Dedifferentiated liposarcoma with chondroblastic osteosarcomatous dedifferentiation.

abstract：:Sarcomatoid carcinoma of the pancreas is an uncommon neoplasm. The immunohistochemical characteristics of this unique type of pancreatic tumor were studied. Histologically, there was diffuse proliferation of atypical spindle cells that had hyperchromatic, short, spindle-shaped nuclei and pale cytoplasm. A few tiny foc...

journal_title：Pathology international

authors： Higashi M,Takao S,Sato E

更新日期：1999-05-01 00:00:00

abstract：:We report a rare case of hepatocellular carcinoma (HCC) with an unusual neuroendocrine component. During a follow-up study for chronic hepatitis C in a 71-year-old man, a nodular lesion showed rapid growth from 1 cm to 4 cm in diameter within 3 months. Histologically, the tumor was consistent with moderately different...

journal_title：Pathology international

authors： Yamaguchi R,Nakashima O,Ogata T,Hanada K,Kumabe T,Kojiro M

更新日期：2004-11-01 00:00:00

abstract：:The KIT, epidermal growth factor receptor (EGFR) and HER-2 oncoproteins have tyrosine kinase activity and are molecular targets in human cancer therapy. To clarify the significance of KIT, EGFR, and HER-2 in undifferentiated thyroid carcinoma (UTC), the expression of these receptors and tyrosine phosphorylation was ex...

journal_title：Pathology international

authors： Murakawa T,Tsuda H,Tanimoto T,Tanabe T,Kitahara S,Matsubara O

更新日期：2005-12-01 00:00:00

abstract：:We herein describe a rare case of low-grade endobronchial tumor that exhibited two distinct features of typical carcinoid and acinic cell carcinoma (ACC) by immunohistochemical and ultrastructure study. ACC was suspected on transbronchial biopsy. The resected specimen showed that the tumor surface comprised an acinic ...

journal_title：Pathology international

authors： Watanabe H,Miyagawa-Hayashino A,Imabayashi T,Kishimoto M,Shimomura M,Honda K,Omatsu I,Shimada E,Inoue M,Takayama K,Konishi E

更新日期：2019-12-01 00:00:00

abstract：:BRN2 is a developmental neural cell-specific POU domain transcription factor and is crucial for cell lineage determination. We investigated the importance of BRN2 in the expression of the lineage-specific transcription factors (achaete-scute homolog-like 1 (ASCL1) and NeuroD1 (ND1)) and neural/neuroendocrine marker mo...

journal_title：Pathology international

authors： Ishii J,Sato H,Sakaeda M,Shishido-Hara Y,Hiramatsu C,Kamma H,Shimoyamada H,Fujiwara M,Endo T,Aoki I,Yazawa T

更新日期：2013-03-01 00:00:00

abstract：:A 7-year-old boy presented with midline swelling in the neck. On fine-needle aspiration cytology it was diagnosed as papillary carcinoma of the thyroid. The patient underwent total thyroidectomy. Histopathological examination, immunohistochemistry and electron microscopy revealed the presence of two intermingled compo...

journal_title：Pathology international

authors： Goyal R,Nada R,Rao KL,Radotra BD

更新日期：2006-02-01 00:00:00

abstract：:We have reported that the function of histamine and its receptors (HRs) has a close relationship with the development of nonalcoholic fatty liver disease (NAFLD). However, much less is known regarding its pathogenic and molecular mechanism(s), including the early stage of hepatic and intestinal function for lipid and ...

journal_title：Pathology international

authors： Yamada S,Guo X,Wang KY,Tanimoto A,Sasaguri Y

更新日期：2016-07-01 00:00:00

abstract：:Phyllodes tumor is a very rare neoplasm which accounts for 2.5% of all fibroepithelial lesions of the breast. The mesenchymal component of a malignant phyllodes tumor frequently contains heterologous components. We report a case of malignant phyllodes tumor. The patient was a 40-year-old woman with a lump on the left ...

journal_title：Pathology international

authors： Kuroda N,Sugimoto T,Ueda S,Takahashi T,Moriki T,Sonobe H,Miyazaki E,Hayashi Y,Toi M,Hiroi M,Enzan H

更新日期：2001-04-01 00:00:00

abstract：:Rheumatoid nodule is a frequent and characteristic extra-articular manifestation of rheumatoid arthritis (RA). Its involvement of central nervous system is a rare occurrence with only a few reported cases. A 78-year-old man with severe arthritis showing the formation of rheumatoid nodule-like granulomas in the dura an...

journal_title：Pathology international

authors： Kamio N,Kuramochi S,Wang RJ,Hirose S,Hosoda Y

更新日期：1996-07-01 00:00:00

abstract：:Alopecia was induced in male and female neonatal C57BL mice by a single intraperitoneal injection of 60 mg/kg N-methyl-N-nitrosourea (MNU). MNU administration was most effective in the 8-day-old mice and less effective in the 5-day-old mice (at active and early anagen stages of the first hair cycle, respectively). No ...

