Double squamous cell carcinomas, verrucous type and poorly differentiated type, of the urinary bladder unassociated with bilharzial infection.

abstract：:Niemann-Pick disease type C (NPC) is a neurovisceral lipid-storage disease. Although NPC patients show lipid storage in anterior horn cells of the spinal cord, little information is available regarding the electron microscopic analyses of the morphologies of intra-endosomal lipid like-materials in the anterior horn ce...

journal_title：Pathology international

authors： Kusunoki-Ii M,Kohama H,Kato K,Nomura Y,Nagashima K,Ninomiya H,Kato M,Kato S

更新日期：2020-07-01 00:00:00

abstract：:Intraductal tubulopapillary neoplasm (ITPN) has been recently reported in pancreas. We experienced an unusual intraductal growing bile duct tumor, which showed the same histopathologic and immunostaining profiles as ITPN of pancreas. A 72-year-old female patient visited hospital due to intrahepatic stone. The hilar bi...

journal_title：Pathology international

authors： Park HJ,Jang KT,Heo JS,Choi YL,Han J,Kim SH

更新日期：2010-09-01 00:00:00

abstract：:In the present study the significance of nuclear/cytoplasmic expression of beta-catenin (CTNNB1) and mutation of the CTNNB1 gene (CTNNB1) in odontogenic tumors was examined. Six ameloblastomas (five follicular ameloblastomas and one plexiform ameloblastoma) and three malignant odontogenic tumors (one metastasizing ame...

journal_title：Pathology international

authors： Miyake T,Tanaka Y,Kato K,Tanaka M,Sato Y,Ijiri R,Inayama Y,Ito Y,Aoki S,Kawabe R,Tohnai I

更新日期：2006-12-01 00:00:00

abstract：:Adenosquamous carcinoma (ASC) is a rare malignant neoplasm of the head and neck regions. We elucidated the relationship between ASC and MUC molecule expression. We selected 14 cases of ASC in the head and neck, and examined them immunohistohcmically. Seven cases of tongue, 3 cases of larynx and 4 cases of hypopharynx ...

journal_title：Pathology international

authors： Kusafuka K,Muramatsu K,Iida Y,Mori K,Miki T,Suda T,Fuke T,Kamijo T,Onitsuka T,Nakajima T

更新日期：2014-03-01 00:00:00

abstract：:So-called 'hybrid' lesion of ameloblastoma, which is composed of desmoplastic ameloblastoma and conventional follicular/plexiform ameloblastoma, is an unusual variant of ameloblastoma and only eight cases of 'hybrid' lesion have been published in the English literature. To enhance knowledge of this interesting tumor, ...

journal_title：Pathology international

authors： Takata T,Miyauchi M,Ogawa I,Zhao M,Kudo Y,Sato S,Takekoshi T,Nikai H,Tanimoto K

更新日期：1999-11-01 00:00:00

abstract：:An 80-year-old woman with a pleomorphic carcinoma (PC) producing hCG was admitted to Nippon Steel Hirohata Hospital because of an abnormal shadow on CT seen during a follow-up examination after surgery for breast cancer. A right upper lobectomy was performed due to rapid growth of the shadow 3 months later. Macroscopi...

journal_title：Pathology international

authors： Hirano H,Yoshida T,Sakamoto T,Yoshimura H,Fukuoka M,Tachibana S,Saito H,Ohkubo E,Nakasho K,Nishigami T

更新日期：2007-10-01 00:00:00

abstract：:The distribution of carcinoembryonic antigen (CEA) in human gastric adenocarcinoma cell lines (HPE-GAC-3 cells and HPE-GAC-2 cells) was determined immunohistochemically by indirect peroxidase-labeled antibody method at the light and electron microscopic levels. In GAC-3 cells that proliferated as non-adherent single c...

journal_title：Pathology international

authors： Ohiwa K,Harada T,Morikawa S,Nakamura T

更新日期：1994-08-01 00:00:00

abstract：:A case of small intestinal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) with monoclonal cryoglobulinemia is described. The patient was a woman in her mid-sixties with purpura of the bilateral lower legs and abdominal pain. An immunoserological investigation showed expre...

journal_title：Pathology international

authors： Saito T,Tamaru J,Kishi H,Kayao J,Kuzuu Y,Wakita H,Adachi A,Itoyama S,Mikata I

更新日期：2004-09-01 00:00:00

abstract：:Anomalous pancreaticobiliary junction (APBJ) is a congenital anomaly in which the pancreatic duct joins the common bile duct proximal to the sphincter of Oddi. Anatomical and immunohistochemical examination of the pancreas with APBJ has rarely been performed. A 72-year-old woman with gallbladder cancer and APBJ died o...

journal_title：Pathology international

authors： Tadokoro H,Takase M,Nobukawa B

更新日期：2008-08-01 00:00:00

abstract：:Diffuse pulmonary ossification (DPO) is a rare condition characterized by diffuse metaplastic bone formation in the lungs. Two patterns have been described: dendriform, with a coral-like network of bone spiculae along the alveolar septa; and nodular, with lobulated fragments in the alveolar spaces. Dendriform DPO is f...

