Abstract:
:Breast cancer patients have a generally increased risk of developing second cancers. The object of this study was to clarify the increased as well as decreased incidence of cancers in breast cancer patients using autopsy cases. 164 211 autopsy cases in the Annual of Pathological Autopsy Cases in Japan from 2002 to 2010 were analyzed for multiple primary cancer (MPC). Female MPC cases (4222 cases) were selected. We investigated the cancer incidence observed in breast cancer associated MPC. The Chi-squared test was used for analysis. All P-values were two-sided, and differences at P < 0.05 were considered significant. Breast cancer associated MPC showed a significantly increased incidence of ovarian, pancreatic, and skin cancer (Odds Ratio [95 % confidence interval (CI)]) = 1.464 [1.03, 2.08], 1.414 [1.08, 1.85] and 2.092 [1.28, 3.41]), and a decreased incidence of colorectal and cervical cancer (OR [95 % CI]) = 0.732 [0.60, 0.90], 0.605 [0.38, 0.96]). Our findings of an increased incidence of malignancies in breast cancer associated MPC cases were consistent with the results of previous population-based studies. This study is the first study to analyze massive autopsy data on MPC which provide new evidence clinically and pathologically.
journal_name
Pathol Intjournal_title
Pathology internationalauthors
Shibahara Y,Sugawara Y,Miki Y,Hata S,Takahashi H,Nakamura Y,Suzuki T,Ohuchi N,Tsuji I,Sasano Hdoi
10.1111/pin.12484subject
Has Abstractpub_date
2016-12-01 00:00:00pages
695-700issue
12eissn
1320-5463issn
1440-1827journal_volume
66pub_type
杂志文章abstract::Malignant transformation of ovarian mature cystic teratomas is reported to occur in about 1% of cases. The most common malignant evolution is that of squamous cell carcinoma and one of the least common is that of small cell carcinoma. We report a case of distant metastasis from a small cell carcinoma arising in a matu...
journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1996.tb03533.x
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1998.tb03939.x
更新日期:1998-07-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/pin.12745
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2008-08-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1994.tb02587.x
更新日期:1994-01-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/pin.12869
更新日期:2019-12-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章,评审
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更新日期:2001-11-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1997.tb04533.x
更新日期:1997-08-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2003.01547.x
更新日期:2003-10-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1995.tb03420.x
更新日期:1995-12-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2005-07-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1997.tb04558.x
更新日期:1997-09-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1320-5463.2003.01463.x
更新日期:2003-04-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章,评审
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更新日期:1999-11-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1996.tb03619.x
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:1997-12-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章,多中心研究,评审
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.1999.00899.x
更新日期:1999-06-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2000.01139.x
更新日期:2000-12-01 00:00:00
abstract::The relationship between the mutation of the p53 gene and the expression of the p53 protein and the Ki-67 antigen has been investigated in 115 cases with non-Hodgkin's lymphoma, using the immunohistochemical double staining technique, single-strand conformational polymorphism and DNA sequencing methods. Eighteen cases...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1996.tb03588.x
更新日期:1996-02-01 00:00:00
abstract::We report a very rare case of combined thymic carcinomas: undifferentiated thymic carcinoma coexisting with type AB thymoma. The precise mechanism underlying the coexistence of these tumors remains unknown. Therefore, we used clonality analysis to ascertain whether the two tumors were clonally related. A 63-year-old w...
journal_title:Pathology international
pub_type:
doi:10.1111/pin.12426
更新日期:2016-07-01 00:00:00
abstract::A case of squamous cell carcinoma arising within an acquired seminal vesicular cyst is described. A 61-year-old man was hospitalized because of hemospermia and dysuria. Under the diagnosis of a left seminal vesicular cyst, surgical resection was performed. Pathological examination revealed squamous cell carcinoma with...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2002.01340.x
更新日期:2002-03-01 00:00:00