journal_title：Pathology international

authors： Yoshizawa K,Nambu H,Yamamoto D,Yang J,Kiyozuka Y,Shikata N,Tsubura A

更新日期：2000-03-01 00:00:00

abstract：:The localization of glutathione peroxidase (GSH-PO) in the human arteriosclerotic lesions was investigated by immunohistochemical methods. GSH-PO is an enzyme that effectively reduces lipid peroxides. It is also known that its synthesis is significantly increased by lipid peroxides, the substrate of the enzyme. Accord...

journal_title：Pathology international

authors： Mori I,Yoshimura S,Watanabe K

更新日期：1995-05-01 00:00:00

abstract：:The value of fluorescence in situ hybridization (FISH) as an aid to deciding the prognosis for lung carcinoma patients, comparing quantitatively the signal from the p53 gene (17p13.1) on chromosome 17, was studied. A dual-labeling technique was used, using probes for the centromeric region of chromosome 17 and for the...

journal_title：Pathology international

authors： Kawai T,Hiroi S,Nakanishi K,Sakurai Y,Torikata C

更新日期：2004-06-01 00:00:00

abstract：:The CDKN2 gene encodes two structurally different proteins: a cyclin-dependent kinase inhibitor, p16, which regulates retinoblastoma protein (pRb)-dependent G1 arrest, and a cell cycle inhibitor, p14ARF, which blocks MDM2-induced p53 degradation resulting in an increase in p53 levels that leads to cell cycle arrest. R...

journal_title：Pathology international

authors： Sano T,Masuda N,Oyama T,Nakajima T

更新日期：2002-05-01 00:00:00

abstract：:A unique case of duodenal stromal tumor in a 51-year-old man is reported. The tumor histologically showed spindle cell proliferation and numerous eosinophilic globules. Most globules were composed of tangled 45 nm thick fibrils, which were ultrastructurally identical to 'skeinoid fibers'. The presence of glycogen gran...

journal_title：Pathology international

authors： Matsukuma S,Doi M,Suzuki M,Ikegawa K,Sato K,Kuwabara N

更新日期：1997-11-01 00:00:00

abstract：:Conditions of preserving DNA, RNA and protein in pathological specimens are of great importance as degradation of such macromolecules would critically affect results of molecular biological analysis. The feasibility of freeze-drying as a means of preserving pathological tissue samples for molecular analysis has previo...

journal_title：Pathology international

authors： Matsuo S,Sugiyama T,Okuyama T,Yoshikawa K,Honda K,Takahashi R,Maeda S

更新日期：1999-05-01 00:00:00

abstract：:A 58-year-old man with a 1 year history of progressive abdominal distension underwent a laparotomy for pseudomyxoma peritonei. The mucin was identified and characterized in the present study. Approximately 6 L of crude mucus in the sol (highly viscous) and gel (semisolid) phases was obtained from the patient's periton...

journal_title：Pathology international

authors： Mall AS,Chirwa N,Govender D,Lotz Z,Tyler M,Rodrigues J,Kahn D,Goldberg P

更新日期：2007-08-01 00:00:00

abstract：:The great majority of the cases clinically diagnosed as primary aldosteronism (PA) have been caused by aldosterone-producing adenoma (APA) or idiopathic hyperaldosteronism (IHA). The differential diagnosis of both subtypes of PA is important due to the different therapeutic modes but clinically it is sometimes difficu...

journal_title：Pathology international

authors： Nakamura Y,Felizola SJ,Satoh F,Konosu-Fukaya S,Sasano H

更新日期：2014-10-01 00:00:00

abstract：:We present a case of uterine intravenous leiomyomatosis associated with multiple pulmonary metastases with bullae-like cystic change. A 53-year-old woman who had undergone hysterectomy 5 years previously underwent an operation for multiple pulmonary nodules with bullae formation. After resection of several large bulla...

journal_title：Pathology international

authors： Matsumoto K,Yamamoto T,Hisayoshi T,Asano G

更新日期：2001-05-01 00:00:00

abstract：:The findings of a 20 year old woman with lymphadenopathy that was probably caused by an acute human herpesvirus-6 (HHV-6) infection are reported. She clinically demonstrated various signs of acute infection such as a high fever, skin rash, liver dysfunction, leukocytosis, an elevation of the erythrocyte sedimentation ...

journal_title：Pathology international

authors： Sumiyoshi Y,Kikuchi M,Ohshima K,Takeshita M,Eizuru Y,Minamishima Y

更新日期：1995-12-01 00:00:00

abstract：:The aim of the present study was to clarify protein profiling in small cell lung carcinoma (SCLC) and pulmonary large cell neuroendocrine carcinoma (LCNEC). The proteomic approach was used, and involved cell lysate from two cell lines (N231 derived from SCLC and LCN1 derived from LCNEC), with 2-D gel electrophoresis (...

journal_title：Pathology international

authors： Nagashio R,Sato Y,Matsumoto T,Kageyama T,Satoh Y,Ryuge S,Masuda N,Jiang SX,Okayasu I