journal_title：Pathology international

authors： Porzionato A,Macchi V,Da Broi U,Giraudo C,Miotto D,Rodriguez D,Moreschi C,De Caro R

更新日期：2015-01-01 00:00:00

abstract：:The CDKN2 gene encodes two structurally different proteins: a cyclin-dependent kinase inhibitor, p16, which regulates retinoblastoma protein (pRb)-dependent G1 arrest, and a cell cycle inhibitor, p14ARF, which blocks MDM2-induced p53 degradation resulting in an increase in p53 levels that leads to cell cycle arrest. R...

journal_title：Pathology international

authors： Sano T,Masuda N,Oyama T,Nakajima T

更新日期：2002-05-01 00:00:00

abstract：:A case of multiple myeloma, who died of congestive heart failure of unknown cause, is presented. Microscopically, Anitschkow cells with caterpillar and owl-eyed nuclei were scattered in the interstitium of the myocardium. To know the pathological significance of their appearance, histological observations of normal, d...

journal_title：Pathology international

authors： Satoh F,Tsutsumi Y

更新日期：1999-01-01 00:00:00

abstract：:The etiological role of human papillomavirus (HPV) in esophageal carcinoma (EC) in relation to p53, mdm2, p21(waf), c-erbB2 and the overall survival (OS) rate was investigated. Tumor and normal tissues from 50 EC were evaluated by polymerase chain reaction and InnoLiPA for HPV. Single strand conformation polymorphism/...

journal_title：Pathology international

authors： Bahnassy AA,Zekri AR,Abdallah S,El-Shehaby AM,Sherif GM

更新日期：2005-02-01 00:00:00

abstract：:Three cell systems (MINT1/2/3) derived from a melanotic neuroectodermal tumor of infancy (MNTI) arising in the mandible of a 1-month-old newborn boy have been established, and their cytological natures have been characterized. The cells had immunopositivities for pan-keratin, vimentin, neuron-specific enolase, S-100 p...

journal_title：Pathology international

authors： Metwaly H,Cheng J,Maruyama S,Ohshiro K,Suzuki I,Hoshina Y,Saku T

更新日期：2005-06-01 00:00:00

abstract：:Pleomorphic hyalinizing angiectatic tumor (PHAT) is a rare, recently recognized neoplasm occurring predominantly in the subcutaneous tissue of the lower limbs of adults. We report a case of PHAT in an 83-year-old woman who presented with a 5.0 x 5.0 x 2.0 cm mass in the soft part of her left thigh. Histologically, the...

journal_title：Pathology international

authors： Matsumoto K,Yamamoto T

更新日期：2002-10-01 00:00:00

abstract：:Circulating leukocytes, particularly neutrophils and monocytes, are important effector cells in the induction of many forms of glomerulonephritis. Adhesion molecules, especially selectins, are also thought to be critical for the development of this disease. We examined the possible suppressive effect of soluble E-sele...

journal_title：Pathology international

authors： Takahashi S,Araki K,Araki M,Ito MR,Nakatani K,Fujii H,Izui S,Vassalli P,Nose M

更新日期：2002-03-01 00:00:00

abstract：:Rheumatoid nodule is a frequent and characteristic extra-articular manifestation of rheumatoid arthritis (RA). Its involvement of central nervous system is a rare occurrence with only a few reported cases. A 78-year-old man with severe arthritis showing the formation of rheumatoid nodule-like granulomas in the dura an...

journal_title：Pathology international

authors： Kamio N,Kuramochi S,Wang RJ,Hirose S,Hosoda Y

更新日期：1996-07-01 00:00:00

abstract：:To test whether a subset of esophageal squamous cell carcinomas (SCC) develop through a deficiency in DNA mismatch repair, we examined microsatellite instability (MSI) using 11 microsatellite markers including BAT-26, hMLH1 protein expression by immunohistochemistry, and methylation status of the hMLH1 promoter by met...

journal_title：Pathology international

authors： Hayashi M,Tamura G,Jin Z,Kato I,Sato M,Shibuya Y,Yang S,Motoyama T

更新日期：2003-05-01 00:00:00

abstract：:Sarcomatoid carcinoma of the pancreas is an uncommon neoplasm. The immunohistochemical characteristics of this unique type of pancreatic tumor were studied. Histologically, there was diffuse proliferation of atypical spindle cells that had hyperchromatic, short, spindle-shaped nuclei and pale cytoplasm. A few tiny foc...

journal_title：Pathology international

authors： Higashi M,Takao S,Sato E

更新日期：1999-05-01 00:00:00

abstract：:The factors conferring the increased malignancy on lung adenocarcinoma with micropapillary component (AC-MPC) remain to be elucidated. On proteomics based on 2-dimensional gel electrophoresis, 19 proteins differentially expressed by more than 1.5-fold between AC-MPC and conventional adenocarcinoma (CAC); in particular...

