MUC expression in adenosquamous carcinoma of the head and neck regions of Japanese patients: immunohistochemical analysis.

abstract：:Macrophage polarization is divided into M1 and M2 type based on membrane receptors, cytokines, and chemokines. M1 expresses CD80, interleukin (IL)-6, IL-12, and chemokine receptor (CCR)7, while M2 expresses CD163, IL10, and chemokine ligand (CCL)22. The aim of the present study was to identify the properties of infilt...

journal_title：Pathology international

authors： Nomura Y,Takeuchi M,Yoshida S,Sugita Y,Niino D,Kimura Y,Shimizu K,Aoki R,Suefuji N,Hirose S,Kikuchi M,Ohshima K

更新日期：2009-09-01 00:00:00

abstract：:Giant cell tumor (GCT) of bone is a primary osteolytic tumor that is characterized by the formation of osteoclast-like giant cells. In addition to GCT of bone, extraskeletal GCT are known to be formed in several soft tissues. Giant cells in GCT of bone were suggested to be identical to osteoclasts, but the characteriz...

journal_title：Pathology international

authors： Ikeda T,Seki S,Maki M,Noguchi N,Kawamura T,Arii S,Igari T,Koike M,Hirokawa K

更新日期：2003-07-01 00:00:00

abstract：:Calcifying fibrous tumor (CFT) is an uncommon lesion of uncertain cause and pathogenesis that has a unique histological appearance. These lesions are described mainly in the subcutaneous or deep soft tissues, followed by subserosal locations. Intrinsic visceral CFT is extremely rare. Herein is described a rare case of...

journal_title：Pathology international

authors： Elpek GO,Küpesiz GY,Ogüs M

更新日期：2006-04-01 00:00:00

abstract：:Immunohistochemical and clinicopathological features of 58 gastrointestinal stromal tumors (GIST) were studied. One occurred in the esophagus, 41 in the stomach, nine in the small intestine, and seven in the large intestine. By using indirect immunoperoxidase staining for Cajal cell markers (c-kit protein and CD34), s...

journal_title：Pathology international

authors： Tazawa K,Tsukada K,Makuuchi H,Tsutsumi Y

更新日期：1999-09-01 00:00:00

abstract：:A case of small intestinal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) with monoclonal cryoglobulinemia is described. The patient was a woman in her mid-sixties with purpura of the bilateral lower legs and abdominal pain. An immunoserological investigation showed expre...

journal_title：Pathology international

authors： Saito T,Tamaru J,Kishi H,Kayao J,Kuzuu Y,Wakita H,Adachi A,Itoyama S,Mikata I

更新日期：2004-09-01 00:00:00

abstract：:The great majority of the cases clinically diagnosed as primary aldosteronism (PA) have been caused by aldosterone-producing adenoma (APA) or idiopathic hyperaldosteronism (IHA). The differential diagnosis of both subtypes of PA is important due to the different therapeutic modes but clinically it is sometimes difficu...

journal_title：Pathology international

authors： Nakamura Y,Felizola SJ,Satoh F,Konosu-Fukaya S,Sasano H

更新日期：2014-10-01 00:00:00

abstract：:Homozygous deletion of 9p21, the locus harboring the p16 gene, has been reported as one of the most common genetic alterations in malignant mesotheliomas (MMs). Previous studies showed that this alteration might be useful for differentiating benign from malignant mesothelial tumors in cytology and surgical specimens. ...

journal_title：Pathology international

authors： Takeda M,Kasai T,Enomoto Y,Takano M,Morita K,Kadota E,Nonomura A

更新日期：2010-05-01 00:00:00

abstract：:The aim of the present study was to clarify protein profiling in small cell lung carcinoma (SCLC) and pulmonary large cell neuroendocrine carcinoma (LCNEC). The proteomic approach was used, and involved cell lysate from two cell lines (N231 derived from SCLC and LCN1 derived from LCNEC), with 2-D gel electrophoresis (...

journal_title：Pathology international

authors： Nagashio R,Sato Y,Matsumoto T,Kageyama T,Satoh Y,Ryuge S,Masuda N,Jiang SX,Okayasu I

更新日期：2010-02-01 00:00:00

abstract：:Schwarz and Benditt found clustering of replicating cells in aortic endothelium in 1976 and discussed how homeostasis of the arterial wall is maintained through this nonrandom distribution of replicating cells. However, it is still unclear how cells of vascular walls turnover. In order to address this issue, we evalua...

journal_title：Pathology international

authors： Takahashi M,Masuda H,Yoshida M,Ito Y,Nanjo H,Sugiyama T,Maeda D,Goto A

更新日期：2015-11-01 00:00:00

abstract：:Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare genetic disorder characterized by cutaneous and uterine leiomyomatosis with RCC. This disorder is caused by a germline mutation in the fumarate hydratase (FH) gene, which encodes an important enzyme of the tricarboxylic acid (TCA) cycle. This mutation d...

journal_title：Pathology international

authors： Matsumoto K,Udaka N,Hasumi H,Nakaigawa N,Nagashima Y,Tanaka R,Kato I,Yao M,Furuya M

