Abstract:
:For the detection of chromosome translocations/chimeric genes and specific genetic abnormalities in soft tissue tumors, we conducted fluorescence in situ hybridization (FISH) analysis on 280 cases of soft tissue and other tumors using formalin-fixed paraffin-embedded tissue sections. The detection rate of the FISH split-signal was 84% (129/154 cases) for the translocation-associated soft tissue tumors, such as Ewing's sarcoma/primitive neuroectodermal tumor, synovial sarcoma, alveolar rhabdomyosarcoma, myxoid liposarcoma, clear cell sarcoma and so forth. Positive split-signals from EWSR1, SS18 and FOXO1A probes were detected in 3% (2/64) of various histological types of carcinoma, lymphoma, melanoma, meningioma and soft tissue tumors. In FISH using the INI1/CEP22 probe, the INI1 deletion signal was detected in 100% (9/9) of epithelioid sarcoma. In well-differentiated and dedifferentiated liposarcomas, detection of MDM2 amplification signals in FISH using the MDM2/CEP12 probe were both as high as 85% (11/13) and 100% (13/13), respectively. In other adipocytic and non-adipocytic tumors requiring differentiation from these types, detection was only 13% (5/39), and CEP12 polysomy was frequently detected. As these results demonstrate the high sensitivity and specificity of FISH, we concluded FISH to be a useful pathological diagnostic adjunct for definite and differential diagnosis of soft tissue tumors.
journal_name
Pathol Intjournal_title
Pathology internationalauthors
Miura Y,Keira Y,Ogino J,Nakanishi K,Noguchi H,Inoue T,Hasegawa Tdoi
10.1111/j.1440-1827.2011.02739.xsubject
Has Abstractpub_date
2012-01-01 00:00:00pages
16-27issue
1eissn
1320-5463issn
1440-1827journal_volume
62pub_type
杂志文章abstract::Histiocytic necrotizing lymphadenitis is rare outside Japan, including Brazil, despite the many Japanese immigrants and descendants who live there. The authors describe the case of a 32 year old white female, who presented with cervical lymph node enlargement and severe anemia. Histological findings of the lymph node ...
journal_title:Pathology international
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1827.1994.tb02606.x
更新日期:1994-07-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1997.tb04440.x
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2002-11-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2000.01021.x
更新日期:2000-03-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1994.tb01724.x
更新日期:1994-08-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1997.tb04459.x
更新日期:1997-11-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.2003.01478.x
更新日期:2003-05-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2004-02-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章,评审
doi:10.1111/pin.12394
更新日期:2016-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1440-1827.2007.02111.x
更新日期:2007-06-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1995.tb03420.x
更新日期:1995-12-01 00:00:00
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journal_title:Pathology international
pub_type:
doi:10.1111/pin.12945
更新日期:2020-08-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1111/j.1440-1827.1995.tb03443.x
更新日期:1995-03-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
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journal_title:Pathology international
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journal_title:Pathology international
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更新日期:1994-01-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2000-05-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
doi:10.1046/j.1440-1827.1999.00927.x
更新日期:1999-08-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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journal_title:Pathology international
pub_type: 杂志文章,评审
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更新日期:2010-07-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章,多中心研究,评审
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更新日期:1995-06-01 00:00:00
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journal_title:Pathology international
pub_type: 杂志文章
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更新日期:2006-03-01 00:00:00