Long-term observation of glomerulonephritis induced by multiple injections with anti-Thy-1 antibody in rats.

Abstract:

:Multiple injections with a mouse monoclonal anti-rat Thy-1 antibody (five times, at weekly intervals) induced marked glomerular sclerotic lesions which are characterized by adhesion of glomerular capillaries to Bowman's capsule and persistent proteinuria in rats. Abnormal production of type I collagen and increased accumulation of type IV collagen and fibronectin were observed in these glomeruli. The glomerular expression of mRNA for these matrix components and transforming growth factor-beta1 (TGF-beta1) were markedly increased at 4 days after the last injections with anti-Thy-1 antibody, but decreased to below the levels of control rats at 5 weeks. This may be down-regulation of mRNA in mesangial cells. The glomerular sclerotic lesions were not progressive but the process of glomerular healing seemed to be retarded. The proteinuria and the glomerular adhesion were irreversible.

journal_name

Pathol Int

journal_title

Pathology international

authors

Yagi M,Yamamoto T,Kato S,Nagano N,Kihara I

doi

10.1111/j.1440-1827.1998.tb03939.x

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

491-8

issue

7

eissn

1320-5463

issn

1440-1827

journal_volume

48

pub_type

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