Clinicopathological features of CpG island methylator phenotype-positive colorectal cancer and its adverse prognosis in relation to KRAS/BRAF mutation.


:CpG island methylator phenotype (CIMP) is a recently described subset of colorectal cancers (CRC) with widespread methylation of multiple promoter CpG islands. But the prognostic implication of CIMP in CRC has not been clarified. Thus, the aim of the present study was to differentiate the unique characteristics of CIMP from those of microsatellite instability (MSI)-high CRC, especially with regard to prognosis. CIMP, MSI, and mutations of KRAS codons 12 and 13 and of BRAF codon 600 were evaluated in 134 sporadic CRC. Patient survival and other clinicopathological variables were correlated with CIMP or genetic changes. High CIMP, high MSI, and mutations in KRAS or BRAF were detected in 31.3%, 14.2%, 33.6%, and 4.5% of overall CRC, respectively. High CIMP was closely associated with MSI and BRAF mutation but not with KRAS mutation. CIMP-high, microsatellite-stable (MSS) CRC were significantly associated with proximal location and nodal metastasis and had close but non-significant associations with liver metastasis. A worse clinical outcome was found for CIMP-high, MSS CRC with KRAS/BRAF mutation but not for those lacking KRAS/BRAF mutation. The findings support the contention that CIMP-high CRC have distinct clinicopathological and epidemiological features and suggest that the alleged poor clinical outcome of CIMP-high CRC patients is closely associated with the presence of KRAS/BRAF mutation.


Pathol Int


Pathology international


Lee S,Cho NY,Choi M,Yoo EJ,Kim JH,Kang GH




Has Abstract


2008-02-01 00:00:00














  • RET finger protein expression is associated with prognosis in lung cancer with epidermal growth factor receptor mutations.

    abstract::The RET finger protein (RFP) is a transcription factor belonging to the TRIM (tripartite motif) superfamily of proteins. RFP is expressed in a variety of human and rodent tumor cell lines and in several kinds of human cancer. Expression of RFP is associated with prognosis of colon and endometrial cancers. In the prese...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Iwakoshi A,Murakumo Y,Kato T,Kitamura A,Mii S,Saito S,Yatabe Y,Takahashi M

    更新日期:2012-05-01 00:00:00

  • Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma arising in patient with a history of EBV-positive mucocutaneous ulcer and EBV-positive nodal polymorphous B-lymphoproliferative disorder.

    abstract::Elderly patients with Epstein-Barr virus (EBV) infection are at increased risk for developing B-cell lymphoproliferative disorder (B-LPD) due to immunosenescence. Here, we describe a case of a 75-year-old man who developed an EBV-positive (EBV+) mucocutaneous ulcer (EBVMCU) in the gingiva with spontaneous regression. ...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Daroontum T,Kohno K,Inaguma Y,Okamoto A,Okamoto M,Kimura Y,Nagahama M,Sakakibara A,Satou A,Nakamura S

    更新日期:2019-01-01 00:00:00

  • Malignant phyllodes tumor of the breast with expression of osteonectin and vinculin.

    abstract::Phyllodes tumor is a very rare neoplasm which accounts for 2.5% of all fibroepithelial lesions of the breast. The mesenchymal component of a malignant phyllodes tumor frequently contains heterologous components. We report a case of malignant phyllodes tumor. The patient was a 40-year-old woman with a lump on the left ...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Kuroda N,Sugimoto T,Ueda S,Takahashi T,Moriki T,Sonobe H,Miyazaki E,Hayashi Y,Toi M,Hiroi M,Enzan H

    更新日期:2001-04-01 00:00:00

  • Epstein-Barr virus-positive multiple early gastric cancers and dysplastic lesions: a case report.

    abstract::Epstein-Barr virus (EBV) has been implicated as a causal virus of gastric cancer with episomal monoclonality, elevated antibodies and a unique morphologic expression in the early intramucosal stage, but the infection mechanisms have not been demonstrated. EBV has been shown only in the cancerous lesions by the highly ...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Arikawa J,Tokunaga M,Tashiro Y,Tanaka S,Sato E,Haraguchi K,Yamamoto A,Toyohira O,Tsuchimochi A

    更新日期:1997-10-01 00:00:00

  • Adult-onset giant juxtaglomerular cell tumor of the kidney.

    abstract::The juxtaglomerular cell tumor (JGCT) of the kidney is a rare neoplasm which commonly secretes renin. This tumor often occurs in teenagers. This paper documents the 14th adult-onset (over 30-years-old) case with a giant JGCT which measured 9.0 x 8.0 x 7.5 cm. Histologically, this tumor was composed of both vascular an...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Kuroda N,Moriki T,Komatsu F,Miyazaki E,Hayashi Y,Naruse K,Nakayama H,Kiyoku H,Hiroi M,Shuin T,Enzan H

