The difference of neovascularization in early intra-alveolar fibrosis between nonspecific interstitial pneumonia and usual interstitial pneumonia.

Abstract:

:Of the idiopathic interstitial pneumonias (IIPs), usual interstitial pneumonia (UIP) and diffuse alveolar damage (DAD) usually have poor prognoses. The prognoses of cryptogenic organizing pneumonia (COP) and nonspecific interstitial pneumonia (NSIP) are usually more favorable. Although several reports have described neovascularization in COP and UIP, this aspect of UIP has not been compared with NSIP. In this study, we evaluated neovascularization in intra-alveolar fibrotic lesion of cases of fibrosing NSIP (f-NSIP) (n = 26) and UIP (n = 25). In the f-NSIP group, a considerable degree of neovascularization was observed compared to the UIP group and bud type intra-alveolar fibrosis showed a greater degree of neovascularization compared to the mural-incorporation and obliterative types of intra-alveolar fibrosis. Real-time reverse transcription polymerase chain reaction revealed a significantly greater expression of VEGF-A mRNA in f-NSIP than in UIP. The expression of matrix metalloproteinase-2 (MMP-2) mRNA also showed significantly higher in f-NSIP than UIP. The greater VEGF-A and MMP-2 expression may play a role in the pathogenesis of neovascularization in early intra-alveolar fibrotic lesions in f-NSIP.

journal_name

Pathol Int

journal_title

Pathology international

authors

Takahashi M,Kunugi S,Terasaki Y,Terasaki M,Urushiyama H,Kuwahara N,Wakamatsu K,Nakayama T,Fukuda Y

doi

10.1111/pin.12058

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

237-44

issue

5

eissn

1320-5463

issn

1440-1827

journal_volume

63

pub_type

杂志文章
  • Clinicopathological findings in patients who have undergone epilepsy surgery in the first year of life.

    abstract::Epilepsy presenting early in childhood may be associated with a neurologically devastating clinical course and have significant implications for the child's development. There are limited published data regarding the clinicopathological features of patients who have undergone epilepsy surgery in the first year of life...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2000.01101.x

    authors: Prayson RA

    更新日期:2000-08-01 00:00:00

  • High expression of Wls is associated with lymph node metastasis and advanced TNM stage in gastric carcinomas.

    abstract::The roles of Wnt protein in carcinogenesis have been well documented in human cancers. Wls is a key modulator for the secretion of Wnt protein. We previously found that Wls was aberrantly expressed in colorectal carcinomas. Studies have revealed that dysregulation of Wnt signal transduction plays an important role in ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12508

    authors: Zhang W,Tao H,Chen X,Sugimura H,Wang J,Zhou P

    更新日期:2017-03-01 00:00:00

  • Ruptured mucinous cystic neoplasm with an associated invasive carcinoma of pancreatic head in a pregnant woman: report of a case and review of literature.

    abstract::Mucinous cystic neoplasm (MCN) of the pancreas is characterized by mucin-producing columnar epithelium and an ovarian-type stroma. It occurs almost exclusively in women and is almost always located in the pancreatic body or tail. Here, we report a case of large MCN located in the pancreatic head but not in the body no...

    journal_title:Pathology international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1827.2010.02609.x

    authors: Naganuma S,Honda K,Noriki S,Kimura S,Murakami M,Koneri K,Katayama K,Yamaguchi A,Itoh H

    更新日期:2011-01-01 00:00:00

  • The World Health Organization classification of malignant lymphoma: incidence and clinical prognosis in HTLV-1-endemic area of Fukuoka.

    abstract::New insights into the pathogenesis of lymphoid malignancies have been gained through novel genetic, molecular and immunological techniques. A new classification system for lymphoid malignancies, known as the new World Health Organization (WHO) classification, has been proposed recently based on these findings. The rel...

    journal_title:Pathology international

    pub_type: 杂志文章,评审

    doi:10.1046/j.1440-1827.2002.01308.x

    authors: Ohshima K,Suzumiya J,Kikuchi M

    更新日期:2002-01-01 00:00:00

  • Sarcomatoid carcinoma of the pancreas: a case report with immunohistochemical study.