更新日期：2010-02-01 00:00:00

abstract：:A complete spontaneous regression of diffuse large B cell lymphoma involving the right breast, confirmed by aspiration cytology, is reported. The patient visited a hospital due to the rapid growth of a tumor in the right breast. Five years previously she underwent a craniotomy for a brain tumor, diagnosed as B-cell ma...

journal_title：Pathology international

authors： Iihara K,Yamaguchi K,Nishimura Y,Iwasaki T,Suzuki K,Hirabayashi Y

更新日期：2004-07-01 00:00:00

abstract：:So-called 'hybrid' lesion of ameloblastoma, which is composed of desmoplastic ameloblastoma and conventional follicular/plexiform ameloblastoma, is an unusual variant of ameloblastoma and only eight cases of 'hybrid' lesion have been published in the English literature. To enhance knowledge of this interesting tumor, ...

journal_title：Pathology international

authors： Takata T,Miyauchi M,Ogawa I,Zhao M,Kudo Y,Sato S,Takekoshi T,Nikai H,Tanimoto K

更新日期：1999-11-01 00:00:00

abstract：:Chronic active Epstein-Barr virus infection (CAEBV) is a syndrome that takes diverse clinical courses and is often associated with lymphoproliferative disorders of T/natural killer (NK)-cell lineage. We describe a patient with CAEBV associated with persistent pharyngeal ulcer, and with subsequent nasal T/NK-cell lymph...

journal_title：Pathology international

authors： Nagata H,Numata T,Konno A,Mikata I,Kurasawa K,Hara S,Nishimura M,Yamamoto K,Shimizu N

更新日期：2001-10-01 00:00:00

abstract：:A case of small intestinal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) with monoclonal cryoglobulinemia is described. The patient was a woman in her mid-sixties with purpura of the bilateral lower legs and abdominal pain. An immunoserological investigation showed expre...

journal_title：Pathology international

authors： Saito T,Tamaru J,Kishi H,Kayao J,Kuzuu Y,Wakita H,Adachi A,Itoyama S,Mikata I

更新日期：2004-09-01 00:00:00

abstract：:Reported herein is a case of benign clear cell tumor of the lung in a 60-year-old man. Chest X-ray and CT examination revealed an abnormal nodule with homogenous density and a clear margin in the lower lobe of the left lung. The resected tumor was 13 mm in size, well-circumscribed and was graysh-white on cut surface. ...

journal_title：Pathology international

authors： Adachi Y,Kitamura Y,Nakamura H,Taniguchi Y,Miwa K,Horie Y,Hayashi K

更新日期：2006-08-01 00:00:00

abstract：:Leiomyomatosis peritonealis disseminata (LPD) is a rare clinicopathological entity typically observed in women of reproductive age. We report a case of LPD with malignant change in a man. A 77-year-old man presented with a mass measuring 10 cm in diameter at the terminal ileum and numerous peritoneal small nodules tha...

journal_title：Pathology international

authors： Yamaguchi T,Imamura Y,Yamamoto T,Fukuda M

更新日期：2003-03-01 00:00:00

abstract：:A case of gliosarcoma composed of glioblastoma and liposarcoma is presented. A 70-year-old Japanese man was admitted to hospital because of dysarthria and aphasia. Magnetic resonance imaging indicated a brain tumor located in the temporal-parietal area of the left hemisphere. He rejected any therapy and died of respir...

journal_title：Pathology international

authors： Fukuda T,Yasumichi K,Suzuki T

更新日期：2008-06-01 00:00:00

abstract：:A multi-institutional study 'Pathobiological Determinants of Atherosclerosis in Youth' (PDAY) was initiated to document the natural history of atherosclerosis, its relationship to risk factors, and pathobiology of lesion development in young subjects. Pathology laboratories in nine centers collected arteries and tissu...

journal_title：Pathology international

authors： Strong JP,Malcom GT,Oalmann MC

更新日期：1995-06-01 00:00:00

abstract：:Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVGC) is defined as a neoplasm comprising monoclonal proliferation of EBV-infected gastric epithelial cells. Although the typical histology is gastric carcinoma with lymphoid stroma (GCLS), the histologic features of the tumor vary. We report herein the case of a...

journal_title：Pathology international

authors： Shimizu A,Takahashi T,Kushima R,Sentani K,Yasui W,Matsuno Y

更新日期：2018-01-01 00:00:00

abstract：:Two cases of carcinosarcoma of the esophagus are reported. Both were polypoid tumors occurring in the middle of the intrathoracic esophagus. The tumors were predominantly composed of spindle-shaped sarcoma cells with some squamous cell carcinomas (SCC). One tumor showed many bizarre giant cells with filamentous materi...

journal_title：Pathology international

authors： Taniyama K,Sasaki N,Mukai T,Uemura N,Miyoshi N,Nakai H,Nakayama H,Tahara E

更新日期：1995-04-01 00:00:00