Abstract:
:A unique case of duodenal stromal tumor in a 51-year-old man is reported. The tumor histologically showed spindle cell proliferation and numerous eosinophilic globules. Most globules were composed of tangled 45 nm thick fibrils, which were ultrastructurally identical to 'skeinoid fibers'. The presence of glycogen granules in the tumor cells and the immunoreactivity for alpha-smooth muscle actin suggested smooth muscle differentiation. Focal ultrastructural findings also supported the smooth muscle nature of this tumor. There were no immunohistochemical and ultrastructural features indicating neural differentiation. In previous studies, the presence of such 'skeinoid fibers' was suggested to be a histological marker for neural differentiation in gastrointestinal stromal tumor. However, the findings in the present case suggest that numerous 'skeinoid fibers' can be identified in duodenal stromal tumor with smooth muscle differentiation, although this condition may be rare.
journal_name
Pathol Intjournal_title
Pathology internationalauthors
Matsukuma S,Doi M,Suzuki M,Ikegawa K,Sato K,Kuwabara Ndoi
10.1111/j.1440-1827.1997.tb04459.xsubject
Has Abstractpub_date
1997-11-01 00:00:00pages
789-93issue
11eissn
1320-5463issn
1440-1827journal_volume
47pub_type
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