Small cell carcinoma arising from the outer urethral orifice: a case report examined by histologic, ultrastructural and immunohistochemical methods.

abstract：:An extremely rare case of unilateral gonadoblastoma with mixed germ cell tumor arising in the ovary of a 27-year-old woman with 46,XX karyotype and two successful pregnancies is reported. The mixed germ cell tumor was composed of choriocarcinoma, embryonal carcinoma, yolk sac tumor, immature teratoma and dysgerminoma....

journal_title：Pathology international

authors： Zhao S,Kato N,Endoh Y,Jin Z,Ajioka Y,Motoyama T

更新日期：2000-04-01 00:00:00

abstract：:Anaplastic large cell lymphoma (ALCL) with TP63 rearrangement is a new entity and has the most dismal prognosis in all types of ALCL. This might be due to the resulting fusion protein having N-terminal truncated p63 with high oncogenic ability. Since this N-terminal domain has the function of tumor suppressor activity...

journal_title：Pathology international

authors： Yamashita T,Higashi M,Kawano R,Momose S,Tokuhira M,Kizaki M,Tamaru JI

更新日期：2019-03-01 00:00:00

abstract：:A pulmonary Langerhans cell histiocytosis is presented in a 40 year-old woman two years after bilateral lung transplantation for emphysema without any signs of Langerhans cells proliferation in the explanted lungs. A microsatellite molecular analysis showed the proliferating cells were generated in a recipient cellula...

journal_title：Pathology international

authors： Gómez-Román J,Zarrabeitia MT,Santurtún A,Parra JA,Azueta Etxebarría A,Cifrian JM,Freire Salinas J

更新日期：2017-12-01 00:00:00

abstract：:One hundred and fifteen patients with chronic hepatitis C were administered interferon (IFN) and classed into two groups: (i) complete responders (CR), HCV-RNA continuously negative 1 year after treatment; and (ii) non-responders (NR), positive 1 year after treatment. Multivariate analysis comprised eight variables: a...

journal_title：Pathology international

authors： Kim SR,Hayashi Y,Yoon S,Taniguchi M,Yang MK,Kim KI,Kim MM,Saeki K,Nukata I,Imoto S

更新日期：1998-03-01 00:00:00

abstract：:A rare case of a macrofollicular variant of papillary thyroid carcinoma occurring in an 18-year-old male is described. The extirpated tumor, 5.5 x 5.5 x 3.5 cm in size, was well demarcated and multinodular, and histopathologically showed a predominantly macrofollicular structure reminiscent of adenomatous goiter or ma...

journal_title：Pathology international

authors： Nakamura T,Moriyama S,Nariya S,Sano K,Shirota H,Kato R

更新日期：1998-06-01 00:00:00

abstract：:Patients with pulmonary small cell carcinoma are well known to have a poor prognosis. However, predictors of prognosis and treatment outcome have not been reported for this type of cancer. We examined whether excision repair cross-complementation group 1 (ERCC1), phosphorylated Akt (p-Akt), phosphorylated mammalian ta...

journal_title：Pathology international

authors： Ikeda S,Takabe K,Inagaki M,Suzuki K

更新日期：2010-11-01 00:00:00

abstract：:Aerobes, including humans, are consistently exposed to oxidative stress by consuming oxygen. The biological significance of oxidative stress via reactive oxygen and nitrogen species consists of two stages: reversible redox regulation and irreversible oxidative molecular damage, which are sometimes intermingled. During...

journal_title：Pathology international

authors： Toyokuni S,Akatsuka S

更新日期：2007-08-01 00:00:00

abstract：:Metallothionein (MT) has been reported to play important physiological roles in the human body, but the distribution and significance of MT is not fully understood. In order to analyze MT expression, three kinds of polyclonal MT fragment antibodies were developed against NH2-terminal, middle regional and COOH-terminal...

journal_title：Pathology international

authors： Nakazato K,Nakajima K,Kusakabe T,Suzuki K,Nagamine T

更新日期：2008-12-01 00:00:00

abstract：:The role of chemokines, especially CXCL10/interferon-gamma-inducible protein 10 kDa (IP-10), a chemokine to attract CXCR3(+) T-helper 1-type CD4(+) T cells, is largely unknown in the pathophysiology of inflammatory bowel disease; ulcerative colitis and Crohn's disease. The authors have earlier shown that IP-10 neutral...

journal_title：Pathology international

authors： Suzuki K,Kawauchi Y,Palaniyandi SS,Veeraveedu PT,Fujii M,Yamagiwa S,Yoneyama H,Han GD,Kawachi H,Okada Y,Ajioka Y,Watanabe K,Hosono M,Asakura H,Aoyagi Y,Narumi S

更新日期：2007-07-01 00:00:00

abstract：:Bcl-6 protein is a recently identified novel transcription factor whose deregulated expression is associated with diffuse large B cell lymphomas. It was recently shown by us that the protein is located in germinal center B cells and their neoplastic counterparts. In the present study, the expression of bcl-6 protein o...

journal_title：Pathology international

authors： Kanazawa N,Moriyama M,Onizuka T,Sugawara K,Mori S

更新日期：1997-09-01 00:00:00

abstract：:Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare genetic disorder characterized by cutaneous and uterine leiomyomatosis with RCC. This disorder is caused by a germline mutation in the fumarate hydratase (FH) gene, which encodes an important enzyme of the tricarboxylic acid (TCA) cycle. This mutation d...

journal_title：Pathology international

authors： Matsumoto K,Udaka N,Hasumi H,Nakaigawa N,Nagashima Y,Tanaka R,Kato I,Yao M,Furuya M

更新日期：2018-05-24 00:00:00

abstract：:Differentiation of malignant pleural mesothelioma (MPM) from benign mesothelial proliferation remains problematic. Loss of nuclear staining of BRCA1-associated protein 1 (BAP1; detected using immunohistochemistry (IHC)) and homozygous deletion (HD) of p16 (detected using fluorescence in situ hybridization (FISH)) are ...

journal_title：Pathology international

authors： Hida T,Hamasaki M,Matsumoto S,Sato A,Tsujimura T,Kawahara K,Iwasaki A,Okamoto T,Oda Y,Honda H,Nabeshima K

更新日期：2016-10-01 00:00:00

abstract：:Mixed epithelial and stromal tumor of the kidney (MESTK) is a rare kidney neoplasm that almost exclusively occurs in perimenopausal women, and long-term estrogen replacement is relevant to its pathogenesis. Herein is described an atypical case of MESTK uncovered in a 12-year-old premenarcheal girl without a history of...

journal_title：Pathology international

authors： Hara N,Kawaguchi M,Murayama S,Maruyama R,Tanikawa T,Takahashi K

更新日期：2005-10-01 00:00:00

abstract：:Herein is presented a case of carcinosarcoma of the pancreas in an 82-year-old woman, analyzed on immunohistochemistry and K-ras sequence. The tumor, which arose in the pancreas head, was removed on pancreaticoduodenectomy. The patient died, however, of disseminated intravascular coagulation syndrome from postoperativ...

journal_title：Pathology international

authors： Nakano T,Sonobe H,Usui T,Yamanaka K,Ishizuka T,Nishimura E,Hanazaki K

更新日期：2008-10-01 00:00:00

abstract：:Stenosing flexor tenosynovitis, trigger finger, is a common clinical disorder causing painful locking or contracture of the involved digits, and most instances are idiopathic. This problem is generally caused by a size mismatch between the swollen flexor tendon and the thickened first annular pulley. Although hypertro...

journal_title：Pathology international

authors： Uchihashi K,Tsuruta T,Mine H,Aoki S,Nishijima-Matsunobu A,Yamamoto M,Kuraoka A,Toda S

更新日期：2014-06-01 00:00:00

abstract：:Several short forms of alternatively spliced Murine double minute 2 (MDM2) transcripts have recently been shown to correlate with high-grade malignancy in a number of human tumors. We examined the frequency of splice variants and their correlation with clinicopathological features in 60 cases of human breast cancer. S...

journal_title：Pathology international

authors： Hori M,Shimazaki J,Inagawa S,Itabashi M,Hori M

更新日期：2000-10-01 00:00:00

abstract：:Circulating leukocytes, particularly neutrophils and monocytes, are important effector cells in the induction of many forms of glomerulonephritis. Adhesion molecules, especially selectins, are also thought to be critical for the development of this disease. We examined the possible suppressive effect of soluble E-sele...

journal_title：Pathology international

authors： Takahashi S,Araki K,Araki M,Ito MR,Nakatani K,Fujii H,Izui S,Vassalli P,Nose M

更新日期：2002-03-01 00:00:00

abstract：:The clinical and pathological findings are reported concerning a 73-year-old woman with progressive metastatic carcinoma of the left breast, who developed interfollicular Hodgkin's disease within the right cervical lymph nodes. Metastatic carcinoma and Hodgkin's disease were present concurrently as a "collision tumor'...

journal_title：Pathology international

authors： Allal AS,Weintraub J,Remadi S,Abele R

更新日期：1996-10-01 00:00:00

abstract：:A complete spontaneous regression of diffuse large B cell lymphoma involving the right breast, confirmed by aspiration cytology, is reported. The patient visited a hospital due to the rapid growth of a tumor in the right breast. Five years previously she underwent a craniotomy for a brain tumor, diagnosed as B-cell ma...

journal_title：Pathology international

authors： Iihara K,Yamaguchi K,Nishimura Y,Iwasaki T,Suzuki K,Hirabayashi Y

更新日期：2004-07-01 00:00:00

abstract：:We report a case of small intestinal type adenocarcinoma arising in retroperitoneal mature cystic teratoma in a young male. The patient initially experienced intermittent abdominal pain, and radiographic workup revealed an encapsulated retroperitoneal mass. A laparotomy was performed and the resected specimen represen...

journal_title：Pathology international

authors： Terado Y,Kurata A,Ishida T,Imamura T,Sakamoto A

更新日期：2010-10-01 00:00:00

abstract：:The biopsy-based diagnosis of autoimmune pancreatitis (AIP) is difficult but is becoming imperative for pathologists due to the increased amount of endoscopic ultrasound-guided biopsy tissue. To cope with this challenge, we propose guidance for the biopsy diagnosis of type 1 AIP. This guidance is for pathologists and ...

journal_title：Pathology international

authors： Notohara K,Kamisawa T,Fukushima N,Furukawa T,Tajiri T,Yamaguchi H,Aishima S,Fukumura Y,Hirabayashi K,Iwasaki E,Kanno A,Kasashima S,Kawashima A,Kojima M,Kubota K,Kuraishi Y,Mitsuhashi T,Naito Y,Naitoh I,Nakase H,Ni

更新日期：2020-10-01 00:00:00

abstract：:Twelve lymph node specimens with necrotizing lymphadenitis and which had florid necrotic lesions were studied immunohistochemically. The majority of viable lymphoid cells in the necrotic foci were CD8+ lymphocytes and KP1+ or PGM1+ phagocytizing macrophages. The CD8+ T cells were Leu1+, Leu2+, Leu3-, Leu4+, Leu5b+, Le...

journal_title：Pathology international

authors： Mori N,Yatabe Y,Asai J,Nagasawa T

更新日期：1997-01-01 00:00:00

abstract：:Bronchiolitis obliterans (BO) is generally believed to be a marker of pulmonary manifestation of graft-versus-host disease (GVHD) in patients who have undergone bone marrow transplantation for hematological malignancy. Pulmonary manifestations reported as GVHD (other than BO) include lymphocytic bronchiolitis with cel...

journal_title：Pathology international

authors： Miyagawa-Hayashino A,Sonobe M,Kubo T,Yoshizawa A,Date H,Manabe T

更新日期：2010-02-01 00:00:00

abstract：:A case of multiple myeloma, who died of congestive heart failure of unknown cause, is presented. Microscopically, Anitschkow cells with caterpillar and owl-eyed nuclei were scattered in the interstitium of the myocardium. To know the pathological significance of their appearance, histological observations of normal, d...

journal_title：Pathology international

authors： Satoh F,Tsutsumi Y

更新日期：1999-01-01 00:00:00

abstract：:Changes in cerebrospinal fluid (CSF) composition have been shown to accurately reflect pathological processes in the CNS, and are potential indicators of abnormal CNS states, such as tumor growth. To detect biomarkers in high-grade astrocytomas, the differential expression of proteins in the cerebrospinal fluid was an...

journal_title：Pathology international

authors： Ohnishi M,Matsumoto T,Nagashio R,Kageyama T,Utsuki S,Oka H,Okayasu I,Sato Y

更新日期：2009-11-01 00:00:00

abstract：:The copper and iron status in the liver of non-tumor bearing Long-Evans Cinnamon (LEC) rats (average age 17 months) was investigated. A direct quantitation of loosely-bound copper and iron was also investigated by using a chelating agent, nitrilotriacetic acid (NTA-chelatable free copper and iron). Besides the total c...

journal_title：Pathology international

authors： Ma Y,Zhang D,Kawabata T,Kiriu T,Toyokuni S,Uchida K,Okada S

更新日期：1997-04-01 00:00:00

abstract：:Of the idiopathic interstitial pneumonias (IIPs), usual interstitial pneumonia (UIP) and diffuse alveolar damage (DAD) usually have poor prognoses. The prognoses of cryptogenic organizing pneumonia (COP) and nonspecific interstitial pneumonia (NSIP) are usually more favorable. Although several reports have described n...

journal_title：Pathology international

authors： Takahashi M,Kunugi S,Terasaki Y,Terasaki M,Urushiyama H,Kuwahara N,Wakamatsu K,Nakayama T,Fukuda Y

更新日期：2013-05-01 00:00:00

abstract：:A quantitative model was devised for the purpose of evaluating interobserver agreement in the judgment of the nuclear atypia score of cancer cells in protocol studies. In this model, the mean nuclear atypia score (mu) among observers was considered to approximate the 'true' nuclear atypia score of the tumor, and with ...

journal_title：Pathology international

authors： Tsuda H,Akiyama F,Kurosumi M,Sakamoto G,Watanabe T

更新日期：2000-02-01 00:00:00

abstract：:Transforming acidic coiled-coil containing protein 3 (TACC3) is known to be involved in the control of normal cell growth and differentiation and in mechanisms of unregulated growth leading to tumorigenesis. The aim of the present paper was to determine the rate of TACC3 expression in a non-small cell lung cancer (NSC...

journal_title：Pathology international

authors： Jung CK,Jung JH,Park GS,Lee A,Kang CS,Lee KY

更新日期：2006-09-01 00:00:00

abstract：:Angioimmunoblastic T cell lymphoma (AITL) is characterized by the presence of atypical lymphocytes with clear cytoplasm and follicular dendritic cells, arborization of high endothelial blood vessels, and infiltration by inflammatory cells, such as epithelioid histiocytes, eosinophils, immunoblasts, and plasma cells. T...

journal_title：Pathology international

authors： Murakami Y,Shimada K,Kosugi H,Mori N

更新日期：2011-05-01 00:00:00