Assessment of hepatic fibrosis by transient elastography in patients with chronic hepatitis B.

Abstract:

:Hepatic ultrasonic transient elastography (FibroScan) is a new diagnostic method for the assessment of hepatic fibrosis. There are limited data available on its use as a follow-up tool for patients with chronic hepatitis B. In this study, 134 patients were enrolled. Hepatic fibrosis was evaluated by liver stiffness measurement and biopsy. The biopsy criteria of the Chinese Program of Prevention and Cure for Viral Hepatitis, Metavir classification, and the modified Chevalier's semiquantitative system were used for histological assessment. The liver stiffness value was correlated with fibrosis stage (r = 0.565, P < 0.001) and fibrosis semiquantitative score (r = 0.727, P < 0.001). The liver stiffness value of G2 was significantly higher than that of G1 within the same fibrosis stage for S1, S3, and S4, respectively. Three patients were graded as G1S1, and had moderate steatosis without distinct fibrosis in the portal area and lobule, while their liver stiffness values were higher than 6.2 kPa. Although belonging to the same fibrosis stage, for thinner thicknesses of the fibrous septa, the liver stiffness value and semiquantitative score were correspondingly lower. Liver stiffness values had a good correlation with hepatic collagen content. However, inflammatory activity and steatosis can influence liver stiffness values to some extent. Transient elastography may be useful as an ideal non-invasive post-treatment follow-up tool.

journal_name

Pathol Int

journal_title

Pathology international

authors

Zhang YG,Wang BE,Wang TL,Ou XJ

doi

10.1111/j.1440-1827.2010.02515.x

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

284-90

issue

4

eissn

1320-5463

issn

1440-1827

pii

PIN2515

journal_volume

60

pub_type

杂志文章
  • Biphasic intra-abdominal desmoplastic small cell tumor in a patient with proximal spinal muscular atrophy.

    abstract::A case is reported of intra-abdominal desmoplastic small cell tumor (IDSCT) with biphasic histologic features in a patient with proximal spinal muscular atrophy. The tumor was composed of small epithelial cell nests with spindle cell sarcomatous areas. Both areas were surrounded by a desmoplastic stroma. Immunohistoch...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1996.tb03533.x

    authors: Motoyama T,Maejima T,Aizawa K,Fukuda T,Watanabe H

    更新日期:1996-01-01 00:00:00

  • A case of small cell carcinoma arising in a mature cystic teratoma of the ovary.

    abstract::Malignant transformation of ovarian mature cystic teratomas is reported to occur in about 1% of cases. The most common malignant evolution is that of squamous cell carcinoma and one of the least common is that of small cell carcinoma. We report a case of distant metastasis from a small cell carcinoma arising in a matu...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1998.tb03846.x

    authors: Lim SC,Choi SJ,Suh CH

    更新日期:1998-10-01 00:00:00

  • Mixed epithelial and stromal tumor of the kidney in a 12-year-old girl.

    abstract::Mixed epithelial and stromal tumor of the kidney (MESTK) is a rare kidney neoplasm that almost exclusively occurs in perimenopausal women, and long-term estrogen replacement is relevant to its pathogenesis. Herein is described an atypical case of MESTK uncovered in a 12-year-old premenarcheal girl without a history of...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2005.01888.x

    authors: Hara N,Kawaguchi M,Murayama S,Maruyama R,Tanikawa T,Takahashi K

    更新日期:2005-10-01 00:00:00

  • Novel function of histamine signaling via histamine receptors in cholesterol and bile acid metabolism: Histamine H2 receptor protects against nonalcoholic fatty liver disease.

    abstract::We have reported that the function of histamine and its receptors (HRs) has a close relationship with the development of nonalcoholic fatty liver disease (NAFLD). However, much less is known regarding its pathogenic and molecular mechanism(s), including the early stage of hepatic and intestinal function for lipid and ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12423

    authors: Yamada S,Guo X,Wang KY,Tanimoto A,Sasaguri Y

    更新日期:2016-07-01 00:00:00

  • Molecular pathogenesis of human amyloidosis: Lessons from β2 -microglobulin-related amyloidosis.

