Abstract:
:A 70-year-old man with metastatic liver tumors showed carcinoid syndrome with clinical symptoms of facial flushing, palpitation, dyspnea, and an itching sensation. Regurgitation of the tricuspid and aortic valves was observed by echocardiography. An elevated serum level of serotonin and a high urine excretion of serotonin metabolites were confirmed. Autopsy confirmed a serotonin-immunoreactive 1 cm ileal carcinoid tumor with metastasis to the liver, bone and peritoneum. The tumor cells were argyrophilic but not argentaffin, and showed erythrophagocytosis in the primary lesion. All the four heart valves and bilateral atrial endocardium showed fibromyxoid thickening, indicating the association of carcinoid heart disease. Desmoplastic reaction with deposition of sulfated acid mucopolysaccharides was also observed in the retroperitoneal space (secondary retroperitoneal fibrosis). Stenosis of the bilateral ureters and inferior mesenteric artery provoked hydronephrosis and lethal ischemic necrosis of the left-sided colon, respectively. Rarity of functioning ileal carcinoid tumor and pathogenesis of systemic fibroplasia are discussed.
journal_name
Pathol Intjournal_title
Pathology internationalauthors
Sakai D,Murakami M,Kawazoe K,Tsutsumi Ydoi
10.1046/j.1440-1827.2000.01053.xsubject
Has Abstractpub_date
2000-05-01 00:00:00pages
404-11issue
5eissn
1320-5463issn
1440-1827pii
pin1053journal_volume
50pub_type
杂志文章abstract::Gonadotropin releasing hormone (GnRH) analogs can cause regression of hormone-dependent breast carcinomas via the specific GnRH receptor (GnRH-R). In an attempt to obtain a better understanding of GnRH actions in human breast carcinoma, the expression of GnRH-R was examined immunohistochemically in 58 invasive ductal ...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2001.01210.x
更新日期:2001-05-01 00:00:00
abstract::Aerobes, including humans, are consistently exposed to oxidative stress by consuming oxygen. The biological significance of oxidative stress via reactive oxygen and nitrogen species consists of two stages: reversible redox regulation and irreversible oxidative molecular damage, which are sometimes intermingled. During...
journal_title:Pathology international
pub_type: 杂志文章,评审
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2002.01412.x
更新日期:2002-11-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2001.01302.x
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:1999-07-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2006-11-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:1997-08-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:Pathology international
pub_type:
doi:10.1111/pin.12445
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1995.tb03431.x
更新日期:1995-02-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2008-10-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1996.tb03664.x
更新日期:1996-09-01 00:00:00
abstract::We report 17 cases of the classic type of Kaposi's sarcoma in Xinjiang, which is located in the north-western area of China surrounded by Mongolia in the east, Russia in the north and Kazakhstan in the west. Fifteen of the patients were of the Uygur people. All patients were male and did not have acquired immunodefici...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2001.01293.x
更新日期:2001-11-01 00:00:00
abstract::An autopsy case of an 18 month old male infant with measles infection is reported. An autopsy revealed generalized lymphadenopathy, splenomegaly and hyperplastic thymus. Histologically, there were many Warthin-Finkeldey cells (WFC) in hyperplastic lymphoid tissues. Although viral particles and inclusions were not dete...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1994.tb01708.x
更新日期:1994-06-01 00:00:00
abstract::CpG island methylator phenotype (CIMP) is a recently described subset of colorectal cancers (CRC) with widespread methylation of multiple promoter CpG islands. But the prognostic implication of CIMP in CRC has not been clarified. Thus, the aim of the present study was to differentiate the unique characteristics of CIM...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.2007.02197.x
更新日期:2008-02-01 00:00:00
abstract::Solitary pulmonary capillary hemangiomas (SPCHs) are recently recognized, rare benign lesions that form solitary nodules owing to capillary proliferation. These lesions are usually detected incidentally as small ground-glass nodules (GGNs) on computed tomography (CT), and progressively enlarge over time. The radiologi...
journal_title:Pathology international
pub_type:
doi:10.1111/pin.12945
更新日期:2020-08-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.1999.00908.x
更新日期:1999-07-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1827.1995.tb03386.x
更新日期:1995-10-01 00:00:00
abstract::A case of small cell carcinoma arising in the outer urethral orifice is presented. The resected tumor showed a proliferation of small round or fusiform neoplastic cells in the submucosa. Tumor cells were arranged in sheets or a trabecular manner and possessed markedly hyperchromatic nuclei with a high N:C ratio, close...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1997.tb04530.x
更新日期:1997-07-01 00:00:00
abstract::S-100 protein, a dimer of S-100 alpha and S-100 beta subunits (S-100 alpha and S-100 beta), is widely distributed in human tissue, and several papers describing S-100 protein expression in follicular cells of the thyroid have been published. In the present study, 105 cases of thyroid carcinoma (of which 96 were papill...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1997.tb04440.x
更新日期:1997-10-01 00:00:00
abstract::The etiological role of human papillomavirus (HPV) in esophageal carcinoma (EC) in relation to p53, mdm2, p21(waf), c-erbB2 and the overall survival (OS) rate was investigated. Tumor and normal tissues from 50 EC were evaluated by polymerase chain reaction and InnoLiPA for HPV. Single strand conformation polymorphism/...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.2005.01804.x
更新日期:2005-02-01 00:00:00
abstract::A complete spontaneous regression of diffuse large B cell lymphoma involving the right breast, confirmed by aspiration cytology, is reported. The patient visited a hospital due to the rapid growth of a tumor in the right breast. Five years previously she underwent a craniotomy for a brain tumor, diagnosed as B-cell ma...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.2004.01652.x
更新日期:2004-07-01 00:00:00
abstract::Therapy related acute lymphoblastic leukemia (t-ALL) of B cell origin is rare and constitutes approximately 2% of all ALL. Previously compiled data on the complete cytogenetic analysis of 48 t-B-ALL cases suggested that MLL rearrangement at 11q23 gene locus is the most common abnormality. Philadelphia chromosome (Ph) ...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/pin.12337
更新日期:2015-10-01 00:00:00
abstract::The aims of this study were to identity the roles of tumor vessels and hormone receptor status in normal, hyperplastic, and neoplastic endometrium, and to explore their relationships with other prognostic factors of endometrial adenocarcinoma. Endometrial curettage specimens of proliferative phase and secretory phase ...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2003.01565.x
更新日期:2003-12-01 00:00:00
abstract::Soft-tissue sarcomas can be divided into translocation-associated (TA) and non-TA sarcomas, the latter of which is often characterized by pleomorphic cytomorphology and aneuploidy. The aberrant expression of MAD2, an essential component of the mitotic spindle checkpoint, has been recently shown to promote aneuploidy. ...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.2008.02232.x
更新日期:2008-06-01 00:00:00
abstract::Pituicytoma is a rare low-grade glial neoplasm that originates in the neurohypophysis or infundibulum. Because of its rare occurrence, the morphology and differentiation of pituicytoma have not been fully clarified. Here, we report a case of pituicytoma with unusual histological features mimicking ependymoma, but exhi...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.2011.02708.x
更新日期:2011-10-01 00:00:00
abstract::Methotrexate (MTX) is currently used as first-line anchor drug for rheumatoid arthritis (RA). Therefore, the number of MTX-associated lymphoproliferative disorders, including Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU), has increased. Some aspects of MTX-associated EBVMCU (MTX-EBVMCU), particularly clinic...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/pin.12745
更新日期:2019-01-01 00:00:00