    更新日期:2000-03-01 00:00:00

  • Pulmonary tumor thrombotic microangiopathy resulting from metastatic signet ring cell carcinoma of the stomach.

    abstract::Pulmonary tumor thrombotic microangiopathy is an unusual malignancy-related respiratory complication characterized by multiple microthrombi and intimal myofibroblast proliferation. Its clinical manifestation is subacute respiratory failure with pulmonary hypertension. Herein is reported a case of pulmonary tumor throm...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Sakashita N,Yokose C,Fujii K,Matsumoto M,Ohnishi K,Takeya M

    更新日期:2007-06-01 00:00:00

  • Infarction of breast fibroadenoma in a postmenopausal woman.

    abstract::Infarction of a breast fibroadenoma usually occurs in young females during pregnancy or lactation. This report describes a rare case of the total infarction of a fibroadenoma in a 58 year old postmenopausal woman. The chief complaint was a rapidly enlarged, slightly painful lump. Medullary carcinoma was suspected on p...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Ichihara S,Matsuyama T,Kubo K,Tamura Z,Aoyama H

    更新日期:1994-05-01 00:00:00

  • Recommendations for the reporting of resected prostate carcinomas. Association of Directors of Anatomic and Surgical Pathology Agency.

    abstract::The Association of Directors of Anatomic and Surgical Pathology has developed recommendations for the surgical reporting of common malignant tumors. The recommendations for prostatic carcinoma are reported herein. ...

    journal_title:Pathology international

    pub_type: 指南,杂志文章



    更新日期:1997-04-01 00:00:00

  • The difference of neovascularization in early intra-alveolar fibrosis between nonspecific interstitial pneumonia and usual interstitial pneumonia.

    abstract::Of the idiopathic interstitial pneumonias (IIPs), usual interstitial pneumonia (UIP) and diffuse alveolar damage (DAD) usually have poor prognoses. The prognoses of cryptogenic organizing pneumonia (COP) and nonspecific interstitial pneumonia (NSIP) are usually more favorable. Although several reports have described n...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Takahashi M,Kunugi S,Terasaki Y,Terasaki M,Urushiyama H,Kuwahara N,Wakamatsu K,Nakayama T,Fukuda Y

    更新日期:2013-05-01 00:00:00

  • Perivascular myoma: case report with immunohistochemical and ultrastructural studies.

    abstract::A subcutaneous myopericytoma-type perivascular myoma arising in the elbow of a 61-year-old woman is described. The tumor was well demarcated and consisted microscopically of small ovoid and spindle cells arranged in a concentric fashion, surrounding small to medium-sized vessels and imparting a superficial resemblance...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Mikami Y,Shiomi T,Manabe T

    更新日期:2002-01-01 00:00:00

  • Oncocytic papillary renal cell carcinoma with inverted nuclear pattern: distinct subtype with an indolent clinical course.

    abstract::Reported herein are seven cases of a histologically distinct oncocytic papillary renal cell carcinoma (OPRCC) with an inverted nuclear pattern. To define its prognostic significance, the clinicopathological features of OPRCC were compared to those of types 1 and 2 PRCC. The median age of the seven patients was 67 year...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Park BH,Ro JY,Park WS,Jee KJ,Kim K,Gong G,Cho YM

    更新日期:2009-03-01 00:00:00

  • Tumor suppressor in lung cancer-1 as a novel ameloblast adhesion molecule and its downregulation in ameloblastoma.

    abstract::Tumor suppressor in lung cancer-1 (TSLC1) is an intercellular adhesion molecule of the immunoglobulin superfamily. There is little information regarding the developmental expression profiles. In an attempt to clarify the distribution of TSLC1 proteins in mouse embryos tissue by immunohistochemistry, it was found that ...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Usami Y,Ito A,Ohnuma K,Fuku T,Komori T,Yokozaki H

    更新日期:2007-02-01 00:00:00

  • A case of pulmonary papillary adenoma: possible relationship between tumor histogenesis/tumorigenesis and fibroblast growth factor receptor 2 IIIb.

    abstract::Pulmonary papillary adenoma is a rare tumor. We analyzed a tumor which appeared in a 16-year-old Japanese woman. The tumor histologically showed papillary proliferation of one-layered tumor cells coating inflammatory fibrovascular cores. At the periphery of the tumor, the tumor cells grew in a lepidic fashion. The tum...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Masunaga A,Nagashio R,Iwamoto S,Takeyama N,Sato Y,Miyazaki A,Mitsuya T

    更新日期:2012-09-01 00:00:00

  • Renal cell carcinoma arising in a long pre-existing angiomyolipoma.

