Abstract:
:The localization of glutathione peroxidase (GSH-PO) in the human arteriosclerotic lesions was investigated by immunohistochemical methods. GSH-PO is an enzyme that effectively reduces lipid peroxides. It is also known that its synthesis is significantly increased by lipid peroxides, the substrate of the enzyme. Accordingly, the increased expression of GSH-PO would indicate the promotion of lipid peroxidation in the site. Immunohistochemistry for Apo-B protein, the major protein component of plasma low density lipoprotein (LDL), was also performed to show the amount of plasma LDL permeation and deposition on the arterial wall. Atheromatous plaques contained numerous GSH-PO positive cells with foamy cytoplasm, while normal arterial walls were almost devoid of GSH-PO positive cells. Immunoelectron microscopically, the GSH-PO reaction products were observed diffusely in the cytoplasm of these cells. The deposition of Apo-B was closely related to the localization of GSH-PO positive cells in the atheromatous lesions. These findings suggest that the lipid peroxidation that surpasses the protective actions of GSH-PO may cause foamy change of smooth muscle cells and macrophages to ultimately form atherosclerotic lesions.
journal_name
Pathol Intjournal_title
Pathology internationalauthors
Mori I,Yoshimura S,Watanabe Kdoi
10.1111/j.1440-1827.1995.tb03467.xsubject
Has Abstractpub_date
1995-05-01 00:00:00pages
343-51issue
5eissn
1320-5463issn
1440-1827journal_volume
45pub_type
杂志文章abstract::An autopsy case of an 18 month old male infant with measles infection is reported. An autopsy revealed generalized lymphadenopathy, splenomegaly and hyperplastic thymus. Histologically, there were many Warthin-Finkeldey cells (WFC) in hyperplastic lymphoid tissues. Although viral particles and inclusions were not dete...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1994.tb01708.x
更新日期:1994-06-01 00:00:00
abstract::A very rare case of a double cancer consisting of adenosquamous and hepatocellular carcinomas of the liver in a 65-year-old-man is discussed. The patient was hospitalized with epigastralgia in May 1997. Abdominal computed axial tomography revealed a tumor located in the left lobe of the liver and a left hepatic lobect...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2001.01302.x
更新日期:2001-12-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1995.tb03420.x
更新日期:1995-12-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/pin.12745
更新日期:2019-01-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.2005.01902.x
更新日期:2005-12-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章,评审
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更新日期:2004-10-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/pin.12508
更新日期:2017-03-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1998.tb03972.x
更新日期:1998-09-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1997.tb04530.x
更新日期:1997-07-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1827.1996.tb03564.x
更新日期:1996-11-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章,评审
doi:10.1046/j.1440-1827.2000.01126.x
更新日期:2000-11-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2001.01210.x
更新日期:2001-05-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2002.01412.x
更新日期:2002-11-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.2005.01861.x
更新日期:2005-08-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/pin.12274
更新日期:2015-05-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1997.tb04440.x
更新日期:1997-10-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章,评审
doi:10.1046/j.1440-1827.2001.01236.x
更新日期:2001-07-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2004-04-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2001-02-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2004-05-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1998.tb03916.x
更新日期:1998-05-01 00:00:00
abstract::Two cases of endometrial low-grade stromal sarcoma with ovarian sex cord-like differentiation occurring in a 39-year-old woman and a 42-year-old woman are presented. Both tumors, which were intramyometrial and measured 7.5 cm and 7.0 cm in greatest diameter, respectively, showed a multinodular, ill-demarcated, and yel...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1997.tb04516.x
更新日期:1997-06-01 00:00:00
abstract::The incidence of lymphoma has rapidly increased over the last 40 years in Japan, following a trend that is very similar to that of breast cancer. In particular, the relative frequency of follicular lymphoma (FL) has reached that in Western countries. Given its indolence, a "watch-and-wait" approach is often applied to...
journal_title:Pathology international
pub_type: 杂志文章,评审
doi:10.1111/pin.12733
更新日期:2018-12-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2001.01276.x
更新日期:2001-10-01 00:00:00
abstract::An unusual tumor in the spinal cord of a 57 year old man is reported. At the age of 42 years, the patient had had a pineal region tumor that subsequently disappeared completely after local radiation therapy only. Eleven and 15 years later, at the ages of 53 and 57 years, respectively, solitary spinal cord tumors were ...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1994.tb01685.x
更新日期:1994-12-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2009-12-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.1999.00927.x
更新日期:1999-08-01 00:00:00
abstract::Malignant transformation of ovarian mature cystic teratomas is reported to occur in about 1% of cases. The most common malignant evolution is that of squamous cell carcinoma and one of the least common is that of small cell carcinoma. We report a case of distant metastasis from a small cell carcinoma arising in a matu...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1998.tb03846.x
更新日期:1998-10-01 00:00:00
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journal_title:Pathology international
pub_type:
doi:10.1111/pin.13006
更新日期:2020-11-01 00:00:00