Numerous eosinophilic globules (skeinoid fibers) in a duodenal stromal tumor: an exceptional case showing smooth muscle differentiation.

Abstract:

:A unique case of duodenal stromal tumor in a 51-year-old man is reported. The tumor histologically showed spindle cell proliferation and numerous eosinophilic globules. Most globules were composed of tangled 45 nm thick fibrils, which were ultrastructurally identical to 'skeinoid fibers'. The presence of glycogen granules in the tumor cells and the immunoreactivity for alpha-smooth muscle actin suggested smooth muscle differentiation. Focal ultrastructural findings also supported the smooth muscle nature of this tumor. There were no immunohistochemical and ultrastructural features indicating neural differentiation. In previous studies, the presence of such 'skeinoid fibers' was suggested to be a histological marker for neural differentiation in gastrointestinal stromal tumor. However, the findings in the present case suggest that numerous 'skeinoid fibers' can be identified in duodenal stromal tumor with smooth muscle differentiation, although this condition may be rare.

journal_name

Pathol Int

journal_title

Pathology international

authors

Matsukuma S,Doi M,Suzuki M,Ikegawa K,Sato K,Kuwabara N

doi

10.1111/j.1440-1827.1997.tb04459.x

subject

Has Abstract

pub_date

1997-11-01 00:00:00

pages

789-93

issue

11

eissn

1320-5463

issn

1440-1827

journal_volume

47

pub_type

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