Duct-acinar-islet cell tumor of the pancreas.

Abstract:

:A case of a rare pancreatic tumor, duct-acinar-islet cell tumor is presented. The tumor was incidentally found in the pancreatic body on computed tomography of a 21 year old male suffering from mumps. It was well demarcated from surrounding pancreas, and spherical in shape, measured 2.5 cm in diameter. Histologic and immunohistochemical examinations showed the tumor to consist of three distinct cell populations: duct, acinar and islet cells. Small cell nests consisting of these cellular components, either solely of one cell type or mixed of the three cell types, were separated by broad desmoplastic stroma. Islet (endocrine) cells, which were most predominant, were arranged in a trabecular pattern or small cell nests. Most of them were positive for glucagon, and a few cells expressed insulin, somatostatin, serotonin or pancreatic polypeptide. These cells were distributed randomly within the cell nests. Ducts, some of which contained goblet cells, were found among the endocrine cell nests. Duct-islet complexes were also observed. The acinar cells were the least conspicuous component. They expressed pancreatic alpha-amylase. An electron microscopic examination revealed duct cells with intercellular attachments and interdigitations, endocrine cells containing secretory granules, and acinar cells with zymogen granules. No definite evidence suggesting malignancy could be obtained.

journal_name

Pathol Int

journal_title

Pathology international

authors

Okada Y,Mori H,Tsutsumi A

doi

10.1111/j.1440-1827.1995.tb03520.x

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

669-76

issue

9

eissn

1320-5463

issn

1440-1827

journal_volume

45

pub_type

杂志文章
  • Aneurysms of the renal arteries associated with segmental arterial mediolysis in a case of polyarteritis nodosa.

    abstract::This is the first report of segmental arterial mediolysis (SAM) accompanied with polyarteritis nodosa (PN), and manifesting aneurysms of the renal arteries. A 73-year-old woman was admitted to hospital because of a high fever. Laboratory tests showed leukocytosis with increased CRP level in the serum. Myeloperoxidase-...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2009.02351.x

    authors: Soga Y,Nose M,Arita N,Komori H,Miyazaki T,Maeda T,Furuya K

    更新日期:2009-03-01 00:00:00

  • A case of mixed adenoneuroendocrine carcinoma of the gallbladder arising from an intracystic papillary neoplasm associated with pancreaticobiliary maljunction.

    abstract::A 54-year-old Japanese woman was referred with a gallbladder tumor. Based on the results of the computed tomography scan, endoscopic retrograde cholangiopancreatography, and magnetic resonance cholangiopancreatography, a mucin-producing neoplasm of the gallbladder associated with pancreaticobiliary maljunction was dia...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12188

    authors: Meguro Y,Fukushima N,Koizumi M,Kasahara N,Hydo M,Morishima K,Sata N,Lefor AT,Yasuda Y

    更新日期:2014-09-01 00:00:00

  • Prediction of efficacy of interferon treatment of chronic hepatitis C by multivariate analysis and a new classification.

    abstract::One hundred and fifteen patients with chronic hepatitis C were administered interferon (IFN) and classed into two groups: (i) complete responders (CR), HCV-RNA continuously negative 1 year after treatment; and (ii) non-responders (NR), positive 1 year after treatment. Multivariate analysis comprised eight variables: a...

    journal_title:Pathology international

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1440-1827.1998.tb03895.x

    authors: Kim SR,Hayashi Y,Yoon S,Taniguchi M,Yang MK,Kim KI,Kim MM,Saeki K,Nukata I,Imoto S

    更新日期:1998-03-01 00:00:00

  • Fibroma of tendon sheath arising from the radio-ulnar joint.

    abstract::A report of a 65-year-old male with a tumor arising from synovial tissue of the radio-ulnar joint. On magnetic resonance imaging, the tumor was demonstrated as a heterogeneous and lobulated mass with a low signal intensity both in T1- and T2-weighted images. Histological findings of the tumor were identical to those o...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.1999.00984.x

    authors: Misawa A,Okada K,Hirano Y,Sageshima M

    更新日期:1999-12-01 00:00:00

  • An autopsy case of giant cell myocarditis probably due to a non-steroidal anti-inflammatory drug.