    abstract::Amyloidosis refers to a group of diseases with amyloid fibrils deposited in various organs and is classified into more than 30 diseases in humans based on the kind of amyloid protein. In order to elucidate the molecular pathogenesis of human amyloidosis, we studied the molecular mechanism of amyloid fibril formation i...

    journal_title:Pathology international

    pub_type: 杂志文章,评审

    doi:10.1111/pin.12394

    authors: Naiki H,Okoshi T,Ozawa D,Yamaguchi I,Hasegawa K

    更新日期:2016-04-01 00:00:00

  • Microwave cell death: molecular analysis using DNA electrophoresis, PCR amplification and TUNEL.

    abstract::Microwave cell death (MCD) is unique in that microscopic morphology and antigenicity are well preserved, while enzymatic activity is lost. The aim of the present study was to carry out DNA electrophoresis, polymerase chain reaction (PCR) amplification and terminal deoxynucleotidyl transferase-mediated dUTP nick end-la...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2009.02368.x

    authors: Mori I,Ozaki T,Tabuse K,Utsunomiya H,Taniguchi E,Kakudo K

    更新日期:2009-05-01 00:00:00

  • Hepatocellular carcinoma with osteoclast-like giant cells: possibility of osteoclastogenesis by hepatocyte-derived cells.

    abstract::Giant cell tumor (GCT) of bone is a primary osteolytic tumor that is characterized by the formation of osteoclast-like giant cells. In addition to GCT of bone, extraskeletal GCT are known to be formed in several soft tissues. Giant cells in GCT of bone were suggested to be identical to osteoclasts, but the characteriz...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2003.01503.x

    authors: Ikeda T,Seki S,Maki M,Noguchi N,Kawamura T,Arii S,Igari T,Koike M,Hirokawa K

    更新日期:2003-07-01 00:00:00

  • Suppressive effects of sairei-to on monoclonal antibody 1-22-3-induced glomerulonephritis: analysis of effective components.

    abstract::The effects of traditional Chinese medicine (Sairei-to) on experimental glomerulonephritis induced in rats by monoclonal antibody (mAb) 1-22-3 injection was examined. The level of proteinuria in the Sairei-to-treated group was significantly lower than that in the PBS treated group. This suppressive effect was caused b...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1997.tb04520.x

    authors: Li P,Kawachi H,Morioka T,Orikasa M,Oite T,Shi ZS,Shimizu F

    更新日期:1997-07-01 00:00:00

  • Gene mutation analysis and immunohistochemical study of beta-catenin in odontogenic tumors.

    abstract::In the present study the significance of nuclear/cytoplasmic expression of beta-catenin (CTNNB1) and mutation of the CTNNB1 gene (CTNNB1) in odontogenic tumors was examined. Six ameloblastomas (five follicular ameloblastomas and one plexiform ameloblastoma) and three malignant odontogenic tumors (one metastasizing ame...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2006.02039.x

    authors: Miyake T,Tanaka Y,Kato K,Tanaka M,Sato Y,Ijiri R,Inayama Y,Ito Y,Aoki S,Kawabe R,Tohnai I

    更新日期:2006-12-01 00:00:00

  • Histiocytic necrotizing lymphadenitis in Brazil: report of a case and review of the literature.

    abstract::Histiocytic necrotizing lymphadenitis is rare outside Japan, including Brazil, despite the many Japanese immigrants and descendants who live there. The authors describe the case of a 32 year old white female, who presented with cervical lymph node enlargement and severe anemia. Histological findings of the lymph node ...

    journal_title:Pathology international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1827.1994.tb02606.x

    authors: Lorand-Metze I,Vassallo J,Mori S

    更新日期:1994-07-01 00:00:00

  • Ovarian nongestational choriocarcinoma and associated adenocarcinoma with the same germ cell origin determined by a molecular genetic approach: A case report.

    abstract::Ovarian non-gestational choriocarcinomas co-existing with adenocarcinoma are extremely rare and have been reported as epithelial ovarian carcinomas of a "non-germ cell origin" with "choriocarcinomatous differentiation". Although the cellular origin of non-gestational choriocarcinoma may be post-meiotic ovarian germ ce...

