Matrix metalloproteinases in tumor invasion: role for cell migration.

abstract：:Gonadotropin releasing hormone (GnRH) analogs can cause regression of hormone-dependent breast carcinomas via the specific GnRH receptor (GnRH-R). In an attempt to obtain a better understanding of GnRH actions in human breast carcinoma, the expression of GnRH-R was examined immunohistochemically in 58 invasive ductal ...

journal_title：Pathology international

authors： Moriya T,Suzuki T,Pilichowska M,Ariga N,Kimura N,Ouchi N,Nagura H,Sasano H

更新日期：2001-05-01 00:00:00

abstract：:We studied the extensive molecular alterations of endometrial endometrioid adenocarcinoma (EEA) using a crypt isolation method. We analyzed copy number variation (CNV) using a single nucleotide polymorphism (SNP) array, genetic mutations (KRAS, BRAF, p53, PIK3CA), DNA methylation and microsatellite instability (MSI) s...

journal_title：Pathology international

authors： Suga Y,Sugai T,Uesugi N,Kawasaki T,Fukagawa T,Yamamoto E,Ishida K,Suzuki H,Sugiyama T

更新日期：2015-05-01 00:00:00

abstract：:Many new members of the S-100 genes are known to be associated with cell differentiation, malignant transformation, and cell cycle. Of the S-100 genes examined in the present study, calcyclin, calpactin I light chain and calvasculin were expressed in most human epithelial tumor cells, and their expression levels diffe...

journal_title：Pathology international

authors： Matsumoto T,Murao S,Kito K,Kihana T,Matsuura S,Ueda N

更新日期：1997-06-01 00:00:00

abstract：:Soft-tissue sarcomas can be divided into translocation-associated (TA) and non-TA sarcomas, the latter of which is often characterized by pleomorphic cytomorphology and aneuploidy. The aberrant expression of MAD2, an essential component of the mitotic spindle checkpoint, has been recently shown to promote aneuploidy. ...

journal_title：Pathology international

authors： Hisaoka M,Matsuyama A,Hashimoto H

更新日期：2008-06-01 00:00:00

abstract：:We investigated the diagnostic and prognostic value of p53 expression and proliferative activity, as indicated by the Ki-67, in endoscopic biopsy specimens. Specimens were immunologically stained with p53 and MIB-1 (Ki-67), and the MIB-1/Ki-67 labeling index (LI) was calculated. Classification of adenomas was based on...

journal_title：Pathology international

authors： Kubota K,Kakuta Y,Kawamura S,Saito S,Seki H,Kuniyoshi T

更新日期：2003-06-01 00:00:00

abstract：:A case of a 9-year-old boy with fibrocartilaginous mesenchymoma located in the distal femur is presented. Fibrocartilaginous mesenchymoma is a rare tumor. There have been 17 cases reported since 1984. The presenting complaint was pain and local discomfort. Radiological examination showed lytic and sclerotic lesions lo...

journal_title：Pathology international

authors： Gedikoglu G,Aksoy MC,Ruacan S

更新日期：2001-08-01 00:00:00

abstract：:Epstein-Barr virus (EBV) has been implicated as a causal virus of gastric cancer with episomal monoclonality, elevated antibodies and a unique morphologic expression in the early intramucosal stage, but the infection mechanisms have not been demonstrated. EBV has been shown only in the cancerous lesions by the highly ...

journal_title：Pathology international

authors： Arikawa J,Tokunaga M,Tashiro Y,Tanaka S,Sato E,Haraguchi K,Yamamoto A,Toyohira O,Tsuchimochi A

更新日期：1997-10-01 00:00:00

abstract：:A 70-year-old man with metastatic liver tumors showed carcinoid syndrome with clinical symptoms of facial flushing, palpitation, dyspnea, and an itching sensation. Regurgitation of the tricuspid and aortic valves was observed by echocardiography. An elevated serum level of serotonin and a high urine excretion of serot...

journal_title：Pathology international

authors： Sakai D,Murakami M,Kawazoe K,Tsutsumi Y

更新日期：2000-05-01 00:00:00

abstract：:The great majority of the cases clinically diagnosed as primary aldosteronism (PA) have been caused by aldosterone-producing adenoma (APA) or idiopathic hyperaldosteronism (IHA). The differential diagnosis of both subtypes of PA is important due to the different therapeutic modes but clinically it is sometimes difficu...

journal_title：Pathology international

authors： Nakamura Y,Felizola SJ,Satoh F,Konosu-Fukaya S,Sasano H

更新日期：2014-10-01 00:00:00

abstract：:The p73 gene is a member of the p53 gene family and the structure and functions of p73 protein are similar to those of p53. However, these two proteins have different roles. In the present study, p73 protein was found immunohistochemically to be distributed in the basal cells of the epidermis, columnar basal cells in ...

