Overexpression of p53 protein and Ki67 proliferative index in hepatocellular carcinoma: an immunohistochemical study on 109 Italian patients.

abstract：:Pathologists are required to integrate data from multiple sources when making a diagnosis. Furthermore, whole slide imaging (WSI) and next generation sequencing will escalate data size and complexity. Development of well-designed databases that can allow efficient navigation between multiple data types is necessary fo...

journal_title：Pathology international

authors： Yagi Y,Riedlinger G,Xu X,Nakamura A,Levy B,Iafrate AJ,Mino-Kenudson M,Klepeis VE

更新日期：2016-02-01 00:00:00

abstract：:The CDKN2 gene encodes two structurally different proteins: a cyclin-dependent kinase inhibitor, p16, which regulates retinoblastoma protein (pRb)-dependent G1 arrest, and a cell cycle inhibitor, p14ARF, which blocks MDM2-induced p53 degradation resulting in an increase in p53 levels that leads to cell cycle arrest. R...

journal_title：Pathology international

authors： Sano T,Masuda N,Oyama T,Nakajima T

更新日期：2002-05-01 00:00:00

abstract：:Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited cancer predisposition syndrome, characterized by development of a variety of neoplasms in multiple organs. Central nervous system hemangioblastoma (CHB) is the most common manifestation of VHL disease. The germline mutations in the VHL tumor suppressor...

journal_title：Pathology international

authors： Zhou J,Wang J,Li N,Zhang X,Zhou H,Zhang R,Ma H,Zhou X

更新日期：2010-06-01 00:00:00

abstract：:A case of low-grade endometrial stromal sarcoma with extensive epithelial-like element (ELE) is reported. This tumor was composed of classical endometrial stromal sarcoma (CESS) showing diffuse proliferation, and ELE occupying approximately 72% of the tumor mass. On immunohistochemistry, ELE was negative for sex-cord ...

journal_title：Pathology international

authors： Ohta Y,Suzuki T,Kojima M,Shiokawa A,Mitsuya T

更新日期：2003-04-01 00:00:00

abstract：:Alterations in cell surface carbohydrates on human lymphoma cell lines with different spontaneous metastatic potential in the severe combined immunodeficiency (SCID) mouse model were analyzed. A difference in cell surface carbohydrates between high- (HBL-2, HBL-7 and HBL-8) and no- or low-(HBL-4, HBL-6, Daudi and Raji...

journal_title：Pathology international

authors： Abe M,Suzuki O,Tasaki K,Tominaga K,Wakasa H

更新日期：1996-12-01 00:00:00

abstract：:A case of serous cystadenocarcinoma of the pancreas in an 85-year-old woman is reported. The tumor extensively involved the body and tail of the pancreas and contiguously invaded the spleen. The histopathology of the tumor was similar to that of serous cystadenoma, but mild nuclear hyperchromatism and atypism were not...

journal_title：Pathology international

authors： Shintaku M,Arimoto A,Sakita N

更新日期：2005-07-01 00:00:00

abstract：:Thymidine phosphorylase (dThdPase)/platelet-derived endothelial cell growth factor, is expressed at higher levels in tumor tissues compared to the adjacent normal tissues in a variety of human carcinomas. The higher expression is associated with an increase of intratumoral microvessel density (IMVD) and an unfavorable...

journal_title：Pathology international

authors： Okamoto E,Osaki M,Kase S,Adachi H,Kaibara N,Ito H

更新日期：2001-03-01 00:00:00

abstract：:Adenomyoma of the small intestine is a rare tumor-like lesion composed of exocrine-type ducts and hypertrophic smooth muscle. We describe two cases of adenomyoma of the small intestine. One was an ileal adenomyoma that presented with intussusception occurring in a 7-month-old boy. The other was a jejunal adenomyoma fo...

journal_title：Pathology international

authors： Park HS,Lee SO,Lee JM,Kang MJ,Lee DG,Chung MJ

更新日期：2003-02-01 00:00:00

abstract：:We have reported that the function of histamine and its receptors (HRs) has a close relationship with the development of nonalcoholic fatty liver disease (NAFLD). However, much less is known regarding its pathogenic and molecular mechanism(s), including the early stage of hepatic and intestinal function for lipid and ...

journal_title：Pathology international

authors： Yamada S,Guo X,Wang KY,Tanimoto A,Sasaguri Y

更新日期：2016-07-01 00:00:00

abstract：:A 56-year-old male treated for a gastric yolk sac tumor with an adenocarcinomatous component is described. A mixed area of reticular and glandular neoplastic components was morphologically identified in this tumor. Immunohistochemically, the yolk sac tumor expressed alpha-fetoprotein (AFP), placental alkaline phosphat...

