Pulmonary epithelioid hemangioendothelioma mimicking mesothelioma.

abstract：:In order to confirm the role of 14-3-3 sigma (sigma) as a tumor suppressor in breast carcinogenesis, we have studied the expression of 14-3-3sigma immunohistochemically in usual ductal hyperplasia (UDH), ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) breast lesions. Immunostaining for estrogen rec...

journal_title：Pathology international

authors： Simooka H,Oyama T,Sano T,Horiguchi J,Nakajima T

更新日期：2004-08-01 00:00:00

abstract：:Immunohistochemical and clinicopathological features of 58 gastrointestinal stromal tumors (GIST) were studied. One occurred in the esophagus, 41 in the stomach, nine in the small intestine, and seven in the large intestine. By using indirect immunoperoxidase staining for Cajal cell markers (c-kit protein and CD34), s...

journal_title：Pathology international

authors： Tazawa K,Tsukada K,Makuuchi H,Tsutsumi Y

更新日期：1999-09-01 00:00:00

abstract：:Cellular senescence is defined as irreversible cell arrest and could work as a safeguard against tumorigenesis. This mechanism was examined in chronic viral hepatitis-related hepatocarcinogenesis. By using surgical resected or wedge biopsied liver specimens from 87 chronic viral hepatitis patients in whom 35 neoplasti...

journal_title：Pathology international

authors： Ikeda H,Sasaki M,Sato Y,Harada K,Zen Y,Mitsui T,Nakanuma Y

更新日期：2009-07-01 00:00:00

abstract：:Multiple myeloma (MM) is a plasma-cell neoplasm that can cause renal disorders. Renal lesions in MM can present with a very rare pathological manifestation involving a specific monoclonal immunoglobulin (Ig). We report the case of a 33-year-old woman who had edema, fatigue, elevated serum creatinine levels, hypoalbumi...

journal_title：Pathology international

authors： Watanabe H,Osawa Y,Goto S,Habuka M,Imai N,Ito Y,Hirose T,Chou T,Ohashi R,Shimizu A,Ehara T,Shimotori T,Narita I

更新日期：2015-01-01 00:00:00

abstract：:Recent studies imply that cancer cells possess the ability to reversibly change their properties between a drug sensitive state and a drug resistant state accompanied by epigenetic changes. This evidence indicates that better understanding of cancer epigenetics is important for efficient cancer therapies. Nevertheless...

journal_title：Pathology international

authors： Matsuda Y,Semi K,Yamada Y

更新日期：2014-07-01 00:00:00

abstract：:Under the condition of obvious iron-overload, there is a zonal hemosiderin (iron) deposition in hepatic lobules. The deposition is heaviest in the periportal (zone 1) and lightest in the perivenous (zone 3) hepatocytes. However, the mechanism for this pattern of iron deposition is obscure. Hepatic tissues from control...

journal_title：Pathology international

authors： Lu JP,Hayashi K

更新日期：1995-03-01 00:00:00

abstract：:Several short forms of alternatively spliced Murine double minute 2 (MDM2) transcripts have recently been shown to correlate with high-grade malignancy in a number of human tumors. We examined the frequency of splice variants and their correlation with clinicopathological features in 60 cases of human breast cancer. S...

journal_title：Pathology international

authors： Hori M,Shimazaki J,Inagawa S,Itabashi M,Hori M

更新日期：2000-10-01 00:00:00

abstract：:Aerobes, including humans, are consistently exposed to oxidative stress by consuming oxygen. The biological significance of oxidative stress via reactive oxygen and nitrogen species consists of two stages: reversible redox regulation and irreversible oxidative molecular damage, which are sometimes intermingled. During...

journal_title：Pathology international

authors： Toyokuni S,Akatsuka S

更新日期：2007-08-01 00:00:00

abstract：:One of the striking microscopic appearances of breast carcinoma is malignant transformation of the epithelium of an entire lobule, although the lobular architecture is still preserved. We termed this pathological feature 'lobular involvement'. An investigation was carried out to determine whether lobular involvement w...

journal_title：Pathology international

authors： Ishige H,Kondo Y,Yagata H,Onoki J,Suzuki M,Oshida M,Nagashima T,Hashimoto H,Nakajima N

更新日期：1999-06-01 00:00:00

abstract：:Nuclear pseudoinclusions (NPIs) are classically found in papillary thyroid carcinoma and meningioma. Although NPIs have been described in melanocytic lesions, there is no systematic analysis of potential relationship between NPIs and other clinicopathological characteristics of melanoma. We examined the presence of NP...

journal_title：Pathology international

authors： Donizy P,Kaczorowski M,Biecek P,Halon A,Matkowski R

更新日期：2018-02-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is a heterodimeric polypeptide growth factor that has pleiotropic roles, including those of mitogen, motogen and morphogen. The HGF receptor is characterized as a c-Met proto-oncogene product (c-Met), which is a heterodimeric tyrosine kinase receptor. Hepatocyte growth factor acts as a m...