journal_title：Pathology international

authors： Kamiya M,Takeuchi Y,Katho M,Yokoo H,Sasaki A,Nakazato Y

更新日期：2004-12-01 00:00:00

abstract：:Chronic active Epstein-Barr virus infection (CAEBV) is a syndrome that takes diverse clinical courses and is often associated with lymphoproliferative disorders of T/natural killer (NK)-cell lineage. We describe a patient with CAEBV associated with persistent pharyngeal ulcer, and with subsequent nasal T/NK-cell lymph...

journal_title：Pathology international

authors： Nagata H,Numata T,Konno A,Mikata I,Kurasawa K,Hara S,Nishimura M,Yamamoto K,Shimizu N

更新日期：2001-10-01 00:00:00

abstract：:Microwave cell death (MCD) is unique in that microscopic morphology and antigenicity are well preserved, while enzymatic activity is lost. The aim of the present study was to carry out DNA electrophoresis, polymerase chain reaction (PCR) amplification and terminal deoxynucleotidyl transferase-mediated dUTP nick end-la...

journal_title：Pathology international

authors： Mori I,Ozaki T,Tabuse K,Utsunomiya H,Taniguchi E,Kakudo K

更新日期：2009-05-01 00:00:00

abstract：:In order to confirm the role of 14-3-3 sigma (sigma) as a tumor suppressor in breast carcinogenesis, we have studied the expression of 14-3-3sigma immunohistochemically in usual ductal hyperplasia (UDH), ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) breast lesions. Immunostaining for estrogen rec...

journal_title：Pathology international

authors： Simooka H,Oyama T,Sano T,Horiguchi J,Nakajima T

更新日期：2004-08-01 00:00:00

abstract：:The roles of Wnt protein in carcinogenesis have been well documented in human cancers. Wls is a key modulator for the secretion of Wnt protein. We previously found that Wls was aberrantly expressed in colorectal carcinomas. Studies have revealed that dysregulation of Wnt signal transduction plays an important role in ...

journal_title：Pathology international

authors： Zhang W,Tao H,Chen X,Sugimura H,Wang J,Zhou P

更新日期：2017-03-01 00:00:00

abstract：:A rare case of an extragonadal teratoma, which occurred primarily in the uterus, is described. The tumor developed in the uterine cervix as a conventional cervical polyp, 3 months after an elective abortion in a 27-year-old woman. Microscopically, the solid 2.2 x 1.8 x 1.5 cm mass was a mature teratoma with exuberant ...

journal_title：Pathology international

authors： Lim SC,Kim YS,Lee YH,Lee MS,Lim JY

更新日期：2003-05-01 00:00:00

abstract：:Niemann-Pick disease type C (NPC) is a neurovisceral lipid-storage disease. Although NPC patients show lipid storage in anterior horn cells of the spinal cord, little information is available regarding the electron microscopic analyses of the morphologies of intra-endosomal lipid like-materials in the anterior horn ce...

journal_title：Pathology international

authors： Kusunoki-Ii M,Kohama H,Kato K,Nomura Y,Nagashima K,Ninomiya H,Kato M,Kato S

更新日期：2020-07-01 00:00:00

abstract：:Breast cancer patients have a generally increased risk of developing second cancers. The object of this study was to clarify the increased as well as decreased incidence of cancers in breast cancer patients using autopsy cases. 164 211 autopsy cases in the Annual of Pathological Autopsy Cases in Japan from 2002 to 201...

journal_title：Pathology international

authors： Shibahara Y,Sugawara Y,Miki Y,Hata S,Takahashi H,Nakamura Y,Suzuki T,Ohuchi N,Tsuji I,Sasano H

更新日期：2016-12-01 00:00:00

abstract：:A case of squamous cell carcinoma arising within an acquired seminal vesicular cyst is described. A 61-year-old man was hospitalized because of hemospermia and dysuria. Under the diagnosis of a left seminal vesicular cyst, surgical resection was performed. Pathological examination revealed squamous cell carcinoma with...

journal_title：Pathology international

authors： Yanagisawa N,Saegusa M,Yoshida T,Okayasu I

更新日期：2002-03-01 00:00:00

abstract：:Collagenous fibroma (desmoplastic fibroblastoma) is a distinctive benign fibrous soft tissue tumor that typically occurs in the subcutaneous tissue or skeletal muscle in adults. We describe a case of collagenous fibroma in a 7-year-old boy who presented with a 1-cm solitary, firm nodule on the volar aspect of the meta...

journal_title：Pathology international

authors： Nishio J,Iwasaki H,Nishijima T,Kikuchi M

更新日期：2002-04-01 00:00:00

abstract：:We recently established a high-speed, label-free, spectral imaging method based on stimulated Raman scattering (SRS). This method enables examination of cellular features within relatively short periods, thus enabling new imaging applications in pathology. Previously, we reported on label-free visualization of mouse t...

journal_title：Pathology international

authors： Satoh S,Otsuka Y,Ozeki Y,Itoh K,Hashiguchi A,Yamazaki K,Hashimoto H,Sakamoto M