更新日期：2018-05-24 00:00:00

abstract：:A case of small cell carcinoma arising in the outer urethral orifice is presented. The resected tumor showed a proliferation of small round or fusiform neoplastic cells in the submucosa. Tumor cells were arranged in sheets or a trabecular manner and possessed markedly hyperchromatic nuclei with a high N:C ratio, close...

journal_title：Pathology international

authors： Fukuda T,Kamishima T,Saito T,Itoh S,Suzuki T

更新日期：1997-07-01 00:00:00

abstract：:Amyloidosis refers to a group of diseases with amyloid fibrils deposited in various organs and is classified into more than 30 diseases in humans based on the kind of amyloid protein. In order to elucidate the molecular pathogenesis of human amyloidosis, we studied the molecular mechanism of amyloid fibril formation i...

journal_title：Pathology international

authors： Naiki H,Okoshi T,Ozawa D,Yamaguchi I,Hasegawa K

更新日期：2016-04-01 00:00:00

abstract：:Interactions among p53, bcl-2 and Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) in nasopharyngeal carcinoma (NPC) cells were evaluated by gene cotransfections. The data showed that bcl-2 expression was not only able to prevent the growth suppression induced by wild-type p53 but was also paradoxically able ...

journal_title：Pathology international

authors： Sheu LF,Chen A,Lee HS,Hsu HY,Yu DS

更新日期：2004-07-01 00:00:00

abstract：:Pituicytoma is a rare low-grade glial neoplasm that originates in the neurohypophysis or infundibulum. Because of its rare occurrence, the morphology and differentiation of pituicytoma have not been fully clarified. Here, we report a case of pituicytoma with unusual histological features mimicking ependymoma, but exhi...

journal_title：Pathology international

authors： Kwon MJ,Suh YL

更新日期：2011-10-01 00:00:00

abstract：:Reported herein is an unusual case of prostatic phyllodes tumor with exuberant glandular hyperplasia that led to misdiagnosis of adenocarcinoma. The tumor was detected in a 52-year-old man who had a 1 year history of dysuria. Adenocarcinoma of the prostate was diagnosed from a needle biopsy specimen. The patient recei...

journal_title：Pathology international

authors： Morikawa T,Nagata M,Tomita K,Kitamura T,Goto A,Chong JM,Fukayama M

更新日期：2006-03-01 00:00:00

abstract：:We previously reported that detection of desmoplastic reaction (DR) in pretreatment biopsy specimens was useful for predicting the depth of submucosal invasion (SM depth) in nonpedunculated early colorectal cancers (ECRCs) in a retrospective study. Here, we performed a prospective multicenter study for verification of...

journal_title：Pathology international

authors： Kimura R,Fujimori T,Ichikawa K,Ajioka Y,Ueno H,Ohkura Y,Kashida H,Togashi K,Yao T,Wada R,Watanabe T,Ochiai A,Sugai T,Sugihara K,Igarashi Y

更新日期：2012-08-01 00:00:00

abstract：:A 35-year-old Japanese man who had experienced hoarseness for 10 years presented with a vocal cord lesion. A gross examination revealed a left vocal cord polyp occupying two-thirds of the vocal space. The endoscopically resected lesion contained scattered atypical fibroblastic, stellate, or ganglion-like cells with mu...

journal_title：Pathology international

authors： Yorita K,Togashi Y,Nakagawa H,Miyazaki K,Sakata S,Baba S,Takeuchi K,Hayashi Y,Murakami I,Kuroda N,Oda Y,Kohashi K,Yamada Y,Kiyozawa D,Michal M,Michal M

更新日期：2019-06-01 00:00:00

abstract：:The roles of Wnt protein in carcinogenesis have been well documented in human cancers. Wls is a key modulator for the secretion of Wnt protein. We previously found that Wls was aberrantly expressed in colorectal carcinomas. Studies have revealed that dysregulation of Wnt signal transduction plays an important role in ...

journal_title：Pathology international

authors： Zhang W,Tao H,Chen X,Sugimura H,Wang J,Zhou P

更新日期：2017-03-01 00:00:00

abstract：:We established a dedifferentiated liposarcoma cell line (NDDLS-1) that produces interleukin-6 (IL-6) and granulocyte-colony stimulating factor (G-CSF). The parental tumor showed high leukemoid reactions. The NDDLS-1 cell line was established from a pleural effusion associated with a lung metastasis. Pleomorphic tumor ...

journal_title：Pathology international

authors： Ariizumi T,Ogose A,Kawashima H,Hotta T,Li G,Xu Y,Hirose T,Endo N

更新日期：2011-08-01 00:00:00

abstract：:The alpha subunit of a GTP-binding protein, Go, was investigated in pulmonary neuroendocrine neoplasms and fetal tissues of the lung by an immunohistochemical method. Positive immunostaining for the alpha subunit of Go (Go alpha) was found predominantly on the cell membrane and found occasionally in the cytoplasm. Typ...

