Multiple epithelial cysts of the spleen and on the splenic capsule, and high serum levels of CA19-9, CA125 and soluble IL-2 receptor.

abstract：:The authors investigated the protein expression of double-stranded RNA-activated protein kinase (PKR), which was identified by using a previous cDNA microarray study, to discover PKR's correlations with several pathological parameters and to elucidate its role in neoplastic transformation and progression of lung adeno...

journal_title：Pathology international

authors： Roh MS,Kwak JY,Kim SJ,Lee HW,Kwon HC,Hwang TH,Choi PJ,Hong YS

更新日期：2005-11-01 00:00:00

abstract：:Methotrexate (MTX) is currently used as first-line anchor drug for rheumatoid arthritis (RA). Therefore, the number of MTX-associated lymphoproliferative disorders, including Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU), has increased. Some aspects of MTX-associated EBVMCU (MTX-EBVMCU), particularly clinic...

journal_title：Pathology international

authors： Satou A,Banno S,Hanamura I,Takahashi E,Takahara T,Nobata H,Katsuno T,Takami A,Ito Y,Ueda R,Nakamura S,Tsuzuki T

更新日期：2019-01-01 00:00:00

abstract：:Multiple carcinomas of the pancreatico-biliary tree are rare. A 53 year old Japanese man was diagnosed as having an adenocarcinoma in the papilla of Vater. During the operation, he was also found to have a polypoid mass in the common bile duct. While cutting the operative specimen into stepwise sections, a small tumor...

journal_title：Pathology international

authors： Nishihara K,Tsuneyoshi M,Shimura H,Yasunami Y

更新日期：1994-04-01 00:00:00

abstract：:Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare genetic disorder characterized by cutaneous and uterine leiomyomatosis with RCC. This disorder is caused by a germline mutation in the fumarate hydratase (FH) gene, which encodes an important enzyme of the tricarboxylic acid (TCA) cycle. This mutation d...

journal_title：Pathology international

authors： Matsumoto K,Udaka N,Hasumi H,Nakaigawa N,Nagashima Y,Tanaka R,Kato I,Yao M,Furuya M

更新日期：2018-05-24 00:00:00

abstract：:Immunodeficient mice are widely used for xenografts of human cells and tissue. The purpose of the present study was to investigate the characteristics of xenograft human tumor models using engraftment of various non-hematopoietic tumors in the NOD/SCID/gamma(c) (null) mouse. For tumor models, human solid tumor tissues...

journal_title：Pathology international

authors： Fujii E,Suzuki M,Matsubara K,Watanabe M,Chen YJ,Adachi K,Ohnishi Y,Tanigawa M,Tsuchiya M,Tamaoki N

更新日期：2008-09-01 00:00:00

abstract：:Matrix metalloproteinases (MMP) play a role in a wide range of tumorigenesis, including early carcinogenesis events, tumor growth and tumor invasion and metastasis. Given that the ability of tumor cells to infiltrate and disseminate widely is what makes the tumors malignant, a role of MMP in cell migration during this...

journal_title：Pathology international

authors： Nabeshima K,Inoue T,Shimao Y,Sameshima T

更新日期：2002-04-01 00:00:00

abstract：:The RET finger protein (RFP) is a transcription factor belonging to the TRIM (tripartite motif) superfamily of proteins. RFP is expressed in a variety of human and rodent tumor cell lines and in several kinds of human cancer. Expression of RFP is associated with prognosis of colon and endometrial cancers. In the prese...

journal_title：Pathology international

authors： Iwakoshi A,Murakumo Y,Kato T,Kitamura A,Mii S,Saito S,Yatabe Y,Takahashi M

更新日期：2012-05-01 00:00:00

abstract：:The findings of a 20 year old woman with lymphadenopathy that was probably caused by an acute human herpesvirus-6 (HHV-6) infection are reported. She clinically demonstrated various signs of acute infection such as a high fever, skin rash, liver dysfunction, leukocytosis, an elevation of the erythrocyte sedimentation ...

