Abstract:
:Two cases of carcinosarcoma of the esophagus are reported. Both were polypoid tumors occurring in the middle of the intrathoracic esophagus. The tumors were predominantly composed of spindle-shaped sarcoma cells with some squamous cell carcinomas (SCC). One tumor showed many bizarre giant cells with filamentous materials in the cytoplasm. Microscopical examination of both tumors revealed transition from SCC to sarcoma cells. Immunohistochemically, the spindle-shaped sarcoma cells in both tumors displayed a strongly positive immunoreaction to alpha-smooth muscle actin, as did the bizarre giant cells of one tumor to sarcomeric actin. SCC and a few spindle-shaped sarcoma cells near the SCC showed a positive immunoreaction to cytokeratin. Electron microscopy revealed that the spindle-shaped cells had many myofilaments with dense bodies and that the bizarre giant cells had sarcomere structures with Z-bands in their cytoplasm. These findings indicate that both tumors were carcinosarcomas of SCC and myogenic sarcoma. We considered that sarcoma cells might originate in SCC, representing its metaplastic differentiation, or that both SCC and sarcoma might originate in a pluripotent stem cell.
journal_name
Pathol Intjournal_title
Pathology internationalauthors
Taniyama K,Sasaki N,Mukai T,Uemura N,Miyoshi N,Nakai H,Nakayama H,Tahara Edoi
10.1111/j.1440-1827.1995.tb03460.xsubject
Has Abstractpub_date
1995-04-01 00:00:00pages
297-302issue
4eissn
1320-5463issn
1440-1827journal_volume
45pub_type
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journal_title:Pathology international
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