    journal_title:Pathology international

    pub_type:

    doi:10.1111/pin.12445

    authors: Koyanagi T,Fujiwara H,Usui H,Ariga H,Machida S,Takei Y,Saga Y,Shozu M,Fukushima N,Niki T,Matsubara S,Suzuki M

    更新日期:2016-09-01 00:00:00

  • Metastatic pineocytoma of the spinal cord after long-term dormancy.

    abstract::An unusual tumor in the spinal cord of a 57 year old man is reported. At the age of 42 years, the patient had had a pineal region tumor that subsequently disappeared completely after local radiation therapy only. Eleven and 15 years later, at the ages of 53 and 57 years, respectively, solitary spinal cord tumors were ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1994.tb01685.x

    authors: Ito T,Takahashi H,Ikuta F,Sato H

    更新日期:1994-12-01 00:00:00

  • Establishment and characterization of a novel dedifferentiated liposarcoma cell line, NDDLS-1.

    abstract::We established a dedifferentiated liposarcoma cell line (NDDLS-1) that produces interleukin-6 (IL-6) and granulocyte-colony stimulating factor (G-CSF). The parental tumor showed high leukemoid reactions. The NDDLS-1 cell line was established from a pleural effusion associated with a lung metastasis. Pleomorphic tumor ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2011.02683.x

    authors: Ariizumi T,Ogose A,Kawashima H,Hotta T,Li G,Xu Y,Hirose T,Endo N

    更新日期:2011-08-01 00:00:00

  • Sparganum mansoni parasitic infection in the lung showing a nodule.

    abstract::Reported herein is a 57-year-old man infected by Sparganum mansoni, a kind of tapeworm, showing a solitary nodule of the middle lobe of the right lung. Because a transbronchial biopsy could not diagnose the nodule, a right middle lobectomy was performed on suspicion of malignant tumor. The lesion was diagnosed as spar...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2006.02028.x

    authors: Iwatani K,Kubota I,Hirotsu Y,Wakimoto J,Yoshioka M,Mori T,Ito T,Nomori H

    更新日期:2006-11-01 00:00:00

  • Autopsy case of desminopathy involving skeletal and cardiac muscle.

    abstract::Desminopathy is a familial or sporadic skeletal and cardiac muscular dystrophy caused by mutation in the desmin gene. Desmin-reactive deposits in the affected muscles are the morphological hallmarks of this disease. Herein is reported an autopsy case of a 57-year-old Japanese man with adult-onset skeletal muscle weakn...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2007.02053.x

    authors: Yuri T,Miki K,Tsukamoto R,Shinde A,Kusaka H,Tsubura A

    更新日期:2007-01-01 00:00:00

  • Epithelioid angiomyolipoma of the kidney.

    abstract::Epithelioid angiomyolipoma (eAMLoma) is an uncommon renal mesenchymal tumor with malignant potential and is frequently associated with tuberous sclerosis (TSC). It is composed of polygonal large-sized tumor cells arranged in an epithelioid manner. Differential diagnosis from renal cell carcinoma (RCC) is often challen...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2008.02322.x

    authors: Kato I,Inayama Y,Yamanaka S,Ohshiro H,Gomi K,Shirai S,Aoki I,Uemura H,Miyoshi Y,Kubota Y,Yao M,Nagashima Y

    更新日期:2009-01-01 00:00:00

  • Anitschkow cells in the human heart.

    abstract::A case of multiple myeloma, who died of congestive heart failure of unknown cause, is presented. Microscopically, Anitschkow cells with caterpillar and owl-eyed nuclei were scattered in the interstitium of the myocardium. To know the pathological significance of their appearance, histological observations of normal, d...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.1999.00827.x

    authors: Satoh F,Tsutsumi Y

    更新日期:1999-01-01 00:00:00

  • The prognostic significance of N-myc downregulated gene 1 in lung adenocarcinoma.