    abstract::Sarcomatoid carcinoma of the pancreas is an uncommon neoplasm. The immunohistochemical characteristics of this unique type of pancreatic tumor were studied. Histologically, there was diffuse proliferation of atypical spindle cells that had hyperchromatic, short, spindle-shaped nuclei and pale cytoplasm. A few tiny foc...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.1999.00877.x

    authors: Higashi M,Takao S,Sato E

    更新日期:1999-05-01 00:00:00

  • Reactivity of antibody YU-311 in formalin-fixed, paraffin-embedded specimens of normal organs, non-hematopoietic tumors, and mast cell tumors.

    abstract::YU-311 is a monoclonal antibody that reacts with a human leukemia cell line resistant for cytosine arabinoside and that identifies a 92 kDa membrane protein. The reactivity of YU-311 in normal organs, various non-hematopoietic tumors and in mast cell tumors in formalin-fixed, paraffin-embedded specimens was examined u...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1997.tb04533.x

    authors: Fukuda T,Kamishima T,Kakihara T,Yamada T,Matsumoto K,Uchiyama M,Suzuki T

    更新日期:1997-08-01 00:00:00

  • Hypoglycemia in a patient with a huge malignant solitary fibrous tumor of the pleura.

    abstract::Solitary fibrous tumor of the pleura (SFTP) is rare. A 73-year-old man, without past history of diabetes mellitus, was admitted to hospital with profound hypoglycemia, loss of consciousness and respiratory failure. CT indicated a huge heterogenous mass lesion (12 x 12 x 17 cm) at the right thoracic cavity with total a...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2007.02175.x

    authors: Chang JC,Su KY,Chao SF,Hsu YH,Yang GG,Chang BS

    更新日期:2007-12-01 00:00:00

  • Anaplastic large cell lymphoma with TP63 rearrangement: A dismal prognosis.

    abstract::Anaplastic large cell lymphoma (ALCL) with TP63 rearrangement is a new entity and has the most dismal prognosis in all types of ALCL. This might be due to the resulting fusion protein having N-terminal truncated p63 with high oncogenic ability. Since this N-terminal domain has the function of tumor suppressor activity...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12758

    authors: Yamashita T,Higashi M,Kawano R,Momose S,Tokuhira M,Kizaki M,Tamaru JI

    更新日期:2019-03-01 00:00:00

  • Expression of phosphorylated Akt in patients with small cell carcinoma of the lung indicates good prognosis.

    abstract::Patients with pulmonary small cell carcinoma are well known to have a poor prognosis. However, predictors of prognosis and treatment outcome have not been reported for this type of cancer. We examined whether excision repair cross-complementation group 1 (ERCC1), phosphorylated Akt (p-Akt), phosphorylated mammalian ta...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2010.02594.x

    authors: Ikeda S,Takabe K,Inagaki M,Suzuki K

    更新日期:2010-11-01 00:00:00

  • Case of mesenchymal tumor with the PPP6R3-USP6 fusion, possible nodular fasciitis with malignant transformation.

    abstract::Nodular fasciitis (NF) is a self-limiting benign disease that is characterized by rapid proliferation of fibroblastic and myofibroblastic cells. The characteristic gene fusion containing the USP6 gene is a genetic hallmark of NF and MYH9-USP6 is the most frequent fusion, suggesting that NF is not a reactive condition ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12851

    authors: Teramura Y,Yamazaki Y,Tanaka M,Sugiura Y,Takazawa Y,Takeuchi K,Nakayama T,Kaneko T,Musha Y,Funauchi Y,Ae K,Matsumoto S,Nakamura T

    更新日期:2019-12-01 00:00:00

  • Analysis of multiple primary cancer autopsy cases associated with breast cancer: 2002-2010.

