Abstract:
:Radiofrequency ablation (RFA) has become a widespread treatment option for liver carcinoma. There is limited knowledge regarding the macroscopic and histomorphological changes of induced lesions. Twelve domestic pigs underwent RFA using a Starburst XL device with ablation diameter of 3 cm. One animal died within 24 h, two animals were killed after 2 weeks, and nine after 4 weeks. Their livers were used for macroscopic and histological investigation. Six human liver resection specimens after previous treatment with RFA were also investigated. In pig samples, acute RFA change showed a necrosis zone demarcated by resorption zone with granulocytes and hyperemia. In subchronic and chronic RFA change, the zone of thermofixation was followed by a fibrous capsule and a liver reaction zone. Small blood vessels in the lesions showed damage involving endothelial destruction and thrombosis. Larger vessels within the lesions were observed with intact vessel walls, surrounded by a rim of vital hepatocytes. In the human samples, tumor-infiltrating lymphocytes were reduced (CD3+ cells: 8.4 +/- 3.7/10 high-power fields (HPF); CD4+ cells: 4.2 +/- 1.9/10 HPF), whereas the number of histiocytes was found to be increased (CD68+ cells: 15.5 +/- 9.02/10 HPF). The recognition of thermofixation and the process of resorption of the RFA lesion is important for the interpretation of biopsies and surgical resection specimens.
journal_name
Pathol Intjournal_title
Pathology internationalauthors
Kasper HU,Bangard C,Gossmann A,Dienes HP,Stippel DLdoi
10.1111/j.1440-1827.2009.02498.xsubject
Has Abstractpub_date
2010-03-01 00:00:00pages
149-55issue
3eissn
1320-5463issn
1440-1827pii
PIN2498journal_volume
60pub_type
杂志文章abstract::Epstein-Barr virus (EBV) has been implicated as a causal virus of gastric cancer with episomal monoclonality, elevated antibodies and a unique morphologic expression in the early intramucosal stage, but the infection mechanisms have not been demonstrated. EBV has been shown only in the cancerous lesions by the highly ...
journal_title:Pathology international
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journal_title:Pathology international
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journal_title:Pathology international
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pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
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journal_title:Pathology international
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journal_title:Pathology international
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journal_title:Pathology international
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journal_title:Pathology international
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journal_title:Pathology international
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