journal_title：Pathology international

authors： Motoi T,Ishida T,Kuroda M,Horiuchi H,Oka T,Matsumoto K,Nakamura T,Machinami R

更新日期：1998-10-01 00:00:00

abstract：:A 28-year-old woman complained of irregular menstruation. Abdominal ultrasound and magnetic resonance imaging (MRI) examinations revealed a cystic tumor in the left ovary. A histological examination of the resected ovary revealed that the lesion was a mature cystic teratoma. In this tumor, components such as skin with...

journal_title：Pathology international

authors： Kuroda N,Hirano K,Inui Y,Yamasaki Y,Toi M,Nakayama H,Hiroi M,Enzan H

更新日期：2001-11-01 00:00:00

abstract：:Eight hepatic atypical adenomatous hyperplasias (AH), 30 hepatocellular carcinomas (HCC) consisting of 11 well-, 13 moderately and six poorly differentiated HCC, and 10 intrahepatic cholangiocarcinomas (CC) were investigated immunohistochemically with anti-alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), CA19-...

journal_title：Pathology international

authors： Tsuji M,Kashihara T,Terada N,Mori H

更新日期：1999-04-01 00:00:00

abstract：:A multi-institutional study 'Pathobiological Determinants of Atherosclerosis in Youth' (PDAY) was initiated to document the natural history of atherosclerosis, its relationship to risk factors, and pathobiology of lesion development in young subjects. Pathology laboratories in nine centers collected arteries and tissu...

journal_title：Pathology international

authors： Strong JP,Malcom GT,Oalmann MC

更新日期：1995-06-01 00:00:00

abstract：:Adenomyoma of the small intestine is a rare tumor-like lesion composed of exocrine-type ducts and hypertrophic smooth muscle. We describe two cases of adenomyoma of the small intestine. One was an ileal adenomyoma that presented with intussusception occurring in a 7-month-old boy. The other was a jejunal adenomyoma fo...

journal_title：Pathology international

authors： Park HS,Lee SO,Lee JM,Kang MJ,Lee DG,Chung MJ

更新日期：2003-02-01 00:00:00

abstract：:Twelve lymph node specimens with necrotizing lymphadenitis and which had florid necrotic lesions were studied immunohistochemically. The majority of viable lymphoid cells in the necrotic foci were CD8+ lymphocytes and KP1+ or PGM1+ phagocytizing macrophages. The CD8+ T cells were Leu1+, Leu2+, Leu3-, Leu4+, Leu5b+, Le...

journal_title：Pathology international

authors： Mori N,Yatabe Y,Asai J,Nagasawa T

更新日期：1997-01-01 00:00:00

abstract：:Malignant myoepithelioma of soft tissue is extremely rare. Presented herein is a case arising in a 17-year-old man. The tumor was initially noticed as a painless deep soft-tissue mass in the right forearm when the patient was aged 3 years. Thereafter, it grew without remarkable symptoms, such as pain or tenderness, un...

journal_title：Pathology international

authors： Harada O,Ota H,Nakayama J

更新日期：2005-08-01 00:00:00

abstract：:Histological grading of prostate cancer is one of the most important tissue-based parameters for prediction of outcome and treatment response. Gleason grading remains the foundation of prostate cancer grading, but has undergone a series of changes in the past 30 years, often initiated by consensus conference decisions...

journal_title：Pathology international

authors： Egevad L,Delahunt B,Yaxley J,Samaratunga H

更新日期：2019-02-01 00:00:00

abstract：:Breast cancer patients have a generally increased risk of developing second cancers. The object of this study was to clarify the increased as well as decreased incidence of cancers in breast cancer patients using autopsy cases. 164 211 autopsy cases in the Annual of Pathological Autopsy Cases in Japan from 2002 to 201...

journal_title：Pathology international

authors： Shibahara Y,Sugawara Y,Miki Y,Hata S,Takahashi H,Nakamura Y,Suzuki T,Ohuchi N,Tsuji I,Sasano H

更新日期：2016-12-01 00:00:00

abstract：:We have found that the MIB-1 grade, based on tumor differentiation/histological type, necrosis and Ki-67 (MIB-1) score, is a valid and reproducible prognostic system for adult soft-tissue sarcomas. However, there are limited data available on Ki-67 labeling indices (LI) from adult soft-tissue sarcomas for testing the ...

journal_title：Pathology international

authors： Hasegawa T,Yamamoto S,Matsuno Y

更新日期：2002-07-01 00:00:00

abstract：:A mixed tumor with apocrine differentiation seen in the external auditory canal of a 39 year old male is reported. The well demarcated polypoid tumor showed proliferation of elongated gland-like or duct-like structures lined by two rows of epithelial cells, occasionally accompanied by foci of keratinization. There wer...

