Critical multi-organ emboli originating from collapsed, vulnerable caseous mitral annular calcification.

abstract：:Epstein-Barr virus (EBV) infection is associated with pathogenesis of various cancers, including extranodal natural killer/T-cell lymphoma, nasal type (ENKL). ENKL tumor cells are positive for EBV-encoded RNA1 (EBER1), which is the most useful marker to identify ENKL tumor cells in histopathology. Currently, EBER1 in ...

journal_title：Pathology international

authors： Ito Y,Makita S,Maeshima AM,Hatta S,Yuda S,Suzuki T,Fukuhara S,Munakata W,Taniguchi H,Suzuki T,Maruyama D,Izutsu K

更新日期：2019-07-01 00:00:00

abstract：:Patients with pulmonary small cell carcinoma are well known to have a poor prognosis. However, predictors of prognosis and treatment outcome have not been reported for this type of cancer. We examined whether excision repair cross-complementation group 1 (ERCC1), phosphorylated Akt (p-Akt), phosphorylated mammalian ta...

journal_title：Pathology international

authors： Ikeda S,Takabe K,Inagaki M,Suzuki K

更新日期：2010-11-01 00:00:00

abstract：:The relationship between the mutation of the p53 gene and the expression of the p53 protein and the Ki-67 antigen has been investigated in 115 cases with non-Hodgkin's lymphoma, using the immunohistochemical double staining technique, single-strand conformational polymorphism and DNA sequencing methods. Eighteen cases...

journal_title：Pathology international

authors： Kuze T,Nakamura N,Hashimoto Y,Hojo H,Abe M,Wakasa H

更新日期：1996-02-01 00:00:00

abstract：:A case of gliosarcoma composed of glioblastoma and liposarcoma is presented. A 70-year-old Japanese man was admitted to hospital because of dysarthria and aphasia. Magnetic resonance imaging indicated a brain tumor located in the temporal-parietal area of the left hemisphere. He rejected any therapy and died of respir...

journal_title：Pathology international

authors： Fukuda T,Yasumichi K,Suzuki T

更新日期：2008-06-01 00:00:00

abstract：:Reported herein is an unusual case of prostatic phyllodes tumor with exuberant glandular hyperplasia that led to misdiagnosis of adenocarcinoma. The tumor was detected in a 52-year-old man who had a 1 year history of dysuria. Adenocarcinoma of the prostate was diagnosed from a needle biopsy specimen. The patient recei...

journal_title：Pathology international

authors： Morikawa T,Nagata M,Tomita K,Kitamura T,Goto A,Chong JM,Fukayama M

更新日期：2006-03-01 00:00:00

abstract：:We recently established a high-speed, label-free, spectral imaging method based on stimulated Raman scattering (SRS). This method enables examination of cellular features within relatively short periods, thus enabling new imaging applications in pathology. Previously, we reported on label-free visualization of mouse t...

journal_title：Pathology international

authors： Satoh S,Otsuka Y,Ozeki Y,Itoh K,Hashiguchi A,Yamazaki K,Hashimoto H,Sakamoto M

更新日期：2014-10-01 00:00:00

abstract：:We herein describe a rare case of low-grade endobronchial tumor that exhibited two distinct features of typical carcinoid and acinic cell carcinoma (ACC) by immunohistochemical and ultrastructure study. ACC was suspected on transbronchial biopsy. The resected specimen showed that the tumor surface comprised an acinic ...

journal_title：Pathology international

authors： Watanabe H,Miyagawa-Hayashino A,Imabayashi T,Kishimoto M,Shimomura M,Honda K,Omatsu I,Shimada E,Inoue M,Takayama K,Konishi E

更新日期：2019-12-01 00:00:00

abstract：:The CDKN2 gene encodes two structurally different proteins: a cyclin-dependent kinase inhibitor, p16, which regulates retinoblastoma protein (pRb)-dependent G1 arrest, and a cell cycle inhibitor, p14ARF, which blocks MDM2-induced p53 degradation resulting in an increase in p53 levels that leads to cell cycle arrest. R...

journal_title：Pathology international

authors： Sano T,Masuda N,Oyama T,Nakajima T

更新日期：2002-05-01 00:00:00

abstract：:We have reported that the function of histamine and its receptors (HRs) has a close relationship with the development of nonalcoholic fatty liver disease (NAFLD). However, much less is known regarding its pathogenic and molecular mechanism(s), including the early stage of hepatic and intestinal function for lipid and ...

journal_title：Pathology international

authors： Yamada S,Guo X,Wang KY,Tanimoto A,Sasaguri Y

更新日期：2016-07-01 00:00:00

abstract：:Malignant lymphoma arising in the stomach of a 23-year-old Japanese man with systemic sarcoidosis is presented. The patient was followed because of systemic sarcoidosis involving the lungs, eyes, and lymph nodes. Biopsy specimens from the stomach were repeated because of recurrent epigastralgia and multiple ulceration...

