Stromal melanocytosis of an adenoid cystic carcinoma arising from the palatal minor salivary gland.

abstract：:Actinic cheilitis (AC) is an early keratocyte neoplasia with inflammation that occurs in the lip vermillion with the potential to develop into invasive squamous cell carcinoma (SCC). The expression of the intracellular enzyme indoleamine 2,3-dioxygenase (IDO) by antigen-presenting cells and/or tumor cells has been des...

journal_title：Pathology international

authors： von Bubnoff D,Zahn S,Wenzel J,Wilms H,Bieber T,Lüftl M

更新日期：2012-02-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is a heterodimeric polypeptide growth factor that has pleiotropic roles, including those of mitogen, motogen and morphogen. The HGF receptor is characterized as a c-Met proto-oncogene product (c-Met), which is a heterodimeric tyrosine kinase receptor. Hepatocyte growth factor acts as a m...

journal_title：Pathology international

authors： Motoi T,Ishida T,Kuroda M,Horiuchi H,Oka T,Matsumoto K,Nakamura T,Machinami R

更新日期：1998-10-01 00:00:00

abstract：:The roles of Wnt protein in carcinogenesis have been well documented in human cancers. Wls is a key modulator for the secretion of Wnt protein. We previously found that Wls was aberrantly expressed in colorectal carcinomas. Studies have revealed that dysregulation of Wnt signal transduction plays an important role in ...

journal_title：Pathology international

authors： Zhang W,Tao H,Chen X,Sugimura H,Wang J,Zhou P

更新日期：2017-03-01 00:00:00

abstract：:Anaplastic large cell lymphoma (ALCL) with TP63 rearrangement is a new entity and has the most dismal prognosis in all types of ALCL. This might be due to the resulting fusion protein having N-terminal truncated p63 with high oncogenic ability. Since this N-terminal domain has the function of tumor suppressor activity...

journal_title：Pathology international

authors： Yamashita T,Higashi M,Kawano R,Momose S,Tokuhira M,Kizaki M,Tamaru JI

更新日期：2019-03-01 00:00:00

abstract：:An 80-year-old woman with a pleomorphic carcinoma (PC) producing hCG was admitted to Nippon Steel Hirohata Hospital because of an abnormal shadow on CT seen during a follow-up examination after surgery for breast cancer. A right upper lobectomy was performed due to rapid growth of the shadow 3 months later. Macroscopi...

journal_title：Pathology international

authors： Hirano H,Yoshida T,Sakamoto T,Yoshimura H,Fukuoka M,Tachibana S,Saito H,Ohkubo E,Nakasho K,Nishigami T

更新日期：2007-10-01 00:00:00

abstract：:Twelve lymph node specimens with necrotizing lymphadenitis and which had florid necrotic lesions were studied immunohistochemically. The majority of viable lymphoid cells in the necrotic foci were CD8+ lymphocytes and KP1+ or PGM1+ phagocytizing macrophages. The CD8+ T cells were Leu1+, Leu2+, Leu3-, Leu4+, Leu5b+, Le...

journal_title：Pathology international

authors： Mori N,Yatabe Y,Asai J,Nagasawa T

更新日期：1997-01-01 00:00:00

abstract：:We report 17 cases of the classic type of Kaposi's sarcoma in Xinjiang, which is located in the north-western area of China surrounded by Mongolia in the east, Russia in the north and Kazakhstan in the west. Fifteen of the patients were of the Uygur people. All patients were male and did not have acquired immunodefici...

journal_title：Pathology international

authors： Dilnur P,Katano H,Wang ZH,Osakabe Y,Kudo M,Sata T,Ebihara Y

更新日期：2001-11-01 00:00:00

abstract：:Schwarz and Benditt found clustering of replicating cells in aortic endothelium in 1976 and discussed how homeostasis of the arterial wall is maintained through this nonrandom distribution of replicating cells. However, it is still unclear how cells of vascular walls turnover. In order to address this issue, we evalua...

journal_title：Pathology international

authors： Takahashi M,Masuda H,Yoshida M,Ito Y,Nanjo H,Sugiyama T,Maeda D,Goto A

更新日期：2015-11-01 00:00:00

abstract：:Tumor suppressor in lung cancer-1 (TSLC1) is an intercellular adhesion molecule of the immunoglobulin superfamily. There is little information regarding the developmental expression profiles. In an attempt to clarify the distribution of TSLC1 proteins in mouse embryos tissue by immunohistochemistry, it was found that ...

journal_title：Pathology international

authors： Usami Y,Ito A,Ohnuma K,Fuku T,Komori T,Yokozaki H

更新日期：2007-02-01 00:00:00

abstract：:In the present study, 62 cases of ocular adnexal lymphoproliferative disorders were reviewed clinicopathologically. Of them, 51 were extranodal marginal zone B-cell lymphoma (MALT lymphoma), five were diffuse large B-cell lymphoma (DLBCL), one was peripheral T-cell lymphoma, one was NK/T cell lymphoma, nasal type, and...

