Preservation of pathological tissue specimens by freeze-drying for immunohistochemical staining and various molecular biological analyses.

abstract：:We describe a case of minute pancreatic ductal adenocarcinoma featuring stenosis of the main pancreatic duct (MPD) and associated with histological findings of periductal elastosis and fibroblast proliferation. A 53-year-old Japanese man with preoperative radiological evidence of MPD stricture and dilation of the dist...

journal_title：Pathology international

authors： Yachida S,Fukushima N,Nakanishi K,Shimada K,Kosuge T,Sakamoto M

更新日期：2002-09-01 00:00:00

abstract：:The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors and has been identified to play a crucial role in a number of biological processes, including the trafficking and homeostasis of immune cells such as T lymphocytes. CXCR4 has also been found to be a prognostic marker in variou...

journal_title：Pathology international

authors： Furusato B,Mohamed A,Uhlén M,Rhim JS

更新日期：2010-07-01 00:00:00

abstract：:Stenosing flexor tenosynovitis, trigger finger, is a common clinical disorder causing painful locking or contracture of the involved digits, and most instances are idiopathic. This problem is generally caused by a size mismatch between the swollen flexor tendon and the thickened first annular pulley. Although hypertro...

journal_title：Pathology international

authors： Uchihashi K,Tsuruta T,Mine H,Aoki S,Nishijima-Matsunobu A,Yamamoto M,Kuraoka A,Toda S

更新日期：2014-06-01 00:00:00

abstract：:Ameloblastoma is an odontogenic tumor of the jaw. It most frequently occurs in the mandible, and less often in the maxilla. Mandibular ameloblastoma harbors a BRAF mutation that causes a valine (V) to glutamic acid (E) substitution at codon 600 (BRAFV600E ). We examined specimens from 32 Japanese patients to detect th...

journal_title：Pathology international

authors： Seki-Soda M,Sano T,Ito K,Yokoo S,Oyama T

更新日期：2020-04-01 00:00:00

abstract：:According to the World Health Organization classification, neoplasms with perivascular epithelioid cell differentiation (PEComas) are mesenchymal tumors composed of histologically and immunohistochemically distinctive PEC. Generally, nearly all PEComas have immunoreactivity for both melanocytic (HMB-45 and/or melan A)...

journal_title：Pathology international

authors： Adachi Y,Horie Y,Kitamura Y,Nakamura H,Taniguchi Y,Miwa K,Fujioka S,Nishimura M,Hayashi K

更新日期：2008-03-01 00:00:00

abstract：:Interactions among p53, bcl-2 and Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) in nasopharyngeal carcinoma (NPC) cells were evaluated by gene cotransfections. The data showed that bcl-2 expression was not only able to prevent the growth suppression induced by wild-type p53 but was also paradoxically able ...

journal_title：Pathology international

authors： Sheu LF,Chen A,Lee HS,Hsu HY,Yu DS

更新日期：2004-07-01 00:00:00

abstract：:Tight junctions are intercellular junctions adjacent to the apical ends of paracellular spaces. They have two classical functions, the barrier function and the fence function. The former regulates the passage of ions, water and various molecules through paracellular spaces, and is thus related to edema, jaundice, diar...

journal_title：Pathology international

authors： Sawada N

更新日期：2013-01-01 00:00:00

abstract：:Nuclear pseudoinclusions (NPIs) are classically found in papillary thyroid carcinoma and meningioma. Although NPIs have been described in melanocytic lesions, there is no systematic analysis of potential relationship between NPIs and other clinicopathological characteristics of melanoma. We examined the presence of NP...

journal_title：Pathology international

authors： Donizy P,Kaczorowski M,Biecek P,Halon A,Matkowski R

更新日期：2018-02-01 00:00:00

abstract：:Aerobes, including humans, are consistently exposed to oxidative stress by consuming oxygen. The biological significance of oxidative stress via reactive oxygen and nitrogen species consists of two stages: reversible redox regulation and irreversible oxidative molecular damage, which are sometimes intermingled. During...

journal_title：Pathology international

authors： Toyokuni S,Akatsuka S

更新日期：2007-08-01 00:00:00

abstract：:Bcl-6 protein is a recently identified novel transcription factor whose deregulated expression is associated with diffuse large B cell lymphomas. It was recently shown by us that the protein is located in germinal center B cells and their neoplastic counterparts. In the present study, the expression of bcl-6 protein o...

journal_title：Pathology international

authors： Kanazawa N,Moriyama M,Onizuka T,Sugawara K,Mori S

更新日期：1997-09-01 00:00:00

abstract：:Telomerase activity is thought to contribute to the immortality of cancers. Recently, some investigators described a correlation between the activity of telomerase and the proliferative activity of cancer cells. The aim of this study was to evaluate the correlation between the expression of telomerase-associated prote...

