Abstract:
:We elucidated clinicopathological characteristics of chondroblastoma (CB) in Japan, and reliable clinicopathologic parameters predicting local recurrence and/or metastasis. Clinicopathological profiles of 103 CB (80 male, 23 female) in extra-craniofacial bones were retrieved. Numerical scoring of nine pathological and five radiological features was statistically analyzed to determine prognostic significance. Age ranged 8-61 years (average 19.6 years). Frequently involved sites were femur, tibia, calcaneus, patella and humerus. Radiologically, tumors were 2-80 mm (average 31.1 mm) in size. Marginal sclerosis and calcification were common. Histologically, pink cartilage, mitoses, and chicken-wire calcification were often seen. Within a follow-up period [2-260 months (average 53.5 months)], the local recurrence rate was 15.5%. No patient had metastasis. Recurrence was most frequently observed at the femur. By log-rank analysis, only cyst formation in images was significant for predicting recurrence free survival (RFS). By Cox hazard analysis with representative clinico-radiological and pathological features, only age (≥16 years) and cyst formation were significant predictors for RFS. Pathological features were not significant in both uni- and multivariate analyses.
journal_name
Pathol Intjournal_title
Pathology internationalauthors
Konishi E,Nakashima Y,Mano M,Tomita Y,Kubo T,Araki N,Morii E,Yoshikawa H,Haga H,Toguchida J,Ueda T,Osawa M,Hoshi M,Inoue T,Aono M,Yanagisawa Adoi
10.1111/pin.12586subject
Has Abstractpub_date
2017-10-01 00:00:00pages
495-502issue
10eissn
1320-5463issn
1440-1827journal_volume
67pub_type
杂志文章abstract::Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare genetic disorder characterized by cutaneous and uterine leiomyomatosis with RCC. This disorder is caused by a germline mutation in the fumarate hydratase (FH) gene, which encodes an important enzyme of the tricarboxylic acid (TCA) cycle. This mutation d...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/pin.12684
更新日期:2018-05-24 00:00:00
abstract::Presented is the first Japanese case of ossifying renal tumor of infancy (ORTI), which is an extremely rare tumor and of which only nine cases have been reported in the literature. The patient was a four-month-old Japanese boy presenting as hematuria. A small nodular tumor (approximately 1 cm in size) protruded into t...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1998.tb03885.x
更新日期:1998-02-01 00:00:00
abstract::There are several reports of pleural adenomatoid (microcystic) mesothelioma, but peritoneal adenomatoid mesothelioma is extremely rare. A 64-year-old Japanese woman presented with no symptoms and no asbestos exposure history. An abdominal computed tomography scan revealed multiple hypervascular masses on the liver sur...
journal_title:Pathology international
pub_type:
doi:10.1111/pin.13006
更新日期:2020-11-01 00:00:00
abstract::A 56-year-old male treated for a gastric yolk sac tumor with an adenocarcinomatous component is described. A mixed area of reticular and glandular neoplastic components was morphologically identified in this tumor. Immunohistochemically, the yolk sac tumor expressed alpha-fetoprotein (AFP), placental alkaline phosphat...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.1999.00907.x
更新日期:1999-06-01 00:00:00
abstract::The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors and has been identified to play a crucial role in a number of biological processes, including the trafficking and homeostasis of immune cells such as T lymphocytes. CXCR4 has also been found to be a prognostic marker in variou...
journal_title:Pathology international
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1827.2010.02548.x
更新日期:2010-07-01 00:00:00
abstract::Pathologists are required to integrate data from multiple sources when making a diagnosis. Furthermore, whole slide imaging (WSI) and next generation sequencing will escalate data size and complexity. Development of well-designed databases that can allow efficient navigation between multiple data types is necessary fo...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/pin.12382
更新日期:2016-02-01 00:00:00
abstract::A case of intraplacental choriocarcinoma associated with a placental hemangioma is presented. Ultrasonic examination revealed a placental hemangioma at 33 weeks gestation. A cesarean section was performed at 37 weeks gestation. Histological examination showed intraplacental choriocarcinoma associated with the hemangio...