journal_title：Pathology international

authors： Adachi A,Tamaru J,Kaneko K,Kuroda H,Miura I,Kojima T,Hoshino S,Ichinohasama R,Itoyama S

更新日期：2004-01-01 00:00:00

abstract：:Accurate diagnosis of lymphoma includes the assessment of lineage-specific markers. Hematopoietic and lymphoid tissues express PAX5 exclusively in pro-B-cell to mature B-cell stages. However, some mature PAX5+ T-cell lymphomas have been reported. We report three cases of primary cutaneous CD30+ T-cell lymphoproliferat...

journal_title：Pathology international

authors： Hagiwara M,Tomita A,Takata K,Shimoyama Y,Yoshino T,Tomita Y,Nakamura S

更新日期：2012-04-01 00:00:00

abstract：:A quantitative model was devised for the purpose of evaluating interobserver agreement in the judgment of the nuclear atypia score of cancer cells in protocol studies. In this model, the mean nuclear atypia score (mu) among observers was considered to approximate the 'true' nuclear atypia score of the tumor, and with ...

journal_title：Pathology international

authors： Tsuda H,Akiyama F,Kurosumi M,Sakamoto G,Watanabe T

更新日期：2000-02-01 00:00:00

abstract：:A case of an inflammatory pseudotumor of the liver in a 75-year-old female with chronic hepatitis C whose radiologic features simulated that of hepatocellular carcinoma (HCC) is presented. On imaging studies, hypervascularity by CO2 ultrasound (US) angiography, enhancement at an early phase and isodensity at a late ph...

journal_title：Pathology international

authors： Kim SR,Hayashi Y,Kudo M,Matsuoka T,Imoto S,Sasaki K,Shintani S,Song KB,Park SY,Kim JH,Ando K,Koterazawa T,Kim KI,Ninomiya T

更新日期：1999-08-01 00:00:00

abstract：:The localization of glutathione peroxidase (GSH-PO) in the human arteriosclerotic lesions was investigated by immunohistochemical methods. GSH-PO is an enzyme that effectively reduces lipid peroxides. It is also known that its synthesis is significantly increased by lipid peroxides, the substrate of the enzyme. Accord...

journal_title：Pathology international

authors： Mori I,Yoshimura S,Watanabe K

更新日期：1995-05-01 00:00:00

abstract：:We report a case of small intestinal type adenocarcinoma arising in retroperitoneal mature cystic teratoma in a young male. The patient initially experienced intermittent abdominal pain, and radiographic workup revealed an encapsulated retroperitoneal mass. A laparotomy was performed and the resected specimen represen...

journal_title：Pathology international

authors： Terado Y,Kurata A,Ishida T,Imamura T,Sakamoto A

更新日期：2010-10-01 00:00:00

abstract：:BRCA1-associated protein 1 (BAP1) or methylthioadenosine phosphorylase (MTAP) immunohistochemistry (IHC) or 9p21 fluorescence in situ hybridization (FISH) are useful for the diagnosis of malignant pleural mesothelioma (MPM). However, the effect of these assays on the diagnostic yield of effusion cytology in MPM cases ...

journal_title：Pathology international

authors： Kinoshita Y,Hamasaki M,Matsumoto S,Yoshimura M,Sato A,Tsujimura T,Kamei T,Kawahara K,Nabeshima K

更新日期：2020-09-01 00:00:00

abstract：:Changes in cerebrospinal fluid (CSF) composition have been shown to accurately reflect pathological processes in the CNS, and are potential indicators of abnormal CNS states, such as tumor growth. To detect biomarkers in high-grade astrocytomas, the differential expression of proteins in the cerebrospinal fluid was an...

journal_title：Pathology international

authors： Ohnishi M,Matsumoto T,Nagashio R,Kageyama T,Utsuki S,Oka H,Okayasu I,Sato Y

更新日期：2009-11-01 00:00:00

abstract：:A case of a rare pancreatic tumor, duct-acinar-islet cell tumor is presented. The tumor was incidentally found in the pancreatic body on computed tomography of a 21 year old male suffering from mumps. It was well demarcated from surrounding pancreas, and spherical in shape, measured 2.5 cm in diameter. Histologic and ...

journal_title：Pathology international

authors： Okada Y,Mori H,Tsutsumi A

更新日期：1995-09-01 00:00:00

abstract：:Nucleobindin (Nuc) was originally found to be an enhancement factor of anti-DNA antibody production secreted by a lymphoid cell line derived from a lymphoproliferative MRL/lpr mouse. It has been shown that Nuc has a unique structure containing a DNA- and two calcium-binding domains, and a leucine zipper motif, but its...

journal_title：Pathology international

authors： Kubota T,Miyauchi M,Miura K,Hirokawa G,Awaya A,Miyasaka N,Kurosawa Y,Kanai Y,Maruyama K

