Pulmonary Langerhans cell histiocytosis "de novo" after lung transplantation.

Abstract:

:A pulmonary Langerhans cell histiocytosis is presented in a 40 year-old woman two years after bilateral lung transplantation for emphysema without any signs of Langerhans cells proliferation in the explanted lungs. A microsatellite molecular analysis showed the proliferating cells were generated in a recipient cellular clone. The patient did not quit smoking after transplantation. No signs of disease were detected in the implanted lungs before surgery. Strict control of immunosupressive drug levels stabilized the disease. A "de novo" monoclonal origin of stem cells, probably from the bone marrow is suggested. The reason she did not develop disease in the native lungs is unknown, although we suggest an interaction between tobacco or some other antigens and local cellular receptors.

journal_name

Pathol Int

journal_title

Pathology international

authors

Gómez-Román J,Zarrabeitia MT,Santurtún A,Parra JA,Azueta Etxebarría A,Cifrian JM,Freire Salinas J

doi

10.1111/pin.12597

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

632-637

issue

12

eissn

1320-5463

issn

1440-1827

journal_volume

67

pub_type

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