Expression of bcl-6 protein in normal skin and epidermal neoplasms.

Abstract:

:Bcl-6 protein is a recently identified novel transcription factor whose deregulated expression is associated with diffuse large B cell lymphomas. It was recently shown by us that the protein is located in germinal center B cells and their neoplastic counterparts. In the present study, the expression of bcl-6 protein on normal epidermis, benign, and malignant tumors originating from epidermal cells, and squamous cell carcinoma (SCC) cell lines are investigated. With the use of immunohistochemistry, bcl-6 protein was shown to stain intensely on normal prickle cells, but none to only slightly on epidermal basal cells. Papillomas and keratoacanthomas copied their normal counterparts in the mode of expression. Various levels of expression were found on seborrheic keratoses, while the expression level on basal cell epitheliomas was low. Peculiarly, eccrine poromas and undifferentiated spindle-shaped basal cell epitheliomas were totally unstained. Squamous cell carcinomas showed a variety of expression levels, while two undifferentiated spindle-shaped carcinomas and one undifferentiated SCC cell line remained unstained. These results suggest that the expression of bcl-6 protein may be associated with morphological differentiation in normal and neoplastic epidermal cells.

journal_name

Pathol Int

journal_title

Pathology international

authors

Kanazawa N,Moriyama M,Onizuka T,Sugawara K,Mori S

doi

10.1111/j.1440-1827.1997.tb04548.x

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

600-7

issue

9

eissn

1320-5463

issn

1440-1827

journal_volume

47

pub_type

杂志文章
  • Intravenous leiomyomatosis of the uterus with multiple pulmonary metastases associated with large bullae-like cyst formation.

    abstract::We present a case of uterine intravenous leiomyomatosis associated with multiple pulmonary metastases with bullae-like cystic change. A 53-year-old woman who had undergone hysterectomy 5 years previously underwent an operation for multiple pulmonary nodules with bullae formation. After resection of several large bulla...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2001.01205.x

    authors: Matsumoto K,Yamamoto T,Hisayoshi T,Asano G

    更新日期:2001-05-01 00:00:00

  • Absence of mutations in the beta-catenin and adenomatous polyposis coli genes in papillary and follicular thyroid carcinomas.

    abstract::beta-Catenin has multiple functions both in intercellular adhesion and in signal transduction. As a signaling molecule, mutations in exon 3 of the beta-catenin gene stabilize this protein in the cytoplasm. Subsequently, accumulated beta-catenin protein translocates to nuclei with T-cell factor-4, and upregulates trans...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2001.01269.x

    authors: Miyake N,Maeta H,Horie S,Kitamura Y,Nanba E,Kobayashi K,Terada T

    更新日期:2001-09-01 00:00:00

  • IgG4-related inflammatory abdominal aortic aneurysm associated with autoimmune pancreatitis.

    abstract::An association between autoimmune pancreatitis (AIP) and inflammatory abdominal aortic aneurysm (AAA) has never been reported. Reported herein is a case of IgG4-related inflammatory AAA accompanying metachronous AIP. A 77-year-old man presented with malaise and intermittent lower abdominal pain. Radiological examinati...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2008.02247.x

    authors: Ito H,Kaizaki Y,Noda Y,Fujii S,Yamamoto S

    更新日期:2008-07-01 00:00:00

  • A case of cytophagic histiocytic panniculitis associated with exertional rhabdomyolysis.

    abstract::An 18-year-old man who suffered from panniculitis involving the entire left lower limb after exertional rhabdomyolysis is reported. A high fever (>39 degrees C) and leukocytosis (>20,000/microL) persisted for 1 week, and his general status deteriorated rapidly into pre-disseminated intravascular coagulation, complicat...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2000.01127.x

    authors: Kanai Y,Iwaya K,Kuroda M,Harada M,Hirata F,Mukai K

    更新日期:2000-10-01 00:00:00

  • Double squamous cell carcinomas, verrucous type and poorly differentiated type, of the urinary bladder unassociated with bilharzial infection.