journal_title:Pathology international
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1827.1998.tb03858.x
更新日期:1998-11-01 00:00:00
abstract::Pilomyxoid astrocytoma, first described by Tihan et al., was recently included as an established variant of pilocytic astrocytoma in the World Health Organization classification of CNS tumors. Histologically, it much resembles pilocytic astrocytoma, but monomorphic myxoid tumor of pilocytic cells with prominent angioc...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.2008.02332.x
更新日期:2009-02-01 00:00:00
abstract::Mucinous cystic neoplasm (MCN) of the pancreas is characterized by mucin-producing columnar epithelium and an ovarian-type stroma. It occurs almost exclusively in women and is almost always located in the pancreatic body or tail. Here, we report a case of large MCN located in the pancreatic head but not in the body no...
journal_title:Pathology international
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1827.2010.02609.x
更新日期:2011-01-01 00:00:00
abstract::A case of ovarian fibrosarcoma producing multiple cytokines is presented. The tumor occurred in the left ovary of a Japanese woman with epigastralgia, remittent fever, leukocytosis and slight thrombocytosis with moderate increase of mast cells in bone marrow, but lack of hormonal abnormality. The resected tumor of the...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2001.01270.x
更新日期:2001-09-01 00:00:00
abstract::Malignant myoepithelioma of soft tissue is extremely rare. Presented herein is a case arising in a 17-year-old man. The tumor was initially noticed as a painless deep soft-tissue mass in the right forearm when the patient was aged 3 years. Thereafter, it grew without remarkable symptoms, such as pain or tenderness, un...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.2005.01861.x
更新日期:2005-08-01 00:00:00
abstract::A case of a rare pancreatic tumor, duct-acinar-islet cell tumor is presented. The tumor was incidentally found in the pancreatic body on computed tomography of a 21 year old male suffering from mumps. It was well demarcated from surrounding pancreas, and spherical in shape, measured 2.5 cm in diameter. Histologic and ...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1995.tb03520.x
更新日期:1995-09-01 00:00:00
abstract::A report of a 65-year-old male with a tumor arising from synovial tissue of the radio-ulnar joint. On magnetic resonance imaging, the tumor was demonstrated as a heterogeneous and lobulated mass with a low signal intensity both in T1- and T2-weighted images. Histological findings of the tumor were identical to those o...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.1999.00984.x
更新日期:1999-12-01 00:00:00
abstract::A quantitative model was devised for the purpose of evaluating interobserver agreement in the judgment of the nuclear atypia score of cancer cells in protocol studies. In this model, the mean nuclear atypia score (mu) among observers was considered to approximate the 'true' nuclear atypia score of the tumor, and with ...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2000.01017.x
更新日期:2000-02-01 00:00:00
abstract::Rhinoscleroma is an uncommon chronic, destructive infection of the respiratory mucosa caused by Klebsiella rhinoscleromatis. This coccobacillus can be found in the typical histiocytes, the Mikulicz cells. Extranasal and nodal involvement in this disease is rare, but documented. Rosai-Dorfman disease or sinus histiocyt...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.2004.01597.x
更新日期:2004-02-01 00:00:00
abstract::Microwave cell death (MCD) is unique in that microscopic morphology and antigenicity are well preserved, while enzymatic activity is lost. The aim of the present study was to carry out DNA electrophoresis, polymerase chain reaction (PCR) amplification and terminal deoxynucleotidyl transferase-mediated dUTP nick end-la...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.2009.02368.x
更新日期:2009-05-01 00:00:00
abstract::Senescence marker protein 30 (SMP 30) is preferentially expressed in the liver. One of its remarkable functions is the protection of cells against various injuries by enhancement of membrane calcium-pump activity. We analyzed the role of SMP 30 in hepatocyte proliferation. SMP 30 expression was decreased initially, th...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2001.01238.x
更新日期:2001-07-01 00:00:00
abstract::A subcutaneous myopericytoma-type perivascular myoma arising in the elbow of a 61-year-old woman is described. The tumor was well demarcated and consisted microscopically of small ovoid and spindle cells arranged in a concentric fashion, surrounding small to medium-sized vessels and imparting a superficial resemblance...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2002.01318.x
更新日期:2002-01-01 00:00:00
abstract::Differentiation of malignant pleural mesothelioma (MPM) from benign mesothelial proliferation remains problematic. Loss of nuclear staining of BRCA1-associated protein 1 (BAP1; detected using immunohistochemistry (IHC)) and homozygous deletion (HD) of p16 (detected using fluorescence in situ hybridization (FISH)) are ...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/pin.12453
更新日期:2016-10-01 00:00:00
abstract::The biopsy-based diagnosis of autoimmune pancreatitis (AIP) is difficult but is becoming imperative for pathologists due to the increased amount of endoscopic ultrasound-guided biopsy tissue. To cope with this challenge, we propose guidance for the biopsy diagnosis of type 1 AIP. This guidance is for pathologists and ...