journal_title：Pathology international

authors： Nakashima H,Jiang SX,Sato Y,Hoshi K,Matsumoto T,Nagashio R,Kobayashi M,Matsuo Y,Shiomi K,Hayakawa K,Saegusa M,Satoh Y

更新日期：2015-04-01 00:00:00

abstract：:New insights into the pathogenesis of lymphoid malignancies have been gained through novel genetic, molecular and immunological techniques. A new classification system for lymphoid malignancies, known as the new World Health Organization (WHO) classification, has been proposed recently based on these findings. The rel...

journal_title：Pathology international

authors： Ohshima K,Suzumiya J,Kikuchi M

更新日期：2002-01-01 00:00:00

abstract：:Interactions among p53, bcl-2 and Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) in nasopharyngeal carcinoma (NPC) cells were evaluated by gene cotransfections. The data showed that bcl-2 expression was not only able to prevent the growth suppression induced by wild-type p53 but was also paradoxically able ...

journal_title：Pathology international

authors： Sheu LF,Chen A,Lee HS,Hsu HY,Yu DS

更新日期：2004-07-01 00:00:00

abstract：:Gastric lipomas are uncommon lesions, usually single and located in the antrum. Common symptoms include upper digestive bleeding, anemia, and intestinal obstruction. Alternatively, they may remain asymptomatic, and detectable only at autopsy. A case of a 72-year-old man, who died of myocardial infarction, was found at...

journal_title：Pathology international

authors： Ventura L,Leocata P,Guadagni S,Ventura T

更新日期：1997-08-01 00:00:00

abstract：:The great majority of the cases clinically diagnosed as primary aldosteronism (PA) have been caused by aldosterone-producing adenoma (APA) or idiopathic hyperaldosteronism (IHA). The differential diagnosis of both subtypes of PA is important due to the different therapeutic modes but clinically it is sometimes difficu...

journal_title：Pathology international

authors： Nakamura Y,Felizola SJ,Satoh F,Konosu-Fukaya S,Sasano H

更新日期：2014-10-01 00:00:00

abstract：:Schwarz and Benditt found clustering of replicating cells in aortic endothelium in 1976 and discussed how homeostasis of the arterial wall is maintained through this nonrandom distribution of replicating cells. However, it is still unclear how cells of vascular walls turnover. In order to address this issue, we evalua...

journal_title：Pathology international

authors： Takahashi M,Masuda H,Yoshida M,Ito Y,Nanjo H,Sugiyama T,Maeda D,Goto A

更新日期：2015-11-01 00:00:00

abstract：:BRCA1-associated protein 1 (BAP1) or methylthioadenosine phosphorylase (MTAP) immunohistochemistry (IHC) or 9p21 fluorescence in situ hybridization (FISH) are useful for the diagnosis of malignant pleural mesothelioma (MPM). However, the effect of these assays on the diagnostic yield of effusion cytology in MPM cases ...

journal_title：Pathology international

authors： Kinoshita Y,Hamasaki M,Matsumoto S,Yoshimura M,Sato A,Tsujimura T,Kamei T,Kawahara K,Nabeshima K

更新日期：2020-09-01 00:00:00

abstract：:A 56-year-old male treated for a gastric yolk sac tumor with an adenocarcinomatous component is described. A mixed area of reticular and glandular neoplastic components was morphologically identified in this tumor. Immunohistochemically, the yolk sac tumor expressed alpha-fetoprotein (AFP), placental alkaline phosphat...

journal_title：Pathology international

authors： Suzuki T,Kimura N,Shizawa S,Yabuki N,Yamaki T,Sasano H,Nagura H

更新日期：1999-06-01 00:00:00

abstract：:The aim of the present study was to clarify protein profiling in small cell lung carcinoma (SCLC) and pulmonary large cell neuroendocrine carcinoma (LCNEC). The proteomic approach was used, and involved cell lysate from two cell lines (N231 derived from SCLC and LCN1 derived from LCNEC), with 2-D gel electrophoresis (...

journal_title：Pathology international

authors： Nagashio R,Sato Y,Matsumoto T,Kageyama T,Satoh Y,Ryuge S,Masuda N,Jiang SX,Okayasu I

更新日期：2010-02-01 00:00:00

abstract：:Nuclear pseudoinclusions (NPIs) are classically found in papillary thyroid carcinoma and meningioma. Although NPIs have been described in melanocytic lesions, there is no systematic analysis of potential relationship between NPIs and other clinicopathological characteristics of melanoma. We examined the presence of NP...

journal_title：Pathology international

authors： Donizy P,Kaczorowski M,Biecek P,Halon A,Matkowski R

更新日期：2018-02-01 00:00:00

abstract：:Many human colorectal adenocarcinoma cell lines have been developed. However, differentiated type colorectal cancer cell lines, particularly, the goblet-cell differentiated type, are scarce. In the present study a novel colorectal adenocarcinoma cell line (designated as COLM-6) with predominant goblet-cell differentia...

journal_title：Pathology international

authors： Yamachika T,Nakanishi H,Yasui K,Ikehara Y,Niwa T,Wanibuchi H,Tatematsu M,Fukushima S

更新日期：2005-09-01 00:00:00