Abstract:
:The clinical and pathological significance of intratumoral lymphangiogenesis (ITL) with human esophageal squamous cell carcinomas (ESCC) remains unclear, as does the role of signaling molecules such as vascular endothelial growth factor (VEGF)-A,C, platelet-derived growth factor (PDGF)-A, and p53, in the regulation of ITL. Lymphatic vessel density (LVD) was significantly increased in VEGF-A and VEGF-C immunohistochemical score 1 and 2-3 groups as compared to the score 0 group and also with high of VEGF-A, VEGF-C and PDGF-A mRNA expression. Both LVD and blood vessel density (BVD) were significantly greater in the p53 gene mutant group than in the wild-type group. Lymph node metastasis was significantly more frequent with than without ITL and Kaplan-Meier analysis indicated a significantly poorer prognosis. Multivariate analysis using Cox proportional hazard method showed that invasion depth, lymph node metastasis and ITL were independent prognostic factors.
journal_name
Pathol Intjournal_title
Pathology internationalauthors
Inoue A,Moriya H,Katada N,Tanabe S,Kobayashi N,Watanabe M,Okayasu I,Ohbu Mdoi
10.1111/j.1440-1827.2008.02279.xsubject
Has Abstractpub_date
2008-10-01 00:00:00pages
611-9issue
10eissn
1320-5463issn
1440-1827pii
PIN2279journal_volume
58pub_type
杂志文章abstract::Resistance to retroviral infection is often regulated by multiple genes that control different aspects of the host-virus interaction. Genetically distinct inbred strains of mice differ in their susceptibility to retrovirus and have allowed the identification of several host-resistant loci that regulate the host defens...
journal_title:Pathology international
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1827.1996.tb03540.x
更新日期:1996-10-01 00:00:00
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journal_title:Pathology international
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journal_title:Pathology international
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journal_title:Pathology international
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journal_title:Pathology international
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2004-04-01 00:00:00
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更新日期:2002-03-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1998-03-01 00:00:00
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更新日期:2019-02-01 00:00:00
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journal_title:Pathology international
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更新日期:2007-02-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:1997-07-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 更正并重新发布的文章,杂志文章
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journal_title:Pathology international
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更新日期:1996-06-01 00:00:00
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journal_title:Pathology international
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