Abstract:
:Collagenous fibroma (desmoplastic fibroblastoma) is a distinctive benign fibrous soft tissue tumor that typically occurs in the subcutaneous tissue or skeletal muscle in adults. We describe a case of collagenous fibroma in a 7-year-old boy who presented with a 1-cm solitary, firm nodule on the volar aspect of the metacarpophalangeal joint of the left little finger. Microscopically, the tumor was composed of spindle- and stellate-shaped cells embedded in a hypovascular, densely collagenous stroma. No mitotic figures, calcifications or necrosis were identified. Immunohistochemically, tumor cells were diffusely positive for vimentin, but negative for smooth muscle actin, muscle-specific actin, desmin, cytokeratin, S-100 protein or CD34. To our knowledge, this is the second reported case of collagenous fibroma in children. Our case report indicates that the clinicopathological features of collagenous fibroma in childhood are similar to those in adults.
journal_name
Pathol Intjournal_title
Pathology internationalauthors
Nishio J,Iwasaki H,Nishijima T,Kikuchi Mdoi
10.1046/j.1440-1827.2002.01351.xsubject
Has Abstractpub_date
2002-04-01 00:00:00pages
322-5issue
4eissn
1320-5463issn
1440-1827pii
1351journal_volume
52pub_type
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