Environmental and genetic risk factors in early human atherogenesis: lessons from the PDAY study. Pathobiological Determinants of Atherosclerosis in Youth.

abstract：:Morphologic features and neoplastic potentials of bile duct adenoma (BDA) and von Meyenburg complex (VMC)-like duct arising in chronic liver disease were unknown. Thirty-five BDAs and 12 VMC-like duct lesions were observed in 39 cases with chronic liver disease. BDAs were divided into the EMA-cytoplasmic type (n = 14)...

journal_title：Pathology international

authors： Aishima S,Tanaka Y,Kubo Y,Shirabe K,Maehara Y,Oda Y

更新日期：2014-11-01 00:00:00

abstract：:Eight hepatic atypical adenomatous hyperplasias (AH), 30 hepatocellular carcinomas (HCC) consisting of 11 well-, 13 moderately and six poorly differentiated HCC, and 10 intrahepatic cholangiocarcinomas (CC) were investigated immunohistochemically with anti-alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), CA19-...

journal_title：Pathology international

authors： Tsuji M,Kashihara T,Terada N,Mori H

更新日期：1999-04-01 00:00:00

abstract：:Phyllodes tumor is a very rare neoplasm which accounts for 2.5% of all fibroepithelial lesions of the breast. The mesenchymal component of a malignant phyllodes tumor frequently contains heterologous components. We report a case of malignant phyllodes tumor. The patient was a 40-year-old woman with a lump on the left ...

journal_title：Pathology international

authors： Kuroda N,Sugimoto T,Ueda S,Takahashi T,Moriki T,Sonobe H,Miyazaki E,Hayashi Y,Toi M,Hiroi M,Enzan H

更新日期：2001-04-01 00:00:00

abstract：:The alpha subunit of a GTP-binding protein, Go, was investigated in pulmonary neuroendocrine neoplasms and fetal tissues of the lung by an immunohistochemical method. Positive immunostaining for the alpha subunit of Go (Go alpha) was found predominantly on the cell membrane and found occasionally in the cytoplasm. Typ...

journal_title：Pathology international

authors： Kawano N,Ito T,Kitamura H,Shibagaki T,Kameda Y,Nakamura N,Kanisawa M

更新日期：1996-06-01 00:00:00

abstract：:The RET finger protein (RFP) is a transcription factor belonging to the TRIM (tripartite motif) superfamily of proteins. RFP is expressed in a variety of human and rodent tumor cell lines and in several kinds of human cancer. Expression of RFP is associated with prognosis of colon and endometrial cancers. In the prese...

journal_title：Pathology international

authors： Iwakoshi A,Murakumo Y,Kato T,Kitamura A,Mii S,Saito S,Yatabe Y,Takahashi M

更新日期：2012-05-01 00:00:00

abstract：:Angiomyxomas are a group of relatively rare mesenchymal myxoid tumors. Three types of angiomyxomas have been identified: superficial angiomyxoma, aggressive angiomyxoma and angiomyofibroblastoma. These tumors have a predilection for occurring in the perineum of middle-aged females and are often clinically diagnosed as...

journal_title：Pathology international

authors： Ustun C,Malazgirt Z,Kandemir B,Kocak I,Bolat I,Gumus S

更新日期：1998-12-01 00:00:00

abstract：:The localization of endothelin (ET)-1/big ET-1, ET-3/big ET-3, ET-A and ET-B receptor was immunohistochemically examined in human adrenal glands composed of 36 normal cases, nine hyperplasia, 70 adenomas and seven carcinomas of cortical cells. In normal adrenals, ET-1/big ET-1 and ET-B receptor were regularly detected...

journal_title：Pathology international

authors： Hiraki H,Hoshi N,Hasegawa H,Tanigawa T,Emura I,Seito T,Yamaki T,Fukuda T,Watanabe K,Suzuki T

更新日期：1997-02-01 00:00:00

abstract：:Macrophage polarization is divided into M1 and M2 type based on membrane receptors, cytokines, and chemokines. M1 expresses CD80, interleukin (IL)-6, IL-12, and chemokine receptor (CCR)7, while M2 expresses CD163, IL10, and chemokine ligand (CCL)22. The aim of the present study was to identify the properties of infilt...

journal_title：Pathology international

authors： Nomura Y,Takeuchi M,Yoshida S,Sugita Y,Niino D,Kimura Y,Shimizu K,Aoki R,Suefuji N,Hirose S,Kikuchi M,Ohshima K

更新日期：2009-09-01 00:00:00

abstract：:Teratoid Wilms' tumor is an unusual morphological entity characterized by a classic triphasic malignancy with predominantly heterologous tissue. The authors describe two cases of teratoid Wilms' tumor with an extrarenal site: one in a 13-year-old girl with vaginal spotting (patient 1) and another in a 1-day-old girl w...