journal_title：Pathology international

authors： Fukuda T,Sato K,Tachikawa S,Ohnuki K,Ohtani H,Suzuki T

更新日期：1997-12-01 00:00:00

abstract：:beta-Catenin has multiple functions both in intercellular adhesion and in signal transduction. As a signaling molecule, mutations in exon 3 of the beta-catenin gene stabilize this protein in the cytoplasm. Subsequently, accumulated beta-catenin protein translocates to nuclei with T-cell factor-4, and upregulates trans...

journal_title：Pathology international

authors： Miyake N,Maeta H,Horie S,Kitamura Y,Nanba E,Kobayashi K,Terada T

更新日期：2001-09-01 00:00:00

abstract：:A 53-year-old woman presented with Cushing's syndrome resulting from an adrenocortical adenoma, 6.5 cm in diameter and 75 g in weight, which is larger than usual. Endocrinological data of this patient showed adrenocorticotropin (ACTH)-independent hypercortisolemia. A computed tomography scan of the adrenal glands reve...

journal_title：Pathology international

authors： Karasawa R,Hotta M,Aiba M,Takano K

更新日期：2004-04-01 00:00:00

abstract：:A 35-year-old Japanese man who had experienced hoarseness for 10 years presented with a vocal cord lesion. A gross examination revealed a left vocal cord polyp occupying two-thirds of the vocal space. The endoscopically resected lesion contained scattered atypical fibroblastic, stellate, or ganglion-like cells with mu...

journal_title：Pathology international

authors： Yorita K,Togashi Y,Nakagawa H,Miyazaki K,Sakata S,Baba S,Takeuchi K,Hayashi Y,Murakami I,Kuroda N,Oda Y,Kohashi K,Yamada Y,Kiyozawa D,Michal M,Michal M

更新日期：2019-06-01 00:00:00

abstract：:Alopecia was induced in male and female neonatal C57BL mice by a single intraperitoneal injection of 60 mg/kg N-methyl-N-nitrosourea (MNU). MNU administration was most effective in the 8-day-old mice and less effective in the 5-day-old mice (at active and early anagen stages of the first hair cycle, respectively). No ...

journal_title：Pathology international

authors： Yoshizawa K,Nambu H,Yamamoto D,Yang J,Kiyozuka Y,Shikata N,Tsubura A

更新日期：2000-03-01 00:00:00

abstract：:This is the first report of segmental arterial mediolysis (SAM) accompanied with polyarteritis nodosa (PN), and manifesting aneurysms of the renal arteries. A 73-year-old woman was admitted to hospital because of a high fever. Laboratory tests showed leukocytosis with increased CRP level in the serum. Myeloperoxidase-...

journal_title：Pathology international

authors： Soga Y,Nose M,Arita N,Komori H,Miyazaki T,Maeda T,Furuya K

更新日期：2009-03-01 00:00:00

abstract：:Tight junctions are intercellular junctions adjacent to the apical ends of paracellular spaces. They have two classical functions, the barrier function and the fence function. The former regulates the passage of ions, water and various molecules through paracellular spaces, and is thus related to edema, jaundice, diar...

journal_title：Pathology international

authors： Sawada N

更新日期：2013-01-01 00:00:00

abstract：:We describe a rare case of dedifferentiated liposarcoma with features resembling chondroblastic osteosarcoma in the dedifferentiated component. The tumor was removed from the left thigh in a 78-year-old male. It consisted of a well-differentiated liposarcoma and an anaplastic component that contained numerous osteoid ...

journal_title：Pathology international

authors： Yamamoto T,Matsushita T,Marui T,Mizuno K,Minami R,Hayashi Y,Hanioka K

更新日期：2000-07-01 00:00:00

abstract：:Solitary fibrous tumor of the pleura (SFTP) is rare. A 73-year-old man, without past history of diabetes mellitus, was admitted to hospital with profound hypoglycemia, loss of consciousness and respiratory failure. CT indicated a huge heterogenous mass lesion (12 x 12 x 17 cm) at the right thoracic cavity with total a...

journal_title：Pathology international

authors： Chang JC,Su KY,Chao SF,Hsu YH,Yang GG,Chang BS

更新日期：2007-12-01 00:00:00

abstract：:A case of primary leiomyosarcoma of a thoracic vertebra associated with a compression fracture in a 75-year-old woman was preoperatively thought to be granulation tissue. Surgical decompression was performed and the histological and immunohistochemical studies established the diagnosis of leiomyosarcoma. Based on the ...

journal_title：Pathology international

authors： Sasaguri T,Tanimoto A,Kimura S,Kohno Y,Hirasawa M,Matsuki Y,Abe K,Hashimoto H,Hamada T,Sasaguri Y

更新日期：2004-01-01 00:00:00

abstract：:A case of low-grade endometrial stromal sarcoma with extensive epithelial-like element (ELE) is reported. This tumor was composed of classical endometrial stromal sarcoma (CESS) showing diffuse proliferation, and ELE occupying approximately 72% of the tumor mass. On immunohistochemistry, ELE was negative for sex-cord ...