journal_title：Pathology international

authors： Sumiyoshi Y,Kikuchi M,Ohshima K,Takeshita M,Eizuru Y,Minamishima Y

更新日期：1995-12-01 00:00:00

abstract：:YU-311 is a monoclonal antibody that reacts with a human leukemia cell line resistant for cytosine arabinoside and that identifies a 92 kDa membrane protein. The reactivity of YU-311 in normal organs, various non-hematopoietic tumors and in mast cell tumors in formalin-fixed, paraffin-embedded specimens was examined u...

journal_title：Pathology international

authors： Fukuda T,Kamishima T,Kakihara T,Yamada T,Matsumoto K,Uchiyama M,Suzuki T

更新日期：1997-08-01 00:00:00

abstract：:The alpha subunit of a GTP-binding protein, Go, was investigated in pulmonary neuroendocrine neoplasms and fetal tissues of the lung by an immunohistochemical method. Positive immunostaining for the alpha subunit of Go (Go alpha) was found predominantly on the cell membrane and found occasionally in the cytoplasm. Typ...

journal_title：Pathology international

authors： Kawano N,Ito T,Kitamura H,Shibagaki T,Kameda Y,Nakamura N,Kanisawa M

更新日期：1996-06-01 00:00:00

abstract：:Alopecia was induced in male and female neonatal C57BL mice by a single intraperitoneal injection of 60 mg/kg N-methyl-N-nitrosourea (MNU). MNU administration was most effective in the 8-day-old mice and less effective in the 5-day-old mice (at active and early anagen stages of the first hair cycle, respectively). No ...

journal_title：Pathology international

authors： Yoshizawa K,Nambu H,Yamamoto D,Yang J,Kiyozuka Y,Shikata N,Tsubura A

更新日期：2000-03-01 00:00:00

abstract：:Accurate diagnosis of lymphoma includes the assessment of lineage-specific markers. Hematopoietic and lymphoid tissues express PAX5 exclusively in pro-B-cell to mature B-cell stages. However, some mature PAX5+ T-cell lymphomas have been reported. We report three cases of primary cutaneous CD30+ T-cell lymphoproliferat...

journal_title：Pathology international

authors： Hagiwara M,Tomita A,Takata K,Shimoyama Y,Yoshino T,Tomita Y,Nakamura S

更新日期：2012-04-01 00:00:00

abstract：:Microscopic pulmonary tumor embolism is difficult to diagnose. Herein is presented the case of a patient who suffered from acute dyspnea and breast cancer on the right side. Two weeks after the breast cancer diagnosis the patient began to experience dyspnea. After 2 weeks of dyspnea, the patient died without an accura...

journal_title：Pathology international

authors： Kawasaki H,Ogura H,Arai Y,Baba S,Kosugi I,Tsutsui Y,Iwashita T

更新日期：2010-03-01 00:00:00

abstract：:Three cell systems (MINT1/2/3) derived from a melanotic neuroectodermal tumor of infancy (MNTI) arising in the mandible of a 1-month-old newborn boy have been established, and their cytological natures have been characterized. The cells had immunopositivities for pan-keratin, vimentin, neuron-specific enolase, S-100 p...

journal_title：Pathology international

authors： Metwaly H,Cheng J,Maruyama S,Ohshiro K,Suzuki I,Hoshina Y,Saku T

更新日期：2005-06-01 00:00:00

abstract：:In order to clarify the relationship between cyclin D1 and D2 (CD1/CD2) overexpression and progression, 191 gastric cancer cases (81 early and 110 advanced cancers) were investigated using the 5D4 monoclonal antibody for both CD1/CD2 in immunohistochemistry. 5D4 immunoreactivity was noted in 68 (35.6%) cases, staining...

