Classic type of Kaposi's sarcoma and human herpesvirus 8 infection in Xinjiang, China.

Abstract:

:We report 17 cases of the classic type of Kaposi's sarcoma in Xinjiang, which is located in the north-western area of China surrounded by Mongolia in the east, Russia in the north and Kazakhstan in the west. Fifteen of the patients were of the Uygur people. All patients were male and did not have acquired immunodeficiency syndrome. Most of the lesions were found in the lower and/or upper extremities, with 16 patients showing multiple lesions. Immunohistochemical examination of the lesions revealed that human herpesvirus 8 (HHV-8)-encoded latency-associated nuclear antigen was expressed in the nuclei of spindle-shaped tumor cells. HHV-8 DNA was detected by polymerase chain reaction in all seven cases examined. Phylogenetic tree analysis revealed that DNA sequences of the HHV-8-encoded K1 gene in the seven Kaposi's sarcoma cases were classified as subtype C that was common in the Mediterranean, the Middle East and East Asian countries. In addition, using immunofluorescence we investigated the seroprevalence of HHV-8 in 73 Uygur patients with diseases other than Kaposi's sarcoma. Surprisingly, the serological study revealed that 34 of the patients (46.6%) were positive for antibodies against HHV-8, suggesting that HHV-8 infection is widespread in Xinjiang area. The occurrence of the classic type of Kaposi's sarcoma with a high seropositivity rate implies that Xinjiang is the most endemic area for HHV-8 infection in the world known to date. Considering that Xinjiang is located at the middle point of the Silk Road that used to extend from Rome to China, these data imply that the virus may have been in circulation in this area due to the migration of the people via the Silk Road.

journal_name

Pathol Int

journal_title

Pathology international

authors

Dilnur P,Katano H,Wang ZH,Osakabe Y,Kudo M,Sata T,Ebihara Y

doi

10.1046/j.1440-1827.2001.01293.x

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

845-52

issue

11

eissn

1320-5463

issn

1440-1827

pii

1293

journal_volume

51

pub_type

杂志文章
  • Small bowel strangulation caused by parasitic peritoneal strand.

    abstract::A 51-year-old woman with a history of eating raw fish over a period of 2 weeks developed a progressive abdominal pain and leukocytosis with signs of small bowel obstruction. Eosinophilia was not detected in the peripheral blood. The patient underwent surgery to clarify the possibility of ileus. Partial small bowel nea...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2006.01970.x

    authors: Masui N,Fujima N,Hasegawa T,Kigawa S,Kagei N,Nagashima K,Shimizu Y

    更新日期:2006-06-01 00:00:00

  • Rheumatoid arthritis complicated by pachy- and leptomeningeal rheumatoid nodule-like granulomas and systemic vasculitis.

    abstract::Rheumatoid nodule is a frequent and characteristic extra-articular manifestation of rheumatoid arthritis (RA). Its involvement of central nervous system is a rare occurrence with only a few reported cases. A 78-year-old man with severe arthritis showing the formation of rheumatoid nodule-like granulomas in the dura an...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1996.tb03649.x

    authors: Kamio N,Kuramochi S,Wang RJ,Hirose S,Hosoda Y

    更新日期:1996-07-01 00:00:00

  • Elastosis in lung carcinoma: Immunohistochemical, ultrastructural and clinical studies.

    abstract::Elastosis is the pathological finding of focal deposits of elastic fibers in abnormal amounts within tissue. It is well described in the case of infiltrating carcinoma of the breast, but elastosis in lung carcinoma has not been previously documented in detail. We investigated the characteristics of elastosis in lung c...

    journal_title:Pathology international

    pub_type: 更正并重新发布的文章,杂志文章

    doi:

    authors: Fukushima M,Fukuda Y,Kawamoto M,Yamanaka N

    更新日期:2000-12-01 00:00:00

  • The utility of balloon enteroscopy in the diagnosis of histiocytic sarcoma of the small intestine: a case report.

    abstract::The diagnosis of the rare neoplasm histiocytic sarcoma (HS) relies on morphology and the presence of immunophenotypic features of histiocytic lineage. More than 57 cases, including 16 cases involving the gastrointestinal (GI) tract, have been described since the World Health Organization issued its classification syst...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12032

    authors: Miyazaki T,Arihiro S,Mitobe J,Aoki Y,Takikawa S,Saruta M,Matsuoka M,Koike K,Kato T,Kashiwagi H,Ikegami M,Tajiri H

    更新日期:2013-02-01 00:00:00

  • Chronic sclerosing sialadenitis of the submandibular gland associated with idiopathic retroperitoneal fibrosis.

