Abstract:
:Elderly patients with Epstein-Barr virus (EBV) infection are at increased risk for developing B-cell lymphoproliferative disorder (B-LPD) due to immunosenescence. Here, we describe a case of a 75-year-old man who developed an EBV-positive (EBV+) mucocutaneous ulcer (EBVMCU) in the gingiva with spontaneous regression. Eighteen months after regression, he had a cervical lymph node enlargement that was diagnosed as EBV+ nodal polymorphous B-LPD, Ann Arbor stage IA. Clinicians decided to observe his clinical course without any treatment. Fourteen months later, the patient developed EBV-positive diffuse large B-cell lymphoma (DLBCL), Ann Arbor stage IIA, and received six courses of age-adjusted dose chemotherapy and achieved a complete remission. No evidence of a clonal relationship was found among these three lesions by standard polymerase chain reaction (PCR) analysis for immunoglobulin heavy chain. However, they all had expression of PD-L1 in the EBV+ large B-cells and Hodgkin Reed-Sternberg-like cells. This is the first case report of a PD-L1-positive (PD-L1+) EBVMCU and the development of multiple EBV-driven B-LPDs in the setting of immunosenescence within a 32-month period.
journal_name
Pathol Intjournal_title
Pathology internationalauthors
Daroontum T,Kohno K,Inaguma Y,Okamoto A,Okamoto M,Kimura Y,Nagahama M,Sakakibara A,Satou A,Nakamura Sdoi
10.1111/pin.12738subject
Has Abstractpub_date
2019-01-01 00:00:00pages
37-41issue
1eissn
1320-5463issn
1440-1827journal_volume
69pub_type
杂志文章abstract::In pulmonary fibrosis, it is known that fibrotic changes develop in the intra-alveolar spaces and that intra-alveolar fibrosis can be classified into three patterns, namely intra-alveolar buds, mural incorporation and obliterative changes. In order to clarify the evolution of intra-alveolar fibrosis, immunohistochemic...
journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1995.tb03503.x
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journal_title:Pathology international
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journal_title:Pathology international
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journal_title:Pathology international
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journal_title:Pathology international
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journal_title:Pathology international
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:1999-07-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章,评审
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更新日期:2002-01-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.2005.01868.x
更新日期:2005-09-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/pin.12312
更新日期:2015-08-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1998.tb03939.x
更新日期:1998-07-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.2005.01815.x
更新日期:2005-04-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2000.01021.x
更新日期:2000-03-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1998.tb03960.x
更新日期:1998-08-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2008-10-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
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journal_title:Pathology international
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更新日期:2012-12-01 00:00:00
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journal_title:Pathology international
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更新日期:2000-09-01 00:00:00
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journal_title:Pathology international
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:1996-05-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:1997-07-01 00:00:00
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journal_title:Pathology international
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