journal_title：Pathology international

authors： Suzuki T,Kimura N,Shizawa S,Yabuki N,Yamaki T,Sasano H,Nagura H

更新日期：1999-06-01 00:00:00

abstract：:Although a seborrheic keratosis is not rare on the skin of the trunk, extremities, head and neck of an elderly person, it is uncommon to originate in the external ear canal. Even rarer, an irritated subtype may arise in this location. We report the case of a 63-year-old man with an irritated seborrheic keratosis arisi...

journal_title：Pathology international

authors： Konishi E,Nakashima Y,Manabe T,Mazaki T,Wada Y

更新日期：2003-09-01 00:00:00

abstract：:Multiple carcinomas of the pancreatico-biliary tree are rare. A 53 year old Japanese man was diagnosed as having an adenocarcinoma in the papilla of Vater. During the operation, he was also found to have a polypoid mass in the common bile duct. While cutting the operative specimen into stepwise sections, a small tumor...

journal_title：Pathology international

authors： Nishihara K,Tsuneyoshi M,Shimura H,Yasunami Y

更新日期：1994-04-01 00:00:00

abstract：:Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVGC) is defined as a neoplasm comprising monoclonal proliferation of EBV-infected gastric epithelial cells. Although the typical histology is gastric carcinoma with lymphoid stroma (GCLS), the histologic features of the tumor vary. We report herein the case of a...

journal_title：Pathology international

authors： Shimizu A,Takahashi T,Kushima R,Sentani K,Yasui W,Matsuno Y

更新日期：2018-01-01 00:00:00

abstract：:A case of intraplacental choriocarcinoma associated with a placental hemangioma is presented. Ultrasonic examination revealed a placental hemangioma at 33 weeks gestation. A cesarean section was performed at 37 weeks gestation. Histological examination showed intraplacental choriocarcinoma associated with the hemangio...

journal_title：Pathology international

authors： Aonahata M,Masuzawa Y,Tsutsui Y

更新日期：1998-11-01 00:00:00

abstract：:Invasive micropapillary carcinoma (IMP) of the breast is a rare variant of invasive breast carcinoma and most cases of IMP are associated with nodal metastasis and lymphatic invasion. Lesions composed of an IMP component alone are rare and almost always coexist with other pathological components. However, few reports ...

journal_title：Pathology international

authors： Ide Y,Horii R,Osako T,Ogura K,Yoshida R,Iwase T,Akiyama F

更新日期：2011-12-01 00:00:00

abstract：:The histology of basaloid squamous cell carcinoma (BSCC) can resemble that of adenoid cystic carcinoma (AdCC). Herein, we report two cases of BSCC with adenoid cystic-like features (BSCC-AdC). We collected cases of AdCC and BSCC of the head and neck region, extracted two cases with unusual histology, and reexamined th...

journal_title：Pathology international

authors： Kusafuka K,Yagi H,Baba S,Inagaki H,Tsuchiya C,Hirata K,Muramatsu A,Suzuki M,Arai K,Terada T

更新日期：2020-10-01 00:00:00

abstract：:Epstein-Barr virus (EBV) has been implicated as a causal virus of gastric cancer with episomal monoclonality, elevated antibodies and a unique morphologic expression in the early intramucosal stage, but the infection mechanisms have not been demonstrated. EBV has been shown only in the cancerous lesions by the highly ...

journal_title：Pathology international

authors： Arikawa J,Tokunaga M,Tashiro Y,Tanaka S,Sato E,Haraguchi K,Yamamoto A,Toyohira O,Tsuchimochi A

更新日期：1997-10-01 00:00:00

abstract：:A case of primary leiomyosarcoma of a thoracic vertebra associated with a compression fracture in a 75-year-old woman was preoperatively thought to be granulation tissue. Surgical decompression was performed and the histological and immunohistochemical studies established the diagnosis of leiomyosarcoma. Based on the ...

journal_title：Pathology international

authors： Sasaguri T,Tanimoto A,Kimura S,Kohno Y,Hirasawa M,Matsuki Y,Abe K,Hashimoto H,Hamada T,Sasaguri Y

更新日期：2004-01-01 00:00:00

abstract：:A case of small cell carcinoma arising in the outer urethral orifice is presented. The resected tumor showed a proliferation of small round or fusiform neoplastic cells in the submucosa. Tumor cells were arranged in sheets or a trabecular manner and possessed markedly hyperchromatic nuclei with a high N:C ratio, close...

journal_title：Pathology international

authors： Fukuda T,Kamishima T,Saito T,Itoh S,Suzuki T

更新日期：1997-07-01 00:00:00

abstract：:BRCA1-associated protein 1 (BAP1) or methylthioadenosine phosphorylase (MTAP) immunohistochemistry (IHC) or 9p21 fluorescence in situ hybridization (FISH) are useful for the diagnosis of malignant pleural mesothelioma (MPM). However, the effect of these assays on the diagnostic yield of effusion cytology in MPM cases ...