    abstract::Breast cancer patients have a generally increased risk of developing second cancers. The object of this study was to clarify the increased as well as decreased incidence of cancers in breast cancer patients using autopsy cases. 164 211 autopsy cases in the Annual of Pathological Autopsy Cases in Japan from 2002 to 201...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12484

    authors: Shibahara Y,Sugawara Y,Miki Y,Hata S,Takahashi H,Nakamura Y,Suzuki T,Ohuchi N,Tsuji I,Sasano H

    更新日期:2016-12-01 00:00:00

  • Leiomyomatosis peritonealis disseminata with malignant change in a man.

    abstract::Leiomyomatosis peritonealis disseminata (LPD) is a rare clinicopathological entity typically observed in women of reproductive age. We report a case of LPD with malignant change in a man. A 77-year-old man presented with a mass measuring 10 cm in diameter at the terminal ileum and numerous peritoneal small nodules tha...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2003.01452.x

    authors: Yamaguchi T,Imamura Y,Yamamoto T,Fukuda M

    更新日期:2003-03-01 00:00:00

  • Diffuse pulmonary ossification in permanent vegetative state.

    abstract::Diffuse pulmonary ossification (DPO) is a rare condition characterized by diffuse metaplastic bone formation in the lungs. Two patterns have been described: dendriform, with a coral-like network of bone spiculae along the alveolar septa; and nodular, with lobulated fragments in the alveolar spaces. Dendriform DPO is f...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12228

    authors: Porzionato A,Macchi V,Da Broi U,Giraudo C,Miotto D,Rodriguez D,Moreschi C,De Caro R

    更新日期:2015-01-01 00:00:00

  • Severe eosinophilic cholangitis with parenchymal destruction of the left hepatic lobe due to hydatid disease.

    abstract::Hydatid cysts of the liver are known to occasionally rupture into the bile ducts and cause cholangitis. The histological features of this complication have not been adequately described in the literature. Herein is reported a case of severe eosinophilic cholangitis of the left hepatic lobe, occurring in a 24-year-old ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2009.02383.x

    authors: Raptou G,Pliakos I,Hytiroglou P,Papavramidis S,Karkavelas G

    更新日期:2009-06-01 00:00:00

  • Tumor suppressor in lung cancer-1 as a novel ameloblast adhesion molecule and its downregulation in ameloblastoma.

    abstract::Tumor suppressor in lung cancer-1 (TSLC1) is an intercellular adhesion molecule of the immunoglobulin superfamily. There is little information regarding the developmental expression profiles. In an attempt to clarify the distribution of TSLC1 proteins in mouse embryos tissue by immunohistochemistry, it was found that ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2006.02064.x

    authors: Usami Y,Ito A,Ohnuma K,Fuku T,Komori T,Yokozaki H

    更新日期:2007-02-01 00:00:00

  • Amyloidosis of pancreatic islets in primary amyloidosis (AL type).

    abstract::Seven cases of primary amyloidosis (AL-type) were studied immunocytochemically for the possible involvement of pancreatic islets. The two cases with extensive organ involvement by AL-amyloidosis revealed amyloid deposits in pancreatic islets by routine HE and Congo red staining, which were positive for amyloid p and a...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2005.01815.x

    authors: Tomita T

    更新日期:2005-04-01 00:00:00

  • Non-specific interstitial pneumonia as a manifestation of graft-versus-host disease following pediatric allogeneic hematopoietic stem cell transplantation.

    abstract::Bronchiolitis obliterans (BO) is generally believed to be a marker of pulmonary manifestation of graft-versus-host disease (GVHD) in patients who have undergone bone marrow transplantation for hematological malignancy. Pulmonary manifestations reported as GVHD (other than BO) include lymphocytic bronchiolitis with cel...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2009.02492.x

    authors: Miyagawa-Hayashino A,Sonobe M,Kubo T,Yoshizawa A,Date H,Manabe T

    更新日期:2010-02-01 00:00:00

  • Copper and iron-induced oxidative damage in non-tumor bearing LEC rats.