journal_title：Pathology international

authors： Kawano N,Ito T,Kitamura H,Shibagaki T,Kameda Y,Nakamura N,Kanisawa M

更新日期：1996-06-01 00:00:00

abstract：:In 2004, two groups reported somatic mutations in the gene for the epidermal growth factor receptor (EGFR) in patients with non-small cell lung cancer (NSCLC), which were highly correlated with the clinical response to the anticancer drug, gefitinib. Since then, a tremendous amount of knowledge has accumulated, and sh...

journal_title：Pathology international

authors： Yatabe Y,Mitsudomi T

更新日期：2007-05-01 00:00:00

abstract：:We report a case of cutaneous squamous cell carcinoma (CSCC), initially coexisting with invasive extramammary Paget's disease (EMPD), in the scrotum of an 84-year-old man. The patient initially had a rash and pruritus before presenting with a pedunculated scrotal mass surrounded by widespread erythema. He underwent to...

journal_title：Pathology international

authors： Kitano A,Izumi M,Tamura K,Tonegawa M,Etou T,Kishida Y

更新日期：2019-10-01 00:00:00

abstract：:Humoral factors from cancer-associated fibroblasts (CAFs) reportedly affect epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistance in cancer cells with EGFR mutations. The aim of this study was to identify the robust humoral factors secreted from CAFs that induce the primary resistance to EGF...

journal_title：Pathology international

authors： Suzuki E,Yamazaki S,Naito T,Hashimoto H,Okubo S,Udagawa H,Goto K,Tsuboi M,Ochiai A,Ishii G

更新日期：2019-08-01 00:00:00

abstract：:A 53-year-old woman presented with Cushing's syndrome resulting from an adrenocortical adenoma, 6.5 cm in diameter and 75 g in weight, which is larger than usual. Endocrinological data of this patient showed adrenocorticotropin (ACTH)-independent hypercortisolemia. A computed tomography scan of the adrenal glands reve...

journal_title：Pathology international

authors： Karasawa R,Hotta M,Aiba M,Takano K

更新日期：2004-04-01 00:00:00

abstract：:The diagnosis of the rare neoplasm histiocytic sarcoma (HS) relies on morphology and the presence of immunophenotypic features of histiocytic lineage. More than 57 cases, including 16 cases involving the gastrointestinal (GI) tract, have been described since the World Health Organization issued its classification syst...

journal_title：Pathology international

authors： Miyazaki T,Arihiro S,Mitobe J,Aoki Y,Takikawa S,Saruta M,Matsuoka M,Koike K,Kato T,Kashiwagi H,Ikegami M,Tajiri H

更新日期：2013-02-01 00:00:00

abstract：:We have previously reported the frequent occurrence of bile duct invasion by liver metastases from colorectal cancer. We found that patients with macroscopic intrabiliary cancer growth survive longer after hepatectomy than those without this feature. In the present study, we analyzed the clinicopathological features o...

journal_title：Pathology international

authors： Kubo M,Sakamoto M,Fukushima N,Yachida S,Nakanishi Y,Shimoda T,Yamamoto J,Moriya Y,Hirohashi S

更新日期：2002-08-01 00:00:00

abstract：:A 7-year-old boy presented with midline swelling in the neck. On fine-needle aspiration cytology it was diagnosed as papillary carcinoma of the thyroid. The patient underwent total thyroidectomy. Histopathological examination, immunohistochemistry and electron microscopy revealed the presence of two intermingled compo...

journal_title：Pathology international

authors： Goyal R,Nada R,Rao KL,Radotra BD

更新日期：2006-02-01 00:00:00

abstract：:To determine the prognostic significance of the methods used to determine the presence of metastasis in second-tier lymph nodes of patients with gastric cancer, the authors studied lymph nodes surgically removed from 100 patients with gastric cancer (55 with early cancer, 45 with progressive). The results of HE staini...

journal_title：Pathology international

authors： Ikeda S,Funakoshi N,Usui S,Takiguchi N,Hiranuma S,Shibata T

更新日期：2008-01-01 00:00:00

abstract：:We studied the extensive molecular alterations of endometrial endometrioid adenocarcinoma (EEA) using a crypt isolation method. We analyzed copy number variation (CNV) using a single nucleotide polymorphism (SNP) array, genetic mutations (KRAS, BRAF, p53, PIK3CA), DNA methylation and microsatellite instability (MSI) s...

journal_title：Pathology international

authors： Suga Y,Sugai T,Uesugi N,Kawasaki T,Fukagawa T,Yamamoto E,Ishida K,Suzuki H,Sugiyama T

更新日期：2015-05-01 00:00:00

abstract：:We investigated the diagnostic and prognostic value of p53 expression and proliferative activity, as indicated by the Ki-67, in endoscopic biopsy specimens. Specimens were immunologically stained with p53 and MIB-1 (Ki-67), and the MIB-1/Ki-67 labeling index (LI) was calculated. Classification of adenomas was based on...

journal_title：Pathology international

authors： Kubota K,Kakuta Y,Kawamura S,Saito S,Seki H,Kuniyoshi T

更新日期：2003-06-01 00:00:00