    abstract::We report a case of a 57-year-old man who developed a fibrosclerosing lesion in the submandibular gland and idiopathic retroperitoneal fibrosis (IRF) involving the unilateral periureteral region within a year. Both lesions were resected surgically because of the suspicion of neoplasm. Pathologic examination revealed s...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.1999.00926.x

    authors: Sekine S,Nagata M,Watanabe T

    更新日期:1999-07-01 00:00:00

  • Gene mutation analysis and immunohistochemical study of beta-catenin in odontogenic tumors.

    abstract::In the present study the significance of nuclear/cytoplasmic expression of beta-catenin (CTNNB1) and mutation of the CTNNB1 gene (CTNNB1) in odontogenic tumors was examined. Six ameloblastomas (five follicular ameloblastomas and one plexiform ameloblastoma) and three malignant odontogenic tumors (one metastasizing ame...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2006.02039.x

    authors: Miyake T,Tanaka Y,Kato K,Tanaka M,Sato Y,Ijiri R,Inayama Y,Ito Y,Aoki S,Kawabe R,Tohnai I

    更新日期:2006-12-01 00:00:00

  • No evidence of a correlation between BCL10 expression and API2-MALT1 gene rearrangement in ocular adnexal MALT lymphoma.

    abstract::In the present study, 62 cases of ocular adnexal lymphoproliferative disorders were reviewed clinicopathologically. Of them, 51 were extranodal marginal zone B-cell lymphoma (MALT lymphoma), five were diffuse large B-cell lymphoma (DLBCL), one was peripheral T-cell lymphoma, one was NK/T cell lymphoma, nasal type, and...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2004.01580.x

    authors: Adachi A,Tamaru J,Kaneko K,Kuroda H,Miura I,Kojima T,Hoshino S,Ichinohasama R,Itoyama S

    更新日期:2004-01-01 00:00:00

  • Immunohistochemical expression of gonadotropin releasing hormone receptor in human breast carcinoma.

    abstract::Gonadotropin releasing hormone (GnRH) analogs can cause regression of hormone-dependent breast carcinomas via the specific GnRH receptor (GnRH-R). In an attempt to obtain a better understanding of GnRH actions in human breast carcinoma, the expression of GnRH-R was examined immunohistochemically in 58 invasive ductal ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2001.01210.x

    authors: Moriya T,Suzuki T,Pilichowska M,Ariga N,Kimura N,Ouchi N,Nagura H,Sasano H

    更新日期:2001-05-01 00:00:00

  • Evolution of three patterns of intra-alveolar fibrosis produced by bleomycin in rats.

    abstract::In pulmonary fibrosis, it is known that fibrotic changes develop in the intra-alveolar spaces and that intra-alveolar fibrosis can be classified into three patterns, namely intra-alveolar buds, mural incorporation and obliterative changes. In order to clarify the evolution of intra-alveolar fibrosis, immunohistochemic...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1995.tb03503.x

    authors: Usuki J,Fukuda Y

    更新日期:1995-08-01 00:00:00

  • A potential case of intraductal tubulopapillary neoplasms of the bile duct.

    abstract::Intraductal tubulopapillary neoplasm (ITPN) has been recently reported in pancreas. We experienced an unusual intraductal growing bile duct tumor, which showed the same histopathologic and immunostaining profiles as ITPN of pancreas. A 72-year-old female patient visited hospital due to intrahepatic stone. The hilar bi...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2010.02572.x

    authors: Park HJ,Jang KT,Heo JS,Choi YL,Han J,Kim SH

    更新日期:2010-09-01 00:00:00

  • Pulmonary epithelioid hemangioendothelioma mimicking mesothelioma.

    abstract::An intrathoracic mass was discovered on magnetic resonance imaging (MRI) of the spine in a 37-year-old Caucasian man with a 1 year history of progressively severe upper back pain. A subsequent chest CT scan indicated a 4 cm left hilar mass, extending to the apex and encasing a portion of the left bronchus and pulmonar...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2008.02301.x

    authors: Bahrami A,Allen TC,Cagle PT

    更新日期:2008-11-01 00:00:00

  • Reactivity of antibody YU-311 in formalin-fixed, paraffin-embedded specimens of normal organs, non-hematopoietic tumors, and mast cell tumors.

    abstract::YU-311 is a monoclonal antibody that reacts with a human leukemia cell line resistant for cytosine arabinoside and that identifies a 92 kDa membrane protein. The reactivity of YU-311 in normal organs, various non-hematopoietic tumors and in mast cell tumors in formalin-fixed, paraffin-embedded specimens was examined u...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1997.tb04533.x

    authors: Fukuda T,Kamishima T,Kakihara T,Yamada T,Matsumoto K,Uchiyama M,Suzuki T

    更新日期:1997-08-01 00:00:00

  • Tight junction-related human diseases.

    abstract::Tight junctions are intercellular junctions adjacent to the apical ends of paracellular spaces. They have two classical functions, the barrier function and the fence function. The former regulates the passage of ions, water and various molecules through paracellular spaces, and is thus related to edema, jaundice, diar...

