Abstract:
:Ovarian non-gestational choriocarcinomas co-existing with adenocarcinoma are extremely rare and have been reported as epithelial ovarian carcinomas of a "non-germ cell origin" with "choriocarcinomatous differentiation". Although the cellular origin of non-gestational choriocarcinoma may be post-meiotic ovarian germ cells or the dedifferentiation of epithelial ovarian carcinoma, detailed genetic evidence has not yet been obtained to support this. We herein present a case of ovarian non-gestational choriocarcinoma co-existing with adenocarcinoma in a 29-year-old woman. The tumor rapidly increased in size and lung metastases appeared soon after parturition. We genetically demonstrated that the cellular origin of ovarian non-gestational choriocarcinoma was a post-meiotic germ cell derivation using a short tandem repeat analysis. The co-existing adenocarcinoma component was also shown to be of the same germ cell origin. These tumors showed the same homozygous pattern. A molecular genetic approach may be important for understanding the clinicopathological features of such tumors.
journal_name
Pathol Intjournal_title
Pathology internationalauthors
Koyanagi T,Fujiwara H,Usui H,Ariga H,Machida S,Takei Y,Saga Y,Shozu M,Fukushima N,Niki T,Matsubara S,Suzuki Mdoi
10.1111/pin.12445subject
Has Abstractpub_date
2016-09-01 00:00:00pages
529-34issue
9eissn
1320-5463issn
1440-1827journal_volume
66pub_type
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