    abstract::The copper and iron status in the liver of non-tumor bearing Long-Evans Cinnamon (LEC) rats (average age 17 months) was investigated. A direct quantitation of loosely-bound copper and iron was also investigated by using a chelating agent, nitrilotriacetic acid (NTA-chelatable free copper and iron). Besides the total c...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1997.tb04481.x

    authors: Ma Y,Zhang D,Kawabata T,Kiriu T,Toyokuni S,Uchida K,Okada S

    更新日期:1997-04-01 00:00:00

  • Experimental osteodystrophy of chronic renal failure induced by aluminum- and ferric-nitrilotriacetate in Wistar rats.

    abstract::The aluminum (AI) and iron (Fe) chelate complexes of nitrilotriacetate (NTA) cause renal insufficiency when they are administered intraperitoneally to rats. Their effects on bone metabolism were studied in 4 week old Wistar rats. Daily intraperitoneal administration of AI-NTA (3mg AI/kg for 11 weeks) induced osteomala...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1995.tb03375.x

    authors: Yukihiro S,Okada S,Takeuchi K,Inoue H

    更新日期:1995-01-01 00:00:00

  • Origin of histiocyte-like cells and multinucleated giant cells in malignant fibrous histiocytoma: neoplastic or reactive?

    abstract::The origin of histiocyte-like cells in malignant fibrous histiocytoma (MFH) remains controversial. To determine whether histiocyte-like cells and multinucleated giant cells show reactive or neoplastic proliferation, we transplanted human storiform-pleomorphic MFH to nude mice and investigated the origin of histiocyte-...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.1999.00819.x

    authors: Hatano H,Tokunaga K,Ogose A,Imaizumi S,Hayami T,Yamagiwa H,Hotta T,Endo N,Takahashi HE,Naito M

    更新日期:1999-01-01 00:00:00

  • Peritoneal adenomatoid (microcystic) mesothelioma.

    abstract::There are several reports of pleural adenomatoid (microcystic) mesothelioma, but peritoneal adenomatoid mesothelioma is extremely rare. A 64-year-old Japanese woman presented with no symptoms and no asbestos exposure history. An abdominal computed tomography scan revealed multiple hypervascular masses on the liver sur...

    journal_title:Pathology international

    pub_type:

    doi:10.1111/pin.13006

    authors: Mori D,Kido S,Hiraki M,Sumi K,Ureshino N,Masuda M,Nabeshima K,Akashi M

    更新日期:2020-11-01 00:00:00

  • Epstein-Barr virus-associated post-transplant primary smooth muscle tumor of the liver: report of an autopsy case.

    abstract::Epstein-Barr (EB) virus-associated primary smooth muscle tumors have been reported in immunosuppressed young patients with acquired immunodeficiency syndrome (AIDS) and young people who have undergone liver transplantation. An autopsy case of EB virus-associated smooth muscle cell tumor in a 21 year old female who rec...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1996.tb03660.x

    authors: Sadahira Y,Moriya T,Shirabe T,Matsuno T,Manabe T

    更新日期:1996-08-01 00:00:00

  • MUC2, MUC5AC and MUC5B in the mucus of a patient with pseudomyxoma peritonei: biochemical and immunohistochemical study.

    abstract::A 58-year-old man with a 1 year history of progressive abdominal distension underwent a laparotomy for pseudomyxoma peritonei. The mucin was identified and characterized in the present study. Approximately 6 L of crude mucus in the sol (highly viscous) and gel (semisolid) phases was obtained from the patient's periton...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2007.02137.x

    authors: Mall AS,Chirwa N,Govender D,Lotz Z,Tyler M,Rodrigues J,Kahn D,Goldberg P

    更新日期:2007-08-01 00:00:00

  • Thymidine phosphorylase expression causes both the increase of intratumoral microvessels and decrease of apoptosis in human esophageal carcinomas.