journal_title：Pathology international

authors： Yasogawa Y,Takano Y,Okayasu I,Kakita A

更新日期：1998-09-01 00:00:00

abstract：:We describe a case of minute pancreatic ductal adenocarcinoma featuring stenosis of the main pancreatic duct (MPD) and associated with histological findings of periductal elastosis and fibroblast proliferation. A 53-year-old Japanese man with preoperative radiological evidence of MPD stricture and dilation of the dist...

journal_title：Pathology international

authors： Yachida S,Fukushima N,Nakanishi K,Shimada K,Kosuge T,Sakamoto M

更新日期：2002-09-01 00:00:00

abstract：:Macrophage polarization is divided into M1 and M2 type based on membrane receptors, cytokines, and chemokines. M1 expresses CD80, interleukin (IL)-6, IL-12, and chemokine receptor (CCR)7, while M2 expresses CD163, IL10, and chemokine ligand (CCL)22. The aim of the present study was to identify the properties of infilt...

journal_title：Pathology international

authors： Nomura Y,Takeuchi M,Yoshida S,Sugita Y,Niino D,Kimura Y,Shimizu K,Aoki R,Suefuji N,Hirose S,Kikuchi M,Ohshima K

更新日期：2009-09-01 00:00:00

abstract：:We have reported that the function of histamine and its receptors (HRs) has a close relationship with the development of nonalcoholic fatty liver disease (NAFLD). However, much less is known regarding its pathogenic and molecular mechanism(s), including the early stage of hepatic and intestinal function for lipid and ...

journal_title：Pathology international

authors： Yamada S,Guo X,Wang KY,Tanimoto A,Sasaguri Y

更新日期：2016-07-01 00:00:00

abstract：:Recent studies imply that cancer cells possess the ability to reversibly change their properties between a drug sensitive state and a drug resistant state accompanied by epigenetic changes. This evidence indicates that better understanding of cancer epigenetics is important for efficient cancer therapies. Nevertheless...

journal_title：Pathology international

authors： Matsuda Y,Semi K,Yamada Y

更新日期：2014-07-01 00:00:00

abstract：:The biopsy-based diagnosis of autoimmune pancreatitis (AIP) is difficult but is becoming imperative for pathologists due to the increased amount of endoscopic ultrasound-guided biopsy tissue. To cope with this challenge, we propose guidance for the biopsy diagnosis of type 1 AIP. This guidance is for pathologists and ...

journal_title：Pathology international

authors： Notohara K,Kamisawa T,Fukushima N,Furukawa T,Tajiri T,Yamaguchi H,Aishima S,Fukumura Y,Hirabayashi K,Iwasaki E,Kanno A,Kasashima S,Kawashima A,Kojima M,Kubota K,Kuraishi Y,Mitsuhashi T,Naito Y,Naitoh I,Nakase H,Ni

更新日期：2020-10-01 00:00:00

abstract：:New insights into the pathogenesis of lymphoid malignancies have been gained through novel genetic, molecular and immunological techniques. A new classification system for lymphoid malignancies, known as the new World Health Organization (WHO) classification, has been proposed recently based on these findings. The rel...

journal_title：Pathology international

authors： Ohshima K,Suzumiya J,Kikuchi M

更新日期：2002-01-01 00:00:00

abstract：:Morphologic features and neoplastic potentials of bile duct adenoma (BDA) and von Meyenburg complex (VMC)-like duct arising in chronic liver disease were unknown. Thirty-five BDAs and 12 VMC-like duct lesions were observed in 39 cases with chronic liver disease. BDAs were divided into the EMA-cytoplasmic type (n = 14)...

journal_title：Pathology international

authors： Aishima S,Tanaka Y,Kubo Y,Shirabe K,Maehara Y,Oda Y

更新日期：2014-11-01 00:00:00

abstract：:A 54-year-old Japanese woman was referred with a gallbladder tumor. Based on the results of the computed tomography scan, endoscopic retrograde cholangiopancreatography, and magnetic resonance cholangiopancreatography, a mucin-producing neoplasm of the gallbladder associated with pancreaticobiliary maljunction was dia...

