Concordance in judgments among c-erbB-2 (HER2/neu) overexpression detected by two immunohistochemical tests and gene amplification detected by Southern blot hybridization in breast carcinoma.

abstract：:We report a very rare case of combined thymic carcinomas: undifferentiated thymic carcinoma coexisting with type AB thymoma. The precise mechanism underlying the coexistence of these tumors remains unknown. Therefore, we used clonality analysis to ascertain whether the two tumors were clonally related. A 63-year-old w...

journal_title：Pathology international

authors： Karino F,Yokose T,Matsukuma S,Miyagi Y,Murakami S,Ito H,Nakayama H,Yamada K

更新日期：2016-07-01 00:00:00

abstract：:Therapy related acute lymphoblastic leukemia (t-ALL) of B cell origin is rare and constitutes approximately 2% of all ALL. Previously compiled data on the complete cytogenetic analysis of 48 t-B-ALL cases suggested that MLL rearrangement at 11q23 gene locus is the most common abnormality. Philadelphia chromosome (Ph) ...

journal_title：Pathology international

authors： Matnani R,Parekh V,Borate U,Brazelton J,Reddy V,Peker D

更新日期：2015-10-01 00:00:00

abstract：:A surgical case of inflammatory myofibroblastic tumor arising in the uterine corpus and exhibiting prominent myxoid change of the stroma is reported. The patient was a 63-year-old woman with a large tumor mass that filled the uterine cavity and measured 11 cm in maximal dimension. The tumor had a gelatinous appearance...

journal_title：Pathology international

authors： Shintaku M,Fukushima A

更新日期：2006-10-01 00:00:00

abstract：:Infantile myofibromatosis (IM) is a rare disorder present at birth or in early infancy with a biphasic histological pattern. We present a neonatal-onset case of generalized IM with visceral (central nervous system, heart, lungs, liver, spleen, small intestine, kidneys and bones) and placental involvement, showing a mo...

journal_title：Pathology international

authors： Iwafuchi H,Tsuzuki T,Ito R,Miyake H,Okita H,Hamazaki M

更新日期：2015-08-01 00:00:00

abstract：:CpG island methylator phenotype (CIMP) is a recently described subset of colorectal cancers (CRC) with widespread methylation of multiple promoter CpG islands. But the prognostic implication of CIMP in CRC has not been clarified. Thus, the aim of the present study was to differentiate the unique characteristics of CIM...

journal_title：Pathology international

authors： Lee S,Cho NY,Choi M,Yoo EJ,Kim JH,Kang GH

更新日期：2008-02-01 00:00:00

abstract：:Angioleiomyoma is a solitary subcutaneous tumor characterized by pain in about half of patients with this tumor, and the pathogenesis of this pain has been a cause of much debate. To clarify the mechanism of pain and cytoskeletal property of tumor cells, 50 angioleiomyomas were studied clinicopathologically and immuno...

journal_title：Pathology international

authors： Hasegawa T,Seki K,Yang P,Hirose T,Hizawa K

更新日期：1994-01-01 00:00:00

abstract：:The factors conferring the increased malignancy on lung adenocarcinoma with micropapillary component (AC-MPC) remain to be elucidated. On proteomics based on 2-dimensional gel electrophoresis, 19 proteins differentially expressed by more than 1.5-fold between AC-MPC and conventional adenocarcinoma (CAC); in particular...

journal_title：Pathology international

authors： Nakashima H,Jiang SX,Sato Y,Hoshi K,Matsumoto T,Nagashio R,Kobayashi M,Matsuo Y,Shiomi K,Hayakawa K,Saegusa M,Satoh Y

更新日期：2015-04-01 00:00:00

abstract：:Perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal neoplasm, and malignant cases are extremely rare. A case of malignant PEComa arising in the colon is described herein. The patient was a 43-year-old Japanese woman without a history of tuberous sclerosis complex. The tumor occurred in the abdominal cav...

journal_title：Pathology international

authors： Yamamoto H,Oda Y,Yao T,Oiwa T,Kobayashi C,Tamiya S,Kawaguchi K,Hino O,Tsuneyoshi M

更新日期：2006-01-01 00:00:00

abstract：:The role of chemokines, especially CXCL10/interferon-gamma-inducible protein 10 kDa (IP-10), a chemokine to attract CXCR3(+) T-helper 1-type CD4(+) T cells, is largely unknown in the pathophysiology of inflammatory bowel disease; ulcerative colitis and Crohn's disease. The authors have earlier shown that IP-10 neutral...

journal_title：Pathology international

authors： Suzuki K,Kawauchi Y,Palaniyandi SS,Veeraveedu PT,Fujii M,Yamagiwa S,Yoneyama H,Han GD,Kawachi H,Okada Y,Ajioka Y,Watanabe K,Hosono M,Asakura H,Aoyagi Y,Narumi S

更新日期：2007-07-01 00:00:00

abstract：:The present study investigates whether lymphatic vessel invasion (LVI) detected by D2-40 staining is a prognostic factor for stage I adenocarcinoma of the lung. We retrospectively reviewed 124 patients who underwent complete resection for stage I adenocarcinoma of the lung from January 1983 to June 2003. LVI was micro...