更新日期：1998-01-01 00:00:00

abstract：:Histiocytic necrotizing lymphadenitis is rare outside Japan, including Brazil, despite the many Japanese immigrants and descendants who live there. The authors describe the case of a 32 year old white female, who presented with cervical lymph node enlargement and severe anemia. Histological findings of the lymph node ...

journal_title：Pathology international

authors： Lorand-Metze I,Vassallo J,Mori S

更新日期：1994-07-01 00:00:00

abstract：:Autosomal recessive polycystic kidney disease (ARPKD) is caused by genetic mutations of the gene encoding fibrocystin, and is characterized by the collecting duct cysts and congenital hepatic fibrosis. We report an autopsy-proven case of ARPKD in a 77-year-old male who presented with rapidly progressive renal and live...

journal_title：Pathology international

authors： Taneda S,Honda K,Aoki A,Nitta K,Tamura T,Yoshioka Y,Oda H

更新日期：2012-12-01 00:00:00

abstract：:A surgical case of inflammatory myofibroblastic tumor arising in the uterine corpus and exhibiting prominent myxoid change of the stroma is reported. The patient was a 63-year-old woman with a large tumor mass that filled the uterine cavity and measured 11 cm in maximal dimension. The tumor had a gelatinous appearance...

journal_title：Pathology international

authors： Shintaku M,Fukushima A

更新日期：2006-10-01 00:00:00

abstract：:Angioimmunoblastic T cell lymphoma (AITL) is characterized by the presence of atypical lymphocytes with clear cytoplasm and follicular dendritic cells, arborization of high endothelial blood vessels, and infiltration by inflammatory cells, such as epithelioid histiocytes, eosinophils, immunoblasts, and plasma cells. T...

journal_title：Pathology international

authors： Murakami Y,Shimada K,Kosugi H,Mori N

更新日期：2011-05-01 00:00:00

abstract：:The classical nomenclature and categorization of neoplastic and non-neoplastic nodular lesions of the liver are being revised due to the tremendous volume of information recently published on this issue. The diagnostic histopathology of non-neoplastic nodular (tumor-like) lesions of the liver that are recognizable in ...

journal_title：Pathology international

authors： Nakanuma Y

更新日期：1995-10-01 00:00:00

abstract：:Tec is a novel non-receptor-type protein tyrosine kinase that was originally identified from a murine liver cDNA library. While the function of Tec remains unknown, it was shown recently that two Tec-related kinases are involved directly in the growth and differentiation of bone marrow stem cells. As the localization ...

journal_title：Pathology international

authors： Kazama A,Mano H,Morishita Y,Mori S

更新日期：1996-05-01 00:00:00

abstract：:An autopsy case of an 18 month old male infant with measles infection is reported. An autopsy revealed generalized lymphadenopathy, splenomegaly and hyperplastic thymus. Histologically, there were many Warthin-Finkeldey cells (WFC) in hyperplastic lymphoid tissues. Although viral particles and inclusions were not dete...

journal_title：Pathology international

authors： Nozawa Y,Ono N,Abe M,Sakuma H,Wakasa H

更新日期：1994-06-01 00:00:00

abstract：:The KIT, epidermal growth factor receptor (EGFR) and HER-2 oncoproteins have tyrosine kinase activity and are molecular targets in human cancer therapy. To clarify the significance of KIT, EGFR, and HER-2 in undifferentiated thyroid carcinoma (UTC), the expression of these receptors and tyrosine phosphorylation was ex...

journal_title：Pathology international

authors： Murakawa T,Tsuda H,Tanimoto T,Tanabe T,Kitahara S,Matsubara O

更新日期：2005-12-01 00:00:00

abstract：:We report a case of cutaneous squamous cell carcinoma (CSCC), initially coexisting with invasive extramammary Paget's disease (EMPD), in the scrotum of an 84-year-old man. The patient initially had a rash and pruritus before presenting with a pedunculated scrotal mass surrounded by widespread erythema. He underwent to...

journal_title：Pathology international

authors： Kitano A,Izumi M,Tamura K,Tonegawa M,Etou T,Kishida Y

更新日期：2019-10-01 00:00:00

abstract：:Conditions of preserving DNA, RNA and protein in pathological specimens are of great importance as degradation of such macromolecules would critically affect results of molecular biological analysis. The feasibility of freeze-drying as a means of preserving pathological tissue samples for molecular analysis has previo...

journal_title：Pathology international

authors： Matsuo S,Sugiyama T,Okuyama T,Yoshikawa K,Honda K,Takahashi R,Maeda S

更新日期：1999-05-01 00:00:00

abstract：:The overexpression of p53 protein and the Ki67 proliferative index was evaluated in 96 hepatocellular carcinomas (HCC), 67 in cirrhotic livers and 29 in non-cirrhotic ones, and in 13 non-carcinomatous lesions, all surgically resected from Italian patients. Overexpression of p53 was detected only in carcinomatous lesio...

journal_title：Pathology international

authors： D'Errico A,Grigioni WF,Fiorentino M,Baccarini P,Grazi GL,Mancini AM

更新日期：1994-09-01 00:00:00