M

更新日期：2016-09-01 00:00:00

abstract：:Metallothionein (MT) has been reported to play important physiological roles in the human body, but the distribution and significance of MT is not fully understood. In order to analyze MT expression, three kinds of polyclonal MT fragment antibodies were developed against NH2-terminal, middle regional and COOH-terminal...

journal_title：Pathology international

authors： Nakazato K,Nakajima K,Kusakabe T,Suzuki K,Nagamine T

更新日期：2008-12-01 00:00:00

abstract：:Computerized morphometrical measurements were made of liver cells and their nuclei taken from biopsy specimens of primary biliary cirrhosis (PBC), alcoholic cirrhosis, posthepatitic cirrhosis (HBV-related), and hepatocellular carcinoma (HCC). The specimens were stained with hematoxylin-eosin (HE), Mallory's stain for ...

journal_title：Pathology international

authors： Rahman SM,Itakura H,Motoda A

更新日期：1996-04-01 00:00:00

abstract：:Pituicytoma is a rare low-grade glial neoplasm that originates in the neurohypophysis or infundibulum. Because of its rare occurrence, the morphology and differentiation of pituicytoma have not been fully clarified. Here, we report a case of pituicytoma with unusual histological features mimicking ependymoma, but exhi...

journal_title：Pathology international

authors： Kwon MJ,Suh YL

更新日期：2011-10-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are multi-functional cytokines, which belong to the transforming growth factor-β (TGF-β) family. In some cancer tissues, aberrant expression of various BMP signal components has been detected. Here, we describe the divergent roles of BMPs during the progression of cancer. BMPs exhibi...

journal_title：Pathology international

authors： Ehata S,Yokoyama Y,Takahashi K,Miyazono K

更新日期：2013-06-01 00:00:00

abstract：:Cerebellar hypoplasia (CH) is one of the congenital abnormalities of the central nervous system and is seen in several diseases and syndromes. This study was conducted in order to examine methods for evaluating CH in fetus and neonate because CH has been diagnosed without any morphometric criteria at autopsy. We sampl...

journal_title：Pathology international

authors： Murakami A,Tanaka M,Ijiri R,Kato K,Yamashita S,Kurosawa K,Arai N,Aoki I,Tanaka Y

更新日期：2016-01-01 00:00:00

abstract：:Bcl-6 protein is a recently identified novel transcription factor whose deregulated expression is associated with diffuse large B cell lymphomas. It was recently shown by us that the protein is located in germinal center B cells and their neoplastic counterparts. In the present study, the expression of bcl-6 protein o...

journal_title：Pathology international

authors： Kanazawa N,Moriyama M,Onizuka T,Sugawara K,Mori S

更新日期：1997-09-01 00:00:00

abstract：:Senescence marker protein 30 (SMP 30) is preferentially expressed in the liver. One of its remarkable functions is the protection of cells against various injuries by enhancement of membrane calcium-pump activity. We analyzed the role of SMP 30 in hepatocyte proliferation. SMP 30 expression was decreased initially, th...

journal_title：Pathology international

authors： Ishigami T,Fujita T,Simbula G,Columbano A,Kikuchi K,Ishigami A,Shimosawa T,Arakawa Y,Maruyama N

更新日期：2001-07-01 00:00:00

abstract：:We investigated the diagnostic and prognostic value of p53 expression and proliferative activity, as indicated by the Ki-67, in endoscopic biopsy specimens. Specimens were immunologically stained with p53 and MIB-1 (Ki-67), and the MIB-1/Ki-67 labeling index (LI) was calculated. Classification of adenomas was based on...

journal_title：Pathology international

authors： Kubota K,Kakuta Y,Kawamura S,Saito S,Seki H,Kuniyoshi T

更新日期：2003-06-01 00:00:00

abstract：:Epstein-Barr (EB) virus-associated primary smooth muscle tumors have been reported in immunosuppressed young patients with acquired immunodeficiency syndrome (AIDS) and young people who have undergone liver transplantation. An autopsy case of EB virus-associated smooth muscle cell tumor in a 21 year old female who rec...

