Abstract:
:We investigated the diagnostic and prognostic value of p53 expression and proliferative activity, as indicated by the Ki-67, in endoscopic biopsy specimens. Specimens were immunologically stained with p53 and MIB-1 (Ki-67), and the MIB-1/Ki-67 labeling index (LI) was calculated. Classification of adenomas was based on findings of H&E-stained preparations into those with low- or high-grade atypia. Well-differentiated tubular and papillary adenocarcinomas were classified as carcinomas with low- or high-grade atypia. There were significant differences among the control and adenoma patients in MIB-1/Ki-67 LI (P < 0.05). No significant difference was identified between adenomas with high grade atypia and carcinomas with low grade atypia. The p53 expression was negative in all adenomas, but it was positive in 68.2% of carcinomas. The current study demonstrated that p53 protein expression in endoscopic biopsy specimens was of preoperative diagnostic value for carcinoma of the ampulla of Vater. The p53 protein positive tumors had a relatively higher malignant potential than p53 protein negative ones. The MIB-1/Ki-67 LI was useful in differentiating non-tumorous lesions from adenomas and adenomas with low- or high-grade atypia. The MIB-1/Ki-67 LI had a prognostic value because clinicopathological factors of carcinoma of ampulla of Vater correlated with MIB-1/Ki-67 LI.
journal_name
Pathol Intjournal_title
Pathology internationalauthors
Kubota K,Kakuta Y,Kawamura S,Saito S,Seki H,Kuniyoshi Tdoi
10.1046/j.1440-1827.2003.01482.xsubject
Has Abstractpub_date
2003-06-01 00:00:00pages
361-70issue
6eissn
1320-5463issn
1440-1827pii
1482journal_volume
53pub_type
杂志文章abstract::The DNA ploidy pattern of nine hepatoblastomas and three normal liver specimens was investigated by flow cytometry. Areas of unlike differentiation in the same tumor were investigated separately. Normal liver tissue and the fetal subtype were always diploid. Aneuploidy was found in the embryonal subtype. The one case ...
journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2008-10-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.2006.01938.x
更新日期:2006-03-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章,评审
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journal_title:Pathology international
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2002-09-01 00:00:00
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journal_title:Pathology international
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pub_type: 杂志文章,评审
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更新日期:2007-06-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
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