journal_title：Pathology international

authors： Song JS,Kim IK,Kim YM,Khang SK,Kim KR,Lee Y

更新日期：2010-01-01 00:00:00

abstract：:Tec is a novel non-receptor-type protein tyrosine kinase that was originally identified from a murine liver cDNA library. While the function of Tec remains unknown, it was shown recently that two Tec-related kinases are involved directly in the growth and differentiation of bone marrow stem cells. As the localization ...

journal_title：Pathology international

authors： Kazama A,Mano H,Morishita Y,Mori S

更新日期：1996-05-01 00:00:00

abstract：:Cerebellar hypoplasia (CH) is one of the congenital abnormalities of the central nervous system and is seen in several diseases and syndromes. This study was conducted in order to examine methods for evaluating CH in fetus and neonate because CH has been diagnosed without any morphometric criteria at autopsy. We sampl...

journal_title：Pathology international

authors： Murakami A,Tanaka M,Ijiri R,Kato K,Yamashita S,Kurosawa K,Arai N,Aoki I,Tanaka Y

更新日期：2016-01-01 00:00:00

abstract：:The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors and has been identified to play a crucial role in a number of biological processes, including the trafficking and homeostasis of immune cells such as T lymphocytes. CXCR4 has also been found to be a prognostic marker in variou...

journal_title：Pathology international

authors： Furusato B,Mohamed A,Uhlén M,Rhim JS

更新日期：2010-07-01 00:00:00

abstract：:We report a case of glomerular cystic kidney disease (GCKD) associated with tuberous sclerosis complex (TSC) in a neonate. The patient displayed progressive abdominal enlargement attributed to GCKD associated with TSC. After birth, the right kidney was resected because it compressed his liver and right lung, and possi...

journal_title：Pathology international

authors： Murakami A,Gomi K,Tanaka M,Ohyama M,Itani Y,Ishikawa H,Aida N,Furuya M,Tanaka Y

更新日期：2012-03-01 00:00:00

abstract：:This is the first report of segmental arterial mediolysis (SAM) accompanied with polyarteritis nodosa (PN), and manifesting aneurysms of the renal arteries. A 73-year-old woman was admitted to hospital because of a high fever. Laboratory tests showed leukocytosis with increased CRP level in the serum. Myeloperoxidase-...

journal_title：Pathology international

authors： Soga Y,Nose M,Arita N,Komori H,Miyazaki T,Maeda T,Furuya K

更新日期：2009-03-01 00:00:00

abstract：:A case is reported of intra-abdominal desmoplastic small cell tumor (IDSCT) with biphasic histologic features in a patient with proximal spinal muscular atrophy. The tumor was composed of small epithelial cell nests with spindle cell sarcomatous areas. Both areas were surrounded by a desmoplastic stroma. Immunohistoch...

journal_title：Pathology international

authors： Motoyama T,Maejima T,Aizawa K,Fukuda T,Watanabe H

更新日期：1996-01-01 00:00:00

abstract：:In the present study, 62 cases of ocular adnexal lymphoproliferative disorders were reviewed clinicopathologically. Of them, 51 were extranodal marginal zone B-cell lymphoma (MALT lymphoma), five were diffuse large B-cell lymphoma (DLBCL), one was peripheral T-cell lymphoma, one was NK/T cell lymphoma, nasal type, and...

journal_title：Pathology international

authors： Adachi A,Tamaru J,Kaneko K,Kuroda H,Miura I,Kojima T,Hoshino S,Ichinohasama R,Itoyama S

更新日期：2004-01-01 00:00:00

abstract：:We report on a rare distinctive variant of infiltrating ductal carcinoma characterized by sebaceous differentiation of tumor cells. The neoplasm was identified in a lumpectomy specimen from a 45-year-old woman with extensive metastatic disease. In addition to conventional in situ and invasive ductal components, approx...

journal_title：Pathology international

authors： Varga Z,Kolb SA,Flury R,Burkhard R,Caduff R

更新日期：2000-01-01 00:00:00

abstract：:The findings of a 20 year old woman with lymphadenopathy that was probably caused by an acute human herpesvirus-6 (HHV-6) infection are reported. She clinically demonstrated various signs of acute infection such as a high fever, skin rash, liver dysfunction, leukocytosis, an elevation of the erythrocyte sedimentation ...

journal_title：Pathology international

authors： Sumiyoshi Y,Kikuchi M,Ohshima K,Takeshita M,Eizuru Y,Minamishima Y

更新日期：1995-12-01 00:00:00

abstract：:The present study attempted to clarify the significance of aberrant expression of beta-catenin protein and mutation of exon 3 of the beta-catenin gene in renal and urothelial carcinogenesis. beta-Catenin expression was examined immunohistochemically and mutation of the beta-catenin gene was analyzed by polymerase chai...

journal_title：Pathology international

authors： Zhu X,Kanai Y,Saito A,Kondo Y,Hirohashi S

更新日期：2000-12-01 00:00:00

abstract：:Stenosing flexor tenosynovitis, trigger finger, is a common clinical disorder causing painful locking or contracture of the involved digits, and most instances are idiopathic. This problem is generally caused by a size mismatch between the swollen flexor tendon and the thickened first annular pulley. Although hypertro...