journal_title：Pathology international

authors： Shimizu K,Funai K,Sugimura H,Sekihara K,Kawase A,Shiiya N

更新日期：2013-04-01 00:00:00

abstract：:Tumor suppressor in lung cancer-1 (TSLC1) is an intercellular adhesion molecule of the immunoglobulin superfamily. There is little information regarding the developmental expression profiles. In an attempt to clarify the distribution of TSLC1 proteins in mouse embryos tissue by immunohistochemistry, it was found that ...

journal_title：Pathology international

authors： Usami Y,Ito A,Ohnuma K,Fuku T,Komori T,Yokozaki H

更新日期：2007-02-01 00:00:00

abstract：:New insights into the pathogenesis of lymphoid malignancies have been gained through novel genetic, molecular and immunological techniques. A new classification system for lymphoid malignancies, known as the new World Health Organization (WHO) classification, has been proposed recently based on these findings. The rel...

journal_title：Pathology international

authors： Ohshima K,Suzumiya J,Kikuchi M

更新日期：2002-01-01 00:00:00

abstract：:Presented is the first Japanese case of ossifying renal tumor of infancy (ORTI), which is an extremely rare tumor and of which only nine cases have been reported in the literature. The patient was a four-month-old Japanese boy presenting as hematuria. A small nodular tumor (approximately 1 cm in size) protruded into t...

journal_title：Pathology international

authors： Ito J,Shinohara N,Koyanagi T,Hanioka K

更新日期：1998-02-01 00:00:00

abstract：:A case of an inflammatory pseudotumor of the liver in a 75-year-old female with chronic hepatitis C whose radiologic features simulated that of hepatocellular carcinoma (HCC) is presented. On imaging studies, hypervascularity by CO2 ultrasound (US) angiography, enhancement at an early phase and isodensity at a late ph...

journal_title：Pathology international

authors： Kim SR,Hayashi Y,Kudo M,Matsuoka T,Imoto S,Sasaki K,Shintani S,Song KB,Park SY,Kim JH,Ando K,Koterazawa T,Kim KI,Ninomiya T

更新日期：1999-08-01 00:00:00

abstract：:Presented herein are two unusual epithelioid angiomyolipomas (AML) displaying prominent stromal sclerosis. Both patients were middle-aged women without a clinical history of tuberous sclerosis. One patient (case 1) had a 2 cm lesion arising in the renal cortex, and another (case 2) had a pararenal retroperitoneal tumo...

journal_title：Pathology international

authors： Matsuyama A,Hisaoka M,Ichikawa K,Fujimori T,Udo K,Uchihashi K,Aoki S,Hashimoto H

更新日期：2008-05-01 00:00:00

abstract：:The clinical and pathological significance of intratumoral lymphangiogenesis (ITL) with human esophageal squamous cell carcinomas (ESCC) remains unclear, as does the role of signaling molecules such as vascular endothelial growth factor (VEGF)-A,C, platelet-derived growth factor (PDGF)-A, and p53, in the regulation of...

journal_title：Pathology international

authors： Inoue A,Moriya H,Katada N,Tanabe S,Kobayashi N,Watanabe M,Okayasu I,Ohbu M

更新日期：2008-10-01 00:00:00

abstract：:High-grade transformation (HGT)/dedifferentiation is an unusual phenomenon in salivary gland carcinomas. Here we report a case of adenoid cystic carcinoma (ACC) with HGT/dedifferentiation to myoepithelial carcinoma, occurring in the epipharynx of a 42-year-old woman. The surgically resected tumor was a pedunculated ma...

journal_title：Pathology international

authors： Tando S,Nagao T,Kayano K,Fushiki S,Itoh K

更新日期：2018-02-01 00:00:00

abstract：:An extremely rare case of unilateral gonadoblastoma with mixed germ cell tumor arising in the ovary of a 27-year-old woman with 46,XX karyotype and two successful pregnancies is reported. The mixed germ cell tumor was composed of choriocarcinoma, embryonal carcinoma, yolk sac tumor, immature teratoma and dysgerminoma....

journal_title：Pathology international

authors： Zhao S,Kato N,Endoh Y,Jin Z,Ajioka Y,Motoyama T

更新日期：2000-04-01 00:00:00

abstract：:We present a case of uterine intravenous leiomyomatosis associated with multiple pulmonary metastases with bullae-like cystic change. A 53-year-old woman who had undergone hysterectomy 5 years previously underwent an operation for multiple pulmonary nodules with bullae formation. After resection of several large bulla...

journal_title：Pathology international

authors： Matsumoto K,Yamamoto T,Hisayoshi T,Asano G

更新日期：2001-05-01 00:00:00

abstract：:Giant cell tumor (GCT) of bone is a primary osteolytic tumor that is characterized by the formation of osteoclast-like giant cells. In addition to GCT of bone, extraskeletal GCT are known to be formed in several soft tissues. Giant cells in GCT of bone were suggested to be identical to osteoclasts, but the characteriz...