    abstract::An autopsy case of giant cell myocarditis (GCM) in a 74-year-old woman is presented. She suffered from hepatic dysfunction, skin eruption and disseminated intravascular coagulation due to the side-effects of a non-steroidal anti-inflammatory drug. After admission, heart failure progressed rapidly, and the patient died...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2001.01166.x

    authors: Adachi Y,Yasumizu R,Hashimoto F,Otsuka Y,Okamura A,Kato Y,Oyaizu H,Ikebukuro K,Fukuhara S,Nakai Y,Ikehara S

    更新日期:2001-02-01 00:00:00

  • Squamous cell carcinoma arising from a seminal vesicular cyst: possible relationship between chronic inflammation and tumor development.

    abstract::A case of squamous cell carcinoma arising within an acquired seminal vesicular cyst is described. A 61-year-old man was hospitalized because of hemospermia and dysuria. Under the diagnosis of a left seminal vesicular cyst, surgical resection was performed. Pathological examination revealed squamous cell carcinoma with...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2002.01340.x

    authors: Yanagisawa N,Saegusa M,Yoshida T,Okayasu I

    更新日期:2002-03-01 00:00:00

  • Sparganum mansoni parasitic infection in the lung showing a nodule.

    abstract::Reported herein is a 57-year-old man infected by Sparganum mansoni, a kind of tapeworm, showing a solitary nodule of the middle lobe of the right lung. Because a transbronchial biopsy could not diagnose the nodule, a right middle lobectomy was performed on suspicion of malignant tumor. The lesion was diagnosed as spar...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2006.02028.x

    authors: Iwatani K,Kubota I,Hirotsu Y,Wakimoto J,Yoshioka M,Mori T,Ito T,Nomori H

    更新日期:2006-11-01 00:00:00

  • EBV-encoded RNA1-positive cells in the bone marrow specimens of patients with EBV-negative lymphomas and sarcomas.

    abstract::Epstein-Barr virus (EBV) infection is associated with pathogenesis of various cancers, including extranodal natural killer/T-cell lymphoma, nasal type (ENKL). ENKL tumor cells are positive for EBV-encoded RNA1 (EBER1), which is the most useful marker to identify ENKL tumor cells in histopathology. Currently, EBER1 in ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12825

    authors: Ito Y,Makita S,Maeshima AM,Hatta S,Yuda S,Suzuki T,Fukuhara S,Munakata W,Taniguchi H,Suzuki T,Maruyama D,Izutsu K

    更新日期:2019-07-01 00:00:00

  • Carcinosarcomas of the esophagus.

    abstract::Two cases of carcinosarcoma of the esophagus are reported. Both were polypoid tumors occurring in the middle of the intrathoracic esophagus. The tumors were predominantly composed of spindle-shaped sarcoma cells with some squamous cell carcinomas (SCC). One tumor showed many bizarre giant cells with filamentous materi...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1995.tb03460.x

    authors: Taniyama K,Sasaki N,Mukai T,Uemura N,Miyoshi N,Nakai H,Nakayama H,Tahara E

    更新日期:1995-04-01 00:00:00

  • Malignant phyllodes tumor of the breast with expression of osteonectin and vinculin.

    abstract::Phyllodes tumor is a very rare neoplasm which accounts for 2.5% of all fibroepithelial lesions of the breast. The mesenchymal component of a malignant phyllodes tumor frequently contains heterologous components. We report a case of malignant phyllodes tumor. The patient was a 40-year-old woman with a lump on the left ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2001.01195.x

    authors: Kuroda N,Sugimoto T,Ueda S,Takahashi T,Moriki T,Sonobe H,Miyazaki E,Hayashi Y,Toi M,Hiroi M,Enzan H