    journal_title:Pathology international

    pub_type: 杂志文章,评审

    doi:10.1111/pin.12021

    authors: Sawada N

    更新日期:2013-01-01 00:00:00

  • Ovarian gonadoblastoma with mixed germ cell tumor in a woman with 46, XX karyotype and successful pregnancies.

    abstract::An extremely rare case of unilateral gonadoblastoma with mixed germ cell tumor arising in the ovary of a 27-year-old woman with 46,XX karyotype and two successful pregnancies is reported. The mixed germ cell tumor was composed of choriocarcinoma, embryonal carcinoma, yolk sac tumor, immature teratoma and dysgerminoma....

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2000.01041.x

    authors: Zhao S,Kato N,Endoh Y,Jin Z,Ajioka Y,Motoyama T

    更新日期:2000-04-01 00:00:00

  • Severe eosinophilic cholangitis with parenchymal destruction of the left hepatic lobe due to hydatid disease.

    abstract::Hydatid cysts of the liver are known to occasionally rupture into the bile ducts and cause cholangitis. The histological features of this complication have not been adequately described in the literature. Herein is reported a case of severe eosinophilic cholangitis of the left hepatic lobe, occurring in a 24-year-old ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2009.02383.x

    authors: Raptou G,Pliakos I,Hytiroglou P,Papavramidis S,Karkavelas G

    更新日期:2009-06-01 00:00:00

  • Ossifying renal tumor of infancy: the first Japanese case with long-term follow-up.

    abstract::Presented is the first Japanese case of ossifying renal tumor of infancy (ORTI), which is an extremely rare tumor and of which only nine cases have been reported in the literature. The patient was a four-month-old Japanese boy presenting as hematuria. A small nodular tumor (approximately 1 cm in size) protruded into t...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1998.tb03885.x

    authors: Ito J,Shinohara N,Koyanagi T,Hanioka K

    更新日期:1998-02-01 00:00:00

  • Epstein-Barr virus-associated post-transplant primary smooth muscle tumor of the liver: report of an autopsy case.

    abstract::Epstein-Barr (EB) virus-associated primary smooth muscle tumors have been reported in immunosuppressed young patients with acquired immunodeficiency syndrome (AIDS) and young people who have undergone liver transplantation. An autopsy case of EB virus-associated smooth muscle cell tumor in a 21 year old female who rec...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1996.tb03660.x

    authors: Sadahira Y,Moriya T,Shirabe T,Matsuno T,Manabe T

    更新日期:1996-08-01 00:00:00

  • Expression of bcl-6 protein in normal skin and epidermal neoplasms.

    abstract::Bcl-6 protein is a recently identified novel transcription factor whose deregulated expression is associated with diffuse large B cell lymphomas. It was recently shown by us that the protein is located in germinal center B cells and their neoplastic counterparts. In the present study, the expression of bcl-6 protein o...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1997.tb04548.x

    authors: Kanazawa N,Moriyama M,Onizuka T,Sugawara K,Mori S

    更新日期:1997-09-01 00:00:00

  • Duct-acinar-islet cell tumor of the pancreas.

    abstract::A case of a rare pancreatic tumor, duct-acinar-islet cell tumor is presented. The tumor was incidentally found in the pancreatic body on computed tomography of a 21 year old male suffering from mumps. It was well demarcated from surrounding pancreas, and spherical in shape, measured 2.5 cm in diameter. Histologic and ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1995.tb03520.x

    authors: Okada Y,Mori H,Tsutsumi A

    更新日期:1995-09-01 00:00:00

  • Clinicopathological and molecular characteristics of gastric and colorectal carcinomas in the elderly.

    abstract::The occurrence of malignant neoplasms increases with advancing age. Although aging and carcinogenesis are basically different processes, there are phenomena common to each such as accumulation of DNA damage and abnormal proteins. Gastric and colorectal carcinomas are representative tumors in which the prevalence and t...

    journal_title:Pathology international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1827.2007.02101.x

    authors: Arai T,Takubo K

    更新日期:2007-06-01 00:00:00

  • Molecular pathogenesis of human amyloidosis: Lessons from β2 -microglobulin-related amyloidosis.

    abstract::Amyloidosis refers to a group of diseases with amyloid fibrils deposited in various organs and is classified into more than 30 diseases in humans based on the kind of amyloid protein. In order to elucidate the molecular pathogenesis of human amyloidosis, we studied the molecular mechanism of amyloid fibril formation i...

    journal_title:Pathology international

    pub_type: 杂志文章,评审

    doi:10.1111/pin.12394

    authors: Naiki H,Okoshi T,Ozawa D,Yamaguchi I,Hasegawa K

    更新日期:2016-04-01 00:00:00

  • Amyloidosis of pancreatic islets in primary amyloidosis (AL type).