    abstract::A case of a 66-year-old Japanese woman with two synchronous urinary bladder tumors, namely verrucous carcinoma and poorly differentiated squamous cell carcinoma, is described. Both tumors were accompanied by widespread squamous metaplasia in the background and unassociated with bilharzial infection. The poorly differe...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1997.tb04558.x

    authors: Oida Y,Yasuda M,Kajiwara H,Onda H,Kawamura N,Osamura RY

    更新日期:1997-09-01 00:00:00

  • A case of intraplacental choriocarcinoma associated with placental hemangioma.

    abstract::A case of intraplacental choriocarcinoma associated with a placental hemangioma is presented. Ultrasonic examination revealed a placental hemangioma at 33 weeks gestation. A cesarean section was performed at 37 weeks gestation. Histological examination showed intraplacental choriocarcinoma associated with the hemangio...

    journal_title:Pathology international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1827.1998.tb03858.x

    authors: Aonahata M,Masuzawa Y,Tsutsui Y

    更新日期:1998-11-01 00:00:00

  • High-grade transformation/dedifferentiation of an adenoid cystic carcinoma of the minor salivary gland to myoepithelial carcinoma.

    abstract::High-grade transformation (HGT)/dedifferentiation is an unusual phenomenon in salivary gland carcinomas. Here we report a case of adenoid cystic carcinoma (ACC) with HGT/dedifferentiation to myoepithelial carcinoma, occurring in the epipharynx of a 42-year-old woman. The surgically resected tumor was a pedunculated ma...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12624

    authors: Tando S,Nagao T,Kayano K,Fushiki S,Itoh K

    更新日期:2018-02-01 00:00:00

  • Lymphoid hyperplasia of the large intestine: a case report with immunohistochemical and gene analysis.

    abstract::A case of lymphoid hyperplasia arising in the large intestine of a 54-year-old woman is described. Barium enema X-ray and colonoscopic examination revealed multiple small polyps in the right side of the colon. Pathological findings from forceps biopsy revealed similar features to a mucosa-associated lymphoid tissue (M...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2000.01107.x

    authors: Nagaoka S,Bandoh T,Takemura T

    更新日期:2000-09-01 00:00:00

  • Progressively increasing density of the solid center of a ground-glass nodule in a solitary pulmonary capillary hemangioma: A case report.

    abstract::Solitary pulmonary capillary hemangiomas (SPCHs) are recently recognized, rare benign lesions that form solitary nodules owing to capillary proliferation. These lesions are usually detected incidentally as small ground-glass nodules (GGNs) on computed tomography (CT), and progressively enlarge over time. The radiologi...

    journal_title:Pathology international

    pub_type:

    doi:10.1111/pin.12945

    authors: Hashimoto H,Matsumoto J,Murakami M,Hiyama N,Yamaguchi H,Kusakabe M,Horiuchi H,Morikawa T

    更新日期:2020-08-01 00:00:00

  • Compound melanocytic nevus arising in a mature cystic teratoma of the ovary.

    abstract::A 28-year-old woman complained of irregular menstruation. Abdominal ultrasound and magnetic resonance imaging (MRI) examinations revealed a cystic tumor in the left ovary. A histological examination of the resected ovary revealed that the lesion was a mature cystic teratoma. In this tumor, components such as skin with...

    journal_title:Pathology international

    pub_type: 杂志文章,评审

    doi:10.1046/j.1440-1827.2001.01288.x

    authors: Kuroda N,Hirano K,Inui Y,Yamasaki Y,Toi M,Nakayama H,Hiroi M,Enzan H

    更新日期:2001-11-01 00:00:00

  • Vocal cord inflammatory myofibroblastic tumor with mucoid deposits harboring TIMP3-ALK fusion: A potential diagnostic pitfall.

    abstract::A 35-year-old Japanese man who had experienced hoarseness for 10 years presented with a vocal cord lesion. A gross examination revealed a left vocal cord polyp occupying two-thirds of the vocal space. The endoscopically resected lesion contained scattered atypical fibroblastic, stellate, or ganglion-like cells with mu...

