Abstract:
:An autopsy case of malignant mesothelioma with asbestosis caused by asbestos exposure for 17 years is reported. Autopsy revealed that mesothelioma spread extensively in all serosal tissues including pleura, pericardium, diaphragm, peritoneum and tunica vaginalis testis. Histopathologically, most of the tumor showed an epithelial form, but sarcomatous and microcystic patterns were also observed. The tumor cells had abundant glycogen and hyaluronic acid and, immunohistochemically, they were positive for cytokeratin, vimentin and epithelial membrane antigen (EMA). Long, slender microvilli were characteristically observed in these tumor cells. All of these data were compatible with malignant mesothelioma. Procollagen type I (procol.l) immunostaining was performed to reveal the mesenchymal character of mesothelioma. Both epithelial-type cells and sarcomatous-type cells showed positive staining for procol.l, although the latter showed stronger immunoreactivity. Immunostaining for procol.l was found to be one of the useful tools for distinguishing mesothelioma from adenocarcinoma. Using an extraction method for asbestos fibers, asbestos bodies were found in many tissues including lymph nodes, liver, small intestine, spleen, kidney, testis and pleura, in addition to lung parenchyma. Although multiple tumor metastases from an undetermined primary site is not ruled out, 'multifocal tumorigenesis' is suspected from the widespread deposit of asbestos fibers.
journal_name
Pathol Intjournal_title
Pathology internationalauthors
Watanabe M,Kimura N,Kato M,Iwami D,Takahashi M,Nagura Hdoi
10.1111/j.1440-1827.1994.tb02927.xsubject
Has Abstractpub_date
1994-10-01 00:00:00pages
785-92issue
10-11eissn
1320-5463issn
1440-1827journal_volume
44pub_type
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journal_title:Pathology international
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journal_title:Pathology international
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journal_title:Pathology international
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journal_title:Pathology international
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journal_title:Pathology international
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pub_type: 杂志文章
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journal_title:Pathology international
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journal_title:Pathology international
pub_type: 杂志文章,评审
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更新日期:1994-07-01 00:00:00