Abstract:
:Immunodeficient mice are widely used for xenografts of human cells and tissue. The purpose of the present study was to investigate the characteristics of xenograft human tumor models using engraftment of various non-hematopoietic tumors in the NOD/SCID/gamma(c) (null) mouse. For tumor models, human solid tumor tissues were serially passaged three or more times to establish tissue lines. A total of 326 fresh tumor specimens, mainly gastrointestinal and female genital tissue, were engrafted with 54 established tissue lines. The types of tissue lines varied and included tumor tissue of both epithelial and mesenchymal origin. In some cases the original surgical specimen was replaced with large mononuclear cells. In the established tumor tissue lines, differentiation and tumor structure were similar to that of the original surgical specimen. The interstitium of the xenograft tissue in the tissue lines was relatively well preserved although slightly decreased and replaced by host tissue. These results indicate that human solid tumors can be successfully engrafted into the NOD/SCID/gamma(c) (null) mouse and that tissue lines with the characteristics of the original tumors can be established. Investigators in the field of tumor research will benefit from the availability of tissue lines that allow the establishment of more relevant in vivo human tissue models.
journal_name
Pathol Intjournal_title
Pathology internationalauthors
Fujii E,Suzuki M,Matsubara K,Watanabe M,Chen YJ,Adachi K,Ohnishi Y,Tanigawa M,Tsuchiya M,Tamaoki Ndoi
10.1111/j.1440-1827.2008.02271.xsubject
Has Abstractpub_date
2008-09-01 00:00:00pages
559-67issue
9eissn
1320-5463issn
1440-1827pii
PIN2271journal_volume
58pub_type
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