    abstract::Thymidine phosphorylase (dThdPase)/platelet-derived endothelial cell growth factor, is expressed at higher levels in tumor tissues compared to the adjacent normal tissues in a variety of human carcinomas. The higher expression is associated with an increase of intratumoral microvessel density (IMVD) and an unfavorable...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2001.01184.x

    authors: Okamoto E,Osaki M,Kase S,Adachi H,Kaibara N,Ito H

    更新日期:2001-03-01 00:00:00

  • Collagenous fibroma (desmoplastic fibroblastoma) of the finger in a child.

    abstract::Collagenous fibroma (desmoplastic fibroblastoma) is a distinctive benign fibrous soft tissue tumor that typically occurs in the subcutaneous tissue or skeletal muscle in adults. We describe a case of collagenous fibroma in a 7-year-old boy who presented with a 1-cm solitary, firm nodule on the volar aspect of the meta...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2002.01351.x

    authors: Nishio J,Iwasaki H,Nishijima T,Kikuchi M

    更新日期:2002-04-01 00:00:00

  • Aberrant expression of beta-catenin and mutation of exon 3 of the beta-catenin gene in renal and urothelial carcinomas.

    abstract::The present study attempted to clarify the significance of aberrant expression of beta-catenin protein and mutation of exon 3 of the beta-catenin gene in renal and urothelial carcinogenesis. beta-Catenin expression was examined immunohistochemically and mutation of the beta-catenin gene was analyzed by polymerase chai...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2000.01139.x

    authors: Zhu X,Kanai Y,Saito A,Kondo Y,Hirohashi S

    更新日期:2000-12-01 00:00:00

  • Concordance in judgments among c-erbB-2 (HER2/neu) overexpression detected by two immunohistochemical tests and gene amplification detected by Southern blot hybridization in breast carcinoma.

    abstract::We compared the c-erbB-2 protein overexpression status detected by the HercepTestTM (DAKO A/S, Grostrup, Denmark) with another conventional immunohistochemistry system using an anti-c-erbB-2 rabbit polyclonal antibody (Nichirei Co., Tokyo, Japan) and with the c-erbB-2 gene amplification status detected by Southern blo...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2001.01163.x

    authors: Tsuda H,Tani Y,Hasegawa T,Fukutomi T

    更新日期:2001-01-01 00:00:00

  • Clinicopathological correlation of childhood IgA glomerulonephritis presenting diffuse endocapillary proliferation.

    abstract::The aim of the present study is to clarify the clinicopathological correlation of childhood IgA glomerulonephritis (GN) presenting diffuse endocapillary proliferation. Twenty-seven patients were used in the present study. The 27 patients were divided into three groups (mild, moderate and severe) according to the perce...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2003.01604.x

    authors: Hisano S,Kiyoshi Y,Tanaka I,Tokieda K,Niimi K,Tsuru N,Takebayashii S,Iwasaki H

    更新日期:2004-03-01 00:00:00

  • Epithelioid angiomyolipoma of the kidney.

    abstract::Epithelioid angiomyolipoma (eAMLoma) is an uncommon renal mesenchymal tumor with malignant potential and is frequently associated with tuberous sclerosis (TSC). It is composed of polygonal large-sized tumor cells arranged in an epithelioid manner. Differential diagnosis from renal cell carcinoma (RCC) is often challen...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2008.02322.x

    authors: Kato I,Inayama Y,Yamanaka S,Ohshiro H,Gomi K,Shirai S,Aoki I,Uemura H,Miyoshi Y,Kubota Y,Yao M,Nagashima Y

    更新日期:2009-01-01 00:00:00

  • Medulloblastoma with myogenic differentiation showing double immunopositivity for synaptophysin and myoglobin.

    abstract::Reported herein is a case of medulloblastoma with myogenic differentiation in a 3-year-old girl who died 1 year after appearance of clinical signs. Magnetic resonance imaging indicated a mass lesion in the cerebellar vermis. She underwent total resection of the tumor, followed by chemotherapy and radiotherapy in the b...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2009.02360.x

    authors: Kido M,Ueno M,Onodera M,Matsumoto K,Imai T,Haba R,Tamiya T,Huang CL,Sakamoto H

    更新日期:2009-04-01 00:00:00