更新日期：2014-10-01 00:00:00

abstract：:The juxtaglomerular cell tumor (JGCT) of the kidney is a rare neoplasm which commonly secretes renin. This tumor often occurs in teenagers. This paper documents the 14th adult-onset (over 30-years-old) case with a giant JGCT which measured 9.0 x 8.0 x 7.5 cm. Histologically, this tumor was composed of both vascular an...

journal_title：Pathology international

authors： Kuroda N,Moriki T,Komatsu F,Miyazaki E,Hayashi Y,Naruse K,Nakayama H,Kiyoku H,Hiroi M,Shuin T,Enzan H

更新日期：2000-03-01 00:00:00

abstract：:The Association of Directors of Anatomic and Surgical Pathology have developed recommendations for the surgical pathology reporting of common malignant tumors. The recommendations for carcinomas of the urinary bladder are reported herein. ...

journal_title：Pathology international

authors：

更新日期：1997-05-01 00:00:00

abstract：:Of the idiopathic interstitial pneumonias (IIPs), usual interstitial pneumonia (UIP) and diffuse alveolar damage (DAD) usually have poor prognoses. The prognoses of cryptogenic organizing pneumonia (COP) and nonspecific interstitial pneumonia (NSIP) are usually more favorable. Although several reports have described n...

journal_title：Pathology international

authors： Takahashi M,Kunugi S,Terasaki Y,Terasaki M,Urushiyama H,Kuwahara N,Wakamatsu K,Nakayama T,Fukuda Y

更新日期：2013-05-01 00:00:00

abstract：:To test whether a subset of esophageal squamous cell carcinomas (SCC) develop through a deficiency in DNA mismatch repair, we examined microsatellite instability (MSI) using 11 microsatellite markers including BAT-26, hMLH1 protein expression by immunohistochemistry, and methylation status of the hMLH1 promoter by met...

journal_title：Pathology international

authors： Hayashi M,Tamura G,Jin Z,Kato I,Sato M,Shibuya Y,Yang S,Motoyama T

更新日期：2003-05-01 00:00:00

abstract：:Presented herein are two unusual epithelioid angiomyolipomas (AML) displaying prominent stromal sclerosis. Both patients were middle-aged women without a clinical history of tuberous sclerosis. One patient (case 1) had a 2 cm lesion arising in the renal cortex, and another (case 2) had a pararenal retroperitoneal tumo...

journal_title：Pathology international

authors： Matsuyama A,Hisaoka M,Ichikawa K,Fujimori T,Udo K,Uchihashi K,Aoki S,Hashimoto H

更新日期：2008-05-01 00:00:00

abstract：:Pleomorphic hyalinizing angiectatic tumor (PHAT) is a rare, recently recognized neoplasm occurring predominantly in the subcutaneous tissue of the lower limbs of adults. We report a case of PHAT in an 83-year-old woman who presented with a 5.0 x 5.0 x 2.0 cm mass in the soft part of her left thigh. Histologically, the...

journal_title：Pathology international

authors： Matsumoto K,Yamamoto T

更新日期：2002-10-01 00:00:00

abstract：:There are several reports of pleural adenomatoid (microcystic) mesothelioma, but peritoneal adenomatoid mesothelioma is extremely rare. A 64-year-old Japanese woman presented with no symptoms and no asbestos exposure history. An abdominal computed tomography scan revealed multiple hypervascular masses on the liver sur...

journal_title：Pathology international

authors： Mori D,Kido S,Hiraki M,Sumi K,Ureshino N,Masuda M,Nabeshima K,Akashi M

更新日期：2020-11-01 00:00:00

abstract：:To examine the relationship between the scavenger receptor A (SRA) index (the number of SRA+ cells observed in 10 high power fields of peripheral blood (PB) smear samples; normal upper limit <30) and coronary thrombus, 389 thrombi obtained from 393 patients with acute ST elevation myocardial infarction were examined. ...

journal_title：Pathology international

authors： Emura I,Usuda H,Fujita T,Ebe K,Nagai T

更新日期：2011-06-01 00:00:00

abstract：:Infarction of a breast fibroadenoma usually occurs in young females during pregnancy or lactation. This report describes a rare case of the total infarction of a fibroadenoma in a 58 year old postmenopausal woman. The chief complaint was a rapidly enlarged, slightly painful lump. Medullary carcinoma was suspected on p...

journal_title：Pathology international

authors： Ichihara S,Matsuyama T,Kubo K,Tamura Z,Aoyama H

更新日期：1994-05-01 00:00:00

abstract：:It has been reported that N-myc downstream regulated gene 1 (NDRG1) is related to the prognosis of non-small cell lung cancer (NSCLC), and associated with c-Myc degradation in NSCLC cell lines. However, the relationship of NDRG1 to prognosis or c-Myc expression in lung adenocarcinoma has not been well clarified. The p...

journal_title：Pathology international

authors： Dai T,Dai Y,Murata Y,Husni RE,Nakano N,Sakashita S,Noguchi M

更新日期：2018-04-01 00:00:00