    abstract::It has been reported that N-myc downstream regulated gene 1 (NDRG1) is related to the prognosis of non-small cell lung cancer (NSCLC), and associated with c-Myc degradation in NSCLC cell lines. However, the relationship of NDRG1 to prognosis or c-Myc expression in lung adenocarcinoma has not been well clarified. The p...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12644

    authors: Dai T,Dai Y,Murata Y,Husni RE,Nakano N,Sakashita S,Noguchi M

    更新日期:2018-04-01 00:00:00

  • Angiomyofibroblastoma of the vulva: case report.

    abstract::Angiomyxomas are a group of relatively rare mesenchymal myxoid tumors. Three types of angiomyxomas have been identified: superficial angiomyxoma, aggressive angiomyxoma and angiomyofibroblastoma. These tumors have a predilection for occurring in the perineum of middle-aged females and are often clinically diagnosed as...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1998.tb03867.x

    authors: Ustun C,Malazgirt Z,Kandemir B,Kocak I,Bolat I,Gumus S

    更新日期:1998-12-01 00:00:00

  • An autopsy case of malignant mesothelioma associated with asbestosis.

    abstract::An autopsy case of malignant mesothelioma with asbestosis caused by asbestos exposure for 17 years is reported. Autopsy revealed that mesothelioma spread extensively in all serosal tissues including pleura, pericardium, diaphragm, peritoneum and tunica vaginalis testis. Histopathologically, most of the tumor showed an...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1994.tb02927.x

    authors: Watanabe M,Kimura N,Kato M,Iwami D,Takahashi M,Nagura H

    更新日期:1994-10-01 00:00:00

  • A case of anaplastic lymphoma kinase-positive renal cell carcinoma coincident with Hodgkin lymphoma.

    abstract::We report a case of ALK-positive renal cell carcinoma coincident with Hodgkin lymphoma. The patient was a 19 year-old-girl without sickle cell trait. The right renal tumor was discovered concomitantly with Hodgkin lymphoma (HL). After chemotherapy for HL, right nephrectomy was performed. Microscopically, the tumor sho...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12592

    authors: Oyama Y,Nishida H,Kusaba T,Kadowaki H,Arakane M,Daa T,Watanabe D,Akita Y,Sato F,Mimata H,Yokoyama S

    更新日期:2017-12-01 00:00:00

  • Collagenous fibroma (desmoplastic fibroblastoma) of the finger in a child.

    abstract::Collagenous fibroma (desmoplastic fibroblastoma) is a distinctive benign fibrous soft tissue tumor that typically occurs in the subcutaneous tissue or skeletal muscle in adults. We describe a case of collagenous fibroma in a 7-year-old boy who presented with a 1-cm solitary, firm nodule on the volar aspect of the meta...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2002.01351.x

    authors: Nishio J,Iwasaki H,Nishijima T,Kikuchi M

    更新日期:2002-04-01 00:00:00

  • Immunoelectron microscopic localization of carcinoembryonic antigen in gastric adenocarcinoma cell lines.

    abstract::The distribution of carcinoembryonic antigen (CEA) in human gastric adenocarcinoma cell lines (HPE-GAC-3 cells and HPE-GAC-2 cells) was determined immunohistochemically by indirect peroxidase-labeled antibody method at the light and electron microscopic levels. In GAC-3 cells that proliferated as non-adherent single c...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1994.tb01724.x

    authors: Ohiwa K,Harada T,Morikawa S,Nakamura T

    更新日期:1994-08-01 00:00:00

  • Guidance for diagnosing autoimmune pancreatitis with biopsy tissues.

    abstract::The biopsy-based diagnosis of autoimmune pancreatitis (AIP) is difficult but is becoming imperative for pathologists due to the increased amount of endoscopic ultrasound-guided biopsy tissue. To cope with this challenge, we propose guidance for the biopsy diagnosis of type 1 AIP. This guidance is for pathologists and ...