journal_title：Pathology international

authors： Ikeda S,Shibata T,Eishi Y,Takizawa T,Koike M

更新日期：2003-11-01 00:00:00

abstract：:In pulmonary fibrosis, it is known that fibrotic changes develop in the intra-alveolar spaces and that intra-alveolar fibrosis can be classified into three patterns, namely intra-alveolar buds, mural incorporation and obliterative changes. In order to clarify the evolution of intra-alveolar fibrosis, immunohistochemic...

journal_title：Pathology international

authors： Usuki J,Fukuda Y

更新日期：1995-08-01 00:00:00

abstract：:Reported herein are seven cases of a histologically distinct oncocytic papillary renal cell carcinoma (OPRCC) with an inverted nuclear pattern. To define its prognostic significance, the clinicopathological features of OPRCC were compared to those of types 1 and 2 PRCC. The median age of the seven patients was 67 year...

journal_title：Pathology international

authors： Park BH,Ro JY,Park WS,Jee KJ,Kim K,Gong G,Cho YM

更新日期：2009-03-01 00:00:00

abstract：:Giant cell tumor (GCT) of bone is a primary osteolytic tumor that is characterized by the formation of osteoclast-like giant cells. In addition to GCT of bone, extraskeletal GCT are known to be formed in several soft tissues. Giant cells in GCT of bone were suggested to be identical to osteoclasts, but the characteriz...

journal_title：Pathology international

authors： Ikeda T,Seki S,Maki M,Noguchi N,Kawamura T,Arii S,Igari T,Koike M,Hirokawa K

更新日期：2003-07-01 00:00:00

abstract：:A case of a 66-year-old Japanese woman with two synchronous urinary bladder tumors, namely verrucous carcinoma and poorly differentiated squamous cell carcinoma, is described. Both tumors were accompanied by widespread squamous metaplasia in the background and unassociated with bilharzial infection. The poorly differe...

journal_title：Pathology international

authors： Oida Y,Yasuda M,Kajiwara H,Onda H,Kawamura N,Osamura RY

更新日期：1997-09-01 00:00:00

abstract：:Elastosis is the pathological finding of focal deposits of elastic fibers in abnormal amounts within tissue. It is well described in the case of infiltrating carcinoma of the breast, but elastosis in lung carcinoma has not been previously documented in detail. We investigated the characteristics of elastosis in lung c...

journal_title：Pathology international

authors： Fukushima M,Fukuda Y,Kawamoto M,Yamanaka N

更新日期：2000-12-01 00:00:00

abstract：:An unusual case of adenoid cystic carcinoma arising from the palatal minor salivary gland in a 63-year-old Japanese female is reported. In addition to the characteristic histopathologic features of adenoid cystic carcinoma, spindle- and dendritic-shaped cells containing excessive amounts of melanin pigment were densel...

journal_title：Pathology international

authors： Takeda Y

更新日期：1996-06-01 00:00:00

abstract：:A small proportion of patients with chronic lymphocytic leukemia (CLL) may progress to large cell lymphoma, or Richter syndrome (RS). The large cells of RS may arise through transformation of the original CLL clone (clonally related) or represent a new neoplasm (clonally unrelated), which might be Epstein-Barr virus (...

journal_title：Pathology international

authors： Chen YA,Wang RC,Yang Y,Chuang SS

更新日期：2016-07-01 00:00:00

abstract：:We report a case of gastrointestinal stromal tumor (GIST) of the stomach mimicking extragastrointestinal origin. The tumor presented as a large isolated mass in the transverse mesocolon with a minor adhesion to the stomach. Microscopic examination revealed c-kit gene protein product (KIT)-positive tumor cells with epi...

journal_title：Pathology international

authors： Nakajima T,Saito S,Sugiyama T,Murata K,Fukushima J,Horiuchi H

更新日期：2011-11-01 00:00:00

abstract：:In 2004, two groups reported somatic mutations in the gene for the epidermal growth factor receptor (EGFR) in patients with non-small cell lung cancer (NSCLC), which were highly correlated with the clinical response to the anticancer drug, gefitinib. Since then, a tremendous amount of knowledge has accumulated, and sh...

journal_title：Pathology international

authors： Yatabe Y,Mitsudomi T

更新日期：2007-05-01 00:00:00

abstract：:Malignant myoepithelioma of soft tissue is extremely rare. Presented herein is a case arising in a 17-year-old man. The tumor was initially noticed as a painless deep soft-tissue mass in the right forearm when the patient was aged 3 years. Thereafter, it grew without remarkable symptoms, such as pain or tenderness, un...

