Abstract:
:Osteosarcoma is one of the neoplasms that may occur following exposure to radiation. A case of osteosarcoma arising in the craniofacial bone with a short latency period of 3 years after radiotherapy for maxillary squamous cell carcinoma is described. A 64-year-old-man underwent right partial maxillectomy and chemoradiotherapy due to squamous cell carcinoma of his right maxillary sinus. Histologically, the tumor was composed of moderately differentiated squamous cell carcinoma with a component of spindle cell carcinoma. Three years later, osteosarcoma developed in the craniofacial bone within the irradiation field of the first tumor. Detailed histological examination demonstrated that there was no component of osteosarcoma in the first tumor or squamous cell carcinoma in the second tumor. Radiation-induced osteosarcoma usually occurs after a long latency period of more than 10 years after the radiotherapy. In this case, osteosarcoma was possibly a radiation-induced osteosarcoma with a short latency period of 3 years.
journal_name
Pathol Intjournal_title
Pathology internationalauthors
Matsuyama A,Yonemitsu N,Hayashida S,Watanabe K,Sugihara H,Inokuchi Adoi
10.1046/j.1440-1827.2003.01427.xsubject
Has Abstractpub_date
2003-01-01 00:00:00pages
46-50issue
1eissn
1320-5463issn
1440-1827pii
1427journal_volume
53pub_type
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