    journal_title:Pathology international

    pub_type:

    doi:10.1111/pin.12796

    authors: Yorita K,Togashi Y,Nakagawa H,Miyazaki K,Sakata S,Baba S,Takeuchi K,Hayashi Y,Murakami I,Kuroda N,Oda Y,Kohashi K,Yamada Y,Kiyozawa D,Michal M,Michal M

    更新日期:2019-06-01 00:00:00

  • Aberrant MAD2 expression in soft-tissue sarcoma.

    abstract::Soft-tissue sarcomas can be divided into translocation-associated (TA) and non-TA sarcomas, the latter of which is often characterized by pleomorphic cytomorphology and aneuploidy. The aberrant expression of MAD2, an essential component of the mitotic spindle checkpoint, has been recently shown to promote aneuploidy. ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2008.02232.x

    authors: Hisaoka M,Matsuyama A,Hashimoto H

    更新日期:2008-06-01 00:00:00

  • Clinicopathological correlation of childhood IgA glomerulonephritis presenting diffuse endocapillary proliferation.

    abstract::The aim of the present study is to clarify the clinicopathological correlation of childhood IgA glomerulonephritis (GN) presenting diffuse endocapillary proliferation. Twenty-seven patients were used in the present study. The 27 patients were divided into three groups (mild, moderate and severe) according to the perce...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2003.01604.x

    authors: Hisano S,Kiyoshi Y,Tanaka I,Tokieda K,Niimi K,Tsuru N,Takebayashii S,Iwasaki H

    更新日期:2004-03-01 00:00:00

  • Ceroid pigment deposition in circulating blood monocytes and T lymphocytes in Hermansky-Pudlak syndrome: an ultrastructural study.

    abstract::An electron microscopic study of peripheral leukocytes obtained from a 39 year old woman with Hermansky-Pudlak syndrome was performed. Ceroid pigment granules were found within the lysosomes in 3.5% of monocytes and 5.4% of lymphocytes. Infrequently, pigment granules were also found in the parallel tubular arrays of l...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1995.tb03407.x

    authors: Sakuma T,Monma N,Satodate R,Satoh T,Takeda R,Kuriya S

    更新日期:1995-11-01 00:00:00

  • Upregulation of nucleobindin expression in human-activated lymphocytes and non-Hodgkin's lymphoma.

    abstract::Nucleobindin (Nuc) was originally found to be an enhancement factor of anti-DNA antibody production secreted by a lymphoid cell line derived from a lymphoproliferative MRL/lpr mouse. It has been shown that Nuc has a unique structure containing a DNA- and two calcium-binding domains, and a leucine zipper motif, but its...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1998.tb03823.x

    authors: Kubota T,Miyauchi M,Miura K,Hirokawa G,Awaya A,Miyasaka N,Kurosawa Y,Kanai Y,Maruyama K

    更新日期:1998-01-01 00:00:00

  • Lobular involvement: prognostic indicator for invasive ductal carcinoma of the breast.

    abstract::One of the striking microscopic appearances of breast carcinoma is malignant transformation of the epithelium of an entire lobule, although the lobular architecture is still preserved. We termed this pathological feature 'lobular involvement'. An investigation was carried out to determine whether lobular involvement w...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.1999.00899.x

    authors: Ishige H,Kondo Y,Yagata H,Onoki J,Suzuki M,Oshida M,Nagashima T,Hashimoto H,Nakajima N

    更新日期:1999-06-01 00:00:00

  • A case of pulmonary papillary adenoma: possible relationship between tumor histogenesis/tumorigenesis and fibroblast growth factor receptor 2 IIIb.

    abstract::Pulmonary papillary adenoma is a rare tumor. We analyzed a tumor which appeared in a 16-year-old Japanese woman. The tumor histologically showed papillary proliferation of one-layered tumor cells coating inflammatory fibrovascular cores. At the periphery of the tumor, the tumor cells grew in a lepidic fashion. The tum...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2012.02841.x

    authors: Masunaga A,Nagashio R,Iwamoto S,Takeyama N,Sato Y,Miyazaki A,Mitsuya T

    更新日期:2012-09-01 00:00:00

  • Desmoplastic reaction in biopsy specimens of early colorectal cancer: a Japanese prospective multicenter study.