    更新日期:2001-04-01 00:00:00

  • Malignant perivascular epithelioid cell tumor of the colon: report of a case with molecular analysis.

    abstract::Perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal neoplasm, and malignant cases are extremely rare. A case of malignant PEComa arising in the colon is described herein. The patient was a 43-year-old Japanese woman without a history of tuberous sclerosis complex. The tumor occurred in the abdominal cav...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2006.01917.x

    authors: Yamamoto H,Oda Y,Yao T,Oiwa T,Kobayashi C,Tamiya S,Kawaguchi K,Hino O,Tsuneyoshi M

    更新日期:2006-01-01 00:00:00

  • Label-free visualization of acetaminophen-induced liver injury by high-speed stimulated Raman scattering spectral microscopy and multivariate image analysis.

    abstract::We recently established a high-speed, label-free, spectral imaging method based on stimulated Raman scattering (SRS). This method enables examination of cellular features within relatively short periods, thus enabling new imaging applications in pathology. Previously, we reported on label-free visualization of mouse t...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12206

    authors: Satoh S,Otsuka Y,Ozeki Y,Itoh K,Hashiguchi A,Yamazaki K,Hashimoto H,Sakamoto M

    更新日期:2014-10-01 00:00:00

  • Clinicopathological correlation of childhood IgA glomerulonephritis presenting diffuse endocapillary proliferation.

    abstract::The aim of the present study is to clarify the clinicopathological correlation of childhood IgA glomerulonephritis (GN) presenting diffuse endocapillary proliferation. Twenty-seven patients were used in the present study. The 27 patients were divided into three groups (mild, moderate and severe) according to the perce...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2003.01604.x

    authors: Hisano S,Kiyoshi Y,Tanaka I,Tokieda K,Niimi K,Tsuru N,Takebayashii S,Iwasaki H

    更新日期:2004-03-01 00:00:00

  • Prevalent and up-regulated vimentin expression in micropapillary components of lung adenocarcinomas and its adverse prognostic significance.

    abstract::The factors conferring the increased malignancy on lung adenocarcinoma with micropapillary component (AC-MPC) remain to be elucidated. On proteomics based on 2-dimensional gel electrophoresis, 19 proteins differentially expressed by more than 1.5-fold between AC-MPC and conventional adenocarcinoma (CAC); in particular...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12257

    authors: Nakashima H,Jiang SX,Sato Y,Hoshi K,Matsumoto T,Nagashio R,Kobayashi M,Matsuo Y,Shiomi K,Hayakawa K,Saegusa M,Satoh Y

    更新日期:2015-04-01 00:00:00

  • Therapy-related B-lymphoblastic leukemia associated with Philadelphia chromosome and MLL rearrangement: Single institution experience and the review of the literature.

    abstract::Therapy related acute lymphoblastic leukemia (t-ALL) of B cell origin is rare and constitutes approximately 2% of all ALL. Previously compiled data on the complete cytogenetic analysis of 48 t-B-ALL cases suggested that MLL rearrangement at 11q23 gene locus is the most common abnormality. Philadelphia chromosome (Ph) ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12337

    authors: Matnani R,Parekh V,Borate U,Brazelton J,Reddy V,Peker D

    更新日期:2015-10-01 00:00:00

  • Molecular analysis of isolated tumor glands from endometrial endometrioid adenocarcinomas.

    abstract::We studied the extensive molecular alterations of endometrial endometrioid adenocarcinoma (EEA) using a crypt isolation method. We analyzed copy number variation (CNV) using a single nucleotide polymorphism (SNP) array, genetic mutations (KRAS, BRAF, p53, PIK3CA), DNA methylation and microsatellite instability (MSI) s...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12274

    authors: Suga Y,Sugai T,Uesugi N,Kawasaki T,Fukagawa T,Yamamoto E,Ishida K,Suzuki H,Sugiyama T

