Abstract:
:CpG island methylator phenotype (CIMP) is a recently described subset of colorectal cancers (CRC) with widespread methylation of multiple promoter CpG islands. But the prognostic implication of CIMP in CRC has not been clarified. Thus, the aim of the present study was to differentiate the unique characteristics of CIMP from those of microsatellite instability (MSI)-high CRC, especially with regard to prognosis. CIMP, MSI, and mutations of KRAS codons 12 and 13 and of BRAF codon 600 were evaluated in 134 sporadic CRC. Patient survival and other clinicopathological variables were correlated with CIMP or genetic changes. High CIMP, high MSI, and mutations in KRAS or BRAF were detected in 31.3%, 14.2%, 33.6%, and 4.5% of overall CRC, respectively. High CIMP was closely associated with MSI and BRAF mutation but not with KRAS mutation. CIMP-high, microsatellite-stable (MSS) CRC were significantly associated with proximal location and nodal metastasis and had close but non-significant associations with liver metastasis. A worse clinical outcome was found for CIMP-high, MSS CRC with KRAS/BRAF mutation but not for those lacking KRAS/BRAF mutation. The findings support the contention that CIMP-high CRC have distinct clinicopathological and epidemiological features and suggest that the alleged poor clinical outcome of CIMP-high CRC patients is closely associated with the presence of KRAS/BRAF mutation.
journal_name
Pathol Intjournal_title
Pathology internationalauthors
Lee S,Cho NY,Choi M,Yoo EJ,Kim JH,Kang GHdoi
10.1111/j.1440-1827.2007.02197.xsubject
Has Abstractpub_date
2008-02-01 00:00:00pages
104-13issue
2eissn
1320-5463issn
1440-1827pii
PIN2197journal_volume
58pub_type
杂志文章abstract::BRCA1-associated protein 1 (BAP1) or methylthioadenosine phosphorylase (MTAP) immunohistochemistry (IHC) or 9p21 fluorescence in situ hybridization (FISH) are useful for the diagnosis of malignant pleural mesothelioma (MPM). However, the effect of these assays on the diagnostic yield of effusion cytology in MPM cases ...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/pin.12973
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2002-03-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2000.01065.x
更新日期:2000-06-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章,评审
doi:10.1111/pin.12200
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:1999-09-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2003-08-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:1998-07-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1995.tb03375.x
更新日期:1995-01-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/pin.12229
更新日期:2015-01-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章,评审
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journal_title:Pathology international
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更新日期:2011-11-01 00:00:00
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journal_title:Pathology international
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:1994-05-01 00:00:00
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pub_type: 杂志文章
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journal_title:Pathology international
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1996.tb03660.x
更新日期:1996-08-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章,评审
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更新日期:1994-07-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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