journal_title：Pathology international

authors： Sadahira Y,Moriya T,Shirabe T,Matsuno T,Manabe T

更新日期：1996-08-01 00:00:00

abstract：:A case of lymphoid hyperplasia arising in the large intestine of a 54-year-old woman is described. Barium enema X-ray and colonoscopic examination revealed multiple small polyps in the right side of the colon. Pathological findings from forceps biopsy revealed similar features to a mucosa-associated lymphoid tissue (M...

journal_title：Pathology international

authors： Nagaoka S,Bandoh T,Takemura T

更新日期：2000-09-01 00:00:00

abstract：:A case of a rare pancreatic tumor, duct-acinar-islet cell tumor is presented. The tumor was incidentally found in the pancreatic body on computed tomography of a 21 year old male suffering from mumps. It was well demarcated from surrounding pancreas, and spherical in shape, measured 2.5 cm in diameter. Histologic and ...

journal_title：Pathology international

authors： Okada Y,Mori H,Tsutsumi A

更新日期：1995-09-01 00:00:00

abstract：:A very rare case of a double cancer consisting of adenosquamous and hepatocellular carcinomas of the liver in a 65-year-old-man is discussed. The patient was hospitalized with epigastralgia in May 1997. Abdominal computed axial tomography revealed a tumor located in the left lobe of the liver and a left hepatic lobect...

journal_title：Pathology international

authors： Zhang Z,Nonaka H,Nagayama T,Hatori T,Ihara F,Zhang L,Akima M,Shiba T

更新日期：2001-12-01 00:00:00

abstract：:A mixed tumor with apocrine differentiation seen in the external auditory canal of a 39 year old male is reported. The well demarcated polypoid tumor showed proliferation of elongated gland-like or duct-like structures lined by two rows of epithelial cells, occasionally accompanied by foci of keratinization. There wer...

journal_title：Pathology international

authors： Tang X,Tamura Y,Tsutsumi Y

更新日期：1994-01-01 00:00:00

abstract：:We compared the c-erbB-2 protein overexpression status detected by the HercepTestTM (DAKO A/S, Grostrup, Denmark) with another conventional immunohistochemistry system using an anti-c-erbB-2 rabbit polyclonal antibody (Nichirei Co., Tokyo, Japan) and with the c-erbB-2 gene amplification status detected by Southern blo...

journal_title：Pathology international

authors： Tsuda H,Tani Y,Hasegawa T,Fukutomi T

更新日期：2001-01-01 00:00:00

abstract：:An 18-year-old man who suffered from panniculitis involving the entire left lower limb after exertional rhabdomyolysis is reported. A high fever (>39 degrees C) and leukocytosis (>20,000/microL) persisted for 1 week, and his general status deteriorated rapidly into pre-disseminated intravascular coagulation, complicat...

journal_title：Pathology international

authors： Kanai Y,Iwaya K,Kuroda M,Harada M,Hirata F,Mukai K

更新日期：2000-10-01 00:00:00

abstract：:We report a case of small intestinal type adenocarcinoma arising in retroperitoneal mature cystic teratoma in a young male. The patient initially experienced intermittent abdominal pain, and radiographic workup revealed an encapsulated retroperitoneal mass. A laparotomy was performed and the resected specimen represen...

journal_title：Pathology international

authors： Terado Y,Kurata A,Ishida T,Imamura T,Sakamoto A

更新日期：2010-10-01 00:00:00

abstract：:This is the first report of segmental arterial mediolysis (SAM) accompanied with polyarteritis nodosa (PN), and manifesting aneurysms of the renal arteries. A 73-year-old woman was admitted to hospital because of a high fever. Laboratory tests showed leukocytosis with increased CRP level in the serum. Myeloperoxidase-...

journal_title：Pathology international

authors： Soga Y,Nose M,Arita N,Komori H,Miyazaki T,Maeda T,Furuya K

更新日期：2009-03-01 00:00:00

abstract：:The incidence of lymphoma has rapidly increased over the last 40 years in Japan, following a trend that is very similar to that of breast cancer. In particular, the relative frequency of follicular lymphoma (FL) has reached that in Western countries. Given its indolence, a "watch-and-wait" approach is often applied to...