    abstract::Angiomyolipoma (AML) is a mixed mesenchymal tumor belonging to the family of perivascular epithelioid cell tumors. Concurrent development of AML and adult renal cell carcinoma (RCC) is very rare. Herein is presented a unique case in which RCC arose within a previously detected AML tumor mass. A 40-year-old woman had b...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Inomoto C,Umemura S,Sasaki Y,Yasuda M,Terachi T,Osamura RY

    更新日期:2007-03-01 00:00:00

  • Absence of mutations in the beta-catenin and adenomatous polyposis coli genes in papillary and follicular thyroid carcinomas.

    abstract::beta-Catenin has multiple functions both in intercellular adhesion and in signal transduction. As a signaling molecule, mutations in exon 3 of the beta-catenin gene stabilize this protein in the cytoplasm. Subsequently, accumulated beta-catenin protein translocates to nuclei with T-cell factor-4, and upregulates trans...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Miyake N,Maeta H,Horie S,Kitamura Y,Nanba E,Kobayashi K,Terada T

    更新日期:2001-09-01 00:00:00

  • Quantitative immunohistochemical evaluation of MIB-1 labeling index in adult soft-tissue sarcomas by computer-assisted image analysis.

    abstract::We have found that the MIB-1 grade, based on tumor differentiation/histological type, necrosis and Ki-67 (MIB-1) score, is a valid and reproducible prognostic system for adult soft-tissue sarcomas. However, there are limited data available on Ki-67 labeling indices (LI) from adult soft-tissue sarcomas for testing the ...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Hasegawa T,Yamamoto S,Matsuno Y

    更新日期:2002-07-01 00:00:00

  • Sebaceous carcinoma of the breast.

    abstract::We report on a rare distinctive variant of infiltrating ductal carcinoma characterized by sebaceous differentiation of tumor cells. The neoplasm was identified in a lumpectomy specimen from a 45-year-old woman with extensive metastatic disease. In addition to conventional in situ and invasive ductal components, approx...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Varga Z,Kolb SA,Flury R,Burkhard R,Caduff R

    更新日期:2000-01-01 00:00:00

  • Clusters of proliferating endothelial cells and smooth muscle cells in rabbit carotid arteries.

    abstract::Schwarz and Benditt found clustering of replicating cells in aortic endothelium in 1976 and discussed how homeostasis of the arterial wall is maintained through this nonrandom distribution of replicating cells. However, it is still unclear how cells of vascular walls turnover. In order to address this issue, we evalua...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Takahashi M,Masuda H,Yoshida M,Ito Y,Nanjo H,Sugiyama T,Maeda D,Goto A

    更新日期:2015-11-01 00:00:00

  • Epidermal growth factor receptor mutations in lung cancers.

    abstract::In 2004, two groups reported somatic mutations in the gene for the epidermal growth factor receptor (EGFR) in patients with non-small cell lung cancer (NSCLC), which were highly correlated with the clinical response to the anticancer drug, gefitinib. Since then, a tremendous amount of knowledge has accumulated, and sh...

    journal_title:Pathology international

    pub_type: 杂志文章,评审


    authors: Yatabe Y,Mitsudomi T

    更新日期:2007-05-01 00:00:00

  • Ossifying renal tumor of infancy: the first Japanese case with long-term follow-up.

    abstract::Presented is the first Japanese case of ossifying renal tumor of infancy (ORTI), which is an extremely rare tumor and of which only nine cases have been reported in the literature. The patient was a four-month-old Japanese boy presenting as hematuria. A small nodular tumor (approximately 1 cm in size) protruded into t...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Ito J,Shinohara N,Koyanagi T,Hanioka K

    更新日期:1998-02-01 00:00:00

  • An autopsy case of clinically un-diagnosed autosomal recessive polycystic kidney disease in 77-year-old male.

    abstract::Autosomal recessive polycystic kidney disease (ARPKD) is caused by genetic mutations of the gene encoding fibrocystin, and is characterized by the collecting duct cysts and congenital hepatic fibrosis. We report an autopsy-proven case of ARPKD in a 77-year-old male who presented with rapidly progressive renal and live...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Taneda S,Honda K,Aoki A,Nitta K,Tamura T,Yoshioka Y,Oda H

    更新日期:2012-12-01 00:00:00

  • The prognostic significance of N-myc downregulated gene 1 in lung adenocarcinoma.

    abstract::It has been reported that N-myc downstream regulated gene 1 (NDRG1) is related to the prognosis of non-small cell lung cancer (NSCLC), and associated with c-Myc degradation in NSCLC cell lines. However, the relationship of NDRG1 to prognosis or c-Myc expression in lung adenocarcinoma has not been well clarified. The p...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Dai T,Dai Y,Murata Y,Husni RE,Nakano N,Sakashita S,Noguchi M

