Abstract:
:YU-311 is a monoclonal antibody that reacts with a human leukemia cell line resistant for cytosine arabinoside and that identifies a 92 kDa membrane protein. The reactivity of YU-311 in normal organs, various non-hematopoietic tumors and in mast cell tumors in formalin-fixed, paraffin-embedded specimens was examined using immunohistochemical methods. In normal organs, YU-311 reacted with fundic glands of the stomach, the intercalated duct of the pancreas, the distal portion and the loop of Henle of renal tubules and tissue mast cells. Benign neoplasms of various organs showed no immunoreaction with YU-311, except for mast cell tumors. Some types of malignant neoplasms were occasionally positive against YU-311, suggesting neoplasms arising from or differentiating along normal YU-311-positive counterparts. Some other types of malignancies were rarely positive for YU-311, although their normal counterparts showed no immunoreactivity with YU-311. None of the non-epithelial tumors reacted with YU-311, except for one case of malignant melanoma. In contrast, normal tissue mast cells and their related tumors, such as urticaria pigmentosa or solitary mastocytoma, were constantly positive for YU-311. None of the non-hematopoietic human tumor cell lines examined in the present study was reactive with YU-311. These findings indicate that YU-311 is a good marker of some types of tumors and mast cell tumors and that an aberrant expression of YU-311 rarely occurs.
journal_name
Pathol Intjournal_title
Pathology internationalauthors
Fukuda T,Kamishima T,Kakihara T,Yamada T,Matsumoto K,Uchiyama M,Suzuki Tdoi
10.1111/j.1440-1827.1997.tb04533.xsubject
Has Abstractpub_date
1997-08-01 00:00:00pages
512-7issue
8eissn
1320-5463issn
1440-1827journal_volume
47pub_type
杂志文章abstract::A small proportion of patients with chronic lymphocytic leukemia (CLL) may progress to large cell lymphoma, or Richter syndrome (RS). The large cells of RS may arise through transformation of the original CLL clone (clonally related) or represent a new neoplasm (clonally unrelated), which might be Epstein-Barr virus (...
journal_title:Pathology international
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journal_title:Pathology international
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journal_title:Pathology international
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journal_title:Pathology international
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journal_title:Pathology international
pub_type: 杂志文章,评审
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journal_title:Pathology international
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journal_title:Pathology international
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pub_type: 杂志文章
doi:10.1111/pin.12869
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:1996-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
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journal_title:Pathology international
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更新日期:2005-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/pin.12188
更新日期:2014-09-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2004-07-01 00:00:00
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journal_title:Pathology international
pub_type: 指南,杂志文章,实务指引
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更新日期:1997-05-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
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pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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journal_title:Pathology international
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journal_title:Pathology international
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2001-12-01 00:00:00
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journal_title:Pathology international
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journal_title:Pathology international
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更新日期:2012-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-08-01 00:00:00