journal_title:Pathology international
pub_type: 杂志文章,评审
doi:10.1111/pin.12994
更新日期:2020-10-01 00:00:00
abstract::Secondary (metastatic) neoplasms to the ovary often cause diagnostic problems, especially those tumors that produce large, symptomatic ovarian tumors that masquerade clinically and pathologically as primary ovarian tumors of surface epithelial type. Most of these tumors arise from organs of the digestive system. Excep...
journal_title:Pathology international
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1827.2005.01819.x
更新日期:2005-05-01 00:00:00
abstract::In 2004, two groups reported somatic mutations in the gene for the epidermal growth factor receptor (EGFR) in patients with non-small cell lung cancer (NSCLC), which were highly correlated with the clinical response to the anticancer drug, gefitinib. Since then, a tremendous amount of knowledge has accumulated, and sh...
journal_title:Pathology international
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1827.2007.02098.x
更新日期:2007-05-01 00:00:00
abstract::Intratumoral ossification has been reported in a number of epithelial tumors, but its presence in intraductal papillary mucinous neoplasms (IPMNs) is very rare. Herein, we present a rare case of IPMN with marked ossification. A 56-year-old Japanese man was under follow-up for a previously diagnosed IPMN. Seven years l...
journal_title:Pathology international
pub_type:
doi:10.1111/pin.12416
更新日期:2016-06-01 00:00:00
abstract::Rheumatoid nodule is a frequent and characteristic extra-articular manifestation of rheumatoid arthritis (RA). Its involvement of central nervous system is a rare occurrence with only a few reported cases. A 78-year-old man with severe arthritis showing the formation of rheumatoid nodule-like granulomas in the dura an...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1996.tb03649.x
更新日期:1996-07-01 00:00:00
abstract::Multiple carcinomas of the pancreatico-biliary tree are rare. A 53 year old Japanese man was diagnosed as having an adenocarcinoma in the papilla of Vater. During the operation, he was also found to have a polypoid mass in the common bile duct. While cutting the operative specimen into stepwise sections, a small tumor...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1994.tb03371.x
更新日期:1994-04-01 00:00:00
abstract::Nuclear pseudoinclusions (NPIs) are classically found in papillary thyroid carcinoma and meningioma. Although NPIs have been described in melanocytic lesions, there is no systematic analysis of potential relationship between NPIs and other clinicopathological characteristics of melanoma. We examined the presence of NP...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/pin.12629
更新日期:2018-02-01 00:00:00
abstract::Computerized morphometrical measurements were made of liver cells and their nuclei taken from biopsy specimens of primary biliary cirrhosis (PBC), alcoholic cirrhosis, posthepatitic cirrhosis (HBV-related), and hepatocellular carcinoma (HCC). The specimens were stained with hematoxylin-eosin (HE), Mallory's stain for ...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1996.tb03609.x
更新日期:1996-04-01 00:00:00
abstract::A 70-year-old man with metastatic liver tumors showed carcinoid syndrome with clinical symptoms of facial flushing, palpitation, dyspnea, and an itching sensation. Regurgitation of the tricuspid and aortic valves was observed by echocardiography. An elevated serum level of serotonin and a high urine excretion of serot...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2000.01053.x
更新日期:2000-05-01 00:00:00
abstract::Ameloblastoma is an odontogenic tumor of the jaw. It most frequently occurs in the mandible, and less often in the maxilla. Mandibular ameloblastoma harbors a BRAF mutation that causes a valine (V) to glutamic acid (E) substitution at codon 600 (BRAFV600E ). We examined specimens from 32 Japanese patients to detect th...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/pin.12899
更新日期:2020-04-01 00:00:00
abstract::The factors conferring the increased malignancy on lung adenocarcinoma with micropapillary component (AC-MPC) remain to be elucidated. On proteomics based on 2-dimensional gel electrophoresis, 19 proteins differentially expressed by more than 1.5-fold between AC-MPC and conventional adenocarcinoma (CAC); in particular...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/pin.12257
更新日期:2015-04-01 00:00:00