    abstract::We previously reported that detection of desmoplastic reaction (DR) in pretreatment biopsy specimens was useful for predicting the depth of submucosal invasion (SM depth) in nonpedunculated early colorectal cancers (ECRCs) in a retrospective study. Here, we performed a prospective multicenter study for verification of...

    journal_title:Pathology international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1440-1827.2012.02840.x

    authors: Kimura R,Fujimori T,Ichikawa K,Ajioka Y,Ueno H,Ohkura Y,Kashida H,Togashi K,Yao T,Wada R,Watanabe T,Ochiai A,Sugai T,Sugihara K,Igarashi Y

    更新日期:2012-08-01 00:00:00

  • Dedifferentiated liposarcoma with chondroblastic osteosarcomatous dedifferentiation.

    abstract::We describe a rare case of dedifferentiated liposarcoma with features resembling chondroblastic osteosarcoma in the dedifferentiated component. The tumor was removed from the left thigh in a 78-year-old male. It consisted of a well-differentiated liposarcoma and an anaplastic component that contained numerous osteoid ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2000.01083.x

    authors: Yamamoto T,Matsushita T,Marui T,Mizuno K,Minami R,Hayashi Y,Hanioka K

    更新日期:2000-07-01 00:00:00

  • Fibroma of tendon sheath arising from the radio-ulnar joint.

    abstract::A report of a 65-year-old male with a tumor arising from synovial tissue of the radio-ulnar joint. On magnetic resonance imaging, the tumor was demonstrated as a heterogeneous and lobulated mass with a low signal intensity both in T1- and T2-weighted images. Histological findings of the tumor were identical to those o...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.1999.00984.x

    authors: Misawa A,Okada K,Hirano Y,Sageshima M

    更新日期:1999-12-01 00:00:00

  • Colitis nucleomigrans: The third type of microscopic colitis (part 1).

    abstract::Microscopic colitis (MC), encompassing collagenous colitis and lymphocytic colitis, is featured by chronic diarrhea, normal-looking endoscopic findings and unique microscopic appearance. After reviewing biopsied nonspecific colitis, we propose the third type of MC: colitis nucleomigrans (CN). Histopathological criteri...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12996

    authors: Tachibana M,Hanaoka T,Watanabe S,Matsushita M,Isono T,Tsutsumi Y

    更新日期:2020-10-01 00:00:00

  • Experimental osteodystrophy of chronic renal failure induced by aluminum- and ferric-nitrilotriacetate in Wistar rats.

    abstract::The aluminum (AI) and iron (Fe) chelate complexes of nitrilotriacetate (NTA) cause renal insufficiency when they are administered intraperitoneally to rats. Their effects on bone metabolism were studied in 4 week old Wistar rats. Daily intraperitoneal administration of AI-NTA (3mg AI/kg for 11 weeks) induced osteomala...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1995.tb03375.x

    authors: Yukihiro S,Okada S,Takeuchi K,Inoue H

    更新日期:1995-01-01 00:00:00

  • Squamous cell carcinoma arising from a seminal vesicular cyst: possible relationship between chronic inflammation and tumor development.

    abstract::A case of squamous cell carcinoma arising within an acquired seminal vesicular cyst is described. A 61-year-old man was hospitalized because of hemospermia and dysuria. Under the diagnosis of a left seminal vesicular cyst, surgical resection was performed. Pathological examination revealed squamous cell carcinoma with...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2002.01340.x

    authors: Yanagisawa N,Saegusa M,Yoshida T,Okayasu I

    更新日期:2002-03-01 00:00:00

  • An immunohistochemical study of hepatic atypical adenomatous hyperplasia, hepatocellular carcinoma, and cholangiocarcinoma with alpha-fetoprotein, carcinoembryonic antigen, CA19-9, epithelial membrane antigen, and cytokeratins 18 and 19.