    journal_title:Pathology international

    pub_type: 杂志文章,评审

    doi:10.1111/pin.12994

    authors: Notohara K,Kamisawa T,Fukushima N,Furukawa T,Tajiri T,Yamaguchi H,Aishima S,Fukumura Y,Hirabayashi K,Iwasaki E,Kanno A,Kasashima S,Kawashima A,Kojima M,Kubota K,Kuraishi Y,Mitsuhashi T,Naito Y,Naitoh I,Nakase H,Ni

    更新日期:2020-10-01 00:00:00

  • Histopathological analysis of aggressive renal cell carcinoma harboring a unique germline mutation in fumarate hydratase.

    abstract::Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare genetic disorder characterized by cutaneous and uterine leiomyomatosis with RCC. This disorder is caused by a germline mutation in the fumarate hydratase (FH) gene, which encodes an important enzyme of the tricarboxylic acid (TCA) cycle. This mutation d...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/pin.12684

    authors: Matsumoto K,Udaka N,Hasumi H,Nakaigawa N,Nagashima Y,Tanaka R,Kato I,Yao M,Furuya M

    更新日期:2018-05-24 00:00:00

  • Malignant myoepithelioma (myoepithelial carcinoma) of soft tissue.

    abstract::Malignant myoepithelioma of soft tissue is extremely rare. Presented herein is a case arising in a 17-year-old man. The tumor was initially noticed as a painless deep soft-tissue mass in the right forearm when the patient was aged 3 years. Thereafter, it grew without remarkable symptoms, such as pain or tenderness, un...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2005.01861.x

    authors: Harada O,Ota H,Nakayama J

    更新日期:2005-08-01 00:00:00

  • Case of postradiation osteosarcoma with a short latency period of 3 years.

    abstract::Osteosarcoma is one of the neoplasms that may occur following exposure to radiation. A case of osteosarcoma arising in the craniofacial bone with a short latency period of 3 years after radiotherapy for maxillary squamous cell carcinoma is described. A 64-year-old-man underwent right partial maxillectomy and chemoradi...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.2003.01427.x

    authors: Matsuyama A,Yonemitsu N,Hayashida S,Watanabe K,Sugihara H,Inokuchi A

    更新日期:2003-01-01 00:00:00

  • Flow cytometric evaluation of nuclear DNA content in hepatoblastoma: further evidence for the inhomogeneity of the different subtypes.

    abstract::The DNA ploidy pattern of nine hepatoblastomas and three normal liver specimens was investigated by flow cytometry. Areas of unlike differentiation in the same tumor were investigated separately. Normal liver tissue and the fetal subtype were always diploid. Aneuploidy was found in the embryonal subtype. The one case ...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.1995.tb03492.x

    authors: Kröber S,Ruck P,Xiao JC,Kaiserling E

    更新日期:1995-07-01 00:00:00

  • Phenotype for activated tissue macrophages in histiocytic necrotizing lymphadenitis.

    abstract::Macrophage polarization is divided into M1 and M2 type based on membrane receptors, cytokines, and chemokines. M1 expresses CD80, interleukin (IL)-6, IL-12, and chemokine receptor (CCR)7, while M2 expresses CD163, IL10, and chemokine ligand (CCL)22. The aim of the present study was to identify the properties of infilt...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1111/j.1440-1827.2009.02418.x

    authors: Nomura Y,Takeuchi M,Yoshida S,Sugita Y,Niino D,Kimura Y,Shimizu K,Aoki R,Suefuji N,Hirose S,Kikuchi M,Ohshima K

    更新日期:2009-09-01 00:00:00

  • An immunohistochemical and clinicopathological study of gastrointestinal stromal tumors.

    abstract::Immunohistochemical and clinicopathological features of 58 gastrointestinal stromal tumors (GIST) were studied. One occurred in the esophagus, 41 in the stomach, nine in the small intestine, and seven in the large intestine. By using indirect immunoperoxidase staining for Cajal cell markers (c-kit protein and CD34), s...

    journal_title:Pathology international

    pub_type: 杂志文章

    doi:10.1046/j.1440-1827.1999.00947.x

    authors: Tazawa K,Tsukada K,Makuuchi H,Tsutsumi Y

    更新日期:1999-09-01 00:00:00