journal_title：Pathology international

authors： Meguro Y,Fukushima N,Koizumi M,Kasahara N,Hydo M,Morishima K,Sata N,Lefor AT,Yasuda Y

更新日期：2014-09-01 00:00:00

abstract：:Mixed epithelial and stromal tumor of the kidney (MESTK) is a rare kidney neoplasm that almost exclusively occurs in perimenopausal women, and long-term estrogen replacement is relevant to its pathogenesis. Herein is described an atypical case of MESTK uncovered in a 12-year-old premenarcheal girl without a history of...

journal_title：Pathology international

authors： Hara N,Kawaguchi M,Murayama S,Maruyama R,Tanikawa T,Takahashi K

更新日期：2005-10-01 00:00:00

abstract：:Breast cancer patients have a generally increased risk of developing second cancers. The object of this study was to clarify the increased as well as decreased incidence of cancers in breast cancer patients using autopsy cases. 164 211 autopsy cases in the Annual of Pathological Autopsy Cases in Japan from 2002 to 201...

journal_title：Pathology international

authors： Shibahara Y,Sugawara Y,Miki Y,Hata S,Takahashi H,Nakamura Y,Suzuki T,Ohuchi N,Tsuji I,Sasano H

更新日期：2016-12-01 00:00:00

abstract：:Several reports have demonstrated the use of whole-slide imaging (WSI) for primary pathological diagnosis, but no such studies have been published from Asia. We retrospectively collected 1070 WSI specimens from 900 biopsies and small surgeries conducted in nine hospitals. Nine pathologists, who participated in this st...

journal_title：Pathology international

authors： Tabata K,Mori I,Sasaki T,Itoh T,Shiraishi T,Yoshimi N,Maeda I,Harada O,Taniyama K,Taniyama D,Watanabe M,Mikami Y,Sato S,Kashima Y,Fujimura S,Fukuoka J

更新日期：2017-11-01 00:00:00

abstract：:Reported herein is a 57-year-old man infected by Sparganum mansoni, a kind of tapeworm, showing a solitary nodule of the middle lobe of the right lung. Because a transbronchial biopsy could not diagnose the nodule, a right middle lobectomy was performed on suspicion of malignant tumor. The lesion was diagnosed as spar...

journal_title：Pathology international

authors： Iwatani K,Kubota I,Hirotsu Y,Wakimoto J,Yoshioka M,Mori T,Ito T,Nomori H

更新日期：2006-11-01 00:00:00

abstract：:There are several reports of pleural adenomatoid (microcystic) mesothelioma, but peritoneal adenomatoid mesothelioma is extremely rare. A 64-year-old Japanese woman presented with no symptoms and no asbestos exposure history. An abdominal computed tomography scan revealed multiple hypervascular masses on the liver sur...

journal_title：Pathology international

authors： Mori D,Kido S,Hiraki M,Sumi K,Ureshino N,Masuda M,Nabeshima K,Akashi M

更新日期：2020-11-01 00:00:00

abstract：:Homozygous deletion of 9p21, the locus harboring the p16 gene, has been reported as one of the most common genetic alterations in malignant mesotheliomas (MMs). Previous studies showed that this alteration might be useful for differentiating benign from malignant mesothelial tumors in cytology and surgical specimens. ...

journal_title：Pathology international

authors： Takeda M,Kasai T,Enomoto Y,Takano M,Morita K,Kadota E,Nonomura A

更新日期：2010-05-01 00:00:00

abstract：:An unusual tumor in the spinal cord of a 57 year old man is reported. At the age of 42 years, the patient had had a pineal region tumor that subsequently disappeared completely after local radiation therapy only. Eleven and 15 years later, at the ages of 53 and 57 years, respectively, solitary spinal cord tumors were ...

journal_title：Pathology international

authors： Ito T,Takahashi H,Ikuta F,Sato H

更新日期：1994-12-01 00:00:00