Abstract:
:Multiple injections with a mouse monoclonal anti-rat Thy-1 antibody (five times, at weekly intervals) induced marked glomerular sclerotic lesions which are characterized by adhesion of glomerular capillaries to Bowman's capsule and persistent proteinuria in rats. Abnormal production of type I collagen and increased accumulation of type IV collagen and fibronectin were observed in these glomeruli. The glomerular expression of mRNA for these matrix components and transforming growth factor-beta1 (TGF-beta1) were markedly increased at 4 days after the last injections with anti-Thy-1 antibody, but decreased to below the levels of control rats at 5 weeks. This may be down-regulation of mRNA in mesangial cells. The glomerular sclerotic lesions were not progressive but the process of glomerular healing seemed to be retarded. The proteinuria and the glomerular adhesion were irreversible.
journal_name
Pathol Intjournal_title
Pathology internationalauthors
Yagi M,Yamamoto T,Kato S,Nagano N,Kihara Idoi
10.1111/j.1440-1827.1998.tb03939.xsubject
Has Abstractpub_date
1998-07-01 00:00:00pages
491-8issue
7eissn
1320-5463issn
1440-1827journal_volume
48pub_type
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journal_title:Pathology international
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