    更新日期:2018-04-01 00:00:00

  • Malignant myoepithelioma (myoepithelial carcinoma) of soft tissue.

    abstract::Malignant myoepithelioma of soft tissue is extremely rare. Presented herein is a case arising in a 17-year-old man. The tumor was initially noticed as a painless deep soft-tissue mass in the right forearm when the patient was aged 3 years. Thereafter, it grew without remarkable symptoms, such as pain or tenderness, un...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Harada O,Ota H,Nakayama J

    更新日期:2005-08-01 00:00:00

  • Macrofollicular variant of papillary thyroid carcinoma.

    abstract::A rare case of a macrofollicular variant of papillary thyroid carcinoma occurring in an 18-year-old male is described. The extirpated tumor, 5.5 x 5.5 x 3.5 cm in size, was well demarcated and multinodular, and histopathologically showed a predominantly macrofollicular structure reminiscent of adenomatous goiter or ma...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Nakamura T,Moriyama S,Nariya S,Sano K,Shirota H,Kato R

    更新日期:1998-06-01 00:00:00

  • Human papillomavirus infection in Egyptian esophageal carcinoma: correlation with p53, p21, mdm2, C-erbB2 and impact on survival.

    abstract::The etiological role of human papillomavirus (HPV) in esophageal carcinoma (EC) in relation to p53, mdm2, p21(waf), c-erbB2 and the overall survival (OS) rate was investigated. Tumor and normal tissues from 50 EC were evaluated by polymerase chain reaction and InnoLiPA for HPV. Single strand conformation polymorphism/...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Bahnassy AA,Zekri AR,Abdallah S,El-Shehaby AM,Sherif GM

    更新日期:2005-02-01 00:00:00

  • Nestin is a wide-spectrum abluminal cell marker of salivary gland tumors.

    abstract::Nestin is an intermediate filament that was first identified in neural progenitor cells. It is expressed in various cell types in the nervous system as well as in other systems. In the present study, we investigated nestin expression in non-neoplastic salivary gland tissue and in salivary gland tumors. In non-neoplast...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Yanai H,Sato Y,Nagatsuka H,Yoshino T

    更新日期:2013-10-01 00:00:00

  • Autopsy case of desminopathy involving skeletal and cardiac muscle.

    abstract::Desminopathy is a familial or sporadic skeletal and cardiac muscular dystrophy caused by mutation in the desmin gene. Desmin-reactive deposits in the affected muscles are the morphological hallmarks of this disease. Herein is reported an autopsy case of a 57-year-old Japanese man with adult-onset skeletal muscle weakn...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Yuri T,Miki K,Tsukamoto R,Shinde A,Kusaka H,Tsubura A

    更新日期:2007-01-01 00:00:00

  • Sparganum mansoni parasitic infection in the lung showing a nodule.

    abstract::Reported herein is a 57-year-old man infected by Sparganum mansoni, a kind of tapeworm, showing a solitary nodule of the middle lobe of the right lung. Because a transbronchial biopsy could not diagnose the nodule, a right middle lobectomy was performed on suspicion of malignant tumor. The lesion was diagnosed as spar...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Iwatani K,Kubota I,Hirotsu Y,Wakimoto J,Yoshioka M,Mori T,Ito T,Nomori H

    更新日期:2006-11-01 00:00:00

  • Immunohistochemical expression of gonadotropin releasing hormone receptor in human breast carcinoma.

    abstract::Gonadotropin releasing hormone (GnRH) analogs can cause regression of hormone-dependent breast carcinomas via the specific GnRH receptor (GnRH-R). In an attempt to obtain a better understanding of GnRH actions in human breast carcinoma, the expression of GnRH-R was examined immunohistochemically in 58 invasive ductal ...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Moriya T,Suzuki T,Pilichowska M,Ariga N,Kimura N,Ouchi N,Nagura H,Sasano H

    更新日期:2001-05-01 00:00:00

  • Expression of transforming acidic coiled-coil containing protein 3 is a novel independent prognostic marker in non-small cell lung cancer.

    abstract::Transforming acidic coiled-coil containing protein 3 (TACC3) is known to be involved in the control of normal cell growth and differentiation and in mechanisms of unregulated growth leading to tumorigenesis. The aim of the present paper was to determine the rate of TACC3 expression in a non-small cell lung cancer (NSC...

    journal_title:Pathology international

    pub_type: 杂志文章


    authors: Jung CK,Jung JH,Park GS,Lee A,Kang CS,Lee KY

    更新日期:2006-09-01 00:00:00