    更新日期:2015-05-01 00:00:00

  • Mature teratoma of the uterine cervix with lymphoid hyperplasia.

    abstract::A rare case of an extragonadal teratoma, which occurred primarily in the uterus, is described. The tumor developed in the uterine cervix as a conventional cervical polyp, 3 months after an elective abortion in a 27-year-old woman. Microscopically, the solid 2.2 x 1.8 x 1.5 cm mass was a mature teratoma with exuberant ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2003.01468.x

    authors: Lim SC,Kim YS,Lee YH,Lee MS,Lim JY

    更新日期:2003-05-01 00:00:00

  • Non-neoplastic nodular lesions in the liver.

    abstract::The classical nomenclature and categorization of neoplastic and non-neoplastic nodular lesions of the liver are being revised due to the tremendous volume of information recently published on this issue. The diagnostic histopathology of non-neoplastic nodular (tumor-like) lesions of the liver that are recognizable in ...

    journal_title:Pathology international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1827.1995.tb03386.x

    authors: Nakanuma Y

    更新日期:1995-10-01 00:00:00

  • A case of endocapillary proliferative glomerulonephritis with macrophages phagocytosing monoclonal immunoglobulin lambda light chain.

    abstract::Multiple myeloma (MM) is a plasma-cell neoplasm that can cause renal disorders. Renal lesions in MM can present with a very rare pathological manifestation involving a specific monoclonal immunoglobulin (Ig). We report the case of a 33-year-old woman who had edema, fatigue, elevated serum creatinine levels, hypoalbumi...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12229

    authors: Watanabe H,Osawa Y,Goto S,Habuka M,Imai N,Ito Y,Hirose T,Chou T,Ohashi R,Shimizu A,Ehara T,Shimotori T,Narita I

    更新日期:2015-01-01 00:00:00

  • Tight junction-related human diseases.

    abstract::Tight junctions are intercellular junctions adjacent to the apical ends of paracellular spaces. They have two classical functions, the barrier function and the fence function. The former regulates the passage of ions, water and various molecules through paracellular spaces, and is thus related to edema, jaundice, diar...

    journal_title:Pathology international

    pub_type: 杂志文章,评审

    doi:10.1111/pin.12021

    authors: Sawada N

    更新日期:2013-01-01 00:00:00

  • Lymphoid hyperplasia of the large intestine: a case report with immunohistochemical and gene analysis.

    abstract::A case of lymphoid hyperplasia arising in the large intestine of a 54-year-old woman is described. Barium enema X-ray and colonoscopic examination revealed multiple small polyps in the right side of the colon. Pathological findings from forceps biopsy revealed similar features to a mucosa-associated lymphoid tissue (M...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2000.01107.x

    authors: Nagaoka S,Bandoh T,Takemura T

    更新日期:2000-09-01 00:00:00

  • Pleural MALT lymphoma diagnosed on thoracoscopic resection under local anesthesia using an insulation-tipped diathermic knife.

    abstract::A 79-year-old man presented with back pain. Chest CT scan showed elevated nodular lesions in the right parietal pleurae with pleural effusion. There were no intrapulmonary or mediastinal abnormalities. Under local anesthesia, right thoracoscopy and subsequent thoracoscopic pleural resection were performed using an ins...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2008.02220.x

    authors: Kawahara K,Sasada S,Nagano T,Suzuki H,Kobayashi M,Matsui K,Takata K,Yoshino T,Michida T,Iwasaki T

    更新日期:2008-04-01 00:00:00

  • Immunohistochemical analysis of nestin and c-kit and their significance in pancreatic tumors.

    abstract::The purpose of the present study was to clarify the difference of expression of two stem cell markers, nestin and c-kit, among various pancreatic epithelial tumors and evaluate their utility. Immunohistochemistry was done for 99 surgically resected pancreatic tumor specimens, including 20 ductal adenocarcinoma (DAC), ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2007.02143.x

    authors: Ohike N,Sato M,Hisayuki T,Imataka H,Sato S,Wada Y,Saito K,Takahashi M,Tajiri T,Kunimura T,Morohoshi T