journal_title：Pathology international

authors： Ikeda T,Seki S,Maki M,Noguchi N,Kawamura T,Arii S,Igari T,Koike M,Hirokawa K

更新日期：2003-07-01 00:00:00

abstract：:This report describes a renal tumor with an unusual histology in a 45-year-old woman. The tumor was white in color, different from usual renal cell carcinoma, and mainly consisted of variously shaped tubules formed by flat or cuboid cells within marked edematous stroma. Elaborated branching or tubules arranged in a pa...

journal_title：Pathology international

authors： He Q,Ohaki Y,Mori O,Asano G,Tuboi N

更新日期：1998-05-01 00:00:00

abstract：:A quantitative model was devised for the purpose of evaluating interobserver agreement in the judgment of the nuclear atypia score of cancer cells in protocol studies. In this model, the mean nuclear atypia score (mu) among observers was considered to approximate the 'true' nuclear atypia score of the tumor, and with ...

journal_title：Pathology international

authors： Tsuda H,Akiyama F,Kurosumi M,Sakamoto G,Watanabe T

更新日期：2000-02-01 00:00:00

abstract：:Pilomyxoid astrocytoma, first described by Tihan et al., was recently included as an established variant of pilocytic astrocytoma in the World Health Organization classification of CNS tumors. Histologically, it much resembles pilocytic astrocytoma, but monomorphic myxoid tumor of pilocytic cells with prominent angioc...

journal_title：Pathology international

authors： Amatya VJ,Akazawa R,Sumimoto Y,Takeshima Y,Inai K

更新日期：2009-02-01 00:00:00

abstract：:The occurrence of malignant neoplasms increases with advancing age. Although aging and carcinogenesis are basically different processes, there are phenomena common to each such as accumulation of DNA damage and abnormal proteins. Gastric and colorectal carcinomas are representative tumors in which the prevalence and t...

journal_title：Pathology international

authors： Arai T,Takubo K

更新日期：2007-06-01 00:00:00

abstract：:The CDKN2 gene encodes two structurally different proteins: a cyclin-dependent kinase inhibitor, p16, which regulates retinoblastoma protein (pRb)-dependent G1 arrest, and a cell cycle inhibitor, p14ARF, which blocks MDM2-induced p53 degradation resulting in an increase in p53 levels that leads to cell cycle arrest. R...

journal_title：Pathology international

authors： Sano T,Masuda N,Oyama T,Nakajima T

更新日期：2002-05-01 00:00:00

abstract：:A 15 month old female, who had suffered from ventricular tachycardia from the prenatal period, experienced cardiac arrest at home. Once she had recovered, ventricular tachycardia occurred repeatedly. She died 7 months after admission. At autopsy, the heart showed many yellowish white nodules in the endocardium. Histol...

journal_title：Pathology international

authors： Otani M,Hoshida H,Saji T,Matsuo N,Kawamura S

更新日期：1995-10-01 00:00:00

abstract：:The aim of the present study was to clarify protein profiling in small cell lung carcinoma (SCLC) and pulmonary large cell neuroendocrine carcinoma (LCNEC). The proteomic approach was used, and involved cell lysate from two cell lines (N231 derived from SCLC and LCN1 derived from LCNEC), with 2-D gel electrophoresis (...

journal_title：Pathology international

authors： Nagashio R,Sato Y,Matsumoto T,Kageyama T,Satoh Y,Ryuge S,Masuda N,Jiang SX,Okayasu I

更新日期：2010-02-01 00:00:00

abstract：:We established a dedifferentiated liposarcoma cell line (NDDLS-1) that produces interleukin-6 (IL-6) and granulocyte-colony stimulating factor (G-CSF). The parental tumor showed high leukemoid reactions. The NDDLS-1 cell line was established from a pleural effusion associated with a lung metastasis. Pleomorphic tumor ...

journal_title：Pathology international

authors： Ariizumi T,Ogose A,Kawashima H,Hotta T,Li G,Xu Y,Hirose T,Endo N

更新日期：2011-08-01 00:00:00

abstract：:Methotrexate (MTX) is currently used as first-line anchor drug for rheumatoid arthritis (RA). Therefore, the number of MTX-associated lymphoproliferative disorders, including Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU), has increased. Some aspects of MTX-associated EBVMCU (MTX-EBVMCU), particularly clinic...

journal_title：Pathology international

authors： Satou A,Banno S,Hanamura I,Takahashi E,Takahara T,Nobata H,Katsuno T,Takami A,Ito Y,Ueda R,Nakamura S,Tsuzuki T

更新日期：2019-01-01 00:00:00

abstract：:Conditions of preserving DNA, RNA and protein in pathological specimens are of great importance as degradation of such macromolecules would critically affect results of molecular biological analysis. The feasibility of freeze-drying as a means of preserving pathological tissue samples for molecular analysis has previo...

journal_title：Pathology international

authors： Matsuo S,Sugiyama T,Okuyama T,Yoshikawa K,Honda K,Takahashi R,Maeda S

更新日期：1999-05-01 00:00:00