journal_title：Pathology international

authors： Uchihashi K,Tsuruta T,Mine H,Aoki S,Nishijima-Matsunobu A,Yamamoto M,Kuraoka A,Toda S

更新日期：2014-06-01 00:00:00

abstract：:Myofibroblasts have ultrastructural and functional characteristics intermediate between fibroblasts and smooth muscle cells. Previous studies indicated that most myofibroblasts express actin and vimentin but not desmin immunophenotypes. Two benign intramuscular myofibroblastic tumors which displayed a desmin-positive ...

journal_title：Pathology international

authors： Yang P,Hirose T,Seki K,Hasegawa T,Hizawa K,Sano T

更新日期：1996-09-01 00:00:00

abstract：:Breast cancer patients have a generally increased risk of developing second cancers. The object of this study was to clarify the increased as well as decreased incidence of cancers in breast cancer patients using autopsy cases. 164 211 autopsy cases in the Annual of Pathological Autopsy Cases in Japan from 2002 to 201...

journal_title：Pathology international

authors： Shibahara Y,Sugawara Y,Miki Y,Hata S,Takahashi H,Nakamura Y,Suzuki T,Ohuchi N,Tsuji I,Sasano H

更新日期：2016-12-01 00:00:00

abstract：:The factors conferring the increased malignancy on lung adenocarcinoma with micropapillary component (AC-MPC) remain to be elucidated. On proteomics based on 2-dimensional gel electrophoresis, 19 proteins differentially expressed by more than 1.5-fold between AC-MPC and conventional adenocarcinoma (CAC); in particular...

journal_title：Pathology international

authors： Nakashima H,Jiang SX,Sato Y,Hoshi K,Matsumoto T,Nagashio R,Kobayashi M,Matsuo Y,Shiomi K,Hayakawa K,Saegusa M,Satoh Y

更新日期：2015-04-01 00:00:00

abstract：:Pulmonary tumor thrombotic microangiopathy is an unusual malignancy-related respiratory complication characterized by multiple microthrombi and intimal myofibroblast proliferation. Its clinical manifestation is subacute respiratory failure with pulmonary hypertension. Herein is reported a case of pulmonary tumor throm...

journal_title：Pathology international

authors： Sakashita N,Yokose C,Fujii K,Matsumoto M,Ohnishi K,Takeya M

更新日期：2007-06-01 00:00:00

abstract：:Many new members of the S-100 genes are known to be associated with cell differentiation, malignant transformation, and cell cycle. Of the S-100 genes examined in the present study, calcyclin, calpactin I light chain and calvasculin were expressed in most human epithelial tumor cells, and their expression levels diffe...

journal_title：Pathology international

authors： Matsumoto T,Murao S,Kito K,Kihana T,Matsuura S,Ueda N

更新日期：1997-06-01 00:00:00

abstract：:We report a case of intrarenal teratoma in a 6-year-old boy. Two years before his operation, multicystic masses had been found in the left side of his abdomen. In the operation, three main cystic masses were located in the upper and lower poles of the left kidney, which were removed in pieces. Histologically, the cyst...

journal_title：Pathology international

authors： Otani M,Tsujimoto S,Miura M,Nagashima Y

更新日期：2001-07-01 00:00:00

abstract：:Malignant transformation of ovarian mature cystic teratomas is reported to occur in about 1% of cases. The most common malignant evolution is that of squamous cell carcinoma and one of the least common is that of small cell carcinoma. We report a case of distant metastasis from a small cell carcinoma arising in a matu...

journal_title：Pathology international

authors： Lim SC,Choi SJ,Suh CH

更新日期：1998-10-01 00:00:00

abstract：:A surgical case of inflammatory myofibroblastic tumor arising in the uterine corpus and exhibiting prominent myxoid change of the stroma is reported. The patient was a 63-year-old woman with a large tumor mass that filled the uterine cavity and measured 11 cm in maximal dimension. The tumor had a gelatinous appearance...

journal_title：Pathology international

authors： Shintaku M,Fukushima A

更新日期：2006-10-01 00:00:00

abstract：:The roles of Wnt protein in carcinogenesis have been well documented in human cancers. Wls is a key modulator for the secretion of Wnt protein. We previously found that Wls was aberrantly expressed in colorectal carcinomas. Studies have revealed that dysregulation of Wnt signal transduction plays an important role in ...

journal_title：Pathology international

authors： Zhang W,Tao H,Chen X,Sugimura H,Wang J,Zhou P

更新日期：2017-03-01 00:00:00

abstract：:Secondary (metastatic) neoplasms to the ovary often cause diagnostic problems, especially those tumors that produce large, symptomatic ovarian tumors that masquerade clinically and pathologically as primary ovarian tumors of surface epithelial type. Most of these tumors arise from organs of the digestive system. Excep...

journal_title：Pathology international

authors： Hart WR

更新日期：2005-05-01 00:00:00