journal_title：Pathology international

authors： Kinoshita Y,Hamasaki M,Matsumoto S,Yoshimura M,Sato A,Tsujimura T,Kamei T,Kawahara K,Nabeshima K

更新日期：2020-09-01 00:00:00

abstract：:Conditions of preserving DNA, RNA and protein in pathological specimens are of great importance as degradation of such macromolecules would critically affect results of molecular biological analysis. The feasibility of freeze-drying as a means of preserving pathological tissue samples for molecular analysis has previo...

journal_title：Pathology international

authors： Matsuo S,Sugiyama T,Okuyama T,Yoshikawa K,Honda K,Takahashi R,Maeda S

更新日期：1999-05-01 00:00:00

abstract：:Microscopic colitis (MC), encompassing collagenous colitis and lymphocytic colitis, is featured by chronic diarrhea, normal-looking endoscopic findings and unique microscopic appearance. After reviewing biopsied nonspecific colitis, we propose the third type of MC: colitis nucleomigrans (CN). Histopathological criteri...

journal_title：Pathology international

authors： Tachibana M,Hanaoka T,Watanabe S,Matsushita M,Isono T,Tsutsumi Y

更新日期：2020-10-01 00:00:00

abstract：:Presented herein are two unusual epithelioid angiomyolipomas (AML) displaying prominent stromal sclerosis. Both patients were middle-aged women without a clinical history of tuberous sclerosis. One patient (case 1) had a 2 cm lesion arising in the renal cortex, and another (case 2) had a pararenal retroperitoneal tumo...

journal_title：Pathology international

authors： Matsuyama A,Hisaoka M,Ichikawa K,Fujimori T,Udo K,Uchihashi K,Aoki S,Hashimoto H

更新日期：2008-05-01 00:00:00

abstract：:The Association of Directors of Anatomic and Surgical Pathology have developed recommendations for the surgical pathology reporting of common malignant tumors. The recommendations for carcinomas of the urinary bladder are reported herein. ...

journal_title：Pathology international

authors：

更新日期：1997-05-01 00:00:00

abstract：:This study aims to evaluate the impact on the implementation of multiple strategies to improve medical student's pathology learning experience. In two consecutive years, medical students after a whole year of enrolling in pathology teaching, were invited to complete questionnaires rating and commenting on the personal...

journal_title：Pathology international

authors： Gopalan V,Kasem K,Pillai S,Olveda D,Ariana A,Leung M,Lam AKY

更新日期：2018-07-24 00:00:00

abstract：:Adenosquamous carcinoma (ASC) is a rare malignant neoplasm of the head and neck regions. We elucidated the relationship between ASC and MUC molecule expression. We selected 14 cases of ASC in the head and neck, and examined them immunohistohcmically. Seven cases of tongue, 3 cases of larynx and 4 cases of hypopharynx ...

journal_title：Pathology international

authors： Kusafuka K,Muramatsu K,Iida Y,Mori K,Miki T,Suda T,Fuke T,Kamijo T,Onitsuka T,Nakajima T

更新日期：2014-03-01 00:00:00

abstract：:We report a rare case of hepatocellular carcinoma (HCC) with an unusual neuroendocrine component. During a follow-up study for chronic hepatitis C in a 71-year-old man, a nodular lesion showed rapid growth from 1 cm to 4 cm in diameter within 3 months. Histologically, the tumor was consistent with moderately different...

journal_title：Pathology international

authors： Yamaguchi R,Nakashima O,Ogata T,Hanada K,Kumabe T,Kojiro M

更新日期：2004-11-01 00:00:00

abstract：:The p73 gene is a member of the p53 gene family and the structure and functions of p73 protein are similar to those of p53. However, these two proteins have different roles. In the present study, p73 protein was found immunohistochemically to be distributed in the basal cells of the epidermis, columnar basal cells in ...

journal_title：Pathology international

authors： Kamiya M,Takeuchi Y,Katho M,Yokoo H,Sasaki A,Nakazato Y

更新日期：2004-12-01 00:00:00

abstract：:The clinical and pathological findings are reported concerning a 73-year-old woman with progressive metastatic carcinoma of the left breast, who developed interfollicular Hodgkin's disease within the right cervical lymph nodes. Metastatic carcinoma and Hodgkin's disease were present concurrently as a "collision tumor'...

journal_title：Pathology international

authors： Allal AS,Weintraub J,Remadi S,Abele R

更新日期：1996-10-01 00:00:00

abstract：:Pilomyxoid astrocytoma, first described by Tihan et al., was recently included as an established variant of pilocytic astrocytoma in the World Health Organization classification of CNS tumors. Histologically, it much resembles pilocytic astrocytoma, but monomorphic myxoid tumor of pilocytic cells with prominent angioc...

journal_title：Pathology international

authors： Amatya VJ,Akazawa R,Sumimoto Y,Takeshima Y,Inai K

更新日期：2009-02-01 00:00:00