Lymphoid hyperplasia of the large intestine: a case report with immunohistochemical and gene analysis.

Abstract:

:A case of lymphoid hyperplasia arising in the large intestine of a 54-year-old woman is described. Barium enema X-ray and colonoscopic examination revealed multiple small polyps in the right side of the colon. Pathological findings from forceps biopsy revealed similar features to a mucosa-associated lymphoid tissue (MALT) lymphoma. A right hemicolectomy with mesenteric lymph node dissection was carried out. Histological sectioning demonstrated hypertrophic lymphoid follicles with well-formed germinal centers. Occasionally, lymphocytes infiltrated the crypts, in a way similar to that found in lymphoepithelial lesions, which was suggestive of a MALT lymphoma diagnosis. Cryptitis was also observed in the lamina propria. Immunohistochemically, proliferating lymphocytes were positive for CD20 (L26) and negative for CD45RO (UCHL-1). Analyses of immunoglobulin gene (IgHJH) rearrangement could not detect any monoclonality in these cells. These findings suggested that the present case should be categorized as lymphoid hyperplasia rather than lymphoma.

journal_name

Pathol Int

journal_title

Pathology international

authors

Nagaoka S,Bandoh T,Takemura T

doi

10.1046/j.1440-1827.2000.01107.x

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

750-3

issue

9

eissn

1320-5463

issn

1440-1827

pii

pin1107

journal_volume

50

pub_type

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