    abstract::Eight hepatic atypical adenomatous hyperplasias (AH), 30 hepatocellular carcinomas (HCC) consisting of 11 well-, 13 moderately and six poorly differentiated HCC, and 10 intrahepatic cholangiocarcinomas (CC) were investigated immunohistochemically with anti-alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), CA19-...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.1999.00865.x

    authors: Tsuji M,Kashihara T,Terada N,Mori H

    更新日期:1999-04-01 00:00:00

  • Critical multi-organ emboli originating from collapsed, vulnerable caseous mitral annular calcification.

    abstract::Mitral annular calcification (MAC) is a generally asymptomatic abnormality found commonly in aged hearts. Some clinical studies have suggested that MAC should be considered an independent risk factor for stroke; however, whether the abnormality is indeed a risk factor remains controversial. We report a case in which d...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2012.02826.x

    authors: Matsuyama TA,Ishibashi-Ueda H,Ikeda Y,Nagatsuka K,Miyashita K,Amaki M,Kanzaki H,Kitakaze M

    更新日期:2012-07-01 00:00:00

  • Peritoneal adenomatoid (microcystic) mesothelioma.

    abstract::There are several reports of pleural adenomatoid (microcystic) mesothelioma, but peritoneal adenomatoid mesothelioma is extremely rare. A 64-year-old Japanese woman presented with no symptoms and no asbestos exposure history. An abdominal computed tomography scan revealed multiple hypervascular masses on the liver sur...

    journal_title:Pathology international

    pub_type:

    doi:10.1111/pin.13006

    authors: Mori D,Kido S,Hiraki M,Sumi K,Ureshino N,Masuda M,Nabeshima K,Akashi M

    更新日期:2020-11-01 00:00:00

  • Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) arising in the small intestine with monoclonal cryoglobulinemia.

    abstract::A case of small intestinal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) with monoclonal cryoglobulinemia is described. The patient was a woman in her mid-sixties with purpura of the bilateral lower legs and abdominal pain. An immunoserological investigation showed expre...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2004.01684.x

    authors: Saito T,Tamaru J,Kishi H,Kayao J,Kuzuu Y,Wakita H,Adachi A,Itoyama S,Mikata I

    更新日期:2004-09-01 00:00:00

  • Prediction of efficacy of interferon treatment of chronic hepatitis C by multivariate analysis and a new classification.

    abstract::One hundred and fifteen patients with chronic hepatitis C were administered interferon (IFN) and classed into two groups: (i) complete responders (CR), HCV-RNA continuously negative 1 year after treatment; and (ii) non-responders (NR), positive 1 year after treatment. Multivariate analysis comprised eight variables: a...

    journal_title:Pathology international

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1440-1827.1998.tb03895.x

    authors: Kim SR,Hayashi Y,Yoon S,Taniguchi M,Yang MK,Kim KI,Kim MM,Saeki K,Nukata I,Imoto S

    更新日期:1998-03-01 00:00:00

  • Multiple epithelial cysts of the spleen and on the splenic capsule, and high serum levels of CA19-9, CA125 and soluble IL-2 receptor.

    abstract::An 18-year-old woman with abdominal pain was diagnosed as having splenic cysts by computed tomography scan. She had high serum levels of CA19-9 (2886.8 U/mL; normal value, <35 U/mL), CA125 (131.1 U/mL; normal value, <35 U/mL) and soluble IL-2 receptor (1490 U/mL; normal range, 220-530 U/mL). The resected spleen weighe...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2004.01630.x

    authors: Hashimoto T,Sugino T,Fukuda T,Hoshi N,Ogura G,Watanabe K,Satoh Y,Hasegawa T,Ohishi A,Haga J,Miyata M,Suzuki T

    更新日期:2004-05-01 00:00:00

  • Neuroendocrine carcinoma of the breast with Merkel cell carcinoma-like features.

    abstract::A case of neuroendocrine carcinoma of the breast with Merkel cell carcinoma-like features occurring in a 38-year-old female is described. A 2.5 x 2.5 x 1.3 cm tumor in the upper-outer quadrant of the right breast was ill-defined, yellowish white and rubbery. Microscopically, the tumor was characterized by a diffuse pr...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1998.tb03949.x

    authors: Fukunaga M

    更新日期:1998-07-01 00:00:00