    abstract::Seven cases of primary amyloidosis (AL-type) were studied immunocytochemically for the possible involvement of pancreatic islets. The two cases with extensive organ involvement by AL-amyloidosis revealed amyloid deposits in pancreatic islets by routine HE and Congo red staining, which were positive for amyloid p and a...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2005.01815.x

    authors: Tomita T

    更新日期:2005-04-01 00:00:00

  • An autopsy case of clinically un-diagnosed autosomal recessive polycystic kidney disease in 77-year-old male.

    abstract::Autosomal recessive polycystic kidney disease (ARPKD) is caused by genetic mutations of the gene encoding fibrocystin, and is characterized by the collecting duct cysts and congenital hepatic fibrosis. We report an autopsy-proven case of ARPKD in a 77-year-old male who presented with rapidly progressive renal and live...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12011

    authors: Taneda S,Honda K,Aoki A,Nitta K,Tamura T,Yoshioka Y,Oda H

    更新日期:2012-12-01 00:00:00

  • Myofibroblastic tumor of soft tissue displaying desmin-positive and actin-negative immunophenotypes.

    abstract::Myofibroblasts have ultrastructural and functional characteristics intermediate between fibroblasts and smooth muscle cells. Previous studies indicated that most myofibroblasts express actin and vimentin but not desmin immunophenotypes. Two benign intramuscular myofibroblastic tumors which displayed a desmin-positive ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1996.tb03674.x

    authors: Yang P,Hirose T,Seki K,Hasegawa T,Hizawa K,Sano T

    更新日期:1996-09-01 00:00:00

  • Yolk sac tumor of the stomach with an adenocarcinomatous component: a case report with immunohistochemical analysis.

    abstract::A 56-year-old male treated for a gastric yolk sac tumor with an adenocarcinomatous component is described. A mixed area of reticular and glandular neoplastic components was morphologically identified in this tumor. Immunohistochemically, the yolk sac tumor expressed alpha-fetoprotein (AFP), placental alkaline phosphat...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.1999.00907.x

    authors: Suzuki T,Kimura N,Shizawa S,Yabuki N,Yamaki T,Sasano H,Nagura H

    更新日期:1999-06-01 00:00:00

  • Clinicopathological findings in patients who have undergone epilepsy surgery in the first year of life.

    abstract::Epilepsy presenting early in childhood may be associated with a neurologically devastating clinical course and have significant implications for the child's development. There are limited published data regarding the clinicopathological features of patients who have undergone epilepsy surgery in the first year of life...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2000.01101.x

    authors: Prayson RA

    更新日期:2000-08-01 00:00:00

  • Generalized infantile myofibromatosis with a monophasic primitive pattern.

    abstract::Infantile myofibromatosis (IM) is a rare disorder present at birth or in early infancy with a biphasic histological pattern. We present a neonatal-onset case of generalized IM with visceral (central nervous system, heart, lungs, liver, spleen, small intestine, kidneys and bones) and placental involvement, showing a mo...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12312

    authors: Iwafuchi H,Tsuzuki T,Ito R,Miyake H,Okita H,Hamazaki M

    更新日期:2015-08-01 00:00:00

  • Mixed medullary and follicular cell carcinoma of the thyroid with lymph node metastasis in a 7-year-old child.

    abstract::A 7-year-old boy presented with midline swelling in the neck. On fine-needle aspiration cytology it was diagnosed as papillary carcinoma of the thyroid. The patient underwent total thyroidectomy. Histopathological examination, immunohistochemistry and electron microscopy revealed the presence of two intermingled compo...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2006.01928.x

    authors: Goyal R,Nada R,Rao KL,Radotra BD

    更新日期:2006-02-01 00:00:00

  • Aberrant MAD2 expression in soft-tissue sarcoma.

    abstract::Soft-tissue sarcomas can be divided into translocation-associated (TA) and non-TA sarcomas, the latter of which is often characterized by pleomorphic cytomorphology and aneuploidy. The aberrant expression of MAD2, an essential component of the mitotic spindle checkpoint, has been recently shown to promote aneuploidy. ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2008.02232.x

    authors: Hisaoka M,Matsuyama A,Hashimoto H

    更新日期:2008-06-01 00:00:00

  • Three synchronous carcinomas of the papilla of Vater, common bile duct and pancreas.

    abstract::Multiple carcinomas of the pancreatico-biliary tree are rare. A 53 year old Japanese man was diagnosed as having an adenocarcinoma in the papilla of Vater. During the operation, he was also found to have a polypoid mass in the common bile duct. While cutting the operative specimen into stepwise sections, a small tumor...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1994.tb03371.x

    authors: Nishihara K,Tsuneyoshi M,Shimura H,Yasunami Y

    更新日期:1994-04-01 00:00:00