    更新日期:2007-09-01 00:00:00

  • Esophageal adenocarcinoma that probably originated in the esophageal gland duct: a case report.

    abstract::A case of primary esophageal adenocarcinoma in a 64-year-old man is reported. An ulcerating tumor was located in the middle intrathoracic esophagus. Histopathological examination revealed a moderately differentiated adenocarcinoma, which had invaded down to the adventitia. The cancerous tubuli were lined by flattened ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.1999.00838.x

    authors: Endoh Y,Miyawaki M,Tamura G,Watanabe H,Motoyama T

    更新日期:1999-02-01 00:00:00

  • Small cell carcinoma of the gall-bladder with intestinal metaplastic epithelium.

    abstract::A case of small cell carcinoma of the gall-bladder is described. Immunohistochemically, the tumor cells were positive for chromogranin A, synaptophysin and neuronspecific enolase, which suggests that they derived from neuroendocrine cells. The overlying and surrounding epithelium of the tumor showed intestinal metapla...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1998.tb03910.x

    authors: Kuwabara H,Uda H

    更新日期:1998-04-01 00:00:00

  • Serous cystadenocarcinoma of the pancreas.

    abstract::A case of serous cystadenocarcinoma of the pancreas in an 85-year-old woman is reported. The tumor extensively involved the body and tail of the pancreas and contiguously invaded the spleen. The histopathology of the tumor was similar to that of serous cystadenoma, but mild nuclear hyperchromatism and atypism were not...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2005.01850.x

    authors: Shintaku M,Arimoto A,Sakita N

    更新日期:2005-07-01 00:00:00

  • CD1a expression in PEComas.

    abstract::According to the World Health Organization classification, neoplasms with perivascular epithelioid cell differentiation (PEComas) are mesenchymal tumors composed of histologically and immunohistochemically distinctive PEC. Generally, nearly all PEComas have immunoreactivity for both melanocytic (HMB-45 and/or melan A)...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2007.02206.x

    authors: Adachi Y,Horie Y,Kitamura Y,Nakamura H,Taniguchi Y,Miwa K,Fujioka S,Nishimura M,Hayashi K

    更新日期:2008-03-01 00:00:00

  • Pericardial malignant mesothelioma: case report and discussion of immunohistochemical and histochemical findings.

    abstract::An extremely rare case of malignant mesothelioma of the pericardium is reported. The tumor appeared to be the biphasic type of diffuse malignant mesothelioma which present many small to fine lipid droplets in the cytoplasm, particularly that of the epithelial cell, and a positive immunohistochemical reaction with anti...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1995.tb03513.x

    authors: Ohmori T,Arita N,Okada K,Kondo M,Tabei R

    更新日期:1995-08-01 00:00:00

  • Abnormalities in chromosome 17 and p53 in lung carcinoma cells detected by fluorescence in situ hybridization.

    abstract::The value of fluorescence in situ hybridization (FISH) as an aid to deciding the prognosis for lung carcinoma patients, comparing quantitatively the signal from the p53 gene (17p13.1) on chromosome 17, was studied. A dual-labeling technique was used, using probes for the centromeric region of chromosome 17 and for the...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2004.01635.x

    authors: Kawai T,Hiroi S,Nakanishi K,Sakurai Y,Torikata C

    更新日期:2004-06-01 00:00:00

  • Incidental calcifying fibrous tumor of the stomach presenting as a polyp.

    abstract::Calcifying fibrous tumor (CFT) is an uncommon lesion of uncertain cause and pathogenesis that has a unique histological appearance. These lesions are described mainly in the subcutaneous or deep soft tissues, followed by subserosal locations. Intrinsic visceral CFT is extremely rare. Herein is described a rare case of...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2006.01951.x

    authors: Elpek GO,Küpesiz GY,Ogüs M

    更新日期:2006-04-01 00:00:00