journal_title：Pathology international

authors： Ohta Y,Suzuki T,Kojima M,Shiokawa A,Mitsuya T

更新日期：2003-04-01 00:00:00

abstract：:Conditions of preserving DNA, RNA and protein in pathological specimens are of great importance as degradation of such macromolecules would critically affect results of molecular biological analysis. The feasibility of freeze-drying as a means of preserving pathological tissue samples for molecular analysis has previo...

journal_title：Pathology international

authors： Matsuo S,Sugiyama T,Okuyama T,Yoshikawa K,Honda K,Takahashi R,Maeda S

更新日期：1999-05-01 00:00:00

abstract：:We report a rare case of hepatocellular carcinoma (HCC) with an unusual neuroendocrine component. During a follow-up study for chronic hepatitis C in a 71-year-old man, a nodular lesion showed rapid growth from 1 cm to 4 cm in diameter within 3 months. Histologically, the tumor was consistent with moderately different...

journal_title：Pathology international

authors： Yamaguchi R,Nakashima O,Ogata T,Hanada K,Kumabe T,Kojiro M

更新日期：2004-11-01 00:00:00

abstract：:Two cases of endometrial low-grade stromal sarcoma with ovarian sex cord-like differentiation occurring in a 39-year-old woman and a 42-year-old woman are presented. Both tumors, which were intramyometrial and measured 7.5 cm and 7.0 cm in greatest diameter, respectively, showed a multinodular, ill-demarcated, and yel...

journal_title：Pathology international

authors： Fukunaga M,Miyazawa Y,Ushigome S

更新日期：1997-06-01 00:00:00

abstract：:Pleomorphic lobular carcinoma (PLC) of the breast is a variant of lobular carcinoma, characterized by loss of E-cadherin expression and high-grade morphologies. Whether the pathogenesis of PLC is in the ductal or the lobular lineage has been discussed. In this report, a case of PLC combined with apocrine carcinoma is ...

journal_title：Pathology international

authors： Ishii A,Oishi T,Kakuda Y,Yasui H,Kawata T,Muramatsu K,Takahashi K,Sugino T

更新日期：2019-05-01 00:00:00

abstract：:Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare clinicopathological entity causing severe pulmonary hypertension. Its histological features include widespread tumor emboli along with fibrocellular intimal proliferation and thrombus formation in the small arteries and arterioles of the lungs. The result is ...

journal_title：Pathology international

authors： Chinen K,Kazumoto T,Ohkura Y,Matsubara O,Tsuchiya E

更新日期：2005-01-01 00:00:00

abstract：:Morphologic features and neoplastic potentials of bile duct adenoma (BDA) and von Meyenburg complex (VMC)-like duct arising in chronic liver disease were unknown. Thirty-five BDAs and 12 VMC-like duct lesions were observed in 39 cases with chronic liver disease. BDAs were divided into the EMA-cytoplasmic type (n = 14)...

journal_title：Pathology international

authors： Aishima S,Tanaka Y,Kubo Y,Shirabe K,Maehara Y,Oda Y

更新日期：2014-11-01 00:00:00

abstract：:We have found that the MIB-1 grade, based on tumor differentiation/histological type, necrosis and Ki-67 (MIB-1) score, is a valid and reproducible prognostic system for adult soft-tissue sarcomas. However, there are limited data available on Ki-67 labeling indices (LI) from adult soft-tissue sarcomas for testing the ...

journal_title：Pathology international

authors： Hasegawa T,Yamamoto S,Matsuno Y

更新日期：2002-07-01 00:00:00

abstract：:A case of intraplacental choriocarcinoma associated with a placental hemangioma is presented. Ultrasonic examination revealed a placental hemangioma at 33 weeks gestation. A cesarean section was performed at 37 weeks gestation. Histological examination showed intraplacental choriocarcinoma associated with the hemangio...

journal_title：Pathology international

authors： Aonahata M,Masuzawa Y,Tsutsui Y

更新日期：1998-11-01 00:00:00

abstract：:Radiofrequency ablation (RFA) has become a widespread treatment option for liver carcinoma. There is limited knowledge regarding the macroscopic and histomorphological changes of induced lesions. Twelve domestic pigs underwent RFA using a Starburst XL device with ablation diameter of 3 cm. One animal died within 24 h,...

journal_title：Pathology international

authors： Kasper HU,Bangard C,Gossmann A,Dienes HP,Stippel DL

更新日期：2010-03-01 00:00:00

abstract：:Nucleobindin (Nuc) was originally found to be an enhancement factor of anti-DNA antibody production secreted by a lymphoid cell line derived from a lymphoproliferative MRL/lpr mouse. It has been shown that Nuc has a unique structure containing a DNA- and two calcium-binding domains, and a leucine zipper motif, but its...

journal_title：Pathology international

authors： Kubota T,Miyauchi M,Miura K,Hirokawa G,Awaya A,Miyasaka N,Kurosawa Y,Kanai Y,Maruyama K

更新日期：1998-01-01 00:00:00