journal_title：Pathology international

authors： Harada O,Ota H,Nakayama J

更新日期：2005-08-01 00:00:00

abstract：:In papillary thyroid carcinoma (PTC) in cytological and surgical specimens, fine chromatin, nuclear grooves and nuclear pseudoinclusions are the hallmarks of diagnosis. We investigated the significance of these nuclear changes in neoplastic non-PTC lesions. Fine needle aspiration biopsies (FNAB) of thyroid lesions wer...

journal_title：Pathology international

authors： Mai KT,Yazdi HM,Commons AS,Perkins DG,MacDonald L

更新日期：1999-07-01 00:00:00

abstract：:We present a case of uterine intravenous leiomyomatosis associated with multiple pulmonary metastases with bullae-like cystic change. A 53-year-old woman who had undergone hysterectomy 5 years previously underwent an operation for multiple pulmonary nodules with bullae formation. After resection of several large bulla...

journal_title：Pathology international

authors： Matsumoto K,Yamamoto T,Hisayoshi T,Asano G

更新日期：2001-05-01 00:00:00

abstract：:The overexpression of p53 protein and the Ki67 proliferative index was evaluated in 96 hepatocellular carcinomas (HCC), 67 in cirrhotic livers and 29 in non-cirrhotic ones, and in 13 non-carcinomatous lesions, all surgically resected from Italian patients. Overexpression of p53 was detected only in carcinomatous lesio...

journal_title：Pathology international

authors： D'Errico A,Grigioni WF,Fiorentino M,Baccarini P,Grazi GL,Mancini AM

更新日期：1994-09-01 00:00:00

abstract：:Actinic cheilitis (AC) is an early keratocyte neoplasia with inflammation that occurs in the lip vermillion with the potential to develop into invasive squamous cell carcinoma (SCC). The expression of the intracellular enzyme indoleamine 2,3-dioxygenase (IDO) by antigen-presenting cells and/or tumor cells has been des...

journal_title：Pathology international

authors： von Bubnoff D,Zahn S,Wenzel J,Wilms H,Bieber T,Lüftl M

更新日期：2012-02-01 00:00:00

abstract：:One hundred and fifteen patients with chronic hepatitis C were administered interferon (IFN) and classed into two groups: (i) complete responders (CR), HCV-RNA continuously negative 1 year after treatment; and (ii) non-responders (NR), positive 1 year after treatment. Multivariate analysis comprised eight variables: a...

journal_title：Pathology international

authors： Kim SR,Hayashi Y,Yoon S,Taniguchi M,Yang MK,Kim KI,Kim MM,Saeki K,Nukata I,Imoto S

更新日期：1998-03-01 00:00:00

abstract：:Histological grading of prostate cancer is one of the most important tissue-based parameters for prediction of outcome and treatment response. Gleason grading remains the foundation of prostate cancer grading, but has undergone a series of changes in the past 30 years, often initiated by consensus conference decisions...

journal_title：Pathology international

authors： Egevad L,Delahunt B,Yaxley J,Samaratunga H

更新日期：2019-02-01 00:00:00

abstract：:We have found that the MIB-1 grade, based on tumor differentiation/histological type, necrosis and Ki-67 (MIB-1) score, is a valid and reproducible prognostic system for adult soft-tissue sarcomas. However, there are limited data available on Ki-67 labeling indices (LI) from adult soft-tissue sarcomas for testing the ...

journal_title：Pathology international

authors： Hasegawa T,Yamamoto S,Matsuno Y

更新日期：2002-07-01 00:00:00

abstract：:Soluble receptor-resistant mutant 7 (ssr7) is isolated from a highly neurovirulent mouse hepatitis virus (MHV) JHMV cl-2 strain (cl-2). srr7 exhibits lower virulence than its maternal strain in infected mice, which is typically manifested in a longer lifespan. In this study, during the course of infection with srr7, s...

journal_title：Pathology international

authors： Kashiwazaki H,Nomura R,Matsuyama S,Taguchi F,Watanabe R

更新日期：2011-04-01 00:00:00

abstract：:Leiomyomatosis peritonealis disseminata (LPD) is a rare clinicopathological entity typically observed in women of reproductive age. We report a case of LPD with malignant change in a man. A 77-year-old man presented with a mass measuring 10 cm in diameter at the terminal ileum and numerous peritoneal small nodules tha...

journal_title：Pathology international

authors： Yamaguchi T,Imamura Y,Yamamoto T,Fukuda M

更新日期：2003-03-01 00:00:00