journal_title：Pathology international

authors： Yoshino T,Takata K,Tanaka T,Sato Y,Tari A,Okada H

更新日期：2018-12-01 00:00:00

abstract：:A case of serous cystadenocarcinoma of the pancreas in an 85-year-old woman is reported. The tumor extensively involved the body and tail of the pancreas and contiguously invaded the spleen. The histopathology of the tumor was similar to that of serous cystadenoma, but mild nuclear hyperchromatism and atypism were not...

journal_title：Pathology international

authors： Shintaku M,Arimoto A,Sakita N

更新日期：2005-07-01 00:00:00

abstract：:Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVGC) is defined as a neoplasm comprising monoclonal proliferation of EBV-infected gastric epithelial cells. Although the typical histology is gastric carcinoma with lymphoid stroma (GCLS), the histologic features of the tumor vary. We report herein the case of a...

journal_title：Pathology international

authors： Shimizu A,Takahashi T,Kushima R,Sentani K,Yasui W,Matsuno Y

更新日期：2018-01-01 00:00:00

abstract：:Autosomal recessive polycystic kidney disease (ARPKD) is caused by genetic mutations of the gene encoding fibrocystin, and is characterized by the collecting duct cysts and congenital hepatic fibrosis. We report an autopsy-proven case of ARPKD in a 77-year-old male who presented with rapidly progressive renal and live...

journal_title：Pathology international

authors： Taneda S,Honda K,Aoki A,Nitta K,Tamura T,Yoshioka Y,Oda H

更新日期：2012-12-01 00:00:00

abstract：:Pulmonary papillary adenoma is a rare tumor. We analyzed a tumor which appeared in a 16-year-old Japanese woman. The tumor histologically showed papillary proliferation of one-layered tumor cells coating inflammatory fibrovascular cores. At the periphery of the tumor, the tumor cells grew in a lepidic fashion. The tum...

journal_title：Pathology international

authors： Masunaga A,Nagashio R,Iwamoto S,Takeyama N,Sato Y,Miyazaki A,Mitsuya T

更新日期：2012-09-01 00:00:00

abstract：:The authors investigated the protein expression of double-stranded RNA-activated protein kinase (PKR), which was identified by using a previous cDNA microarray study, to discover PKR's correlations with several pathological parameters and to elucidate its role in neoplastic transformation and progression of lung adeno...

journal_title：Pathology international

authors： Roh MS,Kwak JY,Kim SJ,Lee HW,Kwon HC,Hwang TH,Choi PJ,Hong YS

更新日期：2005-11-01 00:00:00

abstract：:The purpose of the present study was to clarify the difference of expression of two stem cell markers, nestin and c-kit, among various pancreatic epithelial tumors and evaluate their utility. Immunohistochemistry was done for 99 surgically resected pancreatic tumor specimens, including 20 ductal adenocarcinoma (DAC), ...

journal_title：Pathology international

authors： Ohike N,Sato M,Hisayuki T,Imataka H,Sato S,Wada Y,Saito K,Takahashi M,Tajiri T,Kunimura T,Morohoshi T

更新日期：2007-09-01 00:00:00

abstract：:The effects of traditional Chinese medicine (Sairei-to) on experimental glomerulonephritis induced in rats by monoclonal antibody (mAb) 1-22-3 injection was examined. The level of proteinuria in the Sairei-to-treated group was significantly lower than that in the PBS treated group. This suppressive effect was caused b...

journal_title：Pathology international

authors： Li P,Kawachi H,Morioka T,Orikasa M,Oite T,Shi ZS,Shimizu F

更新日期：1997-07-01 00:00:00

abstract：:We describe a rare case of dedifferentiated liposarcoma with features resembling chondroblastic osteosarcoma in the dedifferentiated component. The tumor was removed from the left thigh in a 78-year-old male. It consisted of a well-differentiated liposarcoma and an anaplastic component that contained numerous osteoid ...

journal_title：Pathology international

authors： Yamamoto T,Matsushita T,Marui T,Mizuno K,Minami R,Hayashi Y,Hanioka K

更新日期：2000-07-01 00:00:00