journal_title：Pathology international

authors： Tang X,Tamura Y,Tsutsumi Y

更新日期：1994-01-01 00:00:00

abstract：:The aluminum (AI) and iron (Fe) chelate complexes of nitrilotriacetate (NTA) cause renal insufficiency when they are administered intraperitoneally to rats. Their effects on bone metabolism were studied in 4 week old Wistar rats. Daily intraperitoneal administration of AI-NTA (3mg AI/kg for 11 weeks) induced osteomala...

journal_title：Pathology international

authors： Yukihiro S,Okada S,Takeuchi K,Inoue H

更新日期：1995-01-01 00:00:00

abstract：:This study aims to evaluate the impact on the implementation of multiple strategies to improve medical student's pathology learning experience. In two consecutive years, medical students after a whole year of enrolling in pathology teaching, were invited to complete questionnaires rating and commenting on the personal...

journal_title：Pathology international

authors： Gopalan V,Kasem K,Pillai S,Olveda D,Ariana A,Leung M,Lam AKY

更新日期：2018-07-24 00:00:00

abstract：:The value of fluorescence in situ hybridization (FISH) as an aid to deciding the prognosis for lung carcinoma patients, comparing quantitatively the signal from the p53 gene (17p13.1) on chromosome 17, was studied. A dual-labeling technique was used, using probes for the centromeric region of chromosome 17 and for the...

journal_title：Pathology international

authors： Kawai T,Hiroi S,Nakanishi K,Sakurai Y,Torikata C

更新日期：2004-06-01 00:00:00

abstract：:The protective effect of Brazilian propolis and its extract Artepillin C against ferric nitrilotriacetate (Fe-NTA)-induced renal lipid peroxidation and carcinogenesis was studied in male ddY mice. Fe-NTA-induced renal lipid peroxidation leads to a high incidence of renal cell carcinoma (RCC) in mice. Administration of...

journal_title：Pathology international

authors： Kimoto T,Koya S,Hino K,Yamamoto Y,Nomura Y,Micallef MJ,Hanaya T,Arai S,Ikeda M,Kurimoto M

更新日期：2000-09-01 00:00:00

abstract：:beta-Catenin has multiple functions both in intercellular adhesion and in signal transduction. As a signaling molecule, mutations in exon 3 of the beta-catenin gene stabilize this protein in the cytoplasm. Subsequently, accumulated beta-catenin protein translocates to nuclei with T-cell factor-4, and upregulates trans...

journal_title：Pathology international

authors： Miyake N,Maeta H,Horie S,Kitamura Y,Nanba E,Kobayashi K,Terada T

更新日期：2001-09-01 00:00:00

abstract：:This report describes a case of an immunocompetent 77-year-old male with Epstein-Barr virus (EBV)-positive lymphoproliferative disorder associated with calcified chronic subdural hematoma (CSH). On the day prior to consultation in our outpatient clinic, the patient fell from his bed, striking his frontal head on the f...

journal_title：Pathology international

authors： Sugita Y,Ohta M,Ohshima K,Niino D,Nakamura Y,Okada Y,Nakashima S

更新日期：2012-06-01 00:00:00

abstract：:Histiocytic necrotizing lymphadenitis is rare outside Japan, including Brazil, despite the many Japanese immigrants and descendants who live there. The authors describe the case of a 32 year old white female, who presented with cervical lymph node enlargement and severe anemia. Histological findings of the lymph node ...

journal_title：Pathology international

authors： Lorand-Metze I,Vassallo J,Mori S

更新日期：1994-07-01 00:00:00

abstract：:Soft-tissue sarcomas can be divided into translocation-associated (TA) and non-TA sarcomas, the latter of which is often characterized by pleomorphic cytomorphology and aneuploidy. The aberrant expression of MAD2, an essential component of the mitotic spindle checkpoint, has been recently shown to promote aneuploidy. ...

journal_title：Pathology international

authors： Hisaoka M,Matsuyama A,Hashimoto H

更新日期：2008-06-01 00:00:00

abstract：:In the present study the significance of nuclear/cytoplasmic expression of beta-catenin (CTNNB1) and mutation of the CTNNB1 gene (CTNNB1) in odontogenic tumors was examined. Six ameloblastomas (five follicular ameloblastomas and one plexiform ameloblastoma) and three malignant odontogenic tumors (one metastasizing ame...

journal_title：Pathology international

authors： Miyake T,Tanaka Y,Kato K,Tanaka M,Sato Y,Ijiri R,Inayama Y,Ito Y,Aoki S,Kawabe R,Tohnai I

更新日期：2006-12-01 00:00:00