Adenocarcinoma of small intestinal type in retroperitoneal mature teratoma.

Abstract:

:We report a case of small intestinal type adenocarcinoma arising in retroperitoneal mature cystic teratoma in a young male. The patient initially experienced intermittent abdominal pain, and radiographic workup revealed an encapsulated retroperitoneal mass. A laparotomy was performed and the resected specimen represented a cystic lesion, the inner surface of which was mostly covered by sebaceous debris with hairs. Microscopically, mature derivatives of all three germ layers as well as completely developed gastrointestinal tract were identified. Adenocarcinoma without stromal invasion was observed adjacent to the small intestinal mucosa. Immunohistochemistry of the adenocarcinoma tissue revealed p53 overexpression and high Ki-67 labeling index as well as positive staining for CD10, cytokeratin 7, and cytokeratin 20. Therefore, the diagnosis of small intestinal adenocarcinoma was made. To our knowledge, this is the first case of small intestinal adenocarcinoma arising in retroperitoneal mature cystic teratoma. A unique feature of this case is that malignant transformation in retroperitoneal mature teratoma arose even in the fully developed intestine. Favorable prognosis due to detection in the 'early stage' is also discussed.

journal_name

Pathol Int

journal_title

Pathology international

authors

Terado Y,Kurata A,Ishida T,Imamura T,Sakamoto A

doi

10.1111/j.1440-1827.2010.02582.x

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

701-5

issue

10

eissn

1320